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    Gss1 Glutathione synthetase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32775, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gss1provided by FlyBase
    Official Full Name
    Glutathione synthetase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030882
    Locus tag
    Dmel_CG6835
    See related
    AllianceGenome:FB:FBgn0030882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6835; CG32497; CG33065; CG6835; Dmel\CG6835; GS; gss; GSS
    Summary
    Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gss1 in Genome Data Viewer
    Location:
    16F1-16F1; 1-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17889547..17898603)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17783580..17792636)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Glutathione synthetase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of permissible maximum-contamination levels of VOC mixture in water on total DNA, antioxidant gene expression, and sequences of ribosomal DNA of Drosophila melanogaster. Doganlar O, et al. Environ Sci Pollut Res Int, 2015 Oct. PMID 26018283
    2. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Ortiz JG, et al. Toxicol Sci, 2009 Feb. PMID 18779381, Free PMC Article
    3. Developmental ethanol exposure causes central nervous system dysfunction and may slow the aging process in a Drosophila model of fetal alcohol spectrum disorder. Belhorma K, et al. Alcohol, 2021 Aug. PMID 33961967
    4. Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. Tsuda M, et al. FEBS Lett, 2010 Aug 4. PMID 20600005
    5. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. Kilwein MD, et al. PLoS Genet, 2023 Aug. PMID 37578970, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione synthetase 1
    Names
    CG6835-PE
    CG6835-PF
    CG6835-PG
    CG6835-PH
    CG6835-PI
    CG6835-PJ
    CG6835-PK
    Gss1-PE
    Gss1-PF
    Gss1-PG
    Gss1-PH
    Gss1-PI
    Gss1-PJ
    Gss1-PK
    glutathione synthase
    glutathione synthetase
    NP_001162782.1
    NP_001162783.1
    NP_001162784.1
    NP_001285394.1
    NP_573256.3
    NP_788925.2
    NP_788926.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17889547..17898603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176752.2 → NP_788925.2  glutathione synthetase 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788925.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP33, A3FP35, Q86B44, Q8IQZ0
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    2. NM_001169311.1 → NP_001162782.1  glutathione synthetase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP35, Q8IQZ1, Q8IQZ2
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    3. NM_133028.3 → NP_573256.3  glutathione synthetase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573256.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX03
      Conserved Domains (1) summary
      cl00170
      Location:20 → 124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. NM_176753.2 → NP_788926.2  glutathione synthetase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788926.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP33, A3FP35, Q86B44, Q8IQZ0
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    5. NM_001169313.1 → NP_001162784.1  glutathione synthetase 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP35, Q8IQZ1, Q8IQZ2
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    6. NM_001169312.1 → NP_001162783.1  glutathione synthetase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RL06
      Conserved Domains (1) summary
      cl00170
      Location:20 → 232
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    7. NM_001298465.1 → NP_001285394.1  glutathione synthetase 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCE7
      Conserved Domains (1) summary
      cl00170
      Location:20 → 124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RL06 Q1RL06
    Q86B44 Q86B44
    Q8IQZ1 Q8IQZ1
    Q9VX03 Q9VX03
    X2JCE7 X2JCE7

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