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Concise Results
Standard Results
Full Results
glutathione synthetase 1, isoform H [Drosophila melanogaster]
Protein Classification
glutathione synthetase ( domain architecture ID 11146104 )
glutathione synthetase catalyzes the ATP-dependent synthesis of glutathione from glycine and L-gamma-glutamyl-L-cysteine
List of domain hits
Name
Accession
Description
Interval
E-value
GSH_synth_ATP
pfam03917 Eukaryotic glutathione synthase, ATP binding domain;
20-552
0e+00
Eukaryotic glutathione synthase, ATP binding domain;
Pssm-ID: 461091
Cd Length: 465
Bit Score: 710.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 20 E DE L L E VTAK AKD Y A IM HG AA MR S K TAF S PDSLNF APF V L V PS S FPRK E FE K AVA L QP II N R L MHN VA H DEEF ITTT L A E 99
Cdd:pfam03917 1 E EQ L E E LVEN AKD W A LA HG LL MR P K EDP S GVLATH APF T L F PS P FPRK L FE Q AVA V QP AY N E L YAR VA Q DEEF LEEI L E E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 100 T IKVD E FTA N L FN IY R KV LAH G FT Q KT SLG ML RSD L ML ES gcpelspralrtaagedrgqdagaavgqiagangaagvgt 179
Cdd:pfam03917 81 V IKVD D FTA K L WE IY E KV KEE G IV Q PI SLG LF RSD Y ML HQ ---------------------------------------- 120
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 180 aagtgskeeehrevqlsrvtkeperratg AQSAYCCW KQVE I NTI A S G FG H L GPASKTIQ R FV LS E LG HADKLH ---- N M 255
Cdd:pfam03917 121 ----------------------------- DEGSSPSL KQVE F NTI S S S FG G L SSKVSELH R YL LS R LG AYPDSL ldde N L 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 256 P D NN A L A GL CD G MV KAW DI Y AK P Q AV I LF IIEDVSY NI C DQR FH E FYIR E TY p H I K V L RRTLTE VHR E G KL - GQSKE L LL 334
Cdd:pfam03917 172 P E NN S L S GL AE G LA KAW KA Y GS P K AV V LF VVQPGER NI F DQR HL E YELW E NH - G I R V I RRTLTE ILE E T KL d DPDRT L FV 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 335 GS QEV A V I YFRAGY E P GH Y H S QAD WDAR Y L M E T S L AIKCPSI HYH LAGTKKVQQ A LA Q P A VLERF IN D P EE IKAVGKI F T 414
Cdd:pfam03917 251 DG QEV S V V YFRAGY A P SD Y P S EKE WDAR L L L E R S R AIKCPSI LTQ LAGTKKVQQ V LA T P G VLERF LP D E EE AARLRET F A 330
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 415 GLY S LDD N E A G NASYEM AL RT PE RF VLKPQREGGGNN V YG V DIP DA LK RMSRV E R SA W ILM D LI H PP LT K G Y M VR P G gdm 494
Cdd:pfam03917 331 GLY P LDD S E E G LEAVKL AL EN PE KY VLKPQREGGGNN I YG E DIP EF LK SLPEE E W SA Y ILM E LI E PP PV K N Y L VR N G --- 407
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 281361040 495 PPQIVDMV SELGI F G VVIGDAEH I VH N Y QAGH M LRTK L S TA NEGGVAAG L G A LDSPYL 552
Cdd:pfam03917 408 EVVKGEVI SELGI Y G TILWGGDE I LE N E QAGH L LRTK G S SS NEGGVAAG F G V LDSPYL 465
Name
Accession
Description
Interval
E-value
GSH_synth_ATP
pfam03917 Eukaryotic glutathione synthase, ATP binding domain;
20-552
0e+00
Eukaryotic glutathione synthase, ATP binding domain;
Pssm-ID: 461091
Cd Length: 465
Bit Score: 710.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 20 E DE L L E VTAK AKD Y A IM HG AA MR S K TAF S PDSLNF APF V L V PS S FPRK E FE K AVA L QP II N R L MHN VA H DEEF ITTT L A E 99
Cdd:pfam03917 1 E EQ L E E LVEN AKD W A LA HG LL MR P K EDP S GVLATH APF T L F PS P FPRK L FE Q AVA V QP AY N E L YAR VA Q DEEF LEEI L E E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 100 T IKVD E FTA N L FN IY R KV LAH G FT Q KT SLG ML RSD L ML ES gcpelspralrtaagedrgqdagaavgqiagangaagvgt 179
Cdd:pfam03917 81 V IKVD D FTA K L WE IY E KV KEE G IV Q PI SLG LF RSD Y ML HQ ---------------------------------------- 120
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 180 aagtgskeeehrevqlsrvtkeperratg AQSAYCCW KQVE I NTI A S G FG H L GPASKTIQ R FV LS E LG HADKLH ---- N M 255
Cdd:pfam03917 121 ----------------------------- DEGSSPSL KQVE F NTI S S S FG G L SSKVSELH R YL LS R LG AYPDSL ldde N L 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 256 P D NN A L A GL CD G MV KAW DI Y AK P Q AV I LF IIEDVSY NI C DQR FH E FYIR E TY p H I K V L RRTLTE VHR E G KL - GQSKE L LL 334
Cdd:pfam03917 172 P E NN S L S GL AE G LA KAW KA Y GS P K AV V LF VVQPGER NI F DQR HL E YELW E NH - G I R V I RRTLTE ILE E T KL d DPDRT L FV 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 335 GS QEV A V I YFRAGY E P GH Y H S QAD WDAR Y L M E T S L AIKCPSI HYH LAGTKKVQQ A LA Q P A VLERF IN D P EE IKAVGKI F T 414
Cdd:pfam03917 251 DG QEV S V V YFRAGY A P SD Y P S EKE WDAR L L L E R S R AIKCPSI LTQ LAGTKKVQQ V LA T P G VLERF LP D E EE AARLRET F A 330
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 415 GLY S LDD N E A G NASYEM AL RT PE RF VLKPQREGGGNN V YG V DIP DA LK RMSRV E R SA W ILM D LI H PP LT K G Y M VR P G gdm 494
Cdd:pfam03917 331 GLY P LDD S E E G LEAVKL AL EN PE KY VLKPQREGGGNN I YG E DIP EF LK SLPEE E W SA Y ILM E LI E PP PV K N Y L VR N G --- 407
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 281361040 495 PPQIVDMV SELGI F G VVIGDAEH I VH N Y QAGH M LRTK L S TA NEGGVAAG L G A LDSPYL 552
Cdd:pfam03917 408 EVVKGEVI SELGI Y G TILWGGDE I LE N E QAGH L LRTK G S SS NEGGVAAG F G V LDSPYL 465
eu-GS
cd00228 Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from ...
15-553
8.41e-176
Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
Pssm-ID: 238140
Cd Length: 471
Bit Score: 504.98
E-value: 8.41e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 15 RL P LAE D E L L E VTAK A K D Y A IMH G AA MR S K T - AF S PDSLNF APF V L V PS S FP RKE FE K AV AL QP II N R L MHNVAH D EE F I 93
Cdd:cd00228 2 PI P DDK D Q L E E LAKD A N D W A VAN G LV MR D K S v QE S SVVASH APF T L L PS P FP EAL FE Q AV EV QP DF N E L VDRISQ D GK F L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 94 TTT L AE T I KVDEFT AN L FN I YR KVL AHGFT Q KTS LG ML RSD L M LE sgcpelspralrtaagedrgqdagaavgqiagang 173
Cdd:cd00228 82 QQS L SS T K KVDEFT SR L LD I HK KVL EENKK Q PVR LG IF RSD Y M FD ----------------------------------- 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 174 aagvgtaagtgske E EHREVQ L srvtkeperratgaqsayccw KQ V EINTI A S G FG H L GPASKTIQ R F VLS E LG HADK L - 252
Cdd:cd00228 127 -------------- E KDGTKG L --------------------- KQ I EINTI S S S FG G L SSRVTELH R Y VLS A LG YSKG L d 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 253 - HNM P D NNA LA G LCDGMV KAW DI Y AK P Q AV I LF IIEDVSY NI C DQRF H E FYIR E TY p H I K V L R R TL TE V HR EG K L GQSKE 331
Cdd:cd00228 172 s NRI P S NNA VK G IAEALA KAW EE Y GD P R AV V LF VVQNEER NI Y DQRF L E AELL E RH - Q I H V I R K TL AD V DE EG S L DDDGT 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 332 L LLGS QEVAV I YFRAGY E P GH Y H S QAD W D AR Y LME T S L AIKCPSI HYH LAGTKK V QQ A LA Q P A VLERF IND PEE IKAVGK 411
Cdd:cd00228 251 L FVDG QEVAV V YFRAGY T P DD Y P S ESE W E AR L LME R S S AIKCPSI STQ LAGTKK I QQ E LA E P G VLERF LPN PEE VAKLRA 330
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 412 I F T GLYSLDD N E A G NASYEM AL RT PE R FVLKPQREGGGNN V YG VDIPD AL KRMSRV E - R S A W ILM DL I H P PLTKG Y MV R P 490
Cdd:cd00228 331 T F A GLYSLDD T E E G DEIVRK AL EK PE L FVLKPQREGGGNN I YG EEMRE AL LKLQGS E e R A A Y ILM EK I F P EPSEN Y LL R A 410
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361040 491 GG dm P PQIVDMV SELGI F G VVIGDAEHI V H N Y Q A GH M LRTK LSTAN EGGVAAG LGA LDS P YL I 553
Cdd:cd00228 411 GG -- P SHKEQAI SELGI Y G TYLRNKDEV V M N K Q S GH L LRTK PISSA EGGVAAG FAV LDS I YL V 471
PLN02977
PLN02977 glutathione synthetase
17-553
3.97e-152
glutathione synthetase
Pssm-ID: 215528
Cd Length: 478
Bit Score: 444.88
E-value: 3.97e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 17 P LAED ELL EVTA - K A KDYAIM HG -- AAM RS KTAFSPDS --- L NF AP FV L V P SS FPR KE F EK A VA L Q P II N R L MHN V AH D E 90
Cdd:PLN02977 8 P GLTK ELL QDLV e E A LVWSSL HG lv VGD RS DQRSGTVP gvg L VH AP IS L L P TP FPR AA F KQ A CE L A P LF N E L VDR V SR D G 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 91 EF ITT TLA E T I KVDEFT AN L FN I YR K VLAHGFTQKTS LG ML RSD L ML ES gcpelspralrtaagedrgqdagaavgqiag 170
Cdd:PLN02977 88 EF LQE TLA R T R KVDEFT SR L LD I HE K MGERNKREDIR LG LH RSD Y ML DE ------------------------------- 136
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 171 angaagvgtaagtgskeeehrevqlsrvtkeperr A TG A qsaycc WK QVE I NTI A S G F GH L GPASKTIQ R FV LS EL G HAD 250
Cdd:PLN02977 137 ----------------------------------- P TG L ------ LL QVE L NTI S S S F PG L SSLVSQLH R SL LS RY G RVL 175
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 251 K L -- HNM P D N N AL AGLC D GMVK AW DIYAK P Q AV I L FIIEDVSY N IC DQR FHE F YIR E TYP h I KVL R R TL T E VHR EG K L GQ 328
Cdd:PLN02977 176 G L dp ERV P E N P AL EQFA D ALAA AW KEFGN P S AV V L MVVQPEER N MY DQR WLS F ALW E RHG - I RTI R K TL A E IAA EG S L DE 254
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 329 SKE L LLGS Q E VAV I YFRAGY E P GH Y H S Q A D W D AR Y L M E T S L A I KCPSI H YHLAGTKKVQQ A LA Q P A VLERF IN D P E E I KA 408
Cdd:PLN02977 255 DGT L TVDG Q P VAV V YFRAGY A P TD Y P S E A E W R AR L L L E R S S A V KCPSI A YHLAGTKKVQQ E LA K P G VLERF LD D K E D I AK 334
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 409 VG K I F T GL Y SLDD n EA GNASYEM A LRT PE R FVLKPQREGGGNN V YG V D IPDA L K R MSRV --- ERS A W ILM DL I H PP LTKG 485
Cdd:PLN02977 335 LR K C F A GL W SLDD - EA AAEIVKL A IEK PE L FVLKPQREGGGNN I YG D D LRET L E R LQKE gge DLA A Y ILM QR I F PP VSRT 413
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281361040 486 Y M VR p G G DM pp QIVDMV SELGI F G VVIGDAEHIVH N Y Q A G HM LRTK LSTAN EGGVAAG LGA LDSPYL I 553
Cdd:PLN02977 414 Y L VR - N G VC -- EEGETI SELGI Y G AYLRNGDKVII N E Q S G YL LRTK AASSD EGGVAAG FAV LDSPYL T 478
glut_syn_euk
TIGR01986 glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione ...
25-552
5.02e-147
glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione synthetase, which shows little resemblance to the analogous enzyme of Gram-negative bacteria (TIGR01380). In the Kinetoplastida, trypanothione replaces glutathione, but can be made from glutathione; a sequence from Leishmania is not included in the seed, is highly divergent, and therefore scores between the trusted and noise cutoffs.
Pssm-ID: 273912
Cd Length: 472
Bit Score: 431.56
E-value: 5.02e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 25 E VTAK A K D Y AI M HG AA M RSKT -- AFS P DSLNF AP FV L V PS SF PR KE F EK AV AL QP II N R L MHNVAH D EE F ITT TL AE T I K 102
Cdd:TIGR01986 3 E LIQE A N D W AI A HG VV M YPPS fe KEG P VNASV AP IT L F PS PI PR AC F DE AV QV QP VF N E L YARISQ D MA F LHK TL SS T A K 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 103 V DEFT AN L FNI Y R K V L -- A HGFT Q KTS LG ML RSD L M LES -- G CPE L spralrtaagedrgqdagaavgqiagangaagvg 178
Cdd:TIGR01986 83 S DEFT GK L WDL Y L K T L ks A QYKK Q NFR LG LF RSD Y M IDK kd G TEQ L ---------------------------------- 128
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 179 taagtgskeeehrevqlsrvtkeperratgaqsayccw KQVE I NTI ASG FG H L GPASKTIQRFV L SELGHAD K -- LH NM P 256
Cdd:TIGR01986 129 -------------------------------------- KQVE F NTI SVS FG G L SEKVSRLHSYL L RSNKYDP K gp IY NM V 170
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 257 D N NALA GL CD G MV KA WDI Y AK PQ ------- AVI LFI IEDVSY NI C DQR FH E FYIR E TY p H IK VL R R T LTE V HREGKLGQS 329
Cdd:TIGR01986 171 I N TSGY GL AK G IA KA VES Y KS PQ sssttsd PIV LFI VQRNER NI F DQR VL E LELL E RF - N IK SI R L T FAD V NDKLSIDDD 249
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 330 KEL L L --- GS QE V AV I Y F R A GY E P GH Y H SQ A DW D AR Y L M E T S L AIKCP S I HYH LAG T KK V QQ A LA Q P A VLERF IN D P E EI 406
Cdd:TIGR01986 250 TGK L F vrd TG QE I AV V Y Y R T GY T P TD Y P SQ K DW E AR L L L E K S F AIKCP D I ATQ LAG S KK I QQ E LA D P G VLERF LS D A E KK 329
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 407 KAVG K I F T GLY S LDD NEA G NASYEM AL RT P ER FVLKPQREGGGNNVYG V DIP DA LK RMSRV E RSAW ILM D LI H P PLTKGY 486
Cdd:TIGR01986 330 ASLR K T F A GLY P LDD TKL G REGIKL AL EK P SK FVLKPQREGGGNNVYG E DIP NF LK GLEEE E WDSY ILM E LI E P EPSENI 409
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281361040 487 MV R P G gdm PPQIVDMV SELGI F G VVIGDAEHI V H N Y Q A G HM LRTK LS T A NEGGVAAG LGA LDS P YL 552
Cdd:TIGR01986 410 IL R D G --- KSYKEQII SELGI Y G CYVRNDKTV V S N E Q S G SL LRTK FN T S NEGGVAAG FAV LDS I YL 472
Name
Accession
Description
Interval
E-value
GSH_synth_ATP
pfam03917 Eukaryotic glutathione synthase, ATP binding domain;
20-552
0e+00
Eukaryotic glutathione synthase, ATP binding domain;
Pssm-ID: 461091
Cd Length: 465
Bit Score: 710.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 20 E DE L L E VTAK AKD Y A IM HG AA MR S K TAF S PDSLNF APF V L V PS S FPRK E FE K AVA L QP II N R L MHN VA H DEEF ITTT L A E 99
Cdd:pfam03917 1 E EQ L E E LVEN AKD W A LA HG LL MR P K EDP S GVLATH APF T L F PS P FPRK L FE Q AVA V QP AY N E L YAR VA Q DEEF LEEI L E E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 100 T IKVD E FTA N L FN IY R KV LAH G FT Q KT SLG ML RSD L ML ES gcpelspralrtaagedrgqdagaavgqiagangaagvgt 179
Cdd:pfam03917 81 V IKVD D FTA K L WE IY E KV KEE G IV Q PI SLG LF RSD Y ML HQ ---------------------------------------- 120
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 180 aagtgskeeehrevqlsrvtkeperratg AQSAYCCW KQVE I NTI A S G FG H L GPASKTIQ R FV LS E LG HADKLH ---- N M 255
Cdd:pfam03917 121 ----------------------------- DEGSSPSL KQVE F NTI S S S FG G L SSKVSELH R YL LS R LG AYPDSL ldde N L 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 256 P D NN A L A GL CD G MV KAW DI Y AK P Q AV I LF IIEDVSY NI C DQR FH E FYIR E TY p H I K V L RRTLTE VHR E G KL - GQSKE L LL 334
Cdd:pfam03917 172 P E NN S L S GL AE G LA KAW KA Y GS P K AV V LF VVQPGER NI F DQR HL E YELW E NH - G I R V I RRTLTE ILE E T KL d DPDRT L FV 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 335 GS QEV A V I YFRAGY E P GH Y H S QAD WDAR Y L M E T S L AIKCPSI HYH LAGTKKVQQ A LA Q P A VLERF IN D P EE IKAVGKI F T 414
Cdd:pfam03917 251 DG QEV S V V YFRAGY A P SD Y P S EKE WDAR L L L E R S R AIKCPSI LTQ LAGTKKVQQ V LA T P G VLERF LP D E EE AARLRET F A 330
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 415 GLY S LDD N E A G NASYEM AL RT PE RF VLKPQREGGGNN V YG V DIP DA LK RMSRV E R SA W ILM D LI H PP LT K G Y M VR P G gdm 494
Cdd:pfam03917 331 GLY P LDD S E E G LEAVKL AL EN PE KY VLKPQREGGGNN I YG E DIP EF LK SLPEE E W SA Y ILM E LI E PP PV K N Y L VR N G --- 407
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 281361040 495 PPQIVDMV SELGI F G VVIGDAEH I VH N Y QAGH M LRTK L S TA NEGGVAAG L G A LDSPYL 552
Cdd:pfam03917 408 EVVKGEVI SELGI Y G TILWGGDE I LE N E QAGH L LRTK G S SS NEGGVAAG F G V LDSPYL 465
eu-GS
cd00228 Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from ...
15-553
8.41e-176
Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
Pssm-ID: 238140
Cd Length: 471
Bit Score: 504.98
E-value: 8.41e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 15 RL P LAE D E L L E VTAK A K D Y A IMH G AA MR S K T - AF S PDSLNF APF V L V PS S FP RKE FE K AV AL QP II N R L MHNVAH D EE F I 93
Cdd:cd00228 2 PI P DDK D Q L E E LAKD A N D W A VAN G LV MR D K S v QE S SVVASH APF T L L PS P FP EAL FE Q AV EV QP DF N E L VDRISQ D GK F L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 94 TTT L AE T I KVDEFT AN L FN I YR KVL AHGFT Q KTS LG ML RSD L M LE sgcpelspralrtaagedrgqdagaavgqiagang 173
Cdd:cd00228 82 QQS L SS T K KVDEFT SR L LD I HK KVL EENKK Q PVR LG IF RSD Y M FD ----------------------------------- 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 174 aagvgtaagtgske E EHREVQ L srvtkeperratgaqsayccw KQ V EINTI A S G FG H L GPASKTIQ R F VLS E LG HADK L - 252
Cdd:cd00228 127 -------------- E KDGTKG L --------------------- KQ I EINTI S S S FG G L SSRVTELH R Y VLS A LG YSKG L d 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 253 - HNM P D NNA LA G LCDGMV KAW DI Y AK P Q AV I LF IIEDVSY NI C DQRF H E FYIR E TY p H I K V L R R TL TE V HR EG K L GQSKE 331
Cdd:cd00228 172 s NRI P S NNA VK G IAEALA KAW EE Y GD P R AV V LF VVQNEER NI Y DQRF L E AELL E RH - Q I H V I R K TL AD V DE EG S L DDDGT 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 332 L LLGS QEVAV I YFRAGY E P GH Y H S QAD W D AR Y LME T S L AIKCPSI HYH LAGTKK V QQ A LA Q P A VLERF IND PEE IKAVGK 411
Cdd:cd00228 251 L FVDG QEVAV V YFRAGY T P DD Y P S ESE W E AR L LME R S S AIKCPSI STQ LAGTKK I QQ E LA E P G VLERF LPN PEE VAKLRA 330
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 412 I F T GLYSLDD N E A G NASYEM AL RT PE R FVLKPQREGGGNN V YG VDIPD AL KRMSRV E - R S A W ILM DL I H P PLTKG Y MV R P 490
Cdd:cd00228 331 T F A GLYSLDD T E E G DEIVRK AL EK PE L FVLKPQREGGGNN I YG EEMRE AL LKLQGS E e R A A Y ILM EK I F P EPSEN Y LL R A 410
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361040 491 GG dm P PQIVDMV SELGI F G VVIGDAEHI V H N Y Q A GH M LRTK LSTAN EGGVAAG LGA LDS P YL I 553
Cdd:cd00228 411 GG -- P SHKEQAI SELGI Y G TYLRNKDEV V M N K Q S GH L LRTK PISSA EGGVAAG FAV LDS I YL V 471
PLN02977
PLN02977 glutathione synthetase
17-553
3.97e-152
glutathione synthetase
Pssm-ID: 215528
Cd Length: 478
Bit Score: 444.88
E-value: 3.97e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 17 P LAED ELL EVTA - K A KDYAIM HG -- AAM RS KTAFSPDS --- L NF AP FV L V P SS FPR KE F EK A VA L Q P II N R L MHN V AH D E 90
Cdd:PLN02977 8 P GLTK ELL QDLV e E A LVWSSL HG lv VGD RS DQRSGTVP gvg L VH AP IS L L P TP FPR AA F KQ A CE L A P LF N E L VDR V SR D G 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 91 EF ITT TLA E T I KVDEFT AN L FN I YR K VLAHGFTQKTS LG ML RSD L ML ES gcpelspralrtaagedrgqdagaavgqiag 170
Cdd:PLN02977 88 EF LQE TLA R T R KVDEFT SR L LD I HE K MGERNKREDIR LG LH RSD Y ML DE ------------------------------- 136
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 171 angaagvgtaagtgskeeehrevqlsrvtkeperr A TG A qsaycc WK QVE I NTI A S G F GH L GPASKTIQ R FV LS EL G HAD 250
Cdd:PLN02977 137 ----------------------------------- P TG L ------ LL QVE L NTI S S S F PG L SSLVSQLH R SL LS RY G RVL 175
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 251 K L -- HNM P D N N AL AGLC D GMVK AW DIYAK P Q AV I L FIIEDVSY N IC DQR FHE F YIR E TYP h I KVL R R TL T E VHR EG K L GQ 328
Cdd:PLN02977 176 G L dp ERV P E N P AL EQFA D ALAA AW KEFGN P S AV V L MVVQPEER N MY DQR WLS F ALW E RHG - I RTI R K TL A E IAA EG S L DE 254
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 329 SKE L LLGS Q E VAV I YFRAGY E P GH Y H S Q A D W D AR Y L M E T S L A I KCPSI H YHLAGTKKVQQ A LA Q P A VLERF IN D P E E I KA 408
Cdd:PLN02977 255 DGT L TVDG Q P VAV V YFRAGY A P TD Y P S E A E W R AR L L L E R S S A V KCPSI A YHLAGTKKVQQ E LA K P G VLERF LD D K E D I AK 334
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 409 VG K I F T GL Y SLDD n EA GNASYEM A LRT PE R FVLKPQREGGGNN V YG V D IPDA L K R MSRV --- ERS A W ILM DL I H PP LTKG 485
Cdd:PLN02977 335 LR K C F A GL W SLDD - EA AAEIVKL A IEK PE L FVLKPQREGGGNN I YG D D LRET L E R LQKE gge DLA A Y ILM QR I F PP VSRT 413
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281361040 486 Y M VR p G G DM pp QIVDMV SELGI F G VVIGDAEHIVH N Y Q A G HM LRTK LSTAN EGGVAAG LGA LDSPYL I 553
Cdd:PLN02977 414 Y L VR - N G VC -- EEGETI SELGI Y G AYLRNGDKVII N E Q S G YL LRTK AASSD EGGVAAG FAV LDSPYL T 478
glut_syn_euk
TIGR01986 glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione ...
25-552
5.02e-147
glutathione synthetase, eukaryotic; This model represents the eukaryotic glutathione synthetase, which shows little resemblance to the analogous enzyme of Gram-negative bacteria (TIGR01380). In the Kinetoplastida, trypanothione replaces glutathione, but can be made from glutathione; a sequence from Leishmania is not included in the seed, is highly divergent, and therefore scores between the trusted and noise cutoffs.
Pssm-ID: 273912
Cd Length: 472
Bit Score: 431.56
E-value: 5.02e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 25 E VTAK A K D Y AI M HG AA M RSKT -- AFS P DSLNF AP FV L V PS SF PR KE F EK AV AL QP II N R L MHNVAH D EE F ITT TL AE T I K 102
Cdd:TIGR01986 3 E LIQE A N D W AI A HG VV M YPPS fe KEG P VNASV AP IT L F PS PI PR AC F DE AV QV QP VF N E L YARISQ D MA F LHK TL SS T A K 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 103 V DEFT AN L FNI Y R K V L -- A HGFT Q KTS LG ML RSD L M LES -- G CPE L spralrtaagedrgqdagaavgqiagangaagvg 178
Cdd:TIGR01986 83 S DEFT GK L WDL Y L K T L ks A QYKK Q NFR LG LF RSD Y M IDK kd G TEQ L ---------------------------------- 128
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 179 taagtgskeeehrevqlsrvtkeperratgaqsayccw KQVE I NTI ASG FG H L GPASKTIQRFV L SELGHAD K -- LH NM P 256
Cdd:TIGR01986 129 -------------------------------------- KQVE F NTI SVS FG G L SEKVSRLHSYL L RSNKYDP K gp IY NM V 170
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 257 D N NALA GL CD G MV KA WDI Y AK PQ ------- AVI LFI IEDVSY NI C DQR FH E FYIR E TY p H IK VL R R T LTE V HREGKLGQS 329
Cdd:TIGR01986 171 I N TSGY GL AK G IA KA VES Y KS PQ sssttsd PIV LFI VQRNER NI F DQR VL E LELL E RF - N IK SI R L T FAD V NDKLSIDDD 249
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 330 KEL L L --- GS QE V AV I Y F R A GY E P GH Y H SQ A DW D AR Y L M E T S L AIKCP S I HYH LAG T KK V QQ A LA Q P A VLERF IN D P E EI 406
Cdd:TIGR01986 250 TGK L F vrd TG QE I AV V Y Y R T GY T P TD Y P SQ K DW E AR L L L E K S F AIKCP D I ATQ LAG S KK I QQ E LA D P G VLERF LS D A E KK 329
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 407 KAVG K I F T GLY S LDD NEA G NASYEM AL RT P ER FVLKPQREGGGNNVYG V DIP DA LK RMSRV E RSAW ILM D LI H P PLTKGY 486
Cdd:TIGR01986 330 ASLR K T F A GLY P LDD TKL G REGIKL AL EK P SK FVLKPQREGGGNNVYG E DIP NF LK GLEEE E WDSY ILM E LI E P EPSENI 409
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281361040 487 MV R P G gdm PPQIVDMV SELGI F G VVIGDAEHI V H N Y Q A G HM LRTK LS T A NEGGVAAG LGA LDS P YL 552
Cdd:TIGR01986 410 IL R D G --- KSYKEQII SELGI Y G CYVRNDKTV V S N E Q S G SL LRTK FN T S NEGGVAAG FAV LDS I YL 472
GSH_synthase
pfam03199 Eukaryotic glutathione synthase;
280-381
3.05e-51
Eukaryotic glutathione synthase;
Pssm-ID: 460845 [Multi-domain]
Cd Length: 102
Bit Score: 170.73
E-value: 3.05e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 280 AV I LF IIEDVSY N IC DQR FH E FYIR E TYP h I K V L RRTLTE VHREGK LG QSKE LL L - G SQ EVAV I YFRAGY E P GH Y H S QAD 358
Cdd:pfam03199 1 AV V LF VVQPNER N VF DQR LL E YELL E RHG - I R V I RRTLTE LLEQTT LG PDRR LL Y d G PF EVAV V YFRAGY S P DD Y P S EKE 79
90 100
....*....|....*....|...
gi 281361040 359 W D AR Y L M E T S L AIKCPSI HYH LA 381
Cdd:pfam03199 80 W E AR L L L E R S R AIKCPSI LTQ LA 102
PTZ00055
PTZ00055 glutathione synthetase; Provisional
52-552
3.08e-46
glutathione synthetase; Provisional
Pssm-ID: 240247
Cd Length: 619
Bit Score: 171.89
E-value: 3.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 52 L NFAP FVL V P SS FPRK EF E KAVALQPIINR L MH N VAH D E E FITTTLAETI K V D E F TAN L FN I YRK V LAH G FTQ ----- KT 126
Cdd:PTZ00055 75 L KMVS FVL F P LP FPRK LL E DCCLCTLLLVE L FD N MSC D L E LLLDVFEQLK K Y D K F VRD L LE I CNE V YGS G ERN ikddi RC 154
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 127 SL G ml RSD LMLESG cpelspral RTAAGEDR G QD agaavgqia GANGAAGVGTAAGTG S KEEEHR E V qlsrvtkeperra 206
Cdd:PTZ00055 155 YI G -- RSD YFIHID --------- NLTKNKTQ G EN --------- EFCKTCYYDHCLCNI S ANNQSL E F ------------- 201
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 207 tgaqsayccw K Q VE I NTI ASG FG H L GP ---- A S K TIQ R F V LS E LGHADK ----------- L HNMPD N NALA G LCDGMV K A 271
Cdd:PTZ00055 202 ---------- K L VE Y NTI SVA FG N L SG llfr A H K KLL R T V YR E CFDLEG kgaerpmvgsi L LEKFK N HFYN G IVTCFK K C 271
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 272 WDI Y A --- KP ---- QA V ILFI I -- ED VS ----- Y NICDQR F HEFY I RETYPH I KV L ----- RRT L ----- T E VHRE G --- 324
Cdd:PTZ00055 272 HRM Y L dey KP lfgk NK V CVMS I vh ED LF nffdk Y KTANEL F DKYG I HVKTLT I NE L illye KKK L flnyp W E TLED G lvr 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 325 --------- KL GQSKE L L - L G SQ ------------- EV A V I YFR AG Y E P G H YH S QAD - W DA R YLM E T S L A I K C PS IHYH L 380
Cdd:PTZ00055 352 vkkyqddlh KL HPGRL L I d L N SQ englnrlykrdcf EV S V V YFR SL Y S P D H ME S DER i W LV R EFL E F S D A V K I PS LPAQ L 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 381 A G T K KV Q QA L AQ P AV L E R FI ------- NDPEE I KAVG K IFTGLYS L DDNEAGNASYEM --- A LRT P ERFV LKPQREGG G N 450
Cdd:PTZ00055 432 V G S K RI Q MY L LD P SI L K R LV slynkrk KSDKQ I NHDM K LLKKTFA L QVDPSLESNEHI vqd A IQN P SNYL LKPQREGG K N 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361040 451 N VY G VD I PDA L K --- RMSRVER S AWI LM DL I H PP LTKGYM VR -- PG G DMPPQIVDMVS ELG IFGVV I G D AEHIVH N Y Q A G 525
Cdd:PTZ00055 512 N LH G NE I SEK L R lgy KNNKEKL S QYV LM QK I F PP SQPAVF VR nl KS G SFEFSPENSLT ELG LYHNF I F D GNECIL N E Q K G 591
570 580
....*....|....*....|....*..
gi 281361040 526 HML RTK LSTANE GG VAA G LGALD S PY L 552
Cdd:PTZ00055 592 YLA RTK NEFETG GG AIS G ISSVN S LL L 618
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
