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    CCMH cytochrome c biogenesis protein family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CCMH
    Official Full Name
    cytochrome c biogenesis protein family
    Primary source
    TAIR:AT1G15220
    Locus tag
    AT1G15220
    See related
    Araport:AT1G15220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCCMH; F9L1.17; F9L1_17
    Summary
    Encodes a protein with oxidoreductase activity present in the inner membrane of mitochondria. CCMH is postulated to play a central role in mitochondrial cytochrome c maturation, probably as part of a heme lyase complex that also holds activity of reducing apocytochrome c. CCMH interacts with apocytochrome AtCYTc-a and is shown to be present in a 500 kDa-complex along with CcmFN2.
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    Genomic context

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    See CCMH in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (5240029..5241541, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene protein-protein interaction regulator family protein Neighboring gene pleiotropic drug resistance 7 Neighboring gene SAWADEE HOMEODOMAIN protein Neighboring gene uncharacterized protein Neighboring gene phox (PX) domain-containing protein Neighboring gene Zinc-binding ribosomal protein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The three mitochondrial encoded CcmF proteins form a complex that interacts with CCMH and c-type apocytochromes in Arabidopsis. Rayapuram N, et al. J Biol Chem, 2008 Sep 12. PMID 18644794
    2. AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c. Meyer EH, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16236729, Free PMC Article
    3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CcmF and CCMH make a complex that performs the assembly of heme with c-type apocytochromes in plant mitochondria
      Title: The three mitochondrial encoded CcmF proteins form a complex that interacts with CCMH and c-type apocytochromes in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_101390.2
    NM_202105.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c biogenesis protein family
    NP_563966.1
    • CCMH; CONTAINS InterPro DOMAIN/s: Cytochrome C biogenesis protein CcmH (InterPro:IPR005616); Has 3193 Blast hits to 3193 proteins in 721 species: Archae - 0; Bacteria - 1884; Metazoa - 0; Fungi - 0; Plants - 31; Viruses - 0; Other Eukaryotes - 1278 (source: NCBI BLink).
    NP_973834.1
    • CCMH; CONTAINS InterPro DOMAIN/s: Cytochrome C biogenesis protein CcmH (InterPro:IPR005616); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5240029..5241541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202105.2 → NP_973834.1  cytochrome c biogenesis protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XI46
      UniProtKB/TrEMBL
      A0A178W6T6, A0A5S9UKR3
      Conserved Domains (1) summary
      pfam03918
      Location:14 → 132
      CcmH; Cytochrome C biogenesis protein

    2. NM_101390.2 → NP_563966.1  cytochrome c biogenesis protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XI46
      UniProtKB/TrEMBL
      A0A178W6T6, A0A5S9UKR3
      Conserved Domains (1) summary
      pfam03918
      Location:14 → 132
      CcmH; Cytochrome C biogenesis protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XI46.1

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