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    FAS2 Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836584, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAS2
    Official Full Name
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    TAIR:AT5G64630
    Locus tag
    AT5G64630
    See related
    Araport:AT5G64630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FASCIATA 2; MUB3.15; MUB3.9; MUB3_15; NFB01; NFB1
    Summary
    Chromatin Assembly Factor-1 (CAF-1) p60 subunit. Involved in organization of the shoot and root apical meristems. In Arabidopsis, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. Mutations in FAS1 or FAS2 lead to increased frequency of homologous recombination and T-DNA integration in Arabidopsis.
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    Genomic context

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    See FAS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (25833165..25836400)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene O-fucosyltransferase family protein Neighboring gene histone acetyltransferase of the MYST family 1 Neighboring gene cell wall / vacuolar inhibitor of fructosidase 2 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene Ribosomal protein L17 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana. Mozgová I, et al. Plant Cell, 2010 Aug. PMID 20699390, Free PMC Article
    2. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. Endo M, et al. EMBO J, 2006 Nov 29. PMID 17110925, Free PMC Article
    3. Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis. Ono T, et al. Genes Cells, 2006 Feb. PMID 16436052
    4. FASCIATA genes for chromatin assembly factor-1 in arabidopsis maintain the cellular organization of apical meristems. Kaya H, et al. Cell, 2001 Jan 12. PMID 11163246
    5. A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana. Jaške K, et al. Chromosoma, 2013 Aug. PMID 23564254

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Telomere shortening is more rapid in fas tert double mutants than in fas1, fas2 or tert single mutant plants.
      Title: A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana.
    2. Mutations in the FAS1 and FAS2 cause a progressive reduction of telomeric and 45S rDNA repeats.
      Title: Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana.
    3. These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development.
      Title: Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development.
    4. We conclude that CAF-1 ensures the stable inheritance of epigenetic states through growth and development in Arabidopsis.
      Title: Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis.
    5. results suggest that chromatin assembly factor CAF-1 functions in heterochromatin formation
      Title: Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana.
    6. Depletion of FAS2 increased the frequency of somatic homologous recombination (HR) in planta approximately 40-fold.
      Title: Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.
    Submit: New GeneRIF Correction

    General gene information

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    NM_125859.4
    NM_203262.3
    NM_203263.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_568990.1
    • FASCIATA 2 (FAS2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: homolog of histone chaperone HIRA (TAIR:AT3G44530.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974991.1
    • FASCIATA 2 (FAS2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: homolog of histone chaperone HIRA (TAIR:AT3G44530.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974992.1
    • FASCIATA 2 (FAS2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: homolog of histone chaperone HIRA (TAIR:AT3G44530.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25833165..25836400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125859.4 → NP_568990.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SXY1
      Conserved Domains (3) summary
      COG2319
      Location:6 → 198
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:16 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:14 → 363
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_203262.3 → NP_974991.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94JQ9, Q9SXY1
      UniProtKB/TrEMBL
      A0A178UH28, A0A5S9YHR6, A0A654GE63
      Conserved Domains (2) summary
      sd00039
      Location:16 → 62
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:14 → 363
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_203263.2 → NP_974992.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KF21
      Conserved Domains (3) summary
      COG2319
      Location:19 → 315
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:56 → 92
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:18 → 304
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SXY1.1

    Gene LinkOut

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