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Conserved domains on  [gi|42573792|ref|NP_974992|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-304 7.03e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 7.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  18 ELLASGADGGELFIWKLHPSEtnqswkVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHY 97
Cdd:cd00200  22 KLLATGSGDGTIKVWDLETGE------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  98 VQGVAWDPLAKYVASLSSDRTCRIY---ANKPQTKSKGVEKmnYVCqHVIMKADQQ--------------RGDETKTIKT 160
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRGHTD--WVN-SVAFSPDGTfvasssqdgtiklwDLRTGKCVAT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 161 HLFHDetlpSFFRRLSWSPDGSFLLIPA--GSFKVSptseavnatyvfsrkDLSRPAL--QLPGASKPVVVVRFCPVAfk 236
Cdd:cd00200 173 LTGHT----GEVNSVAFSPDGEKLLSSSsdGTIKLW---------------DLSTGKClgTLRGHENGVNSVAFSPDG-- 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573792 237 lrgssseegffklpyRLVFAIATLNSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:cd00200 232 ---------------YLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADG 283
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-304 7.03e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 7.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  18 ELLASGADGGELFIWKLHPSEtnqswkVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHY 97
Cdd:cd00200  22 KLLATGSGDGTIKVWDLETGE------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  98 VQGVAWDPLAKYVASLSSDRTCRIY---ANKPQTKSKGVEKmnYVCqHVIMKADQQ--------------RGDETKTIKT 160
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRGHTD--WVN-SVAFSPDGTfvasssqdgtiklwDLRTGKCVAT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 161 HLFHDetlpSFFRRLSWSPDGSFLLIPA--GSFKVSptseavnatyvfsrkDLSRPAL--QLPGASKPVVVVRFCPVAfk 236
Cdd:cd00200 173 LTGHT----GEVNSVAFSPDGEKLLSSSsdGTIKLW---------------DLSTGKClgTLRGHENGVNSVAFSPDG-- 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573792 237 lrgssseegffklpyRLVFAIATLNSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:cd00200 232 ---------------YLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
19-304 6.53e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 6.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  19 LLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYV 98
Cdd:COG2319 176 LLASGSDDGTVRLWDL------ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  99 QGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSWS 178
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLW-------------------------DLATGELLRTLTGH-------SGGVNSVAFS 297

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 179 PDGSFLLipagsfkvspTSEAVNATYVFSRKDlSRPALQLPGASKPVVVVRFCP----VAfklrgSSSEEGffklpyrlv 254
Cdd:COG2319 298 PDGKLLA----------SGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPdgktLA-----SGSDDG--------- 352

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42573792 255 faiatlnSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:COG2319 353 -------TVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-81 1.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42573792     42 SWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWD 81
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
43-81 2.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42573792    43 WKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWD 81
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 15-90 4.28e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792   15 CIRELLASGADGGELFIWKL-HPSETNQSWKVHKS-LSFHRKDVLDLQWSPDDAYLI-SGSVDNSCIIWDV-NKGSVHQI 90
Cdd:PTZ00420  85 CFSEILASGSEDLTIRVWEIpHNDESVKEIKDPQCiLKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIeNEKRAFQI 164
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-304 7.03e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 7.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  18 ELLASGADGGELFIWKLHPSEtnqswkVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHY 97
Cdd:cd00200  22 KLLATGSGDGTIKVWDLETGE------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  98 VQGVAWDPLAKYVASLSSDRTCRIY---ANKPQTKSKGVEKmnYVCqHVIMKADQQ--------------RGDETKTIKT 160
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRGHTD--WVN-SVAFSPDGTfvasssqdgtiklwDLRTGKCVAT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 161 HLFHDetlpSFFRRLSWSPDGSFLLIPA--GSFKVSptseavnatyvfsrkDLSRPAL--QLPGASKPVVVVRFCPVAfk 236
Cdd:cd00200 173 LTGHT----GEVNSVAFSPDGEKLLSSSsdGTIKLW---------------DLSTGKClgTLRGHENGVNSVAFSPDG-- 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573792 237 lrgssseegffklpyRLVFAIATLNSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:cd00200 232 ---------------YLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
19-304 6.53e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 6.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  19 LLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYV 98
Cdd:COG2319 176 LLASGSDDGTVRLWDL------ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  99 QGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSWS 178
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLW-------------------------DLATGELLRTLTGH-------SGGVNSVAFS 297

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 179 PDGSFLLipagsfkvspTSEAVNATYVFSRKDlSRPALQLPGASKPVVVVRFCP----VAfklrgSSSEEGffklpyrlv 254
Cdd:COG2319 298 PDGKLLA----------SGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPdgktLA-----SGSDDG--------- 352

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42573792 255 faiatlnSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:COG2319 353 -------TVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
19-304 1.98e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  19 LLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYV 98
Cdd:COG2319  92 LLASASADGTVRLWDL------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  99 QGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSWS 178
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLW-------------------------DLATGKLLRTLTGH-------TGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 179 PDGSFLLipAGSFKvsptseavNATYVFSRKDlSRPALQLPGASKPVVVVRFCP----VAfklrgSSSEEGffklpyrlv 254
Cdd:COG2319 214 PDGKLLA--SGSAD--------GTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPdgrlLA-----SGSADG--------- 268

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42573792 255 faiatlnSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:COG2319 269 -------TVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDG 310
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-316 2.42e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 2.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  46 HKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYVQGVAWDPLAKYVASLSSDRTCRIYank 125
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 126 pqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHLfhdetlpSFFRRLSWSPDGSFLL--IPAGSFKV--SPTSEAVN 201
Cdd:cd00200  79 ----------------------DLETGECVRTLTGHT-------SYVSSVAFSPDGRILSssSRDKTIKVwdVETGKCLT 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 202 AtyvfsrkdlsrpalqLPGASKPVVVVRFCPVAfklrgssseegffklpyRLVFAIATLNSVYIYDTECVAPIAVLAGlH 281
Cdd:cd00200 130 T---------------LRGHTDWVNSVAFSPDG-----------------TFVASSSQDGTIKLWDLRTGKCVATLTG-H 176

                       250       260       270
                ....*....|....*....|....*....|....*
gi 42573792 282 YAAITDITWSPNASYLALSSQDGYCTLVEFEDKEL 316
Cdd:cd00200 177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-123 4.15e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 4.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  17 RELLASGADGgELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCH 96
Cdd:cd00200 190 EKLLSSSSDG-TIKLWDL------STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN 262

                        90       100
                ....*....|....*....|....*..
gi 42573792  97 YVQGVAWDPLAKYVASLSSDRTCRIYA 123
Cdd:cd00200 263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-185 6.78e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 6.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  18 ELLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHY 97
Cdd:COG2319 259 RLLASGSADGTVRLWDL------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  98 VQGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSW 177
Cdd:COG2319 333 VRSVAFSPDGKTLASGSDDGTVRLW-------------------------DLATGELLRTLTGH-------TGAVTSVAF 380


                ....*...
gi 42573792 178 SPDGSFLL 185
Cdd:COG2319 381 SPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
19-304 1.14e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.14e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  19 LLASGADGGELFIWklhpseTNQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYV 98
Cdd:COG2319  50 RLAAGAGDLTLLLL------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  99 QGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSWS 178
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLW-------------------------DLATGKLLRTLTGH-------SGAVTSVAFS 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 179 PDGSFLLipagsfkvspTSEAVNATYVFSRKDlSRPALQLPGASKPVVVVRFCP----VAfklrgSSSEEGffklpyrlv 254
Cdd:COG2319 172 PDGKLLA----------SGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPdgklLA-----SGSADG--------- 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42573792 255 faiatlnSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:COG2319 227 -------TVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
18-122 1.22e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 1.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  18 ELLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHY 97
Cdd:COG2319 301 KLLASGSDDGTVRLWDL------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        90       100
                ....*....|....*....|....*
gi 42573792  98 VQGVAWDPLAKYVASLSSDRTCRIY 122
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
19-304 1.04e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  19 LLASGADGGELFIWKLHPSETNQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYV 98
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792  99 QGVAWDPLAKYVASLSSDRTCRIYankpqtkskgvekmnyvcqhvimkaDQQRGDETKTIKTHlfhdetlPSFFRRLSWS 178
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLW-------------------------DLATGLLLRTLTGH-------TGAVRSVAFS 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792 179 PDGSFLLipAGSFKvsptseavNATYVFSRKDlSRPALQLPGASKPVVVVRFCP----VAfklrgSSSEEGffklpyrlv 254
Cdd:COG2319 130 PDGKTLA--SGSAD--------GTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPdgklLA-----SGSDDG--------- 184

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42573792 255 faiatlnSVYIYDTECVAPIAVLAGlHYAAITDITWSPNASYLALSSQDG 304
Cdd:COG2319 185 -------TVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADG 226
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-81 1.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42573792     42 SWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWD 81
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
43-81 2.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42573792    43 WKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWD 81
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
18-83 5.01e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 5.01e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42573792  18 ELLASGADGGELFIWKLhpsetnQSWKVHKSLSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVN 83
Cdd:COG2319 343 KTLASGSDDGTVRLWDL------ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-122 4.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 42573792     84 KGSVHQILDAHCHYVQGVAWDPLAKYVASLSSDRTCRIY 122
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 15-90 4.28e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792   15 CIRELLASGADGGELFIWKL-HPSETNQSWKVHKS-LSFHRKDVLDLQWSPDDAYLI-SGSVDNSCIIWDV-NKGSVHQI 90
Cdd:PTZ00420  85 CFSEILASGSEDLTIRVWEIpHNDESVKEIKDPQCiLKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIeNEKRAFQI 164
PTZ00421 PTZ00421
coronin; Provisional
 20-121 5.60e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573792   20 LASGADGGELFIWKLhPSETNQSWK----VHksLSFHRKDVLDLQWSPDDA-YLISGSVDNSCIIWDVNKGSVHQILDAH 94
Cdd:PTZ00421  91 LFTASEDGTIMGWGI-PEEGLTQNIsdpiVH--LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100
                 ....*....|....*....|....*..
gi 42573792   95 CHYVQGVAWDPLAKYVASLSSDRTCRI 121
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-308 6.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 42573792    273 PIAVLAGlHYAAITDITWSPNASYLALSSQDGYCTL 308
Cdd:smart00320   4 LLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
85-122 7.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 42573792    85 GSVHQILDAHCHYVQGVAWDPLAKYVASLSSDRTCRIY 122
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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