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    Asb18 ankyrin repeat and SOCS box-containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 208372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb18provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 18provided by MGI
    Primary source
    MGI:MGI:2655109
    See related
    Ensembl:ENSMUSG00000067081 AllianceGenome:MGI:2655109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-18
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB18 (ankyrin repeat and SOCS box containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 5.5), heart adult (RPKM 2.9) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Asb18 in Genome Data Viewer
    Location:
    1 D; 1 45.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89880313..89942388, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89952591..90014666, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene STARR-seq mESC enhancer starr_01667 Neighboring gene STARR-seq mESC enhancer starr_01669 Neighboring gene STARR-seq mESC enhancer starr_01670 Neighboring gene uncharacterized LOC102637806 Neighboring gene STARR-seq mESC enhancer starr_01674 Neighboring gene gastrulation brain homeobox 2 Neighboring gene predicted gene, 41915 Neighboring gene predicted gene, 34616 Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene RIKEN cDNA 4930434B07 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 18
    Names
    SOCS box protein ASB-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355134.1 → NP_001342063.1  ankyrin repeat and SOCS box protein 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC145621
      UniProtKB/TrEMBL
      A0A571BD84, B7ZP43
      Conserved Domains (4) summary
      cd00204
      Location:81 → 196
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03723
      Location:379 → 426
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      sd00045
      Location:81 → 108
      ANK; ANK repeat [structural motif]
      cl26072
      Location:242 → 325
      Ank_5; Ankyrin repeats (many copies)

    2. NM_139152.2 → NP_631891.1  ankyrin repeat and SOCS box protein 18 isoform 1

      See identical proteins and their annotated locations for NP_631891.1

      Status: VALIDATED

      Source sequence(s)
      AY057054, BC145621
      Consensus CDS
      CCDS15151.1
      UniProtKB/Swiss-Prot
      Q3B7Y5, Q3KNB0, Q8VHA6
      UniProtKB/TrEMBL
      A0A571BD84
      Related
      ENSMUSP00000084095.2, ENSMUST00000086882.8
      Conserved Domains (5) summary
      cd00204
      Location:122 → 237
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03723
      Location:420 → 467
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      pfam12796
      Location:124 → 214
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:283 → 334
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:122 → 149
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_149309.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC107370, BC145621
      Related
      ENSMUST00000154228.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      89880313..89942388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247953.4 → XP_011246255.1  ankyrin repeat and SOCS box protein 18 isoform X2

      Conserved Domains (3) summary
      PTZ00322
      Location:254 → 337
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:93 → 120
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:127 → 220
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_011247952.3 → XP_011246254.1  ankyrin repeat and SOCS box protein 18 isoform X1

      Conserved Domains (3) summary
      PTZ00322
      Location:254 → 337
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:93 → 120
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:127 → 220
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHA6.1 GenPept UniProtKB/Swiss-Prot:Q8VHA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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