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Conserved domains on  [gi|21040227|ref|NP_631891|]
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ankyrin repeat and SOCS box protein 18 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
122-254 4.19e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 4.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 122 TPLCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGC 200
Cdd:COG0666 122 TPLHLAAYNGNLEIVKLLLEAGADVNAqDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21040227 201 ARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGET 254
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGK-TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 420-467 1.49e-23

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239693  Cd Length: 48  Bit Score: 92.89  E-value: 1.49e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21040227 420 HTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC 467
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PTZ00322 super family cl31426
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 283-366 2.10e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


The actual alignment was detected with superfamily member PTZ00322:

Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  283 GGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATcapptapQRTVQVLLNH------ 356
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF-------REVVQLLSRHsqchfe 176

                         90
                 ....*....|.
gi 21040227  357 -GSRSVwPDAF 366
Cdd:PTZ00322 177 lGANAK-PDSF 186
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
122-254 4.19e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 4.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 122 TPLCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGC 200
Cdd:COG0666 122 TPLHLAAYNGNLEIVKLLLEAGADVNAqDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21040227 201 ARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGET 254
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGK-TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 420-467 1.49e-23

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 92.89  E-value: 1.49e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21040227 420 HTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC 467
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
Ank_2 pfam12796
Ankyrin repeats (3 copies);
124-209 6.64e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 6.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   124 LCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHgADPDlLNSEGLAPLHLCrtpASLG--- 199
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYA---ARSGhle 75

                          90
                  ....*....|
gi 21040227   200 CARELLEHGA 209
Cdd:pfam12796  76 IVKLLLEKGA 85
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 421-459 2.77e-13

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 63.72  E-value: 2.77e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21040227   421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLL 459
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 423-461 1.06e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 53.57  E-value: 1.06e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21040227    423 RCLQHLCRCTIRKLFGKesvhlVPQLPLPETLQNYLLLE 461
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 120-191 1.36e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.36e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21040227  120 LTTPLCIAAAHGHESCVRHLLSRKADPNASP-GGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHL 191
Cdd:PTZ00322  82 LTVELCQLAASGDAVGARILLTGGADPNCRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 283-366 2.10e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  283 GGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATcapptapQRTVQVLLNH------ 356
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF-------REVVQLLSRHsqchfe 176

                         90
                 ....*....|.
gi 21040227  357 -GSRSVwPDAF 366
Cdd:PTZ00322 177 lGANAK-PDSF 186
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 116-230 8.75e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 8.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 116 YQREltTPLCIAAAHGHESCVRHLLSRKAD---PNA-----SPGGRGALH--------EACLGNHtACARLLLQHGADPD 179
Cdd:cd22192  87 YQGE--TALHIAVVNQNLNLVRELIARGADvvsPRAtgtffRPGPKNLIYygehplsfAACVGNE-EIVRLLIEHGADIR 163

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 180 LLNSEGLAPLHLCRTPASLGCARELLE-------HGATVQLEGGPGRD--TPLHVAAQRG 230
Cdd:cd22192 164 AQDSLGNTVLHILVLQPNKTFACQMYDlilsydkEDDLQPLDLVPNNQglTPFKLAAKEG 223
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 122-148 5.29e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.29e-05
                           10        20
                   ....*....|....*....|....*..
gi 21040227    122 TPLCIAAAHGHESCVRHLLSRKADPNA 148
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 122-239 4.49e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.68  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   122 TPLCIAAAHGHESCVRHLLSRKADPNA---------SPGGRGALHE-------ACLGNhTACARLLLQHGADPDLLNSEG 185
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPAracgdffvkSQGVDSFYHGesplnaaACLGS-PSIVALLSEDPADILTADSLG 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21040227   186 LAPLHLC---------RTPASLGCARELLEHGA----TVQLEGGPGRD--TPLHVAAQRGLDEHAQLYL 239
Cdd:TIGR00870 209 NTLLHLLvmenefkaeYEELSCQMYNFALSLLDklrdSKELEVILNHQglTPLKLAAKEGRIVLFRLKL 277
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
122-254 4.19e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 4.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 122 TPLCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGC 200
Cdd:COG0666 122 TPLHLAAYNGNLEIVKLLLEAGADVNAqDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21040227 201 ARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGET 254
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGK-TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
120-336 5.39e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.27  E-value: 5.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 120 LTTPLCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASL 198
Cdd:COG0666  54 GALLLLAAALAGDLLVALLLLAAGADINAkDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 199 GCARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETalsaacgaaarspdeharclrlca 278
Cdd:COG0666 134 EIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGET------------------------ 188

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21040227 279 lllrggaaadardedersPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQ 336
Cdd:COG0666 189 ------------------PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 420-467 1.49e-23

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 92.89  E-value: 1.49e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21040227 420 HTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC 467
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
121-254 3.97e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.09  E-value: 3.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 121 TTPLCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLG 199
Cdd:COG0666 154 NTPLHLAAANGNLEIVKLLLEAGADVNArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21040227 200 CARELLEHGATVQLEGGPGrDTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGET 254
Cdd:COG0666 234 IVKLLLEAGADLNAKDKDG-LTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 420-461 6.27e-16

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 71.37  E-value: 6.27e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 21040227 420 HTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLE 461
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 421-461 2.99e-15

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 69.42  E-value: 2.99e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 21040227 421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLE 461
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
124-209 6.64e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 6.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   124 LCIAAAHGHESCVRHLLSRKADPNA-SPGGRGALHEACLGNHTACARLLLQHgADPDlLNSEGLAPLHLCrtpASLG--- 199
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYA---ARSGhle 75

                          90
                  ....*....|
gi 21040227   200 CARELLEHGA 209
Cdd:pfam12796  76 IVKLLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
156-249 9.07e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 9.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   156 LHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCrtpASLG---CARELLEHgatVQLEGGPGRDTPLHVAAQRGLD 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLA---AKNGhleIVKLLLEH---ADVNLKDNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 21040227   233 EHAQLYLGFGARVDARN 249
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 421-459 2.77e-13

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 63.72  E-value: 2.77e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21040227   421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLL 459
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
138-357 1.50e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 1.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 138 HLLSRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGP 217
Cdd:COG0666   7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 218 GrDTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETalSAACGAAARSPD------EHarclrlcalllrgGAAADARD 291
Cdd:COG0666  87 G-NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET--PLHLAAYNGNLEivklllEA-------------GADVNAQD 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21040227 292 EDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATcapptapQRTVQVLLNHG 357
Cdd:COG0666 151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH-------LEIVKLLLEAG 209
Ank_2 pfam12796
Ankyrin repeats (3 copies);
122-182 1.92e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 1.92e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21040227   122 TPLCIAAAHGHESCVRHLLSrKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLN 182
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 423-461 1.06e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 53.57  E-value: 1.06e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21040227    423 RCLQHLCRCTIRKLFGKesvhlVPQLPLPETLQNYLLLE 461
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 120-191 1.36e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.36e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21040227  120 LTTPLCIAAAHGHESCVRHLLSRKADPNASP-GGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHL 191
Cdd:PTZ00322  82 LTVELCQLAASGDAVGARILLTGGADPNCRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
PHA03095 PHA03095
ankyrin-like protein; Provisional
 136-335 4.64e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 4.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  136 VRHLLSRKADPNASPG-GRGALHeACLGN---HTACARLLLQHGADPDLLNSEGLAPLH--LCRTPASLGCARELLEHGA 209
Cdd:PHA03095 100 IKLLIKAGADVNAKDKvGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  210 ---TVQLEggpgRDTPLHVAAQ---------RGLdehaqlyLGFGARVDARNGRGETALSAACGAAArspdehaRCLRLC 277
Cdd:PHA03095 179 dvyAVDDR----FRSLLHHHLQsfkprarivREL-------IRAGCDPAATDMLGNTPLHSMATGSS-------CKRSLV 240

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 21040227  278 ALLLRGGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARAL 335
Cdd:PHA03095 241 LPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMV 298
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 422-459 1.24e-08

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 50.67  E-value: 1.24e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21040227 422 PRCLQHLCRCTIRKLFgkeSVHLVPQLPLPETLQNYLL 459
Cdd:cd03717   3 VRSLQHLCRFVIRQCT---RRDLIDQLPLPRRLKDYLK 37
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 283-366 2.10e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  283 GGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATcapptapQRTVQVLLNH------ 356
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF-------REVVQLLSRHsqchfe 176

                         90
                 ....*....|.
gi 21040227  357 -GSRSVwPDAF 366
Cdd:PTZ00322 177 lGANAK-PDSF 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-172 2.60e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 2.60e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21040227   121 TTPLCIAAAHGHESCVRHLLSRKADPNASPG-GRGALHEACLGNHTACARLLL 172
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGnGETALHFAASNGNVEVLKLLL 54
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 422-461 9.77e-08

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 48.19  E-value: 9.77e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLE 461
Cdd:cd03720   3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 61-250 1.23e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   61 ELPTGVLLGDLDHIRLLMDQCFwdaNAVFEISNG------EMEWQVTSLATFGLSGLWTLEYQR-ELTTPLCIAAAHGHE 133
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGI---NPNFEIYDGispiklAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  134 SCVRHLL--SRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATV 211
Cdd:PHA02875  82 KAVEELLdlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 21040227  212 QLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVD--ARNG 250
Cdd:PHA02875 162 DIEDCCGC-TPLIIAMAKGDIAICKMLLDSGANIDyfGKNG 201
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 421-458 2.97e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 46.79  E-value: 2.97e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21040227 421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYL 458
Cdd:cd03724   2 TPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 168-240 3.54e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.59  E-value: 3.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21040227  168 ARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLG 240
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREVVQLLSR 169
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 422-461 6.76e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 45.76  E-value: 6.76e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLE 461
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 421-459 1.73e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 44.78  E-value: 1.73e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 21040227 421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLL 459
Cdd:cd03729   2 TPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLS 40
PHA03095 PHA03095
ankyrin-like protein; Provisional
 136-341 1.99e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  136 VRHLLSRKADPN-ASPGGRGALHeACLgnHTACA------RLLLQHGADPDLLNSEGLAPLHLCRTPAS-LGCARELLEH 207
Cdd:PHA03095  30 VRRLLAAGADVNfRGEYGKTPLH-LYL--HYSSEkvkdivRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  208 GATVQLEGGPGRdTPLHVAAqRGLDEHA---QLYLGFGARVDARNGRGETalsaACGAAARSPDehaRCLRLCALLLRGG 284
Cdd:PHA03095 107 GADVNAKDKVGR-TPLHVYL-SGFNINPkviRLLLRKGADVNALDLYGMT----PLAVLLKSRN---ANVELLRLLIDAG 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21040227  285 AAADARDEDERSPLHKACG--HARPGLCTLLLRHGADAGALDYGGASPLARALQTATCA 341
Cdd:PHA03095 178 ADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCK 236
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 423-458 3.31e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 43.93  E-value: 3.31e-06
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 21040227 423 RCLQHLCRCTIRKLFGKEsvhLVPQLPLPETLQNYL 458
Cdd:cd03741   4 QSLQHLCRFVIRKLVRRD---HIPALPLPRRLIDYL 36
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 116-230 8.75e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 8.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 116 YQREltTPLCIAAAHGHESCVRHLLSRKAD---PNA-----SPGGRGALH--------EACLGNHtACARLLLQHGADPD 179
Cdd:cd22192  87 YQGE--TALHIAVVNQNLNLVRELIARGADvvsPRAtgtffRPGPKNLIYygehplsfAACVGNE-EIVRLLIEHGADIR 163

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227 180 LLNSEGLAPLHLCRTPASLGCARELLE-------HGATVQLEGGPGRD--TPLHVAAQRG 230
Cdd:cd22192 164 AQDSLGNTVLHILVLQPNKTFACQMYDlilsydkEDDLQPLDLVPNNQglTPFKLAAKEG 223
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 422-458 1.09e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 42.55  E-value: 1.09e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYL 458
Cdd:cd03721   3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYL 39
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 421-458 1.26e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 42.14  E-value: 1.26e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21040227 421 TPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYL 458
Cdd:cd03726   2 QPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYL 39
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 422-458 1.80e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 41.87  E-value: 1.80e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYL 458
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 422-459 2.03e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 42.13  E-value: 2.03e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHL---VPQLPLPETLQNYLL 459
Cdd:cd03731   3 PRPLKHLCRLKIRKLMGLQKLQQpssMKKLPLPPALKRYIL 43
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 136-358 2.39e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  136 VRHLLSRKADPNA-SPGGRGALH-EACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRT-PASLGCARELLEHGATVQ 212
Cdd:PHA02876 290 VPKLLERGADVNAkNIKGETPLYlMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  213 leggpGRD----TPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETALSAACGAAarSPdeharcLRLCALLLRGGAAAD 288
Cdd:PHA02876 370 -----ARDycdkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGT--NP------YMSVKTLIDRGANVN 436

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21040227  289 ARDEDERSPLHKAC-GHARPGLCTLLLRHGADAGALDYGGASPLARALQTatcapptapQRTVQVLLNHGS 358
Cdd:PHA02876 437 SKNKDLSTPLHYACkKNCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY---------HGIVNILLHYGA 498
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 122-249 3.10e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.40  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  122 TPLCIAAAHGHESCVRHLLSRKADPN-ASPGGRGALHEACLGNHTACARLLLQ--HGADP----DLLNseglaplhLCRT 194
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHiRDANGNTALWNAISAKHHKIFRILYHfaSISDPhaagDLLC--------TAAK 631

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21040227  195 PASLGCARELLEHGATVQLEGGPGRdTPLHVAAQRGLDEHAQLYLGFGARVDARN 249
Cdd:PLN03192 632 RNDLTAMKELLKQGLNVDSEDHQGA-TALQVAMAEDHVDMVRLLIMNGADVDKAN 685
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 422-459 4.07e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 40.99  E-value: 4.07e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVH---LVPQLPLPETLQNYLL 459
Cdd:cd03730   3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYIL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
152-192 4.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 4.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21040227   152 GRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLC 192
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFA 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 122-148 5.29e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.29e-05
                           10        20
                   ....*....|....*....|....*..
gi 21040227    122 TPLCIAAAHGHESCVRHLLSRKADPNA 148
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 422-459 5.99e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 5.99e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21040227    422 PRCLQHLCRCTIRKLFGKesvHLVPQLPLPETLQNYLL 459
Cdd:smart00253   7 VPSLQHLCRFTIRRCTRT---DQIKTLPLPPKLKDYLS 41
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 422-461 7.08e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 39.96  E-value: 7.08e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLE 461
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 188-386 7.23e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.44  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  188 PLHLC-RTPASLGCARELLEHGATVQLEGGPGrDTPLHVAAQRGLD-EHAQLYLGFGARVDARNgRGETALSAACGAAAR 265
Cdd:PHA02876 276 PLHHAsQAPSLSRLVPKLLERGADVNAKNIKG-ETPLYLMAKNGYDtENIRTLIMLGADVNAAD-RLYITPLHQASTLDR 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  266 SPDeharclrLCALLLRGGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALdyggASPLARALQTATCAppTA 345
Cdd:PHA02876 354 NKD-------IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAL----SQKIGTALHFALCG--TN 420

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 21040227  346 PQRTVQVLLNHGS--RSVWPDAFPKVLRTCAQ--VPEVIEVLFNS 386
Cdd:PHA02876 421 PYMSVKTLIDRGAnvNSKNKDLSTPLHYACKKncKLDVIEMLLDN 465
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 136-340 7.95e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 7.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  136 VRHLLSRKADPNASP--GGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQL 213
Cdd:PHA02878 150 TKLLLSYGADINMKDrhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  214 EGGPGrDTPLHVAAQRGLD-EHAQLYLGFGARVDARNG-RGETalsaacgaaarspdeharclrlcalllrggaaadard 291
Cdd:PHA02878 230 RDKCG-NTPLHISVGYCKDyDILKLLLEHGVDVNAKSYiLGLT------------------------------------- 271

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 21040227  292 edersPLHKACghARPGLCTLLLRHGADAGALDYGGASPLARALQTATC 340
Cdd:PHA02878 272 -----ALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLC 313
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 425-461 1.11e-04

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 39.77  E-value: 1.11e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21040227 425 LQHLCRCTIRKLFGKESVH---LVPQLPLPETLQNYLLLE 461
Cdd:cd03722   6 LTHLCRLEIRSSLKSERLRsdsFICQLPLPRSLQDYLLYS 45
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 122-243 1.70e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  122 TPLCIAAAHGHESCVRHLLSRKADPNASPGGR-GALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGC 200
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 21040227  201 ARELLEHGATVQLEGGPGRDTPLHVAAQRGLDEHAQLYLGFGA 243
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGA 226
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 423-459 3.09e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 38.17  E-value: 3.09e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21040227 423 RCLQHLCRCTIRKLFgkeSVHLVPQLPLPETLQNYLL 459
Cdd:cd03740   4 RSLQYLCRFVIRQYT---RIDLIQKLPLPNKMKGYLL 37
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 422-459 3.23e-04

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 38.23  E-value: 3.23e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21040227 422 PRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLL 459
Cdd:cd03728   3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLL 40
Ank_5 pfam13857
Ankyrin repeats (many copies);
144-192 3.87e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 3.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 21040227   144 ADPNASPGGRG-ALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLC 192
Cdd:pfam13857   7 IDLNRLDGEGYtPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 152-182 5.76e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 5.76e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 21040227   152 GRGALHEACL-GNHTACARLLLQHGADPDLLN 182
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 152-180 1.23e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.23e-03
                           10        20
                   ....*....|....*....|....*....
gi 21040227    152 GRGALHEACLGNHTACARLLLQHGADPDL 180
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 122-148 1.56e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*...
gi 21040227   122 TPLCIAAAH-GHESCVRHLLSRKADPNA 148
Cdd:pfam00023   4 TPLHLAAGRrGNLEIVKLLLSKGADVNA 31
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 156-336 2.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  156 LHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGPGrDTPLHVAAQRGLDEHA 235
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG-ESPLHNAAEYGDYACI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227  236 QLYLGFGARVDARNGRGETaLSAACGAAARSPDEharclrlcalLLRGGAAADARDEDERSPLHKACGH-ARPGLCTLLL 314
Cdd:PHA02874 207 KLLIDHGNHIMNKCKNGFT-PLHNAIIHNRSAIE----------LLINNASINDQDIDGSTPLHHAINPpCDIDIIDILL 275

                        170       180
                 ....*....|....*....|..
gi 21040227  315 RHGADAGALDYGGASPLARALQ 336
Cdd:PHA02874 276 YHKADISIKDNKGENPIDTAFK 297
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 122-239 4.49e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.68  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040227   122 TPLCIAAAHGHESCVRHLLSRKADPNA---------SPGGRGALHE-------ACLGNhTACARLLLQHGADPDLLNSEG 185
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPAracgdffvkSQGVDSFYHGesplnaaACLGS-PSIVALLSEDPADILTADSLG 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21040227   186 LAPLHLC---------RTPASLGCARELLEHGA----TVQLEGGPGRD--TPLHVAAQRGLDEHAQLYL 239
Cdd:TIGR00870 209 NTLLHLLvmenefkaeYEELSCQMYNFALSLLDklrdSKELEVILNHQglTPLKLAAKEGRIVLFRLKL 277
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 425-458 6.49e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 34.32  E-value: 6.49e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 21040227 425 LQHLCRCTIRKLFgkeSVHLVPQLPLPETLQNYL 458
Cdd:cd03733   6 LQHLCRMALRRVM---TTQQVLALPIPKKMKEFL 36
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 425-458 6.53e-03

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 34.40  E-value: 6.53e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 21040227 425 LQHLCRCTIRKLFGKESVHlvpQLPLPETLQNYL 458
Cdd:cd03746   6 LQHLCRMAIRRVMPTQQVK---ELPIPSKLLEFL 36
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 152-179 6.60e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|....*...
gi 21040227   152 GRGALHEACLGNHTACARLLLQHGADPD 179
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 425-458 6.64e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.44  E-value: 6.64e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 21040227 425 LQHLCRCTIRKLFGKesvhlVPQLPLPETLQNYL 458
Cdd:cd03736   6 LQHLCRITINKCTRQ-----IQELPLPTRLKDYL 34
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 422-460 8.03e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 34.43  E-value: 8.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21040227 422 PRCLQHLCRCTIRKLFGKESV-HLVPQLPLPETLQNYLLL 460
Cdd:cd03727   3 PGTLKALARYAVRRSLGVQYLpEAVKQLPLPRSVKEYLLL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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