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    Rad54l2 RAD54 like 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 81000, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rad54l2provided by MGI
    Official Full Name
    RAD54 like 2 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1933196
    See related
    Ensembl:ENSMUSG00000040661 AllianceGenome:MGI:1933196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arip4; Srisnf2l; D130058C05; G630026H09Rik
    Summary
    Enables several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in central nervous system; embryo; limb; and neural ectoderm. Orthologous to human RAD54L2 (RAD54 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.2), CNS E14 (RPKM 4.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rad54l2 in Genome Data Viewer
    Location:
    9 F1; 9 57.98 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106565279..106666412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106688080..106789213, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, metabotropic 2 Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte-derived neurotrophic factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of androgen receptor-interacting protein-4 in the testis. Domanskyi A, et al. Am J Physiol Endocrinol Metab, 2007 Feb. PMID 17003240
    2. An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation. Zhang FP, et al. Mol Endocrinol, 2007 Jun. PMID 17374848
    3. Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation. Tsuchiya M, et al. Sci Rep, 2015 Sep 28. PMID 26412716, Free PMC Article
    4. Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Sitz JH, et al. Mol Cell Biol, 2004 Jul. PMID 15199138, Free PMC Article
    5. Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Rouleau N, et al. Mol Biol Cell, 2002 Jun. PMID 12058073, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p62 is a novel binding partner for ARIP4, and that its binding regulates the cellular protein level of ARIP4 under conditions of metabolic stress.
      Title: Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.
    2. ARIP4 is an AR coregulator in Sertoli cells in vivo, but the expression in the germ cells implies that it has also AR-independent functions in spermatogenesis.
      Title: Expression and localization of androgen receptor-interacting protein-4 in the testis.
    3. ARIP4 plays an essential role in mouse embryonic development and cell proliferation, and it appears to coordinate multiple essential biological processes, possibly through a complex chromatin remodeling system.
      Title: An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2)  1 citation
    • Transposon induced (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    helicase ARIP4
    Names
    HCMV-interacting protein
    RAD54-like protein 2
    androgen receptor-interacting protein 4
    steroid receptor-interacting SNF2 domain protein
    NP_109655.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030730.2 → NP_109655.2  helicase ARIP4

      Status: VALIDATED

      Source sequence(s)
      AC125188, AK143506, BF455201, CJ123928
      Consensus CDS
      CCDS40759.1
      UniProtKB/Swiss-Prot
      Q3UPJ1, Q99NG0
      UniProtKB/TrEMBL
      E9QKL0
      Related
      ENSMUSP00000045454.6, ENSMUST00000046502.7
      Conserved Domains (4) summary
      cd00046
      Location:300 → 492
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:274 → 628
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:720 → 854
      Helicase_C; Helicase conserved C-terminal domain
      pfam15662
      Location:1123 → 1234
      SPATA3; Spermatogenesis-associated protein 3 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106565279..106666412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NG0.1 GenPept UniProtKB/Swiss-Prot:Q99NG0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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