|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
271-547 |
4.21e-156 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 470.84 E-value: 4.21e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMW 350
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 351 LPAPEALPadskpeEVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLltlkkslatsrpkktkkrshp 430
Cdd:cd18069 81 LPPPEALP------NVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFRL--------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 431 viidldeedrqqefrrefekalcRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 510
Cdd:cd18069 134 -----------------------RPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVR 190
|
250 260 270
....*....|....*....|....*....|....*..
gi 126090612 511 PDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYR 547
Cdd:cd18069 191 PDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
271-547 |
2.12e-110 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 348.51 E-value: 2.12e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYDNLVESleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTP-AKTVLAIVPVNTLQNWLAEFNM 349
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGT--DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPrRSRPLVLCPASTLYNWEDEFKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 WLPaPEALPadskpeevqprfFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSlatsrpkkTKKRSH 429
Cdd:cd18007 79 WLP-PDLRP------------LLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRNLASNAT--------TDPRLK 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 430 pviidldeedrqqefrREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 509
Cdd:cd18007 138 ----------------QEFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFA 201
|
250 260 270
....*....|....*....|....*....|....*...
gi 126090612 510 RPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYR 547
Cdd:cd18007 202 RPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
110-890 |
1.76e-90 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 309.08 E-value: 1.76e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 110 RRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKEYAAPIPTVPLEFLPEEIVLRASDGPQLPPRVLAQEVICLDSSS 189
Cdd:COG0553 87 LLLALLLLALLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLA 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 190 GSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDALNQHDALgrVLVNLNHPPEEENVFLAPQLar 269
Cdd:COG0553 167 LLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAF--RLRRLREALESLPAGLKATL-- 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 270 avKPHQIGGIRFLydnlvesleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNm 349
Cdd:COG0553 243 --RPYQLEGAAWL---------LFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELA- 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 wlpapealpadskpeevqpRFF---KVHILNDEHKtvasRAKvTADWVSEGGVLLMGYEMyrlltlkkslatsrpkktkk 426
Cdd:COG0553 311 -------------------KFApglRVLVLDGTRE----RAK-GANPFEDADLVITSYGL-------------------- 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 427 rshpviidldeedrqqeFRREFEkALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMV 506
Cdd:COG0553 347 -----------------LRRDIE-LLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLL 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 507 DFVRPDFLGTRQEFSNMFERPILNGQcidstpqdvrlmRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQI 586
Cdd:COG0553 409 DFLNPGLLGSLKAFRERFARPIEKGD------------EEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPE 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 587 QRDLYTQFMDRFRDCGTSG---------WLGLNPLKAFCvcckiwNHPDVLyealqkenLANEQDLDVEelgsagtsarc 657
Cdd:COG0553 477 QRALYEAVLEYLRRELEGAegirrrgliLAALTRLRQIC------SHPALL--------LEEGAELSGR----------- 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 658 pphgtkvkgedsalpssmgeatnskflqgvgfnpfqergnnivtyewakelltnyqtgvlenSPKMVLLFHLIEESVKLG 737
Cdd:COG0553 532 --------------------------------------------------------------SAKLEALLELLEELLAEG 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 738 DKILVFSQSLSTLALIEEFLGKRdmpclpgaegqgtqkwvrNVSYFRLDGSTPAFERERLINQFNDPSNltTWLFLLSTR 817
Cdd:COG0553 550 EKVLVFSQFTDTLDLLEERLEER------------------GIEYAYLHGGTSAEERDELVDRFQEGPE--APVFLISLK 609
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126090612 818 AGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVD 890
Cdd:COG0553 610 AGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
271-547 |
8.99e-83 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 271.76 E-value: 8.99e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTP---AKTVLAIVPVNTLQNWLAEF 347
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLCEKlenFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 348 NMWLpapealpADSKPEEVqprfFKVHILnDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSlatsrPKKTKKR 427
Cdd:cd18068 81 EKWQ-------EGLKDEEK----IEVNEL-ATYKRPQERSYKLQRWQEEGGVMIIGYDMYRILAQERN-----VKSREKL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 428 shpviidldeedrqqefRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 507
Cdd:cd18068 144 -----------------KEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVN 206
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 126090612 508 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYR 547
Cdd:cd18068 207 FVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVDVRVMKKR 246
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
273-562 |
7.87e-60 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 205.60 E-value: 7.87e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLYDnlveSLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTP-----AKTVLAIVPVNTLQNWLAEF 347
Cdd:cd18004 3 PHQREGVQFLYD----CLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPygkptAKKALIVCPSSLVGNWKAEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 348 NMWLP----APEALPADSKPEEVQPRFFkvhilndehkTVASRAKVtadwvseggvLLMGYEMyrlltlkkslatsrpkk 423
Cdd:cd18004 79 DKWLGlrriKVVTADGNAKDVKASLDFF----------SSASTYPV----------LIISYET----------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 424 tkkrshpviidldeedrqqeFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYW 503
Cdd:cd18004 122 --------------------LRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFF 181
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 126090612 504 CMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18004 182 ALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
274-628 |
3.44e-59 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 205.61 E-value: 3.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 274 HQIGGIRFLYdnlveSLERFktsSGFGCILAHSMGLGKTLQVISFIDVLFRHTP--AKTVLAIVPVNTLQNWLAEFNMWL 351
Cdd:pfam00176 1 YQIEGVNWML-----SLENN---LGRGGILADEMGLGKTLQTISLLLYLKHVDKnwGGPTLIVVPLSLLHNWMNEFERWV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 pAPEALPAdskpeevqprfFKVHILNDEHKTVASRAKVTADWvsegGVLLMGYEMYRlltlkkslatsrpkktkkrSHPV 431
Cdd:pfam00176 73 -SPPALRV-----------VVLHGNKRPQERWKNDPNFLADF----DVVITTYETLR-------------------KHKE 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 432 IIDldeedrQQEFRRefekalcrpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP 511
Cdd:pfam00176 118 LLK------KVHWHR-------------IVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRP 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 512 DFLGTRQEFSNMFERPILNGQcidstpqdvrlMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLY 591
Cdd:pfam00176 179 GPFGSLSTFRNWFDRPIERGG-----------GKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKLY 247
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 126090612 592 TQFMdRFRDcgtsGWLGLNPLKAFCVCC----------KIWNHPDVL 628
Cdd:pfam00176 248 QTFL-LKKD----LNAIKTGEGGREIKAsllnilmrlrKICNHPGLI 289
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
720-865 |
1.57e-51 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 177.67 E-value: 1.57e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 720 SPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRdmpclpgaegqgtqkwvrNVSYFRLDGSTPAFERERLIN 799
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER------------------GIKYLRLDGSTSSKERQKLVD 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126090612 800 QFNDPSNLTtwLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLV 865
Cdd:cd18793 72 RFNEDPDIR--VFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
272-514 |
3.02e-49 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 173.14 E-value: 3.02e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFLYDNLveslerfktSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKT-VLAIVPVNTLQNWLAEFNMW 350
Cdd:cd17919 2 RPYQLEGLNFLLELY---------ENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGpVLVVCPLSVLENWEREFEKW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 351 LPapealpadskpeevqprFFKVHILndeHKTVASRAKVTAD-WVSEGGVLLMGYEMYRLLTlkkslatsrpkktkkrsh 429
Cdd:cd17919 73 TP-----------------DLRVVVY---HGSQRERAQIRAKeKLDKFDVVLTTYETLRRDK------------------ 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 430 pviidldeedrqqefrrefeKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 509
Cdd:cd17919 115 --------------------ASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFL 174
|
....*
gi 126090612 510 RPDFL 514
Cdd:cd17919 175 DPPFL 179
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
274-881 |
1.31e-48 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 189.63 E-value: 1.31e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 274 HQIGGIRF---LYDNlveslerfktssGFGCILAHSMGLGKTLQVISFIDVL--FR-----HtpaktvLAIVPVNTLQNW 343
Cdd:PLN03142 173 YQLAGLNWlirLYEN------------GINGILADEMGLGKTLQTISLLGYLheYRgitgpH------MVVAPKSTLGNW 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 344 LAEFNMWLPAPealpadskpeevqpRFFKVHILNDEhktvasRAKVTADWVSEGG--VLLMGYEMyrllTLKKslatsrp 421
Cdd:PLN03142 235 MNEIRRFCPVL--------------RAVKFHGNPEE------RAHQREELLVAGKfdVCVTSFEM----AIKE------- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 422 KKTKKRSHpviidldeedrqqeFRrefekalcrpgpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIE 501
Cdd:PLN03142 284 KTALKRFS--------------WR-------------YIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHE 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 502 YWCMVDFVRPDFLGTRQEFSNMFERPILNGQcidstpQDVrlmryrSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILV 581
Cdd:PLN03142 337 LWALLNFLLPEIFSSAETFDEWFQISGENDQ------QEV------VQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKV 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 582 RLSQIQRDLYTQFMDRFRDCGTSGwlG-----LNPLKAFCVCCkiwNHPDVLYEAlqkenlaneqdldveELGsagtsar 656
Cdd:PLN03142 405 GMSQMQKQYYKALLQKDLDVVNAG--GerkrlLNIAMQLRKCC---NHPYLFQGA---------------EPG------- 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 657 cPPHGTkvkgedsalpssmgeatnskflqgvgfnpfqerGNNIVtyewakelltnyqtgvlENSPKMVLLFHLIEESVKL 736
Cdd:PLN03142 458 -PPYTT---------------------------------GEHLV-----------------ENSGKMVLLDKLLPKLKER 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 737 GDKILVFSQSLSTLALIEEFLgkrdmpclpgaegqgtqkWVRNVSYFRLDGSTPAFERERLINQFNDPsNLTTWLFLLST 816
Cdd:PLN03142 487 DSRVLIFSQMTRLLDILEDYL------------------MYRGYQYCRIDGNTGGEDRDASIDAFNKP-GSEKFVFLLST 547
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126090612 817 RAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISK 881
Cdd:PLN03142 548 RAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKK 612
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
271-562 |
2.22e-42 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 155.71 E-value: 2.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYDNLVESLERfktsSGFGCILAHSMGLGKTLQVISFIDVLFRHTP-AKTVL--AIV--PVNTLQNWLA 345
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRRIR----GSHGCIMADEMGLGKTLQCITLMWTLLRQSPqCKPEIdkAIVvsPSSLVKNWAN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 346 EFNMWL-PAPEALPADSKPEEvqprffkvhilNDEHKTVAsrakvtadWVSEGG------VLLMGYEMYRLltlkkslat 418
Cdd:cd18067 77 ELGKWLgGRLQPLAIDGGSKK-----------EIDRKLVQ--------WASQQGrrvstpVLIISYETFRL--------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 419 srpkktkkrshpviidldeedrqqefrreFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNN 498
Cdd:cd18067 129 -----------------------------HVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQND 179
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126090612 499 LIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18067 180 LSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
272-562 |
5.91e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 148.68 E-value: 5.91e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFLYDNLVEslerfktssGFGCILAHSMGLGKTLQVISFIDVLFRHT---------------------PAKT 330
Cdd:cd18005 2 RDYQREGVEFMYDLYKN---------GRGGILGDDMGLGKTVQVIAFLAAVLGKTgtrrdrennrprfkkkppassAKKP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 331 VLAIVPVNTLQNWLAEFNMWlpapealpadskpeevqpRFFKVHILNDEHKTVASRAKVTADWVSeggVLLMGYEMYRLl 410
Cdd:cd18005 73 VLIVAPLSVLYNWKDELDTW------------------GHFEVGVYHGSRKDDELEGRLKAGRLE---VVVTTYDTLRR- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 411 tlkkslatsrpkktkkrshpviiDLDEEDrQQEFrrefekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVL 490
Cdd:cd18005 131 -----------------------CIDSLN-SINW-------------SAVIADEAHRIKNPKSKLTQAMKELKCKVRIGL 173
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126090612 491 TGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18005 174 TGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
271-562 |
6.20e-40 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 148.45 E-value: 6.20e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYdnlvESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTP------AKTVLAIVPVNTLQNWL 344
Cdd:cd18066 1 LRPHQREGIEFLY----ECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvIKRALIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 345 AEFNMWLPAPEalpadskpeevqprfFKVHILNDEHKTvasRAKVTADWVSeggVLLMGYEMyrlltLKKSLatsrpkkt 424
Cdd:cd18066 77 KEFQKWLGSER---------------IKVFTVDQDHKV---EEFIASPLYS---VLIISYEM-----LLRSL-------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 425 kkrshpviidldEEDRQQEFrrefekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWC 504
Cdd:cd18066 123 ------------DQISKLNF-------------DLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFA 177
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090612 505 MVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18066 178 LIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
273-562 |
5.68e-39 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 145.59 E-value: 5.68e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLYdnlveSLErfktSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLP 352
Cdd:cd18001 3 PHQREGVAWLW-----SLH----DGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 353 APealpadskpeevqpRFFKVHILNdehktVASRAKVTADWVSEGGVLLMGYEMyrlltlkkslatsrpkktkkrshpvi 432
Cdd:cd18001 74 GL--------------RVKVFHGTS-----KKERERNLERIQRGGGVLLTTYGM-------------------------- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 433 IDLDEEDRQQEFRREFEKalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP- 511
Cdd:cd18001 109 VLSNTEQLSADDHDEFKW-------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNg 181
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 126090612 512 DFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18001 182 SLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
273-562 |
2.67e-33 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 128.45 E-value: 2.67e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLydnlvesleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWlp 352
Cdd:cd18012 7 PYQKEGFNWL---------SFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKF-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 353 APEalpadskpeevqprfFKVHILndeHKTVASRAKVTAdwVSEGGVLLMGYEMYRLltlkkslatsrpkktkkrshpvi 432
Cdd:cd18012 76 APE---------------LKVLVI---HGTKRKREKLRA--LEDYDLVITSYGLLRR----------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 433 idlDEEDRQQefrREFekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPD 512
Cdd:cd18012 113 ---DIELLKE---VKF---------HYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPG 177
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 126090612 513 FLGTRQEFSNMFERPILNGQCIDSTPQdvrlmryrshvLHSLLEGFVQRR 562
Cdd:cd18012 178 LLGSYKRFKKRFAKPIEKDGDEEALEE-----------LKKLISPFILRR 216
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
302-562 |
1.12e-31 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 123.97 E-value: 1.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 302 ILAHSMGLGKTLQVISFIDVL--FRHTPAKTvLAIVPVNTLQNWLAEFNMWLPAPEALpadskpeevqprffKVHILNDE 379
Cdd:cd17997 26 ILADEMGLGKTLQTISLLGYLkhYKNINGPH-LIIVPKSTLDNWMREFKRWCPSLRVV--------------VLIGDKEE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 380 HKTVASRAKVTADWvsegGVLLMGYEMyrlltlkkslatsrpkktkkrshpVIIDldeedrqqefrrefEKALCRPGPDV 459
Cdd:cd17997 91 RADIIRDVLLPGKF----DVCITSYEM------------------------VIKE--------------KTVLKKFNWRY 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 460 VICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNGQCIDstPQ 539
Cdd:cd17997 129 IIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN----VNNCDD--DN 202
|
250 260
....*....|....*....|...
gi 126090612 540 DVRLMRyrshvLHSLLEGFVQRR 562
Cdd:cd17997 203 QEVVQR-----LHKVLRPFLLRR 220
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
273-514 |
1.06e-30 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 120.12 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLYDnlveslerfKTSSGFGCILAHSMGLGKTLQVISFIDVL-FRHTPAKTVLAIVPVNTLQNWLAEFNMWL 351
Cdd:cd18000 3 KYQQTGVQWLWE---------LHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 PapealpadskpeevqprFFKVHILNDEHKTVASRAKVTADW---------VSEGGVLLMGYEMYRLLtlkkslatsrpk 422
Cdd:cd18000 74 P-----------------PFRVVVLHSSGSGTGSEEKLGSIErksqlirkvVGDGGILITTYEGFRKH------------ 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 423 ktkkrSHPVIidldeedrqqefRREFekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEY 502
Cdd:cd18000 125 -----KDLLL------------NHNW---------QYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKEL 178
|
250
....*....|..
gi 126090612 503 WCMVDFVRPDFL 514
Cdd:cd18000 179 WSLFDFVFPPYL 190
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
272-562 |
1.21e-29 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 118.64 E-value: 1.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGI---RFLYDNlveslerfktssGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFN 348
Cdd:cd18009 5 RPYQLEGMewlRMLWEN------------GINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 349 MWLPAPEALpadskpeevqprffKVHILNDEHKTVAsrakvtadwvseggvllmgyemyrlltlkkslATSRPKKTKKRS 428
Cdd:cd18009 73 RFTPSVPVL--------------LYHGTKEERERLR--------------------------------KKIMKREGTLQD 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 429 HPVIIDLDE---EDRqqefrrefeKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCM 505
Cdd:cd18009 107 FPVVVTSYEiamRDR---------KALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSL 177
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 126090612 506 VDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRR 562
Cdd:cd18009 178 LNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
272-562 |
4.17e-28 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 114.00 E-value: 4.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRF---LYDNLVESlerfktssgfgcILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEF 347
Cdd:cd17996 5 KEYQLKGLQWmvsLYNNNLNG------------ILADEMGLGKTIQTISLITYLMEKKKNNgPYLVIVPLSTLSNWVSEF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 348 NMWLPAPEALPADSKPEeVQPRFFKVHIlndehktvasrakvtadwVSEGGVLLMGYEMyrllTLKKslatsRPKKTKKR 427
Cdd:cd17996 73 EKWAPSVSKIVYKGTPD-VRKKLQSQIR------------------AGKFNVLLTTYEY----IIKD-----KPLLSKIK 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 428 SHPVIIDldeedrqqefrrefekalcrpgpdvvicdEGHRIKNCQASTSQALKN-IRSRRRVVLTGYPLQNNLIEYWCMV 506
Cdd:cd17996 125 WKYMIID-----------------------------EGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALL 175
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090612 507 DFVRPDFLGTRQEFSNMFERPILN--GQCIDSTPQDVRLMRYRShvLHSLLEGFVQRR 562
Cdd:cd17996 176 NFLLPKIFKSCKTFEQWFNTPFANtgEQVKIELNEEETLLIIRR--LHKVLRPFLLRR 231
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
272-511 |
6.18e-27 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 109.40 E-value: 6.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFLydNLVESlerfktsSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWL 351
Cdd:cd17998 2 KDYQLIGLNWL--NLLYQ-------KKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWC 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 PAPEALPADSKPEEvqprffKVHILNDEHKtvasrakvtadwvseggvllmGYEMYRLLTLKKSLATSRPkktkkrshpv 431
Cdd:cd17998 73 PSLKVEPYYGSQEE------RKHLRYDILK---------------------GLEDFDVIVTTYNLATSNP---------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 432 iidldeEDRQQEFRREFekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP 511
Cdd:cd17998 116 ------DDRSFFKRLKL---------NYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
300-524 |
1.43e-23 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 100.79 E-value: 1.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 300 GCILAHSMGLGKTLQVISFIDVLF-RHTPAKTVLAIVPVNTLQNWLAEFNMWLPApEALpadskpeevqprffkVHilnd 378
Cdd:cd17995 21 NCILADEMGLGKTIQSIAFLEHLYqVEGIRGPFLVIAPLSTIPNWQREFETWTDM-NVV---------------VY---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 379 eHKTVASRAkvtadwvseggvLLMGYEMYRlltlkkSLATSRPKKTKKRSHpVIIDLDE---EDRQqefrrEFEKALCRp 455
Cdd:cd17995 81 -HGSGESRQ------------IIQQYEMYF------KDAQGRKKKGVYKFD-VLITTYEmviADAE-----ELRKIPWR- 134
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126090612 456 gpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 524
Cdd:cd17995 135 ---VVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
302-562 |
2.05e-22 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 97.42 E-value: 2.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 302 ILAHSMGLGKTLQVISFIDVLFRHtpaKTV----LAIVPVNTLQNWLAEFNMWLPApealpadskpeevqprfFKVHILN 377
Cdd:cd18003 23 ILADEMGLGKTIQTIALLAHLACE---KGNwgphLIVVPTSVMLNWEMEFKRWCPG-----------------FKILTYY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 378 DEHKtvaSRAKVTADWVSEGG--VLLMGYEMyrlltlkkslatsrpkktkkrshpVIIDldeedrQQEFRREFEKALcrp 455
Cdd:cd18003 83 GSAK---ERKLKRQGWMKPNSfhVCITSYQL------------------------VVQD------HQVFKRKKWKYL--- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 456 gpdvvICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPiLNGQCID 535
Cdd:cd18003 127 -----ILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNP-LTAMSEG 200
|
250 260
....*....|....*....|....*..
gi 126090612 536 STPQDVRLMRYrshvLHSLLEGFVQRR 562
Cdd:cd18003 201 SQEENEELVRR----LHKVLRPFLLRR 223
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
299-562 |
2.53e-21 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 94.66 E-value: 2.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 299 FGCILAHSMGLGKTLQVISFI------------------DVLFRHTPAKTVLAIVPVNTLQNWLAEFNMwlpapealpad 360
Cdd:cd18008 15 RGGILADEMGLGKTIQALALIlatrpqdpkipeeleensSDPKKLYLSKTTLIVVPLSLLSQWKDEIEK----------- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 361 skpeEVQPRFFKVHILndeHKtvASRAKVTADWvSEGGVLLMGYEmyrllTLKKSLATSRPKKTKKRSHPVIIDLdeedR 440
Cdd:cd18008 84 ----HTKPGSLKVYVY---HG--SKRIKSIEEL-SDYDIVITTYG-----TLASEFPKNKKGGGRDSKEKEASPL----H 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 441 QQEFRRefekalcrpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEF 520
Cdd:cd18008 145 RIRWYR-------------VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWF 211
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 126090612 521 snmferpilNGQCIDSTPQDVRLMRYRshvLHSLLEGFVQRR 562
Cdd:cd18008 212 ---------NSDISKPFSKNDRKALER---LQALLKPILLRR 241
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
272-536 |
4.18e-20 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 90.87 E-value: 4.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFLydnlvESLERFKTSSgfgcILAHSMGLGKTLQVISFIDVLFRHTPAKT------VLAIVPVNTLQNWLA 345
Cdd:cd17999 2 RPYQQEGINWL-----AFLNKYNLHG----ILCDDMGLGKTLQTLCILASDHHKRANSFnsenlpSLVVCPPTLVGHWVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 346 EFNMWLPAPealpadskpeevqprFFKVHILndeHKTVASRAKVTADwVSEGGVLLMGYEMYRlltlkkslatsrpkktk 425
Cdd:cd17999 73 EIKKYFPNA---------------FLKPLAY---VGPPQERRRLREQ-GEKHNVIVASYDVLR----------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 426 krshpviidldeedRQQEFRREFEKALCrpgpdvvICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCM 505
Cdd:cd17999 117 --------------NDIEVLTKIEWNYC-------VLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSL 175
|
250 260 270
....*....|....*....|....*....|.
gi 126090612 506 VDFVRPDFLGTRQEFSNMFERPILngQCIDS 536
Cdd:cd17999 176 FDFLMPGYLGTEKQFQRRFLKPIL--ASRDS 204
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
297-575 |
4.47e-20 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 91.27 E-value: 4.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 297 SGFGCILAHSMGLGKTLQVISFIDVL--FRHTPAKTvLAIVPVNTLQNWLAEFNMWLPAPEAlpadskpeevqprffkVH 374
Cdd:cd18064 33 NGINGILADEMGLGKTLQTISLLGYMkhYRNIPGPH-MVLVPKSTLHNWMAEFKRWVPTLRA----------------VC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 375 ILNDEHKtvasRAKVTADWV--SEGGVLLMGYEMyrlLTLKKSLatsrpkktkkrshpviidldeedrqqefrreFEKAL 452
Cdd:cd18064 96 LIGDKDQ----RAAFVRDVLlpGEWDVCVTSYEM---LIKEKSV-------------------------------FKKFN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 453 CRpgpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNGQ 532
Cdd:cd18064 138 WR----YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD----TNN 209
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 126090612 533 CIDstpqDVRLMRYrshvLHSLLEGFVQRRGHTVLKIHLPAKE 575
Cdd:cd18064 210 CLG----DQKLVER----LHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
273-525 |
5.70e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 89.42 E-value: 5.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLydnlvesleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEFNMWl 351
Cdd:cd17994 3 PYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEMW- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 papealpadskpeevQPRFFKVHILNDEhktvasrakvtadwvseggVLLMGYEmyrLLTLKKSLATSrpkktkkrshpv 431
Cdd:cd17994 73 ---------------APDFYVVTYVGDH-------------------VLLTSYE---LISIDQAILGS------------ 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 432 iIDLdeedrqqefrrefekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP 511
Cdd:cd17994 104 -IDW----------------------AVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTP 160
|
250
....*....|....
gi 126090612 512 DFLGTRQEFSNMFE 525
Cdd:cd17994 161 ERFNNLQGFLEEFA 174
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
301-562 |
1.47e-19 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 88.95 E-value: 1.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 301 CILAHSMGLGKTLQVISFIDVLF-RHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALpadskpeevqprffkVHILNde 379
Cdd:cd17993 23 GILADEMGLGKTVQTISFLSYLFhSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI---------------VYLGD-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 380 hktVASRAkvtadwvseggvLLMGYEMYrlltlkkslatsrPKKTKKRSHPVIIDLDE---EDRQ--QEFRREFekalcr 454
Cdd:cd17993 86 ---IKSRD------------TIREYEFY-------------FSQTKKLKFNVLLTTYEiilKDKAflGSIKWQY------ 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 455 pgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFsnmferpilngqci 534
Cdd:cd17993 132 -----LAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEF-------------- 192
|
250 260
....*....|....*....|....*...
gi 126090612 535 DSTPQDVRLMRYRShvLHSLLEGFVQRR 562
Cdd:cd17993 193 EEEHDEEQEKGIAD--LHKELEPFILRR 218
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
271-562 |
3.12e-19 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 88.95 E-value: 3.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFL---YDNlveslerfktssGFGCILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAE 346
Cdd:cd18062 24 LKQYQIKGLEWLvslYNN------------NLNGILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 347 FNMWLPAPEALPADSKPeevqprffkvhilndehktVASRAKVTADWVSEGGVLLMGYEMyrLLTLKKSLATSRPKktkk 426
Cdd:cd18062 92 FDKWAPSVVKVSYKGSP-------------------AARRAFVPQLRSGKFNVLLTTYEY--IIKDKQILAKIRWK---- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 427 rshpviidldeedrqqefrrefekalcrpgpdVVICDEGHRIKNCQASTSQALK-NIRSRRRVVLTGYPLQNNLIEYWCM 505
Cdd:cd18062 147 --------------------------------YMIVDEGHRMKNHHCKLTQVLNtHYVAPRRLLLTGTPLQNKLPELWAL 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 126090612 506 VDFVRPDFLGTRQEFSNMFERPI-LNGQCIDSTPQDVRLMRYRshvLHSLLEGFVQRR 562
Cdd:cd18062 195 LNFLLPTIFKSCSTFEQWFNAPFaMTGEKVDLNEEETILIIRR---LHKVLRPFLLRR 249
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
722-854 |
8.66e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.03 E-value: 8.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 722 KMVLLFHLIEEsvKLGDKILVFSQSLSTLAliEEFLGKRdmpclpgaegqgtqkwvRNVSYFRLDGSTPAFERERLINQF 801
Cdd:pfam00271 2 KLEALLELLKK--ERGGKVLIFSQTKKTLE--AELLLEK-----------------EGIKVARLHGDLSQEEREEILEDF 60
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 126090612 802 NDPSNLttwlFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYG 854
Cdd:pfam00271 61 RKGKID----VLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
297-562 |
1.03e-18 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 87.00 E-value: 1.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 297 SGFGCILAHSMGLGKTLQVISFIDVL--FRHTPAKTvLAIVPVNTLQNWLAEFNMWLPAPEAlpadskpeevqprffkVH 374
Cdd:cd18065 33 NGVNGILADEMGLGKTLQTIALLGYLkhYRNIPGPH-MVLVPKSTLHNWMNEFKRWVPSLRA----------------VC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 375 ILNDEHktvaSRAKVTADWVSEG--GVLLMGYEMYrlltlkkslatsrpkktkkrshpviidLDEEDRQQEFRREFekal 452
Cdd:cd18065 96 LIGDKD----ARAAFIRDVMMPGewDVCVTSYEMV---------------------------IKEKSVFKKFNWRY---- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 453 crpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNGQ 532
Cdd:cd18065 141 -------LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD----TKN 209
|
250 260 270
....*....|....*....|....*....|
gi 126090612 533 CIDstpqDVRLMRYrshvLHSLLEGFVQRR 562
Cdd:cd18065 210 CLG----DQKLVER----LHAVLKPFLLRR 231
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
302-562 |
1.42e-18 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 87.04 E-value: 1.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 302 ILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPeevqprffkvhilndeh 380
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTP----------------- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 381 ktVASRAKVTADWVSEGGVLLMGYEMyrLLTLKKSLATSRPKktkkrshpviidldeedrqqefrrefekalcrpgpdVV 460
Cdd:cd18063 109 --AMRRSLVPQLRSGKFNVLLTTYEY--IIKDKHILAKIRWK------------------------------------YM 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 461 ICDEGHRIKNCQASTSQALK-NIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPI-LNGQCIDSTP 538
Cdd:cd18063 149 IVDEGHRMKNHHCKLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNE 228
|
250 260
....*....|....*....|....
gi 126090612 539 QDVRLMRYRshvLHSLLEGFVQRR 562
Cdd:cd18063 229 EETILIIRR---LHKVLRPFLLRR 249
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
302-562 |
2.62e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 85.83 E-value: 2.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 302 ILAHSMGLGKTLQVISFIDVLF-RHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALpadskpeevqprffkVHILNdeh 380
Cdd:cd18054 43 ILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV---------------VYIGD--- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 381 ktVASRAKVTA-DWVSEG------GVLLMGYEMyrLLTLKKSLATsrpkktkkrshpviidldeedrqqeFRREFekalc 453
Cdd:cd18054 105 --LMSRNTIREyEWIHSQtkrlkfNALITTYEI--LLKDKTVLGS-------------------------INWAF----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 454 rpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGqc 533
Cdd:cd18054 151 ------LGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENG-- 222
|
250 260
....*....|....*....|....*....
gi 126090612 534 idstpqdvrlmrYRShvLHSLLEGFVQRR 562
Cdd:cd18054 223 ------------YQS--LHKVLEPFLLRR 237
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
778-854 |
4.49e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 77.25 E-value: 4.49e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090612 778 RNVSYFRLDGSTPAFERERLINQFNDPSNLttwlFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYG 854
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKIK----VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
271-562 |
1.07e-16 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 81.01 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLYdNLVESlerfktssGFGCILAHSMGLGKTLQVISFIDVLF-RHTPAKTVLAIVPVNTLQNWLAEFNM 349
Cdd:cd18002 1 LKEYQLKGLNWLA-NLYEQ--------GINGILADEMGLGKTVQSIAVLAHLAeEHNIWGPFLVIAPASTLHNWQQEISR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 WLPAPEALP--ADSKPEEVQPRFFkvhilndEHKTVASRAkvtadwvSEGGVLLMGYEMyrlltlkkslatsrpkktkkr 427
Cdd:cd18002 72 FVPQFKVLPywGNPKDRKVLRKFW-------DRKNLYTRD-------APFHVVITSYQL--------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 428 shpVIIDldeedrqqefrrefEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 507
Cdd:cd18002 117 ---VVQD--------------EKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLH 179
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 126090612 508 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRyrshvLHSLLEGFVQRR 562
Cdd:cd18002 180 FIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKR-----LHMILKPFMLRR 229
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
271-562 |
1.25e-16 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 80.56 E-value: 1.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLydnlvesLERFKTssGFGCILAHSMGLGKTLQVISFIDVL-FRHTPAKTVLAIVPVNTLQNWLAEFNM 349
Cdd:cd18006 1 LRPYQLEGVNWL-------LQCRAE--QHGCILGDEMGLGKTCQTISLLWYLaGRLKLLGPFLVLCPLSVLDNWKEELNR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 WLPAPEALPADSKPEEvqprffkvhilndehktvasRAKVTADWVSEG--GVLLMGYEMyrlltlkkslatsrpkktkkr 427
Cdd:cd18006 72 FAPDLSVITYMGDKEK--------------------RLDLQQDIKSTNrfHVLLTTYEI--------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 428 shpVIIDldeedrqQEFRREFEKAlcrpgpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 507
Cdd:cd18006 111 ---CLKD-------ASFLKSFPWA-------SLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLS 173
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 126090612 508 FVRPDFLG--TRQEFSNMFERpilngqcIDSTPQDVRlmryrshVLHSLLEGFVQRR 562
Cdd:cd18006 174 FIEPNVFPkdKLDDFIKAYSE-------TDDESETVE-------ELHLLLQPFLLRR 216
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
271-524 |
1.52e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 80.49 E-value: 1.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLydnlvesleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEFNM 349
Cdd:cd18057 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKgPYLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 WlpapealpadskpeevQPRFFKVHILNDEHktvaSRAKVTADWVS-EGGVLLMGYEMYRLltlkkslatsrPKKTKKRS 428
Cdd:cd18057 72 W----------------APDFYVVTYTGDKE----SRSVIRENEFSfEDNAIRSGKKVFRM-----------KKEAQIKF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 429 HPVIIDLDEEDRQQEFRREFEKAlcrpgpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDF 508
Cdd:cd18057 121 HVLLTSYELITIDQAILGSIEWA-------CLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNF 193
|
250
....*....|....*.
gi 126090612 509 VRPDFLGTRQEFSNMF 524
Cdd:cd18057 194 LTPERFNNLEGFLEEF 209
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
297-531 |
1.83e-15 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 77.51 E-value: 1.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 297 SGFGCILAHSMGLGKTLQVISFIdvLFRHTpaktvLAIVPVNTLQNWLAEFNmwlpapealpadskpEEVQPRFFKVHIL 376
Cdd:cd18071 47 LVRGGILADDMGLGKTLTTISLI--LANFT-----LIVCPLSVLSNWETQFE---------------EHVKPGQLKVYTY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 377 NDEHKTVASRakvtadwvseggvLLMGYEMyrLLTLKKSLATsrpKKTKKRSHPViidldeedRQQEFRRefekalcrpg 456
Cdd:cd18071 105 HGGERNRDPK-------------LLSKYDI--VLTTYNTLAS---DFGAKGDSPL--------HTINWLR---------- 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126090612 457 pdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNG 531
Cdd:cd18071 149 ---VVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMG 220
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
301-524 |
1.77e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 74.32 E-value: 1.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 301 CILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALpadskpeevqprffkvhilndEH 380
Cdd:cd18060 22 CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIV---------------------YH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 381 KTVASRAkvtadwvseggvLLMGYEMYrlltLKKSLATSRPKKTK----KRSHPVIIDLDEEDRQQEFRrefekalcrpg 456
Cdd:cd18060 81 GSLASRQ------------MIQQYEMY----CKDSRGRLIPGAYKfdalITTFEMILSDCPELREIEWR----------- 133
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126090612 457 pdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 524
Cdd:cd18060 134 --CVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF 199
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
272-520 |
2.69e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 74.32 E-value: 2.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFL--YDNLVESLERFKTS--SGFGCILAHSMGLGKTLQVISFIDVLF-RHTPAKTVLAIVPVNTLQNWLAE 346
Cdd:cd18053 9 QPSYIGGHEGLelRDYQLNGLNWLAHSwcKGNSCILADEMGLGKTIQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 347 FNMWLPAPEAlpadskpeevqprffkVHILNDehktVASRAKV-TADWVseggvllmgyemyrlltlkkslatsRPKKTK 425
Cdd:cd18053 89 IQTWAPQMNA----------------VVYLGD----INSRNMIrTHEWM-------------------------HPQTKR 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 426 KRSHPVIIDLDEEDRQQEFRREFEKALcrpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCM 505
Cdd:cd18053 124 LKFNILLTTYEILLKDKSFLGGLNWAF-------IGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSL 196
|
250
....*....|....*
gi 126090612 506 VDFVRPDFLGTRQEF 520
Cdd:cd18053 197 LHFIMPEKFSSWEDF 211
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
292-523 |
3.05e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 73.89 E-value: 3.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 292 RFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEFNMWlpapealpadskpeevQPRF 370
Cdd:cd18055 13 RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKgPFLVSAPLSTIINWEREFQMW----------------APDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 371 FKVHILNDEHktvaSRAKVTADWVSeggvllmgYEMYRLLTLKKSLATSRPKKTKkrSHPVIIDLDEEDRQQEFRREFEK 450
Cdd:cd18055 77 YVVTYTGDKD----SRAIIRENEFS--------FDDNAVKGGKKAFKMKREAQVK--FHVLLTSYELVTIDQAALGSIRW 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126090612 451 AlcrpgpdVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFL----GTRQEFSNM 523
Cdd:cd18055 143 A-------CLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFnnleGFLEEFADI 212
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
271-523 |
5.63e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 73.18 E-value: 5.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 271 VKPHQIGGIRFLydnlvesleRFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAK-TVLAIVPVNTLQNWLAEFNM 349
Cdd:cd18056 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 350 WLPAPEALP----ADSKPEEVQPRF-FKVHILNDEHKtvASRAKVTADwvSEGGVLLMGYEmyrLLTLKKSLATSrpkkt 424
Cdd:cd18056 72 WAPDMYVVTyvgdKDSRAIIRENEFsFEDNAIRGGKK--ASRMKKEAS--VKFHVLLTSYE---LITIDMAILGS----- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 425 kkrshpviIDLdeedrqqefrrefekalcrpgpDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWC 504
Cdd:cd18056 140 --------IDW----------------------ACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFH 189
|
250 260
....*....|....*....|...
gi 126090612 505 MVDFVRPDFL----GTRQEFSNM 523
Cdd:cd18056 190 LLNFLTPERFhnleGFLEEFADI 212
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
301-524 |
3.11e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 70.83 E-value: 3.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 301 CILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWlpapealpadskpEEVQPRFFkvhilndeH 380
Cdd:cd18059 22 CILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTW-------------TELNVVVY--------H 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 381 KTVASRAKVTAdwvseggvllmgYEMYRLLTLKKSLATSRPKKTKKRSHPVIIDLDEEDRQQEFRrefekalcrpgpdVV 460
Cdd:cd18059 81 GSQASRRTIQL------------YEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWR-------------CV 135
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126090612 461 ICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 524
Cdd:cd18059 136 VIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF 199
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
272-520 |
4.05e-13 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 69.93 E-value: 4.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFlydnlveSLERfktssGFGCILAHSMGLGKTLQVISFIDVLFRHTPaktVLAIVPVNTLQNWLAEFNMWL 351
Cdd:cd18010 2 LPFQREGVCF-------ALRR-----GGRVLIADEMGLGKTVQAIAIAAYYREEWP---LLIVCPSSLRLTWADEIERWL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 PapealpadskpeEVQPRffkvhilnDEHKTVASRAKVTADWvseGGVLLMGYEMyrLLTLKKSLAtsrpkktkkrshpv 431
Cdd:cd18010 67 P------------SLPPD--------DIQVIVKSKDGLRDGD---AKVVIVSYDL--LRRLEKQLL-------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 432 iidldeedrQQEFRrefekalcrpgpdVVICDEGHRIKNCQASTSQALKNI--RSRRRVVLTGYPLQNNLIEYWCMVDFV 509
Cdd:cd18010 108 ---------ARKFK-------------VVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDAL 165
|
250
....*....|.
gi 126090612 510 RPDFLGTRQEF 520
Cdd:cd18010 166 DPKLFGRFHDF 176
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
301-524 |
3.15e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 67.76 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 301 CILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWlpapealpadskpEEVQPRFFkvhilndeH 380
Cdd:cd18058 22 CILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTW-------------TEMNAIVY--------H 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 381 KTVASRAkvtadwvseggvLLMGYEMYRlltlkkSLATSRPKKTKKRSHPVIIDLdeedrqqefrrEFEKALCrpgPDV- 459
Cdd:cd18058 81 GSQISRQ------------MIQQYEMYY------RDEQGNPLSGIFKFQVVITTF-----------EMILADC---PELk 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126090612 460 ------VICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 524
Cdd:cd18058 129 kinwscVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
301-524 |
3.19e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 64.64 E-value: 3.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 301 CILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWlpapealpadskpeevqprffkVHI-LNDE 379
Cdd:cd18061 22 CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW----------------------TDLnVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 380 HKTVASRAkvtadwvseggvLLMGYEMYRLLTLKKSLATSRPKKTKKRSHPVIIDLDEEDRQQEFRrefekalcrpgpdV 459
Cdd:cd18061 80 HGSLISRQ------------MIQQYEMYFRDSQGRIIRGAYRFQAIITTFEMILGGCPELNAIDWR-------------C 134
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126090612 460 VICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 524
Cdd:cd18061 135 VIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF 199
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
273-544 |
3.69e-10 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 61.15 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIggirflyDNLVESLERFKtssgFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFN--MW 350
Cdd:cd18011 3 PHQI-------DAVLRALRKPP----VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQdkFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 351 LPAPEALPADSKPEEvqprffkvhilndehktvasrakvtadwvseggvllmgyemyrlltlkkslatSRPKKTKKRSHP 430
Cdd:cd18011 72 LPFLILDRETAAQLR-----------------------------------------------------RLIGNPFEEFPI 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 431 VIIDLDEEDRQqefrREFEKALCRPGPDVVICDEGHRIKNCQASTSQ----ALKNI--RSRRRVVLTGYPLQNNLIEYWC 504
Cdd:cd18011 99 VIVSLDLLKRS----EERRGLLLSEEWDLVVVDEAHKLRNSGGGKETkrykLGRLLakRARHVLLLTATPHNGKEEDFRA 174
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 126090612 505 MVDFVRPDFlgtrqefsnmFERPILNGQCIDSTPQDVRLM 544
Cdd:cd18011 175 LLSLLDPGR----------FAVLGRFLRLDGLREVLAKVL 204
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
273-514 |
5.28e-10 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 60.58 E-value: 5.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 273 PHQIGGIRFLYDNLveslerfktssgFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTL-QNWLAEFNMWL 351
Cdd:smart00487 11 PYQKEAIEALLSGL------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 352 PapealpadskpeevqPRFFKVHILNDEHKTVASRAKVTADwvsEGGVLLMGYEMYRLLTLKKSLATSRpkktkkrshpv 431
Cdd:smart00487 79 P---------------SLGLKVVGLYGGDSKREQLRKLESG---KTDILVTTPGRLLDLLENDKLSLSN----------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 432 iidldeedrqqefrrefekalcrpgPDVVICDEGHRIKNcqASTSQALKNI-----RSRRRVVLTGYP---LQNNLIEYW 503
Cdd:smart00487 130 -------------------------VDLVILDEAHRLLD--GGFGDQLEKLlkllpKNVQLLLLSATPpeeIENLLELFL 182
|
250
....*....|.
gi 126090612 504 CMVDFVRPDFL 514
Cdd:smart00487 183 NDPVFIDVGFT 193
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
300-510 |
1.13e-06 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 51.33 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 300 GCILAHSMGLGKTLQVISFI------------------DVLFRH-----TPAKTVLAIVPVNTLQNWLAEFNmwlpapea 356
Cdd:cd18072 22 GGILADDMGLGKTLTMIALIlaqkntqnrkeeekekalTEWESKkdstlVPSAGTLVVCPASLVHQWKNEVE-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 357 lpadSKPEEVQPRFFKVHILNDEhktvaSRAKVTADWvsegGVLLMGYEmyrllTLKKSLATsrpKKTKKRSHPViidld 436
Cdd:cd18072 94 ----SRVASNKLRVCLYHGPNRE-----RIGEVLRDY----DIVITTYS-----LVAKEIPT---YKEESRSSPL----- 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126090612 437 eedrqqeFRREFEKalcrpgpdvVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 510
Cdd:cd18072 148 -------FRIAWAR---------IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
272-350 |
8.61e-04 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 42.34 E-value: 8.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 272 KPHQIGGIRFLYDNLVeslerfktssgfGCILAhSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQN-WLAEFNMW 350
Cdd:cd18013 2 HPYQKVAINFIIEHPY------------CGLFL-DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKW 68
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1112-1445 |
2.54e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.62 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1112 SDGRIFAVRATGKPKAPEDGRMAASGSQGPSLASTSNGRHSASSPKAPDPEGLARPvspdsPEIISELQQYADVAAARES 1191
Cdd:PHA03247 2657 APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP-----HALVSATPLPPGPAAARQA 2731
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1192 RQSSPSVSAALPGPPGQLMDNSTipgTALGTEPclgghclnssllVTGQPSGGRHPVLDLRGHKRKLATPSVTQESVRRR 1271
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGP---ARPARPP------------TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1272 SrkghLPAPVQPYEHGYPVSGGFAMPPVSLN--HNLTTPFTSQAGENSLFMGSNPSYYQLSNLLA---DARLVFPVTTDP 1346
Cdd:PHA03247 2797 S----LPSPWDPADPPAAVLAPAAALPPAASpaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApggDVRRRPPSRSPA 2872
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1347 LVPAGPVSSSSTATSVTASNPS---FMLNPSVPGMLPSYSLPfSQPLLSEPRMFAPFPSPGLPSNLSRGVSVYPGYMSPH 1423
Cdd:PHA03247 2873 AKPAAPARPPVRRLARPAVSRStesFALPPDQPERPPQPQAP-PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
|
330 340
....*....|....*....|..
gi 126090612 1424 AGYPAGGLLRSQVPPFDSHEVA 1445
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGRVA 2973
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1106-1443 |
4.81e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1106 GTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQ--GPSLASTSNGRHSASSPKAPDPEGLARPVSPDSPEIiselqqya 1183
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPrrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-------- 2818
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1184 dvaaaresrqsSPSVSAALPGPPgqlmdnstiPGTALGTEPCLGGHCLNSSLlvtgQPSGGRHPVLDLRghKRKLATPSV 1263
Cdd:PHA03247 2819 -----------PPAASPAGPLPP---------PTSAQPTAPPPPPGPPPPSL----PLGGSVAPGGDVR--RRPPSRSPA 2872
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1264 TQESVRRRSRKGHLPAPVQPyehgyPVSGGFAMPPVSLNHnlttPFTSQAGENSLFMGSNPSYYQLSNLLadarlvfPVT 1343
Cdd:PHA03247 2873 AKPAAPARPPVRRLARPAVS-----RSTESFALPPDQPER----PPQPQAPPPPQPQPQPPPPPQPQPPP-------PPP 2936
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1344 TDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGMLPSYSLPFSQPLLSEPrmfAPFPSPGLPSNLS-RGVSVYPGYMSP 1422
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE---APASSTPPLTGHSlSRVSSWASSLAL 3013
|
330 340
....*....|....*....|...
gi 126090612 1423 H--AGYPAGGLLRSQVPPFDSHE 1443
Cdd:PHA03247 3014 HeeTDPPPVSLKQTLWPPDDTED 3036
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1112-1300 |
5.65e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.31 E-value: 5.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1112 SDGRIFAVRATGKPKAPEDGRMAASGSQGPSLASTSNGRHSASSPKAPDPE------GLARPVSPDSPE-----IISELQ 1180
Cdd:PHA03307 79 APANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSpapdlsEMLRPVGSPGPPpaaspPAAGAS 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126090612 1181 QYADVAAARESRQSS---PSVSAALPGPPGQLMDNSTIPGTALGTEPCLGGHCLNSSLLVTGQPSGGRHPVLDlRGHKRK 1257
Cdd:PHA03307 159 PAAVASDAASSRQAAlplSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADD-AGASSS 237
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 126090612 1258 LATPSVTQ------ESVRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVS 1300
Cdd:PHA03307 238 DSSSSESSgcgwgpENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAS 286
|
|
| |
