Rps19bp1 ribosomal protein S19 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps19bp1provided by MGI
Official Full Name: ribosomal protein S19 binding protein 1provided by MGI
Primary source: MGI:MGI:1913788
See related: Ensembl:ENSMUSG00000051518 AllianceGenome:MGI:1913788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S19BP; 2510038A11Rik
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Located in nucleolus and nucleoplasm. Is expressed in brain; male reproductive gland or organ; and metanephros. Orthologous to human RPS19BP1 (ribosomal protein S19 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 16.4), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (80144815..80148507, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (80260614..80264306, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.
Title: SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.
identified a novel protein, which was named S19 binding protein (S19BP). No known functional motifs were found in S19BP except a short polylysine tract embedded in a putative nucleolar localization signal.
Title: A novel nucleolar protein interacts with ribosomal protein S19.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: active regulator of SIRT1

Names: 40S ribosomal protein S19-binding protein 1; RPS19-binding protein 1; S19 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.