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Conserved domains on  [gi|30424711|ref|NP_780318|]
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active regulator of SIRT1 [Mus musculus]

Protein Classification

AROS domain-containing protein( domain architecture ID 11238879)

AROS domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AROS pfam15684
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of ...
 20-140 1.48e-33

Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localizes to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.


:

Pssm-ID: 464802  Cd Length: 125  Bit Score: 114.07  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30424711    20 RAVPGQVQASGTPAKR---------TRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPE 90
Cdd:pfam15684   1 QAKKKKKKPSGSGVLEliptnhrgiRKQLKRLKKRLGKSKATVKGKSIKSAVEEYRKRQKKDHTEENLKYLSSNGSKLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30424711    91 SVTQQILQQNQGRKACDRLVAktknkKKKKKKAEGTVFTEEDFQKFQREY 140
Cdd:pfam15684  81 STTNKILQRNRGRKARDQPDE-----KTKKKKEEESVFTEEDFQKFEKEY 125
 
Name Accession Description Interval E-value
AROS pfam15684
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of ...
 20-140 1.48e-33

Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localizes to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.


Pssm-ID: 464802  Cd Length: 125  Bit Score: 114.07  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30424711    20 RAVPGQVQASGTPAKR---------TRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPE 90
Cdd:pfam15684   1 QAKKKKKKPSGSGVLEliptnhrgiRKQLKRLKKRLGKSKATVKGKSIKSAVEEYRKRQKKDHTEENLKYLSSNGSKLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30424711    91 SVTQQILQQNQGRKACDRLVAktknkKKKKKKAEGTVFTEEDFQKFQREY 140
Cdd:pfam15684  81 STTNKILQRNRGRKARDQPDE-----KTKKKKEEESVFTEEDFQKFEKEY 125
 
Name Accession Description Interval E-value
AROS pfam15684
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of ...
 20-140 1.48e-33

Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1; AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localizes to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.


Pssm-ID: 464802  Cd Length: 125  Bit Score: 114.07  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30424711    20 RAVPGQVQASGTPAKR---------TRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPE 90
Cdd:pfam15684   1 QAKKKKKKPSGSGVLEliptnhrgiRKQLKRLKKRLGKSKATVKGKSIKSAVEEYRKRQKKDHTEENLKYLSSNGSKLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30424711    91 SVTQQILQQNQGRKACDRLVAktknkKKKKKKAEGTVFTEEDFQKFQREY 140
Cdd:pfam15684  81 STTNKILQRNRGRKARDQPDE-----KTKKKKEEESVFTEEDFQKFEKEY 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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