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    Ift56 intraflagellar transport 56 [ Mus musculus (house mouse) ]

    Gene ID: 264134, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ift56provided by MGI
    Official Full Name
    intraflagellar transport 56provided by MGI
    Primary source
    MGI:MGI:2444853
    See related
    Ensembl:ENSMUSG00000056832 AllianceGenome:MGI:2444853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hop; hpy; Ttc26; 9330141E21Rik; 9430097H08Rik
    Summary
    Enables intraciliary transport particle B binding activity. Involved in cilium organization; protein localization to cilium; and smoothened signaling pathway. Acts upstream of or within manchette assembly. Located in centrosome; ciliary basal body; and neuron projection. Part of intraciliary transport particle B. Is expressed in spinal cord. Orthologous to human IFT56 (intraflagellar transport 56). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 4.0), CNS E11.5 (RPKM 2.9) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ift56 in Genome Data Viewer
    Location:
    6 B1; 6 17.76 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38358400..38404582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38381464..38427647)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15622 Neighboring gene UPF0547 protein C16orf87 homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38331316-38331499 Neighboring gene ribosomal protein L30, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38383641-38383885 Neighboring gene predicted gene, 53284 Neighboring gene ubinuclein 2 Neighboring gene microRNA 7670 Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    hop-sterile
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC28016

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intraciliary transport particle B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables intraciliary transport particle B binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intraciliary anterograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intraciliary anterograde transport IC
    Inferred by Curator
    more info
    PubMed 
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within manchette assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within photoreceptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    intraflagellar transport protein 56
    Names
    TPR repeat protein 26
    hydrocephalic-polydactyl
    protein hop-sterile
    tetratricopeptide repeat domain 26
    tetratricopeptide repeat protein 26

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153600.2NP_705828.2  intraflagellar transport protein 56

      See identical proteins and their annotated locations for NP_705828.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066060
      Consensus CDS
      CCDS51750.1
      UniProtKB/Swiss-Prot
      Q8BS45
      Related
      ENSMUSP00000124369.2, ENSMUST00000162554.8
      Conserved Domains (2) summary
      TIGR02917
      Location:33346
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:5886
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      38358400..38404582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506152.5XP_006506215.1  intraflagellar transport protein 56 isoform X1

      Conserved Domains (2) summary
      TIGR02917
      Location:33346
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:5886
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_003956200.2 RNA Sequence

      Related
      ENSMUST00000159145.8