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Conserved domains on  [gi|568941927|ref|XP_006506215|]
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intraflagellar transport protein 56 isoform X1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-246 2.25e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  29 KLEDLLSQR-DFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 108 KQAEAAGFKAPKSRLQN-RLLFHLAHKFNDEKKLMNFHQNLQD-IKED------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKaLKLDpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941927 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLkACNHFRLYNGKAAEAELKSLM 246
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLERQL 272
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-246 2.25e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  29 KLEDLLSQR-DFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 108 KQAEAAGFKAPKSRLQN-RLLFHLAHKFNDEKKLMNFHQNLQD-IKED------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKaLKLDpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941927 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLkACNHFRLYNGKAAEAELKSLM 246
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLERQL 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-346 6.00e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927   33 LLSQRDFTGAITLLEfkRHVGEQEDDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMY--- 107
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFeea 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  108 -KQAEAAGFKAPKSRLQNRLLfhlahkfndekklmnfhqnlqdikedqlslASIHYMRSHYQEAIDIYKRILLDNREYLA 186
Cdd:TIGR02917 247 eKHADALLKKAPNSPLAHYLK------------------------------ALVDFQKKNYEDARETLQDALKSAPEYLP 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  187 LNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSP-------------- 252
Cdd:TIGR02917 297 ALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDpaalsllgeaylal 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  253 ---------FEFAKEL------IRHNLVVF-------RGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKD 310
Cdd:TIGR02917 377 gdfekaaeyLAKATELdpenaaARTQLGISklsqgdpSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKK 456

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568941927  311 LE---PTTPQEYILKGVVNAALGQEMGSRDH----MKIAQQFF 346
Cdd:TIGR02917 457 LEkkqPDNASLHNLLGAIYLGKGDLAKAREAfekaLSIEPDFF 499
TPR_19 pfam14559
Tetratricopeptide repeat;
71-112 2.50e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.41  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568941927   71 GDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEA 112
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEA 43
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-246 2.25e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  29 KLEDLLSQR-DFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 108 KQAEAAGFKAPKSRLQN-RLLFHLAHKFNDEKKLMNFHQNLQD-IKED------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKaLKLDpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941927 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLkACNHFRLYNGKAAEAELKSLM 246
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 58-252 6.77e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  58 DTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKAPKSRLQN----RLLFHLAHK 133
Cdd:COG2956   43 EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaealRLLAEIYEQ 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 134 FNDEKKLMNFHQNLQDIKEDQ----LSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLA 209
Cdd:COG2956  123 EGDWEKAIEVLERLLKLGPENahayCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALE 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568941927 210 VYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSP 252
Cdd:COG2956  203 RALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
58-312 1.01e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  58 DTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKApksrlqnrllfhLAHKFNDE 137
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQA------------LELDPDDA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 138 KKLMNfhqnlqdikedqlsLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPD 217
Cdd:COG0457   77 EALNN--------------LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 218 STIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLR 297
Cdd:COG0457  143 DADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAEL 222

                        250
                 ....*....|....*
gi 568941927 298 QDDVQEAYNLIKDLE 312
Cdd:COG0457  223 LLLALALLLALRLAA 237
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 71-311 1.56e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  71 GDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKAPKSRLQN-RLLFHLAHKFNDEKKL---MNFHQN 146
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaEALLELAQDYLKAGLLdraEELLEK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 147 LQDIKED----QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIAL 222
Cdd:COG2956  102 LLELDPDdaeaLRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARAL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 223 NLKACNHFRLYNGKAAEAELKSLMDNASSpFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPE--ARLNLVIYYLRQDD 300
Cdd:COG2956  182 LLLAELYLEQGDYEEAIAALERALEQDPD-YLPALPRLAELYEKLGDPEEALELLRKALELDPSddLLLALADLLERKEG 260

                        250
                 ....*....|.
gi 568941927 301 VQEAYNLIKDL 311
Cdd:COG2956  261 LEAALALLERQ 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-261 2.37e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  33 LLSQRDFTGAITLleFKRHVGEQEDDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQA 110
Cdd:COG0457   18 YRRLGRYEEAIED--YEKALELDPDDAEALynLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 111 EAAGFKApksrlqnrllfhLAHKFNDEKKLMNfhqnlqdikedqlsLASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:COG0457   96 LEDYDKA------------LELDPDDAEALYN--------------LGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941927 191 VALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIR 261
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 54-218 4.17e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.42  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  54 EQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAgfkapksrlqnrllfhlahk 133
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVL-------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 134 fndekklmnFHQNLQDIKED---QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAV 210
Cdd:COG4783   61 ---------LHEALELDPDEpeaRLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131


                 ....*...
gi 568941927 211 YLQQIPDS 218
Cdd:COG4783  132 ALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-249 1.86e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  33 LLSQRDFTGAITLleFKRHVGEQEDDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQA 110
Cdd:COG0457   52 YLRLGRYEEALAD--YEQALELDPDDAEALnnLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 111 EAAGFKApksrlqnrllfhLAHKFNDEKKLMNfhqnlqdikedqlsLASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:COG0457  130 IEAYERA------------LELDPDDADALYN--------------LGIALEKLGRYEEALELLEKLEAAALAALLAAAL 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568941927 191 VAlcYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNA 249
Cdd:COG0457  184 GE--AALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 45-178 2.47e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  45 LLEFKRHVGEQEDDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKApksrl 122
Cdd:COG4235    3 IARLRQALAANPNDAEGWLllGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA----- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568941927 123 qnrllfhLAHKFNDEKKLMNfhqnlqdikedqlsLASIHYMRSHYQEAIDIYKRIL 178
Cdd:COG4235   78 -------LALDPDNPEALYL--------------LGLAAFQQGDYAEAIAAWQKLL 112
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-346 6.00e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927   33 LLSQRDFTGAITLLEfkRHVGEQEDDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMY--- 107
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFeea 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  108 -KQAEAAGFKAPKSRLQNRLLfhlahkfndekklmnfhqnlqdikedqlslASIHYMRSHYQEAIDIYKRILLDNREYLA 186
Cdd:TIGR02917 247 eKHADALLKKAPNSPLAHYLK------------------------------ALVDFQKKNYEDARETLQDALKSAPEYLP 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  187 LNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSP-------------- 252
Cdd:TIGR02917 297 ALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDpaalsllgeaylal 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  253 ---------FEFAKEL------IRHNLVVF-------RGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKD 310
Cdd:TIGR02917 377 gdfekaaeyLAKATELdpenaaARTQLGISklsqgdpSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKK 456

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568941927  311 LE---PTTPQEYILKGVVNAALGQEMGSRDH----MKIAQQFF 346
Cdd:TIGR02917 457 LEkkqPDNASLHNLLGAIYLGKGDLAKAREAfekaLSIEPDFF 499
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-317 3.24e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927   33 LLSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCN-PEVWVNLACTYFFLGM----- 106
Cdd:TIGR02917  66 YLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGaAELLALRGLAYLGLGQlelaq 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  107 --YKQAEAAGFKAPKSRLQnrlLFHLAHKFNDEKKLMNF-HQNLQ-DIKE-DQLSL-ASIHYMRSHYQEAIDIYKRILLD 180
Cdd:TIGR02917 146 ksYEQALAIDPRSLYAKLG---LAQLALAENRFDEARALiDEVLTaDPGNvDALLLkGDLLLSLGNIELALAAYRKAIAL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRlyNGKAAEAeLKSLMDNASSPFEFAKELI 260
Cdd:TIGR02917 223 RPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQ--KKNYEDA-RETLQDALKSAPEYLPALL 299

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941927  261 RHNLVVFRGG--EGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQ 317
Cdd:TIGR02917 300 LAGASEYQLGnlEQAYQYLNQILKYAPNshqARRLLASIQLRLGRVDEAIATLSPALGLDPD 361
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-113 3.42e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  31 EDLLSQRDFTGAITLLEfkRHVGEQEDDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYK 108
Cdd:COG4783   12 QALLLAGDYDEAEALLE--KALELDPDNPEAFalLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89


                 ....*
gi 568941927 109 QAEAA 113
Cdd:COG4783   90 EALAL 94
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 32-113 4.40e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 42.67  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  32 DLLSQRDFTGAITLLE-----FKRHvgEQEDDTNLWIGYCAFHLGDYKRALEEYENATK---EENCNPEVWVNLACTYFF 103
Cdd:COG1729    2 ALLKAGDYDEAIAAFKaflkrYPNS--PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLE 79

                         90
                 ....*....|
gi 568941927 104 LGMYKQAEAA 113
Cdd:COG1729   80 LGDYDKARAT 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-192 8.30e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 8.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  33 LLSQRDFTGAITLLEfkRHVGEQEDDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQA 110
Cdd:COG0457   86 LQALGRYEEALEDYD--KALELDPDDAEALynLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 111 EAAGFKAPKSRLQNRLLFHLAHKFNDEKKLMNFHQNLQDIKEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:COG0457  164 LELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQY 243


                 ..
gi 568941927 191 VA 192
Cdd:COG0457  244 RA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 30-230 1.06e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  30 LEDLLSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQ 109
Cdd:COG3914   85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 110 AEAAgfkapksrlqnrllFHLAHKFNDEkkLMNFHQNlqdikedqlsLASIHYMRSHYQEAIDIYKRILLDNREYLALNV 189
Cdd:COG3914  165 AIAA--------------LRRALELDPD--NAEALNN----------LGNALQDLGRLEEAIAAYRRALELDPDNADAHS 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941927 190 YVALCYYKL---DYYDVSQEVLAVYLQQ-----------IPDSTIALNLKACNHF 230
Cdd:COG3914  219 NLLFALRQAcdwEVYDRFEELLAALARGpselspfallyLPDDDPAELLALARAW 273
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-232 2.65e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  64 GYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAgFKApksrlqnrllfHLAHKFNDEKKLMNf 143
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALED-FDR-----------ALELDPDYAYAYLN- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 144 hqnlqdikedqlsLASIHYMRSHYQEAIDIYKR--ILLDNREYLALNVYvaLCYYKLDYydvsQEVLAVYLQQIPDSTIA 221
Cdd:COG4785  147 -------------RGIALYYLGRYELAIADLEKalELDPNDPERALWLY--LAERKLDP----EKALALLLEDWATAYLL 207

                        170
                 ....*....|...
gi 568941927 222 LNL--KACNHFRL 232
Cdd:COG4785  208 QGDteEARELFKL 220
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 27-117 3.82e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  27 IPKLEDLLSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGM 106
Cdd:COG5010   24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGD 103

                         90
                 ....*....|.
gi 568941927 107 YKQAEAAGFKA 117
Cdd:COG5010  104 KDEAKEYYEKA 114
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 144-317 5.96e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.67  E-value: 5.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 144 HQNLQDIKEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALN 223
Cdd:COG3914   71 AAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 224 LKACNHFRLYNGKAAEAELkslmdnasspfefakelirhnlvvfrggEGALQVLPPLvdviPEARLNLVIYYLRQDDVQE 303
Cdd:COG3914  151 NLGEALRRLGRLEEAIAAL----------------------------RRALELDPDN----AEALNNLGNALQDLGRLEE 198

                        170
                 ....*....|....*..
gi 568941927 304 A---YNLIKDLEPTTPQ 317
Cdd:COG3914  199 AiaaYRRALELDPDNAD 215
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
66-186 6.03e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 6.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  66 CAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAagfkapksrlqnrllFHLAHKFNdekklmnfhq 145
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA---------------LEKALKLD---------- 55

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568941927 146 nlQDIKEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLA 186
Cdd:COG3063   56 --PNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 154-246 1.89e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 154 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 233
Cdd:COG4783   41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120

                         90
                 ....*....|...
gi 568941927 234 NGKAAEAELKSLM 246
Cdd:COG4783  121 RPDEAIAALEKAL 133
TPR_19 pfam14559
Tetratricopeptide repeat;
71-112 2.50e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.41  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568941927   71 GDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEA 112
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEA 43
TPR_19 pfam14559
Tetratricopeptide repeat;
167-226 4.52e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 4.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  167 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-331 4.52e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 157 LASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGK 236
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927 237 AAEAELKSLMDNASSPFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIK--- 309
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAE--IYEQEGdWEKAIEVLERLLKLGPEnahAYCELAELYLEQGDYDEAIEALEkal 171

                        170       180
                 ....*....|....*....|..
gi 568941927 310 DLEPTTPQEYILKGVVNAALGQ 331
Cdd:COG2956  172 KLDPDCARALLLLAELYLEQGD 193
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 34-343 6.52e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927   34 LSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAA 113
Cdd:TIGR02917 408 LSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREA 487

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  114 GFKAPKSRLQN-RLLFHLAHKFNDEKKLMNFHQNLQDI-------KEDQLSLASIHYMRSHYQEAIDIYKR-ILLDNREY 184
Cdd:TIGR02917 488 FEKALSIEPDFfPAAANLARIDIQEGNPDDAIQRFEKVltidpknLRAILALAGLYLRTGNEEEAVAWLEKaAELNPQEI 567

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  185 ---LALNVYvalcYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIr 261
Cdd:TIGR02917 568 epaLALAQY----YLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLA- 642

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  262 HNLVVFRGGEGALQVLPPLVDVIP---EARLNLVIYYLRQDDVQEAYNLIKDLEPTTPqeyilkgvvNAALGQEMGSRDH 338
Cdd:TIGR02917 643 DAYAVMKNYAKAITSLKRALELKPdntEAQIGLAQLLLAAKRTESAKKIAKSLQKQHP---------KAALGFELEGDLY 713


                  ....*
gi 568941927  339 MKIAQ 343
Cdd:TIGR02917 714 LRQKD 718
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
33-113 6.98e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 6.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941927  33 LLSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALeEYENATKEENCNPEVWVNLACTYFFLGMYKQAEA 112
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80


                 .
gi 568941927 113 A 113
Cdd:COG3063   81 Y 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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