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    Cdip1 cell death-inducing p53 target 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360480, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdip1provided by RGD
    Official Full Name
    cell death-inducing p53 target 1provided by RGD
    Primary source
    RGD:1310686
    See related
    EnsemblRapid:ENSRNOG00000003328 AllianceGenome:RGD:1310686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310686
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be active in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. Orthologous to human CDIP1 (cell death inducing p53 target 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 126.8), Brain (RPKM 114.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11278213..11303415)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10773538..10796979)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10966819..10989937)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 16 open reading frame 96 Neighboring gene uncharacterized LOC134480753 Neighboring gene high mobility group nucleosomal binding domain 4, pseudogene 3 Neighboring gene heme oxygenase 2 Neighboring gene NmrA like redox sensor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. Qin W, et al. Biochem J, 2016 Nov 1. PMID 27582497, Free PMC Article
    2. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. Brown L, et al. EMBO J, 2007 Jul 25. PMID 17599062, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94589

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic side of lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell death-inducing p53-target protein 1
    Names
    LITAF-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008360.1 → NP_001008361.1  cell death-inducing p53-target protein 1

      See identical proteins and their annotated locations for NP_001008361.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085860
      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Related
      ENSRNOP00000084999.1, ENSRNOT00000100719.2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11278213..11303415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086264.2 → XP_038942192.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    2. XM_006245813.5 → XP_006245875.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245875.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    3. XM_063269294.1 → XP_063125364.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A6K4R2

    4. XM_006245815.5 → XP_006245877.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245877.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    5. XM_006245811.5 → XP_006245873.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245873.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    6. XM_006245812.5 → XP_006245874.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245874.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    7. XM_006245814.5 → XP_006245876.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245876.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Related
      ENSRNOP00000004999.3, ENSRNOT00000004999.6
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    8. XM_063269296.1 → XP_063125366.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A6K4R2

    9. XM_063269297.1 → XP_063125367.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A6K4R2

    10. XM_039086265.2 → XP_038942193.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    11. XM_063269295.1 → XP_063125365.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A6K4R2

    12. XM_006245816.4 → XP_006245878.1  cell death-inducing p53-target protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245878.1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain

    13. XM_063269298.1 → XP_063125368.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A6K4R2

    14. XM_039086266.2 → XP_038942194.1  cell death-inducing p53-target protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U6
      UniProtKB/TrEMBL
      A0A8I6A313, A6K4R2
      Conserved Domains (1) summary
      pfam10601
      Location:137 → 205
      zf-LITAF-like; LITAF-like zinc ribbon domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2U6.1 GenPept UniProtKB/Swiss-Prot:Q5U2U6

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