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    Klhl4 kelch-like family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317196, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl4provided by RGD
    Official Full Name
    kelch-like family member 4provided by RGD
    Primary source
    RGD:1565441
    See related
    EnsemblRapid:ENSRNOG00000005215 AllianceGenome:RGD:1565441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565441
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in centriolar satellite. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL4 (kelch like family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 47.9), Brain (RPKM 42.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl4 in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (83626047..83916328)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (79429193..79719482)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (86125929..86229565)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 1, pseudogene 6 Neighboring gene uncharacterized LOC134484147 Neighboring gene influenza virus NS1A binding protein, pseudogene 2 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 4
    Names
    kelch-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108244.2 → NP_001101714.1  kelch-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001101714.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IVB0, D3ZHI3
      Related
      ENSRNOP00000006992.7, ENSRNOT00000006992.8
      Conserved Domains (6) summary
      smart00612
      Location:570 → 616
      Kelch; Kelch domain
      PHA03098
      Location:175 → 697
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:465 → 508
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:171 → 275
      BTB; BTB/POZ domain
      pfam01344
      Location:464 → 509
      Kelch_1; Kelch motif
      pfam07707
      Location:283 → 382
      BACK; BTB And C-terminal Kelch

    2. NM_001434069.1 → NP_001420998.1  kelch-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434070.1 → NP_001420999.1  kelch-like protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    4. NM_001434071.1 → NP_001421000.1  kelch-like protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      83626047..83916328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099723.2 → XP_038955651.1  kelch-like protein 4 isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:77 → 599
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:367 → 410
      Kelch; KELCH repeat [structural motif]

    2. XM_063280013.1 → XP_063136083.1  kelch-like protein 4 isoform X3

    3. XM_006257199.5 → XP_006257261.1  kelch-like protein 4 isoform X1

      UniProtKB/TrEMBL
      D3ZHI3
      Conserved Domains (6) summary
      smart00612
      Location:564 → 610
      Kelch; Kelch domain
      PHA03098
      Location:175 → 691
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:459 → 502
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:171 → 275
      BTB; BTB/POZ domain
      pfam01344
      Location:458 → 503
      Kelch_1; Kelch motif
      pfam07707
      Location:283 → 382
      BACK; BTB And C-terminal Kelch

    4. XM_039099724.2 → XP_038955652.1  kelch-like protein 4 isoform X4

      Conserved Domains (2) summary
      PHA03098
      Location:26 → 548
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:316 → 359
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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