NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

422-690

3.99e-66

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 219.64 E-value: 3.99e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 422 PRKSTVGAL-----YAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSG-RRLQFGVAVVDNKLYVVGGRDG----LKTLNT 491
Cdd:COG3055   12 PRSEAAAALldgkvYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 492 VECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTV-GVVALNNK 570
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 571 LYAIGGRDGSSclksmeyfdpHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGGHDAPAPNhcsrlsdcVERYDPKSDSWS 650
Cdd:COG3055  172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 157818009 651 TVAPLSVPRDAVAVCPLGDKLYVVGGYD----GHTYLNTVESYD 690
Cdd:COG3055  234 ALGELPTPRHGHAAVLTDGKVYVIGGETkpgvRTPLVTSAEVYD 277

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

283-383

2.83e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 137.29 E-value: 2.83e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009  283 CLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQQD 362
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|.
gi 157818009  363 LAKLLSYIRLPLLSPQLLADL 383
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNL 101

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

283-382

3.54e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 128.61 E-value: 3.54e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009   283 CLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQQD 362
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 157818009   363 LAKLLSYIRLPLLSPQLLAD 382
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

Name

Accession

Description

Interval

E-value

PHA03098

kelch-like protein; Provisional

175-697

3.38e-97

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 310.55 E-value: 3.38e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 175 LKEKKLCD--VLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEarqEEVKMEGvDPNALNSLVQYAYTGVLQLREDTIE 252
Cdd:PHA03098   4 FELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 253 NLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLC 332
Cdd:PHA03098  80 DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 333 SDDINVPDEETIFHALMQWVGHDAQARQQDLAKLLSYIRLPLLSPQLLADLENssMFSGDLECQKLLMEAMKYHLLPERR 412
Cdd:PHA03098 160 DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKR--WKLRIKKKKIVFNKRCIKIIYSKKY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 413 SmlqSPRTKPRKSTVGALYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTmsGRRLQFGVAVVDNKLYVVGGRDG-LKTLNT 491
Cdd:PHA03098 238 N---LNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDI--HYVYCFGSVVLNNVIYFIGGMNKnNLSVNS 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 492 VECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNKL 571
Cdd:PHA03098 313 VVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 572 YAIGG-RDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGGHdapapNHCSRLS--DCVERYDPKSDS 648
Cdd:PHA03098 393 YVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGI-----SYIDNIKvyNIVESYNPVTNK 467

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 157818009 649 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWK 697
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-287

8.91e-79

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 247.65 E-value: 8.91e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18336    1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIR 287
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

277-382

1.43e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 222.59 E-value: 1.43e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 157818009 357 QARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFLAD 106

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

277-382

2.22e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 222.10 E-value: 2.22e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 157818009 357 QARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-284

3.55e-68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 218.77 E-value: 3.55e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                         90       100
                 ....*....|....*....|....*
gi 157818009 260 LLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18234   81 LLQLSEVVEACCGFLMKQLHPSNCL 105

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

422-690

3.99e-66

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 219.64 E-value: 3.99e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 422 PRKSTVGAL-----YAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSG-RRLQFGVAVVDNKLYVVGGRDG----LKTLNT 491
Cdd:COG3055   12 PRSEAAAALldgkvYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 492 VECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTV-GVVALNNK 570
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 571 LYAIGGRDGSSclksmeyfdpHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGGHDAPAPNhcsrlsdcVERYDPKSDSWS 650
Cdd:COG3055  172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 157818009 651 TVAPLSVPRDAVAVCPLGDKLYVVGGYD----GHTYLNTVESYD 690
Cdd:COG3055  234 ALGELPTPRHGHAAVLTDGKVYVIGGETkpgvRTPLVTSAEVYD 277

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-287

7.40e-62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 202.97 E-value: 7.40e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18335    1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIR 287
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-287

6.41e-61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 200.29 E-value: 6.41e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQ 237
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157818009 238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIR 287
Cdd:cd18337   81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

278-382

5.28e-60

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 197.17 E-value: 5.28e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|....*
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLLAD 106

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

454-709

3.90e-59

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 201.15 E-value: 3.90e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 454 SWIHIGTMSGRRLQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMST-HRHGLGVATLEGPMYAVGG--- 529
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftg 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 530 -HDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGG 608
Cdd:COG3055   82 aNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 609 VGVATH-NGYLYVVGGHDAPAPNhcsrlsdcverydpksDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGhtYLNTVE 687
Cdd:COG3055  162 LAAAVLpDGKILVIGGRNGSGFS----------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVE 223

                        250       260
                 ....*....|....*....|..
gi 157818009 688 SYDAQKDEWKEEVPVNIGRAGA 709
Cdd:COG3055  224 AYDPATNTWTALGELPTPRHGH 245

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

277-382

6.43e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 194.13 E-value: 6.43e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....*.
gi 157818009 357 QARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

278-382

7.67e-48

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 164.33 E-value: 7.67e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100
                 ....*....|....*....|....*
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18445   81 NRKEHLAELLEHVRLPLLSPEYLVQ 105

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

278-412

1.60e-46

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 161.41 E-value: 1.60e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD-LENSSMFSGDLECQKLLMEAMKYHLLPERR 412
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDvVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-280

5.38e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 148.34 E-value: 5.38e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18235    4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18235   84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

548-714

2.74e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 149.15 E-value: 2.74e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 548 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS-KRRGGVGVATHNGYLYVVGGHDA 626
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 627 PAPNhcSRLSDCVERYDPKSDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWKEEVPVNIGR 706
Cdd:COG3055   82 ANPS--STPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159


                 ....*...
gi 157818009 707 AGACVVVV 714
Cdd:COG3055  160 DHLAAAVL 167

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-277

1.76e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 141.26 E-value: 1.76e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSN 89

                         90       100
                 ....*....|....*....|....*..
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQ 277
Cdd:cd18247   90 VQSLLVGASFLQLQSVKDACCEFLKER 116

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-285

4.56e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 140.66 E-value: 4.56e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQ 237
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157818009 238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18249   81 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

278-406

6.21e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 140.17 E-value: 6.21e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD-LENSSMFSGDLECQKLLMEAMKYH 406
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQrVEEETLVKNSSACKDYLIEAMKYH 130

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

283-383

2.83e-38

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 137.29 E-value: 2.83e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009  283 CLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQQD 362
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|.
gi 157818009  363 LAKLLSYIRLPLLSPQLLADL 383
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNL 101

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

278-382

3.66e-38

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 137.05 E-value: 3.66e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD 382
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTD 105

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-283

2.40e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 135.65 E-value: 2.40e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18242   84 TVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-285

4.63e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 134.84 E-value: 4.63e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

160-285

1.04e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 133.77 E-value: 1.04e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 160 SRNHADYTLCkMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYA 239
Cdd:cd18237    2 AKLLADFMGV-MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157818009 240 YTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18237   81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-285

2.93e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 132.41 E-value: 2.93e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 174 YLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIEN 253
Cdd:cd18238    9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQS 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157818009 254 LLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18238   89 LLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

278-406

1.01e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 131.34 E-value: 1.01e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157818009 358 ARQQDLAKLLSYIRLPLLSPQLLAD-LENSSMFSGDLECQKLLMEAMKYH 406
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQtVEEEALIKNNNTCKDFLIEAMKYH 130

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

283-382

3.54e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 128.61 E-value: 3.54e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009   283 CLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQQD 362
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 157818009   363 LAKLLSYIRLPLLSPQLLAD 382
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-280

1.63e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 121.88 E-value: 1.63e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

277-376

7.96e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 119.07 E-value: 7.96e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90       100
                 ....*....|....*....|
gi 157818009 357 QARQQDLAKLLSYIRLPLLS 376
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLLS 100

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

277-373

3.07e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 114.33 E-value: 3.07e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 157818009 357 QARQQDLAKLLSYIRLP 373
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

278-376

1.07e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 113.17 E-value: 1.07e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*....
gi 157818009 358 ARQQDLAKLLSYIRLPLLS 376
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLS 99

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

171-278

4.98e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 111.20 E-value: 4.98e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009  171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLqLREDT 250
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 157818009  251 IENLLSAACLLQLTQVIDVCCNFLIKQL 278
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

170-280

4.99e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 109.04 E-value: 4.99e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 170 KMESYLKEKK-LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLRE 248
Cdd:cd18339   10 KVMNELRSKQlLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTE 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157818009 249 DTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18339   90 ENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-280

5.53e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 109.01 E-value: 5.53e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18338   12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEEN 91

                         90       100       110
                 ....*....|....*....|....*....|
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18338   92 VQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

154-280

8.40e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 108.96 E-value: 8.40e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 154 SEDHYRSRNHADYTLCkMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALN 233
Cdd:cd18246   14 SISHNSKRHYHDAFVS-MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALE 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157818009 234 SLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18246   93 QLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-261

2.03e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 105.71 E-value: 2.03e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 157818009 260 LL 261
Cdd:cd18186   81 KL 82

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-278

2.16e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 107.47 E-value: 2.16e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAG----PLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQ 237
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18248   83 FAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-283

6.04e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 105.87 E-value: 6.04e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18240   13 LEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELL 92

                         90       100
                 ....*....|....*....|....*...
gi 157818009 256 SAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18240   93 PAADQFNIMGIVKACCDFLEDQLCPENC 120

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-283

6.06e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 105.94 E-value: 6.06e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMeSYLKEKK-LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18255    1 HSVTLLQGL-NALRAKGqLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-286

9.02e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 105.64 E-value: 9.02e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 168 LCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLR 247
Cdd:cd18268   11 LRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILIT 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157818009 248 EDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18268   91 RDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-286

1.06e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 105.42 E-value: 1.06e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 168 LCKMEsylKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLR 247
Cdd:cd18306    9 LNALR---KNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVP 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157818009 248 EDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18306   86 ADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-283

1.41e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 104.85 E-value: 1.41e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-283

2.03e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 104.53 E-value: 2.03e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-285

2.17e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 104.55 E-value: 2.17e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18236   15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18236   95 VQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

279-380

2.21e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 103.65 E-value: 2.21e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 279 HPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQA 358
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 157818009 359 RQQDLAKLLSYIRLPLLSPQLL 380
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102

PHA02790

Kelch-like protein; Provisional

227-696

4.32e-26

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 112.44 E-value: 4.32e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 227 VDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIRSFGDAQGCMELQNVAHKYT 306
Cdd:PHA02790  69 LDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFI 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 307 MEHFI----DVVKNQEFLllpanEISKLLCSDDINVPDEETIFHALMQWVghdaQARQQDLAKLL----SYIRLPLLSPQ 378
Cdd:PHA02790 149 AKHFLeledDIIDNFDYL-----SMKLILESDELNVPDEDYVVDFVIKWY----MKRRNRLGNLLllikNVIRSNYLSPR 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 379 LLADLENSSMFSGDLECQKLLMEAMKYHLLPERRSMLQsprtkprkstvgalyavggmdaakgttTIEKYDLRTNSwiHI 458
Cdd:PHA02790 220 GINNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNMDQ---------------------------IIDIFHMCTST--HV 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 459 GTMsgrrlqfgvavvdnkLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSylnT 538
Cdd:PHA02790 271 GEV---------------VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT---S 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 539 VERWDPDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRdgSSCLKSMEYFDPHTNKWSL-----------CAPMSKRRg 607
Cdd:PHA02790 333 VERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH--SETDTTTEYLLPNHDQWQFgpstyyphyksCALVFGRR- 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 608 gvgvathngyLYVVGGHdapapnhcsrlsdcVERYDPKSDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE 687
Cdd:PHA02790 410 ----------LFLVGRN--------------AEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIE 465


                 ....*....
gi 157818009 688 SYDAQKDEW 696
Cdd:PHA02790 466 VYNNRTYSW 474

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-285

5.47e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 103.76 E-value: 5.47e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18259   14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18259   94 GKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

281-355

1.20e-25

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 100.56 E-value: 1.20e-25

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818009 281 SNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHD 355
Cdd:cd18508    3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-286

1.23e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 102.48 E-value: 1.23e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 175 LKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENL 254
Cdd:cd18269   22 LDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDI 101

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157818009 255 LSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18269  102 FALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

278-376

1.36e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 101.18 E-value: 1.36e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*....
gi 157818009 358 ARQQDLAKLLSYIRLPLLS 376
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLLS 99

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

182-278

1.50e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 101.23 E-value: 1.50e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009   182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLL 261
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 157818009   262 QLTQVIDVCCNFLIKQL 278
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-286

1.89e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 102.76 E-value: 1.89e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKM-EGVDPNALNSLV 236
Cdd:cd18267   18 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLL 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157818009 237 QYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18267   98 DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-285

1.59e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 99.32 E-value: 1.59e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKM-EGVDPNALNSLVQYAY 240
Cdd:cd18254    4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157818009 241 TGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18254   84 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

277-367

1.82e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 97.75 E-value: 1.82e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 157818009 357 QARQQDLAKLL 367
Cdd:cd18458   81 ENRRQYLEALL 91

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-286

2.02e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 99.51 E-value: 2.02e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLL-IAGPLK-------IPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDP 229
Cdd:cd18273    4 LEDAAHARALLAQLKSFYDARLLTDVTIeVNGPGSgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818009 230 NALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18273   84 ESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

160-283

3.19e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 98.72 E-value: 3.19e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 160 SRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYA 239
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFI 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157818009 240 YTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18264   88 YTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

157-284

3.52e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 98.50 E-value: 3.52e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 157 HYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLV 236
Cdd:cd18261    5 LCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQAL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157818009 237 QYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18261   85 DFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-284

5.01e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 98.15 E-value: 5.01e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 168 LCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLR 247
Cdd:cd18270   14 LEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAIN 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157818009 248 EDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18270   94 DSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-285

1.07e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 96.76 E-value: 1.07e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18265    6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18265   86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-286

1.31e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 96.83 E-value: 1.31e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 168 LCKMesyLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLR 247
Cdd:cd18340   18 LKDL---LDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEIT 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157818009 248 EDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18340   95 EQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-286

1.44e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 96.84 E-value: 1.44e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18341   18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGN 97

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18341   98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-275

1.55e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 93.34 E-value: 1.55e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQ 237
Cdd:cd18251    1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILD 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157818009 238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLI 275
Cdd:cd18251   81 FIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLM 118

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

281-359

1.66e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 92.00 E-value: 1.66e-22

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818009 281 SNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQAR 359
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

277-354

2.61e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 91.30 E-value: 2.61e-22

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGH 354
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-286

3.32e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 92.74 E-value: 3.32e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLK-IPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18274   85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-284

5.19e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 92.26 E-value: 5.19e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQ 237
Cdd:cd18266    3 YRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVID 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157818009 238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18266   83 FLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

276-378

6.01e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 90.97 E-value: 6.01e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 276 KQLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHD 355
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|...
gi 157818009 356 AQARQQDLAKLLSYIRLPLLSPQ 378
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQ 103

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-286

1.55e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 90.63 E-value: 1.55e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18276   84 DLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

278-355

2.80e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 88.44 E-value: 2.80e-21

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVK-NQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHD 355
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-274

3.11e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 89.32 E-value: 3.11e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQE--EVKMEGVDPNALNSLVQYAYTGVLQLRE 248
Cdd:cd18245    5 LNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSE 84

                         90       100
                 ....*....|....*....|....*.
gi 157818009 249 DTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18245   85 DNIQDIVQAADLLLMTDLKDLCCEFL 110

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

278-377

8.07e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 87.91 E-value: 8.07e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|
gi 157818009 358 ARQQDLAKLLSYIRLPLLSP 377
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDP 100

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-283

3.36e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 86.78 E-value: 3.36e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPL--KIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSL 235
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGdeTFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

195-285

5.55e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 86.42 E-value: 5.55e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 195 HRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18252   37 HKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFL 116

                         90
                 ....*....|.
gi 157818009 275 IKQLHPSNCLG 285
Cdd:cd18252  117 VRHLDIDNCLG 127

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

280-380

6.13e-20

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 85.22 E-value: 6.13e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 280 PSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQAR 359
Cdd:cd18466    3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90       100
                 ....*....|....*....|.
gi 157818009 360 QQDLAKLLSYIRLPLLSPQLL 380
Cdd:cd18466   83 KKHVVEVLEPVRFPLLPPQRL 103

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

278-377

6.79e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 85.16 E-value: 6.79e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 157818009 358 ARQQDLAKLLSYIRLPLLSP 377
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

159-286

1.45e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 85.27 E-value: 1.45e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 159 RSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQY 238
Cdd:cd18271    3 VAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157818009 239 AYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18271   83 AYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

280-368

1.79e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 83.91 E-value: 1.79e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 280 PSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQAR 359
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                 ....*....
gi 157818009 360 QQDLAKLLS 368
Cdd:cd18455   82 KVHLKDLMS 90

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-283

2.66e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 84.62 E-value: 2.66e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 156 DHYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSL 235
Cdd:cd18244    6 EVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18244   86 LQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133

PHA02713

hypothetical protein; Provisional

150-577

1.09e-18

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 90.07 E-value: 1.09e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 150 MNVISEDHYRSrnhadyTLCKMESYLKEKKLCDVLLIAGP-LKIPAHRLVLSAVSDYFAAMFTNDVLeARQ--EEVKMEG 226
Cdd:PHA02713   1 MDIDDIKHNRR------VVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMI-IRDlvTRVNLQM 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 227 VDPNALNSLVQYAYTgvlqlREDTIENllsaacllqltqVIDV--CCNFLIKQLHPSNCLG-IRSFGDAQGCMELQnvaH 303
Cdd:PHA02713  74 FDKDAVKNIVQYLYN-----RHISSMN------------VIDVlkCADYLLIDDLVTDCESyIKDYTNHDTCIYMY---H 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 304 K-YTMEHfIDVVKNQEFLLLpaNEISKLLCSDD------------INVPDEETIFHA------LMQWVGHDAQARQQDLA 364
Cdd:PHA02713 134 RlYEMSH-IPIVKYIKRMLM--SNIPTLITTDAfkktvfeilfdiISTNDNVYLYREgykvtiLLKWLEYNYITEEQLLC 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 365 kLLSYIRLPLL---SPQLLADLENSSMFSgdlECQKLLMEAMKYHLLPERRSMLQSPRTKprkstvgalYAVGgmdaakg 441
Cdd:PHA02713 211 -ILSCIDIQNLdkkSRLLLYSNKTINMYP---SCIQFLLDNKQNRNIIPRQLCLVCHDTK---------YNVC------- 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 442 TTTIEKYDLRTNSWIHIGTMSGRRLQFGVAVVDNKLYVVGGRD-GLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATL 520
Cdd:PHA02713 271 NPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVI 350

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157818009 521 EGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 577
Cdd:PHA02713 351 DDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGR 407

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

279-375

1.35e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 81.39 E-value: 1.35e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 279 HPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQA 358
Cdd:cd18464    1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                         90
                 ....*....|....*..
gi 157818009 359 RQQDLAKLLSYIRLPLL 375
Cdd:cd18464   81 RHEVLPELLRSVRLALL 97

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

281-375

7.45e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 79.42 E-value: 7.45e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 281 SNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQ 360
Cdd:cd18516    4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                         90
                 ....*....|....*
gi 157818009 361 QDLAKLLSYIRLPLL 375
Cdd:cd18516   84 KALPVLLESIRFRLM 98

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

171-284

1.05e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 79.47 E-value: 1.05e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18263    4 IEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWEN 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18263   84 LFEATCTALQLQISGALALCLDFLQREISPARCL 117

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-284

1.41e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 79.09 E-value: 1.41e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDvleARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKD---PSLQRVELNDISPLGLATVITYAYTG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18260   78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

278-373

2.41e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 77.59 E-value: 2.41e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 157818009 358 ARQQDLAKLLSY-IRLP 373
Cdd:cd18483   81 KREMHLPEIFAKcIRMP 97

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

159-273

2.86e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 78.30 E-value: 2.86e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 159 RSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTnDVLEARQEEVKMEGVDPNALNSLVQY 238
Cdd:cd18212    2 HSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLEGMVAETFGALLEF 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157818009 239 AYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNF 273
Cdd:cd18212   81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

278-375

3.19e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 77.58 E-value: 3.19e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*...
gi 157818009 358 ARQQDLAKLLSYIRLPLL 375
Cdd:cd18514   81 KRKDYLPELLRNVRLALL 98

Kelch

Kelch domain;

570-616

3.93e-17

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 75.29 E-value: 3.93e-17

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157818009   570 KLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATHNG 616
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

279-375

4.71e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 76.94 E-value: 4.71e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 279 HPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQA 358
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*..
gi 157818009 359 RQQDLAKLLSYIRLPLL 375
Cdd:cd18515   81 RHCYLSELLQTVRLALL 97

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-274

9.58e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 76.84 E-value: 9.58e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18328    7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18328   87 STLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

278-375

1.16e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 76.03 E-value: 1.16e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*...
gi 157818009 358 ARQQDLAKLLSYIRLPLL 375
Cdd:cd18477   81 NRQKALPTVFESIRFRLL 98

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-274

1.43e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 76.44 E-value: 1.43e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18198    7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18198   87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-283

2.86e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 76.05 E-value: 2.86e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLI---AGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKME------GVDPNALNSLVQYAYTGVLQL 246
Cdd:cd18241   19 KQGLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDTVEAVIQYMYTGRIRV 98

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157818009 247 REDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18241   99 STGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

180-262

3.59e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 73.74 E-value: 3.59e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEaRQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPD-EHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ...
gi 157818009 260 LLQ 262
Cdd:cd18315   80 LLQ 82

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

277-374

4.27e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 74.32 E-value: 4.27e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 277 QLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*...
gi 157818009 357 QARQQDLAKLLSYIRLPL 374
Cdd:cd18447   81 PNRQPYMVDILAKVRFPL 98

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-274

1.28e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 73.43 E-value: 1.28e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18326   25 LCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAAR 104

                         90
                 ....*....|....*
gi 157818009 260 LLQLTQVIDVCCNFL 274
Cdd:cd18326  105 LLEIPAVSHVCADLL 119

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

278-375

1.63e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 72.52 E-value: 1.63e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*...
gi 157818009 358 ARQQDLAKLLSYIRLPLL 375
Cdd:cd18460   81 HRQHFWPELLQHVRLPFV 98

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

464-509

2.34e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 70.33 E-value: 2.34e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157818009  464 RRLQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMS 509
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

278-375

2.68e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 72.11 E-value: 2.68e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*...
gi 157818009 358 ARQQDLAKLLSYIRLPLL 375
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLM 98

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-286

3.53e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 73.00 E-value: 3.53e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18272   23 MDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEE 102

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18272  103 LQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

278-377

3.92e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 71.31 E-value: 3.92e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDInVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 157818009 358 ARQQDLAKLLSYIRLPLLSP 377
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

282-374

5.00e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 71.30 E-value: 5.00e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 282 NCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQQ 361
Cdd:cd18462    5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                         90
                 ....*....|...
gi 157818009 362 DLAKLLSYIRLPL 374
Cdd:cd18462   85 CAYDLLSSIKLDL 97

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-274

9.38e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 71.11 E-value: 9.38e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18287    4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157818009 242 GVLQL---REDTIENLLSAA---CLLQLTQVIdvcCNFL 274
Cdd:cd18287   84 GRLTLtdlKEDVLLDVLGLAhqyGFEELEAAI---SDYL 119

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

282-372

1.04e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 70.09 E-value: 1.04e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 282 NCLGIRSFGDAQGCMELQNVAhKYTMEHFIDVVKNQE-FLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQ 360
Cdd:cd18479    5 NCVRLLSFADLFSCEELKQSA-KRMVEHKFTAVYHQEaFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRS 83

                         90
                 ....*....|..
gi 157818009 361 QDLAKLLSYIRL 372
Cdd:cd18479   84 QYLSSVLSQIRI 95

Kelch

Kelch domain;

476-522

2.71e-14

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 67.20 E-value: 2.71e-14

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157818009   476 KLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEG 522
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

PLN02193

nitrile-specifier protein

455-676

3.48e-14

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 75.38 E-value: 3.48e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 455 WIHI---GTMSGRRLQFGVAVVDNKLYVVGGRdglKTLNT-----VECFNPVTKTWVVMPPMSTHRH----GLGVATLEG 522
Cdd:PLN02193 153 WIKVeqkGEGPGLRCSHGIAQVGNKIYSFGGE---FTPNQpidkhLYVFDLETRTWSISPATGDVPHlsclGVRMVSIGS 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 523 PMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMS---TPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 599
Cdd:PLN02193 230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 600 APMSKR---RGGVGVATHNGYLYVVGGHdapapNHCSrlSDCVERYDPKSDSWSTVAPLSV---PRDAVAVCPLGDKLYV 673
Cdd:PLN02193 310 STPGDSfsiRGGAGLEVVQGKVWVVYGF-----NGCE--VDDVHYYDPVQDKWTQVETFGVrpsERSVFASAAVGKHIVI 382


                 ...
gi 157818009 674 VGG 676
Cdd:PLN02193 383 FGG 385

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

558-603

7.32e-14

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 66.10 E-value: 7.32e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157818009  558 PRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS 603
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

179-277

8.66e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 68.45 E-value: 8.66e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 179 KLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMF---TNDVLEARqeEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18207   26 RFCDVLLRVGEESFPAHRAVLAACSEYFESVFsaqEGDGGTPR--ELEMHTISSKVFGDILDFAYTSRIVVRLESFPELM 103

                         90       100
                 ....*....|....*....|..
gi 157818009 256 SAACLLQLTQVIDVcCNFLIKQ 277
Cdd:cd18207  104 TAAKFLLMRSVIDI-CQEVIKQ 124

Kelch

Kelch domain;

525-569

1.62e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 65.27 E-value: 1.62e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 157818009   525 YAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNN 569
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

282-354

2.03e-13

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 65.83 E-value: 2.03e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818009 282 NCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGH 354
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

278-352

3.82e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 65.10 E-value: 3.82e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWV 352
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

182-274

4.23e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 65.70 E-value: 4.23e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGP-LKIPAHRLVLSAVSDYFAAMFTNdvlearQEEVKMEG-VDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18299   14 DVVFILQGgVRIFAHRIVLAAASSVFADLFLM------MTVVTLDSdITPEAFRRVLEFLYTGVLDENEDDLKELKDAAE 87

                         90
                 ....*....|....*
gi 157818009 260 LLQLTQVIDVCCNFL 274
Cdd:cd18299   88 LLELFDLVMMCTNVL 102

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-274

4.63e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 66.41 E-value: 4.63e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFT------NDVLEARQEEV-KMEGVDPNALNSLVQYAYTGVLQLREDTIE 252
Cdd:cd18327   25 LCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTgggggsGDLGAGGGQDVcELDFVGPEALGALLEFAYTATLTISSSNMR 104

                         90       100
                 ....*....|....*....|..
gi 157818009 253 NLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18327  105 EVLRAARLLEIPCVADACADIL 126

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

157-280

1.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 65.23 E-value: 1.09e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 157 HYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFtndvLEARQEEVKMEGV-DPNALNSL 235
Cdd:cd18214    2 HFRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQF----LLNDSREVQISILqNSEVGRQL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18214   78 LLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

279-333

1.55e-12

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 62.68 E-value: 1.55e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157818009 279 HPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCS 333
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

182-270

2.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 63.52 E-value: 2.03e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLL 261
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                 ....*....
gi 157818009 262 QLTQVIDVC 270
Cdd:cd18314   88 QVPDLEKLC 96

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

281-356

3.01e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 62.52 E-value: 3.01e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157818009 281 SNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356
Cdd:cd18474    4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

182-276

5.77e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 63.05 E-value: 5.77e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLRED-TIENLLSAACL 260
Cdd:cd18286   19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDvNLGELLSLADM 98

                         90
                 ....*....|....*.
gi 157818009 261 LQLTQVIDVCCNFLIK 276
Cdd:cd18286   99 YGLDGLKDVVAYTLRR 114

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

172-278

5.99e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 62.64 E-value: 5.99e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 172 ESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLRE--D 249
Cdd:cd18300    1 KLFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdgD 80

                         90       100
                 ....*....|....*....|....*....
gi 157818009 250 TIEnLLSAACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18300   81 CVG-LIVLANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

7.78e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 62.96 E-value: 7.78e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMF-----TNDVLEARQE-------EVKMEGVDPn 230
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasPRLVLVSPAGkcvldlhHVTVTGFAP- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157818009 231 alnsLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18228   81 ----LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-274

9.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 62.66 E-value: 9.06e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFT----NDVLEARQEEVKMEGVDPnaln 233
Cdd:cd18278    9 YESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVgqteNDLVVSLPEEVTARGFGP---- 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 234 sLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18278   85 -LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

182-275

1.29e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 61.91 E-value: 1.29e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAvSDYFAAMFTNDVLEARQEEVKMEGVDPN----ALNSLVQYAYTGVLQLREDTIENLLSA 257
Cdd:cd18305   17 DITICALGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLEIPDDNitveALNVVFGSLYRDEIEIKPSRVVSILAA 95

                         90
                 ....*....|....*...
gi 157818009 258 ACLLQLTQVIDVCCNFLI 275
Cdd:cd18305   96 ATLLQLDGLIQQCSEVMK 113

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

169-258

1.30e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 61.88 E-value: 1.30e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 169 CKMESYLKEKKLCDVLLIAGPLKIP--AHRLVLSAVSDYFAAMF-TNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQ 245
Cdd:cd18294    3 ADMKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVT 82

                         90
                 ....*....|...
gi 157818009 246 LREDTIENLLSAA 258
Cdd:cd18294   83 LSNHTVIEVLAAA 95

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

511-556

1.79e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 59.16 E-value: 1.79e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157818009  511 HRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMS 556
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

670-714

1.79e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 59.49 E-value: 1.79e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 157818009   670 KLYVVGGYDGHTYLNTVESYDAQKDEWKEEVPVNIGRAGACVVVV 714
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

182-286

1.99e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 60.96 E-value: 1.99e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLearqeevKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLL 261
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDIL-------KVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                         90       100
                 ....*....|....*....|....*
gi 157818009 262 QLTQVIDVCCNFLIKQLHPSNCLGI 286
Cdd:cd18275   79 QMPCAAQCAVDAVRAQLCLGNCYEV 103

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-280

2.08e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 61.43 E-value: 2.08e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVkMEGvdPNALNSLVQYAYTG 242
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSL-MHS--SRVVADLLLSCYTG 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18203   85 ALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

282-376

2.55e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 60.66 E-value: 2.55e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 282 NCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDaQARQQ 361
Cdd:cd18470    5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                         90
                 ....*....|....*
gi 157818009 362 DLAKLLSYIRLPLLS 376
Cdd:cd18470   84 YAADLLSNIRFGTIS 98

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

191-268

4.04e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 60.73 E-value: 4.04e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818009 191 KIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVID 268
Cdd:cd18295   30 SFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAKQCRLEELIE 107

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

5.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 60.61 E-value: 5.04e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAaMFTNDVLEARqEEVKMEG--VDPNALNSLVQYAYTGVLQLREDTIENLLSA 257
Cdd:cd18194   23 LCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKR-DLVRLNSdiVTAPAFGLLLDFMYEGRLALRDLPVEDVLAA 100

                         90
                 ....*....|...
gi 157818009 258 ACLLQLTQVIDVC 270
Cdd:cd18194  101 ASYLHMYDIVKVC 113

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

605-656

5.30e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 58.01 E-value: 5.30e-11

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157818009  605 RRGGVGVATHNGYLYVVGGHDApapnhcSRLSDCVERYDPKSDSWSTVAPLS 656
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-270

5.58e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 59.95 E-value: 5.58e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNdvlEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGE 77

                         90       100
                 ....*....|....*....|....*...
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18218   78 SVEVQPGELRPLLEAARALEVESLEEAC 105

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-274

6.69e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 59.40 E-value: 6.69e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFT----NDVLEARQEEVKMEGVDPnalnsLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVC 75

                         90
                 ....*....|....*....
gi 157818009 256 SAACLLQLTQVIDVCCNFL 274
Cdd:cd18955   76 RCAEFLGVHNIEKACFDFL 94

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

181-273

1.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 58.66 E-value: 1.07e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 181 CDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQE---EVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSA 257
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                         90
                 ....*....|....*.
gi 157818009 258 ACLLQLTQVIDVCCNF 273
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

1.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 59.83 E-value: 1.07e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFaAMFTNDVLEARQEEVKMEG--VDPNALNSLVQYAYTGVLQLREDTIENLLSA 257
Cdd:cd18956   23 LCDCTVLVGDARFPAHRAVLAACSVYF-HLFYRDRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101

                         90
                 ....*....|...
gi 157818009 258 ACLLQLTQVIDVC 270
Cdd:cd18956  102 ASYLHMYDIVKVC 114

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-270

1.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 59.55 E-value: 1.08e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 172 ESYLKEKKLCDVLLIAGPLK--IPAHRLVLSAVSDYFAAMFTNDVlEARQEEVKMEGVDPNALNSLVQYAYTGVLQLRED 249
Cdd:cd18231    6 EQRLFQPDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSC 84

                         90       100
                 ....*....|....*....|.
gi 157818009 250 TIENLLSAACLLQLTQVIDVC 270
Cdd:cd18231   85 NVQDVLNAAAVLQMNDIAASC 105

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-285

1.12e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 59.60 E-value: 1.12e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQE---EVKMEGVDPNALNSLVQYAYTGVLQLREDTIE 252
Cdd:cd18258   13 RAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYTGSLIIDSANAK 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 253 NLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLG 285
Cdd:cd18258   93 TLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

181-270

1.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 59.03 E-value: 1.40e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 181 CDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEV-KMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18293   16 CDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAAR 95

                         90
                 ....*....|.
gi 157818009 260 LLQLTQVIDVC 270
Cdd:cd18293   96 RLQISELESLC 106

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-274

1.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 58.92 E-value: 1.60e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTN----DVLEARQEEVKMEGVDPnaln 233
Cdd:cd18277    5 YESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGqadaELNITLPEEVTVKGFEP---- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157818009 234 sLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18277   81 -LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

3.58e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 57.94 E-value: 3.58e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFtndvLEARQEEVKM----EGVDPNALNSLVQY 238
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF----SGRVGEGVSVltlpSGLEARGFQLLLDF 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157818009 239 AYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18332   78 MYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-244

5.36e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 57.19 E-value: 5.36e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818009 172 ESYLKEKkLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEArQEEVKMEGVDPNALNSLVQYAYTGVL 244
Cdd:cd18209   11 EERLKGQ-LCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSSSL 81

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-274

5.54e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 57.30 E-value: 5.54e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGP----LKIPAHRLVLSAVSDYFAAMFTNDVLEARQeEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18349    8 MADVHFIVGPpgasQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATL 86

                         90
                 ....*....|....*....
gi 157818009 256 SAACLLQLTQVIDVCCNFL 274
Cdd:cd18349   87 YAAKKYIVPALAKACVNFL 105

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-282

7.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 57.45 E-value: 7.31e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAG----PLKIPAHRLVLSAVSDYFAAMFtNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18281   22 LSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 157818009 256 SAACLLQLTQVIDVCCNFLIKQLHPSN 282
Cdd:cd18281  101 YTAKKYAVPALESACVEFLKKNLSSDN 127

Kelch

Kelch domain;

618-669

9.41e-10

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 54.49 E-value: 9.41e-10

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157818009   618 LYVVGGHdapapNHCSRLSDcVERYDPKSDSWSTVAPLSVPRDAVAVCPLGD 669
Cdd:smart00612   2 IYVVGGF-----DGGQRLKS-VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

658-698

1.01e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 54.54 E-value: 1.01e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157818009  658 PRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWKE 698
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-274

1.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 56.39 E-value: 1.10e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAamftNDVLEARQEEVKMEGV-DPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18210   18 EGKLCDISIHVQGRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKLTMLADEIVNYL 93

                         90
                 ....*....|....*....
gi 157818009 256 SAACLLQLTQVIDVCCNFL 274
Cdd:cd18210   94 TVGSVLQMWHIVDKCTELL 112

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

169-258

1.59e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 56.00 E-value: 1.59e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 169 CKMESYLKE----KKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVL 244
Cdd:cd18279    3 CRLAEDLGNlwenSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKA 82

                         90
                 ....*....|....
gi 157818009 245 QLREDTIENLLSAA 258
Cdd:cd18279   83 PNLDKMADDLLAAA 96

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-273

1.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 56.03 E-value: 1.66e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNF 273
Cdd:cd18215   82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

Kelch

Kelch domain;

430-475

2.71e-09

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 53.33 E-value: 2.71e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 157818009   430 LYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSGRRLQFGVAVVDN 475
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

278-352

3.30e-09

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 54.55 E-value: 3.30e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEET-IFHALMQWV 352
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQELESINERkLCQLVLEWV 76

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

3.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 55.81 E-value: 3.44e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAaMFTNDVLEARQ-EEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd18324   23 LCDCTVLVGDAQFRAHRAVLASCSMYFH-LFYKDQLDKRDiVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAA 101

                         90
                 ....*....|..
gi 157818009 259 CLLQLTQVIDVC 270
Cdd:cd18324  102 SYLHMYDIVKVC 113

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

4.11e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 55.22 E-value: 4.11e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAaMFTNDVLEARQEE-VKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd18323   23 LCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVcINNEIVTAPAFSLLLEFMYEGRLSFNDTPVEDVLAAA 101

                         90
                 ....*....|..
gi 157818009 259 CLLQLTQVIDVC 270
Cdd:cd18323  102 SYLHMNDIVKVC 113

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

188-282

4.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 55.45 E-value: 4.16e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 188 GPLKIPAHRLVLSAVSDYFAAMFtNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVI 267
Cdd:cd18346   40 GAQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                         90
                 ....*....|....*
gi 157818009 268 DVCCNFLIKQLHPSN 282
Cdd:cd18346  119 AHCVEFLTKHLRADN 133

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-282

4.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 55.05 E-value: 4.37e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDvlearqeEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18243   15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYLYTA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSN 282
Cdd:cd18243   88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

179-280

4.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 55.05 E-value: 4.72e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 179 KLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTndVLEARQE----EVKMEGVDPNALNSLVQYAYTGVLQLREDTIENL 254
Cdd:cd18196   20 QLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT--VAEGDQTmnmiQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDV 97

                         90       100
                 ....*....|....*....|....*.
gi 157818009 255 LSAACLLQLTQVIDVCCNFLIKQLHP 280
Cdd:cd18196   98 LLAASHLHLNSVVKACKHYLTTRTLP 123

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

4.82e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 54.86 E-value: 4.82e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTnDVLEARQEEVKME-GVDPNALNSLVQYAYT 241
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINLDpEINPEGFNILLDFMYT 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18331   86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

167-273

7.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 54.21 E-value: 7.38e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 167 TLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTND-VLEARQEEVKMEGvDPN---ALNSLVQYAYTG 242
Cdd:cd18292    4 FLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELVE-DPEcaaVFEKFLRYLYTG 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNF 273
Cdd:cd18292   83 QISVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

7.86e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 54.27 E-value: 7.86e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAaMFTNDVLEARQ-EEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd18325   23 LCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLDKRDiVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAA 101

                         90
                 ....*....|..
gi 157818009 259 CLLQLTQVIDVC 270
Cdd:cd18325  102 SYLHMYDIVKVC 113

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-274

8.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 53.97 E-value: 8.52e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEA-RQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENL 254
Cdd:cd18199   14 KQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVIEV 93

                         90       100
                 ....*....|....*....|
gi 157818009 255 LSAACLLQLTQVIDVCCNFL 274
Cdd:cd18199   94 MSAASYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-270

8.79e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 53.60 E-value: 8.79e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMF---TNDVLEARQEEVKMEGvdpnaLNSLVQYAYTGVLQLREDTIENLLS 256
Cdd:cd18217   18 LCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYkdtEDNIVFLDQSQVSADG-----FQKLLEFIYTGNLNLDSWNVAEIHQ 92

                         90
                 ....*....|....
gi 157818009 257 AACLLQLTQVIDVC 270
Cdd:cd18217   93 AASYLGMEEVVAKC 106

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-273

9.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 53.78 E-value: 9.78e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNdvleaRQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18206   22 LCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD-----QKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVAT 96

                         90
                 ....*....|....
gi 157818009 260 LLQLTQVIDVCCNF 273
Cdd:cd18206   97 FLQMQDIVTACHAL 110

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

1.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 53.36 E-value: 1.24e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDvlEARQEEV-KMEGVDPNALNSLVQYAYT 241
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNS--SSQKNDVfHLDIKNVGGIGQILDFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18233   79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

182-278

1.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 53.17 E-value: 1.32e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPL----KIPAHRLVLSAVSDYFAAMFTNDVLEARQeEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSA 257
Cdd:cd18282    9 DVHFIVGPPggtqRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYA 87

                         90       100
                 ....*....|....*....|.
gi 157818009 258 ACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18282   88 AKKYLVPHLARACVQFLETSL 108

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

169-258

1.65e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 53.31 E-value: 1.65e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 169 CKMESYL----KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVL 244
Cdd:cd18345    3 CRLSDDLgllfERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKA 82

                         90
                 ....*....|....
gi 157818009 245 QLREDTIENLLSAA 258
Cdd:cd18345   83 PNLDKMADDLLAAA 96

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

1.69e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 53.29 E-value: 1.69e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEV-KMEGVDPNALNSLVQYAYT 241
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDFVYS 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18329   84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

171-242

2.75e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 52.78 E-value: 2.75e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157818009 171 MESYLKE--KKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPN--ALNSLVQYAYTG 242
Cdd:cd18309    9 MEAFLESvgGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSrqAFDSLLRYIYYG 84

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-270

2.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 52.24 E-value: 2.89e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEA-RQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENL 254
Cdd:cd18330   14 KRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEV 93

                         90
                 ....*....|....*.
gi 157818009 255 LSAACLLQLTQVIDVC 270
Cdd:cd18330   94 MSAASYLQMTDVVNFC 109

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-283

3.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 52.33 E-value: 3.32e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 173 SYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAmftndVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIE 252
Cdd:cd18303   11 SLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSN-----ENLASTNELDLSDISYEVVLALLRWLYTDELDLTLDDEF 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 253 --NLLSAACLLQLTQVIDVCCNFLIKQLHPSNC 283
Cdd:cd18303   86 llELMKAAKRFQLTDLVERCERALMSSVNVDNC 118

Kelch_6

Kelch motif;

465-508

3.52e-08

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 50.03 E-value: 3.52e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 157818009  465 RLQFGVAVVDNKLYVVGGR-DGLKTLNTVECFNPVTKTWVVMPPM 508
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

283-375

3.76e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 51.45 E-value: 3.76e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 283 CLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAqARQQD 362
Cdd:cd18465    6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDP-SRRAS 84

                         90
                 ....*....|...
gi 157818009 363 LAKLLSYIRLPLL 375
Cdd:cd18465   85 ASHVLCHIRFPLM 97

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-278

3.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 51.89 E-value: 3.89e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 174 YLKEKKLCDV-LLIAGPLkIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG---VLQLRED 249
Cdd:cd18297    6 YVNNPEMSDVtFLVEGRP-FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQD 84

                         90       100
                 ....*....|....*....|....*....
gi 157818009 250 TIENLLSAACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18297   85 DALELLRAASFFQLDGLKRHCEILLSQQI 113

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-274

4.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 52.25 E-value: 4.37e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAamftNDVLEARQEEVKMEGV-DPNALNSLVQYAY 240
Cdd:cd18227    7 DFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFC----DQVLLKNSRRIVLPDVmNPRVFENILLSCY 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157818009 241 TGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18227   83 TGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

PRK14131

N-acetylneuraminate epimerase;

563-712

6.30e-08

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 55.41 E-value: 6.30e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 563 GVVAL-NNKLYaIG-GRDGSSCLKsMEYFDPHtNKWSLCA--PMSKRRGGVGVAThNGYLYVVGG----HDAPAPnhcsR 634
Cdd:PRK14131  32 GTGAIdNNTVY-VGlGSAGTSWYK-LDLNAPS-KGWTKIAafPGGPREQAVAAFI-DGKLYVFGGigktNSEGSP----Q 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 635 LSDCVERYDPKSDSWSTVAPLSvPRD---AVAVCPLGDKLYVVGGY-----DGH-------------------TYLNT-- 685
Cdd:PRK14131 104 VFDDVYKYDPKTNSWQKLDTRS-PVGlagHVAVSLHNGKAYITGGVnknifDGYfedlaaagkdktpkdkindAYFDKkp 182

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 157818009 686 --------VESYDAQKDEWKE--EVPVnIGRAGACVV 712
Cdd:PRK14131 183 edyffnkeVLSYDPSTNQWKNagESPF-LGTAGSAVV 218

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-274

6.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 51.54 E-value: 6.44e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDT 250
Cdd:cd18343   12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKM 91

                         90       100
                 ....*....|....*....|....*...
gi 157818009 251 IENLLSAACLLQLTQVIDVC----CNFL 274
Cdd:cd18343   92 ADNLLAAADKYALERLKVMCeealCNNL 119

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-274

8.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 50.80 E-value: 8.07e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDvlearQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTA 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157818009 243 VLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18205   76 TLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

PLN02153

epithiospecifier protein

455-652

8.28e-08

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 54.99 E-value: 8.28e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 455 WIHI----GTMSGRRLQFGVAVVDNKLYVVGGRdgLKTLNTVE----CFNPVTKTWVVMPP------MSThrHGLGVATL 520
Cdd:PLN02153   9 WIKVeqkgGKGPGPRCSHGIAVVGDKLYSFGGE--LKPNEHIDkdlyVFDFNTHTWSIAPAngdvprISC--LGVRMVAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 521 EGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMST-----PRSTVGVVALNNKLYAIGGRDGSSCLK------SMEYF 589
Cdd:PLN02153  85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAY 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818009 590 DPHTNKW-SLCAPMS--KRRGGVGVATHNGYLYVVGGH-DAPAPNHCSRL-SDCVERYDPKSDSWSTV 652
Cdd:PLN02153 165 NIADGKWvQLPDPGEnfEKRGGAGFAVVQGKIWVVYGFaTSILPGGKSDYeSNAVQFFDPASGKWTEV 232

PLN02193

nitrile-specifier protein

423-576

9.62e-08

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 54.96 E-value: 9.62e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 423 RKSTVGA-LYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMS---GRRLQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPV 498
Cdd:PLN02193 223 RMVSIGStLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIV 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 499 TKTWV--VMPPMS-THRHGLGVATLEGPMYAVGGHDGWSyLNTVERWDPDGRQWNYVASMS---TPRSTVGVVALNNKLY 572
Cdd:PLN02193 303 DKKWFhcSTPGDSfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIV 381


                 ....
gi 157818009 573 AIGG 576
Cdd:PLN02193 382 IFGG 385

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-276

1.19e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 50.81 E-value: 1.19e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 175 LKEKKL----CDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNdvleARQEEVKMEG-VDPNALNSLVQYAYTGVLQLRED 249
Cdd:cd18290   18 LNEQRLqglyCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSFCYTGRLSMNVG 93

                         90       100
                 ....*....|....*....|....*..
gi 157818009 250 TIENLLSAACLLQLTQVIDVCCNFLIK 276
Cdd:cd18290   94 DQFLLMYTAGFLQIQEIMEKGTEFFLK 120

BTB_POZ_ARMC5

cd18191

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

183-274

1.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349500 [Multi-domain] Cd Length: 100 Bit Score: 50.19 E-value: 1.27e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 183 VLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAY--TGVLQLREDTIENLLSAACL 260
Cdd:cd18191    5 RFLLDGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHgcRGCDANEDDEKSDQSPEGDL 84

                         90
                 ....*....|....*.
gi 157818009 261 LQ--LTQVIDVCCNFL 274
Cdd:cd18191   85 MKssLGQTLEVAGRFL 100

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

168-264

1.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 50.28 E-value: 1.28e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 168 LCKMESYLKEKKLCDVLL-IAGPLKIPAHRLVLSAVSDYFAamftndVLEARQEEVKMEGVDPN-----ALNSLVQYAYT 241
Cdd:cd18311    2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFN------VLEQTCEIVDDTLIMPNelqadAVVPVINFMYT 75

                         90       100
                 ....*....|....*....|...
gi 157818009 242 GVLQLREDTIENLLSAACLLQLT 264
Cdd:cd18311   76 GQLEFEEKSYGKLLRTAKELNMT 98

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-282

1.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 50.46 E-value: 1.65e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGP----LKIPAHRLVLSAVSDYFAAMFtNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18347   22 LSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 157818009 256 SAACLLQLTQVIDVCCNFLIKQLHPSN 282
Cdd:cd18347  101 YTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

181-258

1.66e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 50.41 E-value: 1.66e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 181 CDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVL------------QLRE 248
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsdssSLDT 94

                         90
                 ....*....|
gi 157818009 249 DTIENLLSAA 258
Cdd:cd18280   95 TMAQHLLAAA 104

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-282

2.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 50.40 E-value: 2.48e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGP----LKIPAHRLVLSAVSDYFAAMFTNDVLEARqEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18348   21 MADIHFVVGPpggtQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATL 99

                         90       100
                 ....*....|....*....|....*..
gi 157818009 256 SAACLLQLTQVIDVCCNFLIKQLHPSN 282
Cdd:cd18348  100 YAAKKYIVPHLARACVNFLETSLSAKN 126

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-270

2.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 49.58 E-value: 2.88e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLearqEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNL----INLDTDMVNPTVFRQILDFIYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVL----QLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18334   79 GKLltsdQPGEQNFNALLTAASYLQLHDLAALC 111

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

183-258

4.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 48.05 E-value: 4.27e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157818009 183 VLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

Kelch_6

Kelch motif;

611-659

4.96e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 46.94 E-value: 4.96e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157818009  611 VATHNGYLYVVGGHDAPapnhcSRLSDCVERYDPKSDSWSTVAPLSVPR 659
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNA-----SPALNKLEVYNPLTKSWEELPPLPTPR 50

PLN02153

epithiospecifier protein

418-630

6.24e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 51.91 E-value: 6.24e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 418 PRTKPRKSTVG-ALYAVGGmdAAKGTTTIEK----YDLRTNSWiHIGTMSG---RRLQFGV--AVVDNKLYVVGGRDGLK 487
Cdd:PLN02153  22 PRCSHGIAVVGdKLYSFGG--ELKPNEHIDKdlyvFDFNTHTW-SIAPANGdvpRISCLGVrmVAVGTKLYIFGGRDEKR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 488 TLNTVECFNPVTKTWVVMPPMSTH-----RHGLGVATLEGPMYAVGGHDGWSYLNTVERWD-------PDGRqWnyvASM 555
Cdd:PLN02153  99 EFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKTPERFRtieayniADGK-W---VQL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 556 STP------RSTVGVVALNNKLYAI---------GGRDGSSClKSMEYFDPHTNKWSLCAPMSKRRGGVGVATH---NGY 617
Cdd:PLN02153 175 PDPgenfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKPSARSVFAHavvGKY 253

                        250
                 ....*....|...
gi 157818009 618 LYVVGGHDAPAPN 630
Cdd:PLN02153 254 IIIFGGEVWPDLK 266

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-274

6.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 48.89 E-value: 6.59e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFA-AMFTNDVLEARQEEVKmegvDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18222   22 QGRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIK----NPTVFEQLLSFCYTGRICLQLADIISYL 97

                         90
                 ....*....|....*....
gi 157818009 256 SAACLLQLTQVIDVCCNFL 274
Cdd:cd18222   98 TAASFLQMQHIIDKCTQIL 116

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

278-361

7.10e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 47.65 E-value: 7.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 278 LHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQ 357
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....
gi 157818009 358 ARQQ 361
Cdd:cd18451   81 ERER 84

BTB2_POZ_RHOBTB3

cd18360

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

171-278

7.23e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349669 [Multi-domain] Cd Length: 110 Bit Score: 48.31 E-value: 7.23e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 171 MESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT------GVL 244
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdsccpaSIL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157818009 245 QLRedtieNLLSAACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18360   81 QAM-----ALLICAEMYQVSRLQHICELYIITQL 109

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-274

9.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 48.48 E-value: 9.02e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMegvDPNALNSLVQYAYTGVLQLREDTIENLLS 256
Cdd:cd18220   22 QGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIK---NPNVFEQLLSFCYTGRMSLQLKDVVSFLT 98

                         90
                 ....*....|....*...
gi 157818009 257 AACLLQLTQVIDVCCNFL 274
Cdd:cd18220   99 AASFLQMQCVIDKCTQIL 116

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-270

1.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 47.59 E-value: 1.74e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVkmegVDPNALNSLVQYAYT 241
Cdd:cd18333    3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEM----VSPGIFRLILDYIYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818009 242 GVL----QLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18333   79 GRLsegdPGSEQNLGAVLAAASYLQIPDLVALC 111

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

182-278

2.23e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 47.29 E-value: 2.23e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQE-----EVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLS 256
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                         90       100
                 ....*....|....*....|..
gi 157818009 257 AACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18296   99 VADMYLLPGLKRLCGTVLAQSL 120

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-268

2.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 46.74 E-value: 2.44e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18192    3 SHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYL 82

                         90       100
                 ....*....|....*....|....*..
gi 157818009 242 GVLQLREDTIENLLSAACLLQLTQVID 268
Cdd:cd18192   83 GKIMTAPSDFEQLKVAMNYLQLYYIPE 109

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

163-258

2.75e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 46.43 E-value: 2.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSdyfaAMFTNDVLEARQEEVKMEG-VDPNALNSLVQYAYT 241
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVS----SLFRERLLGSNGPLPPLSLeVTPVGWEAVLTFAYT 76

                         90
                 ....*....|....*..
gi 157818009 242 GVLQLREDTIENLLSAA 258
Cdd:cd18262   77 GVLGRNPATVGDILVAA 93

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-274

2.87e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 46.98 E-value: 2.87e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEV-KMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd18230   21 LCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAA 100

                         90
                 ....*....|....*.
gi 157818009 259 CLLQLTQVIDVCCNFL 274
Cdd:cd18230  101 SYLQMTDIVQACHNFI 116

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-282

2.93e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 47.02 E-value: 2.93e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18342   18 ENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLL 97

                         90       100
                 ....*....|....*....|....*..
gi 157818009 256 SAACLLQLTQVIDVCCNFLIKQLHPSN 282
Cdd:cd18342   98 AAADKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-274

3.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 46.39 E-value: 3.66e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFA-AMFTNDVLEARQEEVkmegVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18200   15 EGKFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNCLVLPSV----IEAAAFENLLQLIYSGRLTLCMDALPSHL 90

                         90
                 ....*....|....*....
gi 157818009 256 SAACLLQLTQVIDVCCNFL 274
Cdd:cd18200   91 LVASGLQMWQVVDRCSELL 109

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

182-259

3.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 45.58 E-value: 3.85e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKME--GVDPNALNSLVQYAYTGVLQL-REDTIENLLSAA 258
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLDLfSVENVHEVLELA 80


                 .
gi 157818009 259 C 259
Cdd:cd18190   81 S 81

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

428-462

3.85e-06

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 44.14 E-value: 3.85e-06

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157818009  428 GALYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMS 462
Cdd:pfam01344  12 GKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

PLN02193

nitrile-specifier protein

516-698

4.56e-06

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 49.95 E-value: 4.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 516 GVATLEGPMYAVGGH-------DGWSYLntverWDPDGRQWNYV-ASMSTPR-STVGV--VALNNKLYAIGGRDGSSCLK 584
Cdd:PLN02193 170 GIAQVGNKIYSFGGEftpnqpiDKHLYV-----FDLETRTWSISpATGDVPHlSCLGVrmVSIGSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 585 SMEYFDPHTNKWSLCAPMSK---RRGGVGVATHNGYLYVVGGHDAPApnhcsRLsDCVERYDPKSDSW---STVAPLSVP 658
Cdd:PLN02193 245 GFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSATA-----RL-KTLDSYNIVDKKWfhcSTPGDSFSI 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 157818009 659 RDAVAVCPLGDKLYVVGGYDGhTYLNTVESYDAQKDEWKE 698
Cdd:PLN02193 319 RGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQ 357

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

295-373

5.74e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 45.11 E-value: 5.74e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 295 CMELQNVAHKYTM---EHFID---------VVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDaQARQQD 362
Cdd:cd18449    6 CVEIGRIANTYHLtevDKYVNdfilknfpaLLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQF 84

                         90
                 ....*....|.
gi 157818009 363 LAKLLSYIRLP 373
Cdd:cd18449   85 AAKLMENIRFP 95

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-274

9.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 45.20 E-value: 9.06e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 166 YTLCKmesylkEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTN-DVLearqeEVKMEGVDPNALNSLVQYAYTGVL 244
Cdd:cd18225   15 HTLRK------EQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDStDTI-----SIDASVVSPEEFALLLEMVYTGKL 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 157818009 245 QLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18225   84 PPGKHNFTKIISVADSLQMFDVAVSCKNLL 113

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-267

9.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 44.99 E-value: 9.66e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTndvlEARQEE-VKMEGVDPNALNSLVQYAYT 241
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ----DFTQEPlVEIEGVSNMAFRHLIEFTYT 76

                         90       100
                 ....*....|....*....|....*..
gi 157818009 242 GVLQLR-EDTIENLLSAACLLQLTQVI 267
Cdd:cd18221   77 AKLMVQgEEEANDVWKAAEYLQMQEAI 103

PRK14131

N-acetylneuraminate epimerase;

516-676

1.31e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 48.09 E-value: 1.31e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 516 GVATLEGPMYAVG---GHDGWSYLNTverwDPDGRQWNYVASM-STPRSTVGVVALNNKLYAIGG-----RDGSSCLKSM 586
Cdd:PRK14131  32 GTGAIDNNTVYVGlgsAGTSWYKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSPQVFDD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 587 EY-FDPHTNKWSLCAPMSKR--RGGVGVATHNGYLYVVGGH-----------------DAPAPNHCSR-----------L 635
Cdd:PRK14131 108 VYkYDPKTNSWQKLDTRSPVglAGHVAVSLHNGKAYITGGVnknifdgyfedlaaagkDKTPKDKINDayfdkkpedyfF 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 157818009 636 SDCVERYDPKSDSWS--TVAPLSvPRDAVAVCPLGDKLYVVGG 676
Cdd:PRK14131 188 NKEVLSYDPSTNQWKnaGESPFL-GTAGSAVVIKGNKLWLING 229

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

157-274

1.83e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 44.48 E-value: 1.83e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 157 HYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFtndvLEARQEEVKMEGVDPNAL-NSL 235
Cdd:cd18197    2 HFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQF----LLNQSKQVRITILQSAEVgRKL 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18197   78 LLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-270

2.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 44.07 E-value: 2.31e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDV-LLIAGPlKIPAHRLVLSAVSDYFAAMFTNDVLEARQEE-VKMEGVDPNALNSLVQYAY 240
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVtLLIEGE-EYKAHKSVLAANSEYFRELFIEKGAVSSHEAvVDLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 157818009 241 TGVLQLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

180-278

2.40e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 43.89 E-value: 2.40e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 180 LCDVLLIAGPLK-IPAHRLVLSAVSDYFAAMFTNDVLE-ARQEEVKMEgVDPNALNSLVQYAYTgvlqlreDTIENLLSA 257
Cdd:cd18302    5 LYDVTIVSEDGKeFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMP-IPSDILEIILDYLYT-------DEASAVKES 76

                         90       100
                 ....*....|....*....|.
gi 157818009 258 ACLLQLTQVIDVCCNFLIKQL 278
Cdd:cd18302   77 QNVEFLCNVLVIADQLLITRL 97

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

157-270

2.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 43.90 E-value: 2.74e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 157 HYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFaamftNDVLEARQEEVKMEGV-DPNALNSL 235
Cdd:cd18208    2 SINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF-----QDKLLLGYSDIEIPSVvSVQSVQKL 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18208   77 IDFMYSGVLRVSQSEALQILTAASILQIKTVIDEC 111

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

172-258

2.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 44.01 E-value: 2.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 172 ESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTI 251
Cdd:cd18352    5 EQYVNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIA 84


                 ....*..
gi 157818009 252 ENLLSAA 258
Cdd:cd18352   85 KDLLRAA 91

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

181-270

3.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 43.70 E-value: 3.03e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 181 CDVLLIAGPLKIPAHRLVLSAVSDYFaamftNDVLEARQEEVKMEGVDP-NALNSLVQYAYTGVLQLREDTIENLLSAAC 259
Cdd:cd18229   19 CDVTVRIHDASLRAHRCVLAAGSPFF-----HDKLLLGHSEIEVPPVVPaQTVRQLVEFMYSGSLVVAQSEALQILTAAS 93

                         90
                 ....*....|.
gi 157818009 260 LLQLTQVIDVC 270
Cdd:cd18229   94 ILQIKTVIDEC 104

Kelch_6

Kelch motif;

558-606

3.55e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.55 E-value: 3.55e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818009  558 PRSTVGVVALNNKLYAIGGR-DGSSCLKSMEYFDPHTNKWSLCAPMSKRR 606
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

464-508

3.98e-05

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 41.55 E-value: 3.98e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157818009  464 RRLQFGVAVVDNKLYVVGGRDGLK--TLNTVECFNPVTKTWVVMPPM 508
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

182-242

6.46e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 42.27 E-value: 6.46e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTND----VLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSlltsEDAVGCDVVHIEKVPPEIFEQLLQFIYTD 84

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

281-371

7.03e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 42.49 E-value: 7.03e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 281 SNCLGIRSFGDAQGCMELQNVAHKYTMEHF-IDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQAR 359
Cdd:cd18482    4 SNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                         90
                 ....*....|..
gi 157818009 360 QQDLAKLLSYIR 371
Cdd:cd18482   84 AASAAEVLKCVR 95

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-258

7.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 42.96 E-value: 7.07e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 173 SYLKEKKL----CDVLLIAGPLKIPAHRLVLSAVSDYF-------------AAMFTNDVLEARQEEVKMEGVDPNALNSL 235
Cdd:cd18195    7 LQLNEQRLrglfCDVTLIAGDTKFRAHRSVLAASSPYFrellssplplgaaAVAAAPGATQSPERVLELPGVKAGVFSDV 86

                         90       100
                 ....*....|....*....|...
gi 157818009 236 VQYAYTGVLQLREDTIENLLSAA 258
Cdd:cd18195   87 LNFIYSSRVALPGSAAAKELGAA 109

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

298-375

7.10e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 42.20 E-value: 7.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 298 LQNVAHKYTMEHFIDVVKN--QEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDaqARQQDLAKLLSYIRLPLL 375
Cdd:cd18471   21 LEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CRYQYMDELLQYVRFGLM 98

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-273

8.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 42.44 E-value: 8.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNdvleARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLS 256
Cdd:cd18232   15 EGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGD----GTSGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVLL 90

                         90
                 ....*....|....*..
gi 157818009 257 AACLLQLTQVIDVCCNF 273
Cdd:cd18232   91 AAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

194-270

1.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 42.53 E-value: 1.03e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818009 194 AHRLVLSAVSDYFAAMFTND-VLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18211   43 AHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

177-272

1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 41.95 E-value: 1.50e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 177 EKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNdvLEARQEEV-KMEGVDPNALNSLVQYAYTGVLQLREDTIENLL 255
Cdd:cd18204   15 EGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSViEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMM 92

                         90
                 ....*....|....*..
gi 157818009 256 SAACLLQLtQVIDVCCN 272
Cdd:cd18204   93 SSGQILGI-RFLDKLCS 108

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

257-383

1.80e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 41.06 E-value: 1.80e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 257 AACLLQLTQVIDVCCNFLIKqlhpsnclgirsfgdaqgcmelqnvahkytmeHFIDVVKNQEFLLLPANEISKLLCSDDI 336
Cdd:cd14822   12 VASLYSLDDLCQTCCQFMDR--------------------------------NAQEVLSSEGFLTLSKSALKELLSRDSF 59

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157818009 337 NVPdEETIFHALMQWVGHDAQaRQQDLAKLLSYIRLPLLSpqlLADL 383
Cdd:cd14822   60 CAP-EVDIFNAVRRWCEHNPD-SKEDAKEILEAVRLPLMS---LTEL 101

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

184-242

2.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 41.48 E-value: 2.42e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157818009 184 LLIAGPlKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKMEGVDPNALNSLVQYAYTG 242
Cdd:cd18344   28 LLVAGH-EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTG 85

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-274

2.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 41.48 E-value: 2.64e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 176 KEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAM--FTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIEN 253
Cdd:cd18201   17 KKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLycFTNKESCDQTTVTHLDVVAVQGFSVILDFMYSGNLVLTSQNAIE 96

                         90       100
                 ....*....|....*....|.
gi 157818009 254 LLSAACLLQLTQVIDVCCNFL 274
Cdd:cd18201   97 VMSVASYLQMTEVVQSCRNFI 117

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

658-698

2.71e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 39.24 E-value: 2.71e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 157818009  658 PRDAVAVCPLGDKLYVVGGYDGH--TYLNTVESYDAQKDEWKE 698
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTE 43

Kelch_6

Kelch motif;

511-559

4.11e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.47 E-value: 4.11e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157818009  511 HRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDPDGRQWNYVASMSTPR 559
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

162-270

4.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 40.59 E-value: 4.32e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 162 NHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLearqEEVKMEGVDPNALNSLVQYAYT 241
Cdd:cd18216    2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNL----IHLDQDMVSPTVFQQILDFIYT 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157818009 242 GVL---QLREDTIENLLSAACLLQLTQVIDVC 270
Cdd:cd18216   78 GKLldsLFEEPNLSEVLAAANYLQLPDLAALC 109

Kelch_4

pfam13418

Galactose oxidase, central domain;

463-508

4.68e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 38.36 E-value: 4.68e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157818009  463 GRRLQFGVAVVDNKLYVVGGRDGL-KTLNTVECFNPVTKTWVVMPPM 508
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSL 47

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

160-244

5.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 40.20 E-value: 5.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 160 SRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVkMEGVDPNALNSLVQYA 239
Cdd:cd18224    6 SSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFI 84


                 ....*
gi 157818009 240 YTGVL 244
Cdd:cd18224   85 YTSEL 89

Kelch_4

pfam13418

Galactose oxidase, central domain;

605-655

7.29e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 37.98 E-value: 7.29e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157818009  605 RRGGVGVATHNGYLYVVGGHDAPApnhcSRLSDCvERYDPKSDSWSTVAPL 655
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDG----TLLSDL-WVFDLSTNEWTRLGSL 47

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

182-265

7.95e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 39.24 E-value: 7.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 182 DVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKME--GVDPNALNSLVQYAYTGVLQLREDTIENLlsaAC 259
Cdd:cd18283    4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTGEFGSEDSRSQNL---DV 80


                 ....*.
gi 157818009 260 LLQLTQ 265
Cdd:cd18283   81 LIQLSE 86

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-284

1.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 39.58 E-value: 1.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818009 174 YLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVlEARQEEVKMEGVDPNALNSLVQYAYTG---VLQLREDT 250
Cdd:cd18351   18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKP-SAENTCIEISYVKYHIFQLVMQYLYCGgteSLLIKNNE 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157818009 251 IENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284
Cdd:cd18351   97 IMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

163-212

1.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 39.39 E-value: 1.19e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 157818009 163 HADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTN 212
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSS 50

Kelch_6