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    fnip1 folliculin interacting protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 324863, updated on 9-Dec-2024

    Summary

    Official Symbol
    fnip1provided by ZNC
    Official Full Name
    folliculin interacting protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3586
    See related
    Ensembl:ENSDARG00000102171 AllianceGenome:ZFIN:ZDB-GENE-030131-3586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc45f03; wu:fc45f03; zgc:175140
    Summary
    Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be located in lysosomal membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See fnip1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45510511..45553241)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45468159..45510904)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene serine-rich adhesin for platelets Neighboring gene uncharacterized LOC137488852 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6-like Neighboring gene acyl-CoA synthetase long chain family member 6

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    folliculin-interacting protein 1
    Names
    folliculin-interacting protein 1-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127465.2NP_001120937.2  folliculin-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      CU207269
      UniProtKB/TrEMBL
      A0A0R4IT71, A0A8M1NHL9
      Related
      ENSDARP00000140081.1, ENSDART00000167914.2
      Conserved Domains (3) summary
      pfam14636
      Location:40155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:317549
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:8891073
      FNIP_C; Folliculin-interacting protein C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      45510511..45553241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173917.5XP_005173974.2  folliculin-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IV00, A0A8M2BL92
      Related
      ENSDARP00000138891.2, ENSDART00000160494.2
      Conserved Domains (3) summary
      pfam14636
      Location:40155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:289521
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:8611045
      FNIP_C; Folliculin-interacting protein C-terminus
    2. XM_005173916.5XP_005173973.2  folliculin-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QEV8, A0A8M2BL88
      Related
      ENSDARP00000153464.1, ENSDART00000183665.1
      Conserved Domains (3) summary
      pfam14636
      Location:23138
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:300532
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:8721056
      FNIP_C; Folliculin-interacting protein C-terminus