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Conserved domains on  [gi|688606959|ref|XP_005173974|]
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folliculin-interacting protein 1 isoform X2 [Danio rerio]

Protein Classification

folliculin-interacting protein( domain architecture ID 10630352)

folliculin-interacting protein is a binding partner of the GTPase-activating protein FLCN, and is involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 289-521 2.13e-99

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


:

Pssm-ID: 434087  Cd Length: 226  Bit Score: 312.66  E-value: 2.13e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   289 ESSGPSLGVARKKKIAIGVIFQLSPNEEEntKFQDFFFSHFPLFESHMNKLKSAIEQAMILSRrsadanqraLAYSRMVD 368
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLSESSES--EFEQFLFEHFPLLESHMSRLRVAIENASGRKQ---------SFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   369 GLNEFRTTICNLYTMPRVPEPVWLTMMSGPPEKNQLCGHFMRELALLMEQASKNQ---FLPALLTAVLTNHLAWVPTVMP 445
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688606959   446 NGQP-PIQIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLSRTVVVGRRQELVQRLLYLLTYFIRCSEL 521
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 861-1045 2.74e-96

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


:

Pssm-ID: 464229  Cd Length: 189  Bit Score: 302.64  E-value: 2.74e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   861 LPLPGAKLVENYS-KPSIANFGRSLFGGYCPSYVPDFVLQGVPN-DEKLKQNLVSDLAHAVQHPVLDEPIAEAVCIIADT 938
Cdd:pfam14638    1 LPLPKSKSISNSEdMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   939 EKWTVTVASSQRR--SSEKLGKEVLVSSLVSGLLQSTLQLYRLNLSPNFCIMHLEDRLQELYFKSKMLAEYLRGQTRVHV 1016
Cdd:pfam14638   81 DKWTVQVLSSQTSdlKNNGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 688606959  1017 KELGMVLGIESNDLPLLAAIASTHSPHVA 1045
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 40-159 5.69e-34

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


:

Pssm-ID: 464228  Cd Length: 125  Bit Score: 126.62  E-value: 5.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959    40 QIRLIVYQD-CERRGRNVLFDSDArKRSTEDGPATRVCGEAQVKMFGRCCQLRPTGGSSSSLDSSSSCASEP-----KEQ 113
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHA-VAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRPlvsqtSET 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 688606959   114 NRFQASSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQMML 159
Cdd:pfam14636   80 DPQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 289-521 2.13e-99

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 312.66  E-value: 2.13e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   289 ESSGPSLGVARKKKIAIGVIFQLSPNEEEntKFQDFFFSHFPLFESHMNKLKSAIEQAMILSRrsadanqraLAYSRMVD 368
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLSESSES--EFEQFLFEHFPLLESHMSRLRVAIENASGRKQ---------SFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   369 GLNEFRTTICNLYTMPRVPEPVWLTMMSGPPEKNQLCGHFMRELALLMEQASKNQ---FLPALLTAVLTNHLAWVPTVMP 445
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688606959   446 NGQP-PIQIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLSRTVVVGRRQELVQRLLYLLTYFIRCSEL 521
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 861-1045 2.74e-96

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 302.64  E-value: 2.74e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   861 LPLPGAKLVENYS-KPSIANFGRSLFGGYCPSYVPDFVLQGVPN-DEKLKQNLVSDLAHAVQHPVLDEPIAEAVCIIADT 938
Cdd:pfam14638    1 LPLPKSKSISNSEdMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   939 EKWTVTVASSQRR--SSEKLGKEVLVSSLVSGLLQSTLQLYRLNLSPNFCIMHLEDRLQELYFKSKMLAEYLRGQTRVHV 1016
Cdd:pfam14638   81 DKWTVQVLSSQTSdlKNNGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 688606959  1017 KELGMVLGIESNDLPLLAAIASTHSPHVA 1045
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 40-159 5.69e-34

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 126.62  E-value: 5.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959    40 QIRLIVYQD-CERRGRNVLFDSDArKRSTEDGPATRVCGEAQVKMFGRCCQLRPTGGSSSSLDSSSSCASEP-----KEQ 113
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHA-VAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRPlvsqtSET 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 688606959   114 NRFQASSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQMML 159
Cdd:pfam14636   80 DPQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Name Accession Description Interval E-value
FNIP_M pfam14637
Folliculin-interacting protein middle domain; This is the middle domain of ...
 289-521 2.13e-99

Folliculin-interacting protein middle domain; This is the middle domain of folliculin-interacting proteins.


Pssm-ID: 434087  Cd Length: 226  Bit Score: 312.66  E-value: 2.13e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   289 ESSGPSLGVARKKKIAIGVIFQLSPNEEEntKFQDFFFSHFPLFESHMNKLKSAIEQAMILSRrsadanqraLAYSRMVD 368
Cdd:pfam14637    1 ATPSSSPPRRKKAKLALAIIISLSESSES--EFEQFLFEHFPLLESHMSRLRVAIENASGRKQ---------SFVQRIYR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   369 GLNEFRTTICNLYTMPRVPEPVWLTMMSGPPEKNQLCGHFMRELALLMEQASKNQ---FLPALLTAVLTNHLAWVPTVMP 445
Cdd:pfam14637   70 AWEEFRQWICDLYTAPRLKEPVWLNLVSSPNDKRTLAERFLEELCSLLERYDTKDtnfFLSTLLTAVLTHHLGWVATVAP 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688606959   446 NGQP-PIQIFLEKHSSQSVDMLAKTHPYNPLWAQLGDLYGAIGSPVRLSRTVVVGRRQELVQRLLYLLTYFIRCSEL 521
Cdd:pfam14637  150 PDSStPSNSFLGKHSSDKLDLLAQTHPYNPLWAQLGDLYGAIGSPVRLAKTIVVGSPQELVAKILYVLSYFIRCSEV 226
FNIP_C pfam14638
Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting ...
 861-1045 2.74e-96

Folliculin-interacting protein C-terminus; This is the C-terminus of folliculin-interacting proteins. This region is responsible for binding to folliculin.


Pssm-ID: 464229  Cd Length: 189  Bit Score: 302.64  E-value: 2.74e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   861 LPLPGAKLVENYS-KPSIANFGRSLFGGYCPSYVPDFVLQGVPN-DEKLKQNLVSDLAHAVQHPVLDEPIAEAVCIIADT 938
Cdd:pfam14638    1 LPLPKSKSISNSEdMWTVRNFGRSLFAGYCDHYVPDFVLQGTTKpDEKWKEVLSADLSHASQHSVLDEPVAEAVCIVADT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959   939 EKWTVTVASSQRR--SSEKLGKEVLVSSLVSGLLQSTLQLYRLNLSPNFCIMHLEDRLQELYFKSKMLAEYLRGQTRVHV 1016
Cdd:pfam14638   81 DKWTVQVLSSQTSdlKNNGLGEVVSMSQLVSSMLESFVQLYKLKLSAEFCIMHLEDRLQEIYLKSKMLAEYLRGTTRCHL 160

                          170       180
                   ....*....|....*....|....*....
gi 688606959  1017 KELGMVLGIESNDLPLLAAIASTHSPHVA 1045
Cdd:pfam14638  161 KELTSALGLDSSDLPLLLAVASTHSPYVA 189
FNIP_N pfam14636
Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting ...
 40-159 5.69e-34

Folliculin-interacting protein N-terminus; This is the N-terminus of folliculin-interacting proteins.


Pssm-ID: 464228  Cd Length: 125  Bit Score: 126.62  E-value: 5.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688606959    40 QIRLIVYQD-CERRGRNVLFDSDArKRSTEDGPATRVCGEAQVKMFGRCCQLRPTGGSSSSLDSSSSCASEP-----KEQ 113
Cdd:pfam14636    1 DVRVIIMQDaLGDRGRTLLFDSHA-VAKPPEPAPPLSPSDRPSSPGGRHSQTSSRRGPSSPRKSSLSQGSRPlvsqtSET 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 688606959   114 NRFQASSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQMML 159
Cdd:pfam14636   80 DPQYQYREYRDDINTLGECIFGSSAMSYKGTSTKVHILPSDPRSML 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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