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    pam peptidylglycine alpha-amidating monooxygenase [ Danio rerio (zebrafish) ]

    Gene ID: 570822, updated on 27-Dec-2024

    Summary

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    Official Symbol
    pamprovided by ZNC
    Official Full Name
    peptidylglycine alpha-amidating monooxygenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-384
    See related
    Ensembl:ENSDARG00000100170 AllianceGenome:ZFIN:ZDB-GENE-090313-384
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-35f12.2
    Summary
    Enables peptidylglycine monooxygenase activity. Acts upstream of or within ciliary basal body-plasma membrane docking and microvillus assembly. Predicted to be located in membrane. Is expressed in floor plate; gut; otic vesicle; and ventricular system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pam in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5689547..5787285)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5688296..5786069)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene spleen tyrosine kinase Neighboring gene DIRAS family GTPase 2 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Neighboring gene interleukin 6 cytokine family signal transduce Neighboring gene ankyrin repeat domain 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme. Kumar D, et al. Sci Rep, 2018 Mar 14. PMID 29540787, Free PMC Article
    2. RESA identifies mRNA-regulatory sequences at high resolution. Yartseva V, et al. Nat Methods, 2017 Feb. PMID 28024160, Free PMC Article
    3. Peptidomics of the zebrafish Danio rerio: In search for neuropeptides. Van Camp KA, et al. J Proteomics, 2017 Jan 6. PMID 27705817
    4. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. Maugars G, et al. PLoS One, 2014. PMID 25386660, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylamidoglycolate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylglycine monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ciliary basal body-plasma membrane docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-glycine alpha-amidating monooxygenase
    XP_005155561.1
    XP_009303381.1
    XP_068079990.1
    XP_699436.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      5689547..5787285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694344.6 → XP_699436.4  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      See identical proteins and their annotated locations for XP_699436.4

      UniProtKB/TrEMBL
      A0A8M2B2D2
      Related
      ENSDARP00000134889.1, ENSDART00000172632.2
      Conserved Domains (4) summary
      COG0810
      Location:781 → 905
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd14958
      Location:494 → 803
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59 → 176
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:199 → 345
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    2. XM_068223889.1 → XP_068079990.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3B606

    3. XM_005155504.5 → XP_005155561.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      See identical proteins and their annotated locations for XP_005155561.1

      UniProtKB/TrEMBL
      A0A8M2B2D2
      Conserved Domains (4) summary
      COG0810
      Location:781 → 905
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd14958
      Location:494 → 803
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59 → 176
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:199 → 345
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    4. XM_009305106.4 → XP_009303381.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3B606
      Conserved Domains (4) summary
      COG0810
      Location:680 → 804
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd14958
      Location:393 → 702
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59 → 176
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:199 → 345
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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