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Conserved domains on  [gi|292618017|ref|XP_699436|]
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peptidyl-glycine alpha-amidating monooxygenase isoform X1 [Danio rerio]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 494-803 1.69e-140

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 422.44  E-value: 1.69e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  494 EVSDWPEADLQLGQVSGLALNSNGDLVIFHRGDHIWGIDSFNMNaIYQLRdqGPIQQSTILLVDSvKGKVLKASGKNMFY 573
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDAN-VYVFK--GPIEEDTILVFDP-DGGFLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  574 LPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAFEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYCNSRILQF 653
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  654 SPEGKYISHWGAGSSDrkrRVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKEIkKDVFGGEVFAIAYSPaq 733
Cdd:cd14958   156 SPDGKLLKSWGEPGSG---PGQFNLPHSIALDEDGR-VYVADRENGRIQVFDAD-GKFLTEW-TNPELGRPYALAIDP-- 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292618017  734 GGLLYAVNGEPPYGQAAPLQGFVINYSSKEILDSFSPDT---QVFKLPHDIVVTADGTVFVGDAAADSVMKFI 803
Cdd:cd14958   228 DGLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 198-345 1.81e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 205.95  E-value: 1.81e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   198 FIAGMYLMMSV---DTLIPPGKKVTNADIACTY--TSSPM-----YPFAFRTHTHSLGKVVSGYRVRNGQ-WTQIGRQSP 266
Cdd:pfam03712    1 YDAGILLLGTVyspKMAIPPGQKVFHLEGYCTIdcTDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   267 LLP--QAFYPATNTIDVKDGDILAARCVFTGEGRTTTTQIGGTSNDEMCNFYIMYYmdntHAVPYMNCRDDGSSELFRNI 344
Cdd:pfam03712   81 YSPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNY 156


                   .
gi 292618017   345 P 345
Cdd:pfam03712  157 F 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-177 3.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 107.34  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017    60 LDIRLPGV-VPTESDSYYCMAVPVPT-SREAYIVDFVP---HASMDTAHHMILYGCKTPYATQ--GY-WDCG------KE 125
Cdd:pfam01082    1 FDLLNPNVtVPAKDTTYWCTVFKLPDlTKKHHIIRFEPviqPGNEGLVHHMLLYECEGDPNEPspGYgGDCYsadnmpDD 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 292618017   126 LGTCRdqaKIMYAWARNAPPTKLPKDVGFKVGGDTRINYFVLQIHYgdvNNF 177
Cdd:pfam01082   81 LDPCS---SVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY---NNP 126
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 494-803 1.69e-140

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 422.44  E-value: 1.69e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  494 EVSDWPEADLQLGQVSGLALNSNGDLVIFHRGDHIWGIDSFNMNaIYQLRdqGPIQQSTILLVDSvKGKVLKASGKNMFY 573
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDAN-VYVFK--GPIEEDTILVFDP-DGGFLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  574 LPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAFEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYCNSRILQF 653
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  654 SPEGKYISHWGAGSSDrkrRVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKEIkKDVFGGEVFAIAYSPaq 733
Cdd:cd14958   156 SPDGKLLKSWGEPGSG---PGQFNLPHSIALDEDGR-VYVADRENGRIQVFDAD-GKFLTEW-TNPELGRPYALAIDP-- 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292618017  734 GGLLYAVNGEPPYGQAAPLQGFVINYSSKEILDSFSPDT---QVFKLPHDIVVTADGTVFVGDAAADSVMKFI 803
Cdd:cd14958   228 DGLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 198-345 1.81e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 205.95  E-value: 1.81e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   198 FIAGMYLMMSV---DTLIPPGKKVTNADIACTY--TSSPM-----YPFAFRTHTHSLGKVVSGYRVRNGQ-WTQIGRQSP 266
Cdd:pfam03712    1 YDAGILLLGTVyspKMAIPPGQKVFHLEGYCTIdcTDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   267 LLP--QAFYPATNTIDVKDGDILAARCVFTGEGRTTTTQIGGTSNDEMCNFYIMYYmdntHAVPYMNCRDDGSSELFRNI 344
Cdd:pfam03712   81 YSPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNY 156


                   .
gi 292618017   345 P 345
Cdd:pfam03712  157 F 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-177 3.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 107.34  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017    60 LDIRLPGV-VPTESDSYYCMAVPVPT-SREAYIVDFVP---HASMDTAHHMILYGCKTPYATQ--GY-WDCG------KE 125
Cdd:pfam01082    1 FDLLNPNVtVPAKDTTYWCTVFKLPDlTKKHHIIRFEPviqPGNEGLVHHMLLYECEGDPNEPspGYgGDCYsadnmpDD 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 292618017   126 LGTCRdqaKIMYAWARNAPPTKLPKDVGFKVGGDTRINYFVLQIHYgdvNNF 177
Cdd:pfam01082   81 LDPCS---SVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY---NNP 126
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
575-802 3.67e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 76.98  E-value: 3.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLsgNGKDQQLlvlgEAFEPGSdkkhFCQPTDVAVDPvTGNVYVSDGYcNSRILQFS 654
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRL--DPATGEF----TEYPLGG----GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  655 P-EGKYISHWGAGSSDRkrrvpfriPHSLTFLPDKReLCVADRDNGRIQCFMADTGEfVKEIKKDVFGGEVFAIAYSPaQ 733
Cdd:COG4257    87 PkTGEITTFALPGGGSN--------PHGIAFDPDGN-LWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDP-D 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  734 GGLLYAVNG-----------------EPPYGQAAPL------QG--FVINYSSKEILdSFSPDTQVFK---------LPH 779
Cdd:COG4257   156 GNLWVTDFGanaigridpdtgtlteyALPTPGAGPRglavdpDGnlWVADTGSGRIG-RFDPKTGTVTeyplpgggaRPY 234

                         250       260
                  ....*....|....*....|...
gi 292618017  780 DIVVTADGTVFVGDAAADSVMKF 802
Cdd:COG4257   235 GVAVDGDGRVWFAESGANRIVRF 257
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 624-653 2.24e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 292618017   624 FCQPTDVAVDPvTGNVYVSDgYCNSRILQF 653
Cdd:pfam01436    1 FNRPHGVAVDS-NGDIYVAD-SENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 494-803 1.69e-140

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 422.44  E-value: 1.69e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  494 EVSDWPEADLQLGQVSGLALNSNGDLVIFHRGDHIWGIDSFNMNaIYQLRdqGPIQQSTILLVDSvKGKVLKASGKNMFY 573
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDAN-VYVFK--GPIEEDTILVFDP-DGGFLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  574 LPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAFEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYCNSRILQF 653
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  654 SPEGKYISHWGAGSSDrkrRVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKEIkKDVFGGEVFAIAYSPaq 733
Cdd:cd14958   156 SPDGKLLKSWGEPGSG---PGQFNLPHSIALDEDGR-VYVADRENGRIQVFDAD-GKFLTEW-TNPELGRPYALAIDP-- 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292618017  734 GGLLYAVNGEPPYGQAAPLQGFVINYSSKEILDSFSPDT---QVFKLPHDIVVTADGTVFVGDAAADSVMKFI 803
Cdd:cd14958   228 DGLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 198-345 1.81e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 205.95  E-value: 1.81e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   198 FIAGMYLMMSV---DTLIPPGKKVTNADIACTY--TSSPM-----YPFAFRTHTHSLGKVVSGYRVRNGQ-WTQIGRQSP 266
Cdd:pfam03712    1 YDAGILLLGTVyspKMAIPPGQKVFHLEGYCTIdcTDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017   267 LLP--QAFYPATNTIDVKDGDILAARCVFTGEGRTTTTQIGGTSNDEMCNFYIMYYmdntHAVPYMNCRDDGSSELFRNI 344
Cdd:pfam03712   81 YSPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNY 156


                   .
gi 292618017   345 P 345
Cdd:pfam03712  157 F 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 504-802 2.25e-37

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 141.69  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  504 QLGQVSGLALNSNGDLVIFHRGDHiwGIDSFNmnaiyqlrdqgpiQQSTILLVDSVKGkvlkaSGKNMFYLPHGITTDHD 583
Cdd:cd05819     6 ELNNPQGIAVDSSGNIYVADTGNN--RIQVFD-------------PDGNFITSFGSFG-----SGDGQFNEPAGVAVDSD 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  584 DNYWVTDVALHQVFKLSGNGKdqqllVLGEAFEPGSDKKHFCQPTDVAVDPvTGNVYVSDgYCNSRILQFSPEGKYISHW 663
Cdd:cd05819    66 GNLYVADTGNHRIQKFDPDGN-----FLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTF 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  664 GAGSSDRKrrvPFRIPHSLTFLPDKrELCVADRDNGRIQCFMADtGEFVKEIKKDVFGGEVFA----IAYSPAqgGLLYA 739
Cdd:cd05819   139 GSGGSGPG---QFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPD-GNFLTTFGSTGTGPGQFNyptgIAVDSD--GNIYV 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292618017  740 VNgeppyGQAAPLQGFVINYSSKEILDSFSPDTQVFKLPHDIVVTADGTVFVGDAAADSVMKF 802
Cdd:cd05819   212 AD-----SGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 486-802 5.67e-28

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 114.30  E-value: 5.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  486 DQQGAHLVEVSDWPEADLQLGQVSGLALNSNGDLvifhrgdhiWGIDSFNmnaiYQLRDQGPiqQSTILLVDSVKGkvlk 565
Cdd:cd14956    40 DKDGTFLRRFGTTGDGPGQFGRPRGLAVDKDGWL---------YVADYWG----DRIQVFTL--TGELQTIGGSSG---- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  566 aSGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKdqqllVLGEAFEPGSDKKHFCQPTDVAVDPVtGNVYVSDGY 645
Cdd:cd14956   101 -SGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  646 cNSRILQFSPEGKYISHWGAGSSDRKRrvpFRIPHSLTFLPDkRELCVADRDNGRIQCFMADtGEFVKeikkdVFGgevf 725
Cdd:cd14956   174 -NDRIQVFDNDGAFLRKWGGRGTGPGQ---FNYPYGIAIDPD-GNVFVADFGNNRIQKFTAD-GTFLT-----SWG---- 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 292618017  726 aiayspaqggllyaVNGEPPyGQaaplqgfvinysskeildsfspdtqvFKLPHDIVVTADGTVFVGDAAADSVMKF 802
Cdd:cd14956   239 --------------SPGTGP-GQ--------------------------FKNPWGVVVDADGTVYVADSNNNRVQRF 274
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-177 3.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 107.34  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017    60 LDIRLPGV-VPTESDSYYCMAVPVPT-SREAYIVDFVP---HASMDTAHHMILYGCKTPYATQ--GY-WDCG------KE 125
Cdd:pfam01082    1 FDLLNPNVtVPAKDTTYWCTVFKLPDlTKKHHIIRFEPviqPGNEGLVHHMLLYECEGDPNEPspGYgGDCYsadnmpDD 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 292618017   126 LGTCRdqaKIMYAWARNAPPTKLPKDVGFKVGGDTRINYFVLQIHYgdvNNF 177
Cdd:pfam01082   81 LDPCS---SVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY---NNP 126
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-802 4.18e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 94.57  E-value: 4.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKdqqllVLGEAFEPGSDKKHFCQPTDVAVDPVtGNVYVSDGYc 646
Cdd:cd14955    57 SGDGQFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTGT-----FLTKWGSSGSGDGQFNSPSGIAVDSA-GNVYVTDSG- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  647 NSRILQFSPEGKYISHWG-AGSSDRkrrvPFRIPHSLTfLPDKRELCVADRDNGRIQCFMAdTGEFVKeiKKDVFGGEvf 725
Cdd:cd14955   130 NNRIQKFDSSGTFITKWGsFGSGDG----QFNSPTGIA-VDSAGNVYVADTGNNRIQKFTS-TGTFLT--KWGSEGSG-- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  726 aiayspaqggllyavNGE--PPYGQAAPLQGFV----INYSSKEILDSF-----------SPDTQvFKLPHDIVVTADGT 788
Cdd:cd14955   200 ---------------DGQfnAPYGIAVDSAGNVyvadTGNNRIQKFDSSgtfitkwgsegSGDGQ-FNSPSGIAVDSAGN 263

                         250
                  ....*....|....
gi 292618017  789 VFVGDAAADSVMKF 802
Cdd:cd14955   264 VYVADSGNNRIQKF 277
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 567-799 1.41e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 89.66  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVA--LHQVFKLSGNGKDqqllvlgeAFEPGSDKKHFCQPTDVAVDpvTGNVYVSD- 643
Cdd:cd14963    50 TGPGEFKYPYGIAVDSDGNIYVADLYngRIQVFDPDGKFLK--------YFPEKKDRVKLISPAGLAID--DGKLYVSDv 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  644 GYcnSRILQFSPEGKYISHWGAGSSDRKRrvpFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKEIKKDVFGGE 723
Cdd:cd14963   120 KK--HKVIVFDLEGKLLLEFGKPGSEPGE---LSYPNGIAVDEDGN-IYVADSGNGRIQVFDKN-GKFIKELNGSPDGKS 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  724 VFA----IAYSPaQGGLLYAVNgeppygqaapLQGFVINYS----SKEILDSFSPDTQVFKLPHDIVVTADGTVFVGDAA 795
Cdd:cd14963   193 GFVnprgIAVDP-DGNLYVVDN----------LSHRVYVFDeqgkELFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTDRE 261


                  ....
gi 292618017  796 ADSV 799
Cdd:cd14963   262 NNRV 265
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-705 1.14e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 87.25  E-value: 1.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGkdQQLLVLGEafePGSDKKHFCQPTDVAVDPVtGNVYVSDGYc 646
Cdd:cd14955   151 SGDGQFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAVDSA-GNVYVADTG- 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 292618017  647 NSRILQFSPEGKYISHWGAGSSDRKrrvPFRIPHSLTFLPDKReLCVADRDNGRIQCFM 705
Cdd:cd14955   224 NNRIQKFDSSGTFITKWGSEGSGDG---QFNSPSGIAVDSAGN-VYVADSGNNRIQKFA 278
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-802 1.64e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 86.86  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKdqqllVLGEAFEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYc 646
Cdd:cd14955    10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGT-----FLTKWGSSGSGDGQFYSPTGIAVDS-DGNVYVADTG- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  647 NSRILQFSPEGKYISHWGA-GSSDRkrrvPFRIPHSLTFlpDKR-ELCVADRDNGRIQCFmADTGEFVKEikkdvFGGev 724
Cdd:cd14955    83 NHRIQKFDSTGTFLTKWGSsGSGDG----QFNSPSGIAV--DSAgNVYVTDSGNNRIQKF-DSSGTFITK-----WGS-- 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292618017  725 faiayspaqggllyavngeppYGqaaplqgfvinysskeildsfSPDTQvFKLPHDIVVTADGTVFVGDAAADSVMKF 802
Cdd:cd14955   149 ---------------------FG---------------------SGDGQ-FNSPTGIAVDSAGNVYVADTGNNRIQKF 183
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 567-802 6.46e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 85.04  E-value: 6.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYwVTDVALH--QVFKLSGNGKdqqlLVLGEafePGSDKKHFCQPTDVAVDPvTGNVYVSDG 644
Cdd:cd14963     4 PFGDPLNKPMGVAVSDGRIY-VADTNNHrvQVFDYEGKFK----KSFGG---PGTGPGEFKYPYGIAVDS-DGNIYVADL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  645 YcNSRILQFSPEGKYISHWGAGSSDRKRRVPfriphsLTFLPDKRELCVADRDNGRIQCFmADTGEFVKEI-KKDVFGGE 723
Cdd:cd14963    75 Y-NGRIQVFDPDGKFLKYFPEKKDRVKLISP------AGLAIDDGKLYVSDVKKHKVIVF-DLEGKLLLEFgKPGSEPGE 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  724 VF---AIAYSPAqgGLLYAV---NGEppygqaapLQGFVINYSSKEILDSFSPDTQVFKLPHDIVVTADGTVFVGDAAAD 797
Cdd:cd14963   147 LSypnGIAVDED--GNIYVAdsgNGR--------IQVFDKNGKFIKELNGSPDGKSGFVNPRGIAVDPDGNLYVVDNLSH 216


                  ....*
gi 292618017  798 SVMKF 802
Cdd:cd14963   217 RVYVF 221
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 557-793 1.27e-16

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 81.09  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  557 DSVKGKV--LKASGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAFEpgsdkkhfcQPTDVAVDP 634
Cdd:cd14962    39 DLPNGKVfvIGNAGPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALFK---------RPTGIAVDP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  635 VTGNVYVSDGYcNSRILQFSPEGKYISHWG-AGSSDrkrrVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVK 713
Cdd:cd14962   110 AGKRLYVVDTL-AHKVKVFDLDGRLLFDIGkRGSGP----GEFNLPTDLAVDRDGN-LYVTDTMNFRVQIFDAD-GKFLR 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  714 EIkkdvfgGEV------FAIAYSPA--QGGLLYAVNgeppygqaAPLQGFVInysskeildsFSPDTQV----------- 774
Cdd:cd14962   183 SF------GERgdgpgsFARPKGIAvdSEGNIYVVD--------AAFDNVQI----------FNPEGELlltvggpgsgp 238

                         250       260
                  ....*....|....*....|.
gi 292618017  775 --FKLPHDIVVTADGTVFVGD 793
Cdd:cd14962   239 geFYLPSGIAIDKDDRIYVVD 259
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 567-793 5.58e-16

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 79.51  E-value: 5.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGNgkdqQLLVLGEAfepGSDKKHFCQPTDVAVDPvTGNVYVSDG 644
Cdd:cd14954    65 SRDGQFDRPAGVAVNSRGRIIVADKDNHriQVFDLNGR----FLLKFGER---GTKNGQFNYPWGVAVDS-EGRIYVSDT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  645 YcNSRILQFSPEGKYISHWGagsSDRKRRVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKeikkdVFGGEv 724
Cdd:cd14954   137 R-NHRVQVFDSDGQFIRKFG---FEGAGPGQLDSPRGVAVNPDGN-IVVSDFNNHRLQVFDPD-GQFLR-----FFGSE- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  725 faiaySPAQGGLLYavngepPYGQAAPLQGFVInysskeILDS-------FSPDTQV-------------FKLPHDIVVT 784
Cdd:cd14954   205 -----GSGNGQFKR------PRGVAVDDEGNII------VADSgnhrvqvFSPDGEFlcsfgtegngegqFDRPSGVAVT 267


                  ....*....
gi 292618017  785 ADGTVFVGD 793
Cdd:cd14954   268 PDGRIVVVD 276
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 575-704 1.01e-15

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 78.74  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQllVLGeafEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYcNSRILQFS 654
Cdd:cd14954   167 PRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLR--FFG---SEGSGNGQFKRPRGVAVDD-EGNIIVADSG-NHRVQVFS 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 292618017  655 PEGKYISH---WGAGSSDRKRrvpfriPHSLTFLPDKReLCVADRDNGRIQCF 704
Cdd:cd14954   240 PDGEFLCSfgtEGNGEGQFDR------PSGVAVTPDGR-IVVVDRGNHRIQVF 285
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
575-802 3.67e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 76.98  E-value: 3.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLsgNGKDQQLlvlgEAFEPGSdkkhFCQPTDVAVDPvTGNVYVSDGYcNSRILQFS 654
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRL--DPATGEF----TEYPLGG----GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  655 P-EGKYISHWGAGSSDRkrrvpfriPHSLTFLPDKReLCVADRDNGRIQCFMADTGEfVKEIKKDVFGGEVFAIAYSPaQ 733
Cdd:COG4257    87 PkTGEITTFALPGGGSN--------PHGIAFDPDGN-LWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDP-D 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  734 GGLLYAVNG-----------------EPPYGQAAPL------QG--FVINYSSKEILdSFSPDTQVFK---------LPH 779
Cdd:COG4257   156 GNLWVTDFGanaigridpdtgtlteyALPTPGAGPRglavdpDGnlWVADTGSGRIG-RFDPKTGTVTeyplpgggaRPY 234

                         250       260
                  ....*....|....*....|...
gi 292618017  780 DIVVTADGTVFVGDAAADSVMKF 802
Cdd:COG4257   235 GVAVDGDGRVWFAESGANRIVRF 257
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-793 1.56e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 72.30  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGngkdQQLLVLGeafEPGSDKKHFCQPTDVAVDPvTGNVYVSDg 644
Cdd:cd14957    12 SGNGQFNTPRGIAVDSAGNIYVADTGNNriQVFTSSG----VYSYSIG---SGGTGSGQFNSPYGIAVDS-NGNIYVAD- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  645 YCNSRILQFSPEGKYISHWGAGSSDrkrRVPFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFVKEIKKDVFGGEV 724
Cdd:cd14957    83 TDNNRIQVFNSSGVYQYSIGTGGSG---DGQFNGPYGIAVDSNGN-IYVADTGNHRIQVFTSS-GTFSYSIGSGGTGPGQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  725 FAIayspaqggllyavngepPYGQAAPLQG--FVINY---------SSKEILDSF----SPDTQvFKLPHDIVVTADGTV 789
Cdd:cd14957   158 FNG-----------------PQGIAVDSDGniYVADTgnhriqvftSSGTFQYTFgssgSGPGQ-FSDPYGIAVDSDGNI 219


                  ....
gi 292618017  790 FVGD 793
Cdd:cd14957   220 YVAD 223
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 509-723 7.96e-13

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 70.27  E-value: 7.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  509 SGLALNSNGDLVIFHRGDHiwGIDSFNMNAIYQLR--DQGpiqqstillvdsvkgkvlkaSGKNMFYLPHGITTDHDDNY 586
Cdd:cd14954    74 AGVAVNSRGRIIVADKDNH--RIQVFDLNGRFLLKfgERG--------------------TKNGQFNYPWGVAVDSEGRI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  587 WVTDVALH--QVFKLSGNgkdqqlLVLGEAFEpGSDKKHFCQPTDVAVDPvTGNVYVSDgYCNSRILQFSPEGKYISHWG 664
Cdd:cd14954   132 YVSDTRNHrvQVFDSDGQ------FIRKFGFE-GAGPGQLDSPRGVAVNP-DGNIVVSD-FNNHRLQVFDPDGQFLRFFG 202

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 292618017  665 AGSSDRKRrvpFRIPHSLTFLPDKRELcVADRDNGRIQCFMADtGEFVKeikkdVFGGE 723
Cdd:cd14954   203 SEGSGNGQ---FKRPRGVAVDDEGNII-VADSGNHRVQVFSPD-GEFLC-----SFGTE 251
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
627-799 1.02e-12

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 68.95  E-value: 1.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  627 PTDVAVDPVTGN-VYVSDGYcNSRILQFSPE-GKYISHWGAGSSdrkrrvpfriPHSLTFLPDKRELCVADRDNGRIQCF 704
Cdd:COG3391    69 DADGADAGADGRrLYVANSG-SGRVSVIDLAtGKVVATIPVGGG----------PRGLAVDPDGGRLYVADSGNGRVSVI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  705 MADTGEFVKEIKkdvFGGEVFAIAYSPAqGGLLYAVNGEPpyGQAAPLQgFVINYSSKEILDSFSpdtqVFKLPHDIVVT 784
Cdd:COG3391   138 DTATGKVVATIP---VGAGPHGIAVDPD-GKRLYVANSGS--NTVSVIV-SVIDTATGKVVATIP----VGGGPVGVAVS 206

                         170
                  ....*....|....*.
gi 292618017  785 ADG-TVFVGDAAADSV 799
Cdd:COG3391   207 PDGrRLYVANRGSNTS 222
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-704 1.90e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 68.83  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGNGKDqqllvlgeAF-EPGSDKKHFCQPTDVAVDPVtGNVYVSD 643
Cdd:cd14957   153 TGPGQFNGPQGIAVDSDGNIYVADTGNHriQVFTSSGTFQY--------TFgSSGSGPGQFSDPYGIAVDSD-GNIYVAD 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 292618017  644 gYCNSRILQFSPEGKYISHWGAGSSDRKrrvPFRIPHSLTFlpDKR-ELCVADRDNGRIQCF 704
Cdd:cd14957   224 -TGNHRIQVFTSSGAYQYSIGTSGSGNG---QFNYPYGIAV--DNDgKIYVADSNNNRIQVF 279
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
575-743 5.47e-12

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 66.64  E-value: 5.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNY-WVTDVALHQVFKL-SGNGKDQQLLVLGEafepgsdkkhfcQPTDVAVDPVTGNVYVSDGYcNSRILQ 652
Cdd:COG3391    70 ADGADAGADGRRlYVANSGSGRVSVIdLATGKVVATIPVGG------------GPRGLAVDPDGGRLYVADSG-NGRVSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  653 FSPE-GKYISHWGAGSSdrkrrvpfriPHSLTFLPDKRELCVADRDNGRIQCFM----ADTGEFVKEIKkdvFGGEVFAI 727
Cdd:COG3391   137 IDTAtGKVVATIPVGAG----------PHGIAVDPDGKRLYVANSGSNTVSVIVsvidTATGKVVATIP---VGGGPVGV 203

                         170
                  ....*....|....*.
gi 292618017  728 AYSPAqGGLLYAVNGE 743
Cdd:COG3391   204 AVSPD-GRRLYVANRG 218
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 552-664 2.11e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 65.69  E-value: 2.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  552 TILLVDSVKGKVL----------KASGKNMFYLPHGITTDHDDNY-WVTDVALHQVFKLSGNGKdqQLLVLGEafePGSD 620
Cdd:cd14962    69 NLYVSDAELGKVFvfdrdgkflrAIGAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDLDGR--LLFDIGK---RGSG 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 292618017  621 KKHFCQPTDVAVDPvTGNVYVSDGYcNSRILQFSPEGKYISHWG 664
Cdd:cd14962   144 PGEFNLPTDLAVDR-DGNLYVTDTM-NFRVQIFDADGKFLRSFG 185
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
686-804 1.08e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.79  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  686 PDKRELCVADRDNGRIQCFMADTGEFVKEIKkdvFGGEVFAIAYSPAqGGLLYAVNGEPpyGQAaplqgFVINYSSKEIL 765
Cdd:COG3391    77 ADGRRLYVANSGSGRVSVIDLATGKVVATIP---VGGGPRGLAVDPD-GGRLYVADSGN--GRV-----SVIDTATGKVV 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 292618017  766 DSFSpdtqVFKLPHDIVVTADG-TVFVGDAAADSVMKFIQ 804
Cdd:COG3391   146 ATIP----VGAGPHGIAVDPDGkRLYVANSGSNTVSVIVS 181
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 567-802 1.43e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 63.05  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGNgkdqqllvlgeaFE-----PGSDKKHFCQPTDVAVDPvTGNV 639
Cdd:cd14957    59 TGSGQFNSPYGIAVDSNGNIYVADTDNNriQVFNSSGV------------YQysigtGGSGDGQFNGPYGIAVDS-NGNI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  640 YVSDGYcNSRILQFSPEGKYISHWGAGSSDRKRrvpFRIPHSLTFLPDKReLCVADRDNGRIQCFMADtGEFvkeikkdv 719
Cdd:cd14957   126 YVADTG-NHRIQVFTSSGTFSYSIGSGGTGPGQ---FNGPQGIAVDSDGN-IYVADTGNHRIQVFTSS-GTF-------- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  720 fggeVFAIAYSPAQGGLLYAvngepPYGQAAPLQG--FVINY---------SSKEILDSFS----PDTQvFKLPHDIVVT 784
Cdd:cd14957   192 ----QYTFGSSGSGPGQFSD-----PYGIAVDSDGniYVADTgnhriqvftSSGAYQYSIGtsgsGNGQ-FNYPYGIAVD 261

                         250
                  ....*....|....*...
gi 292618017  785 ADGTVFVGDAAADSVMKF 802
Cdd:cd14957   262 NDGKIYVADSNNNRIQVF 279
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 548-704 2.11e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 62.69  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  548 IQQSTILLVDsVKGKVLK-----ASGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGNGKDQqllVLGEAFEPGSd 620
Cdd:cd14963   119 VKKHKVIVFD-LEGKLLLefgkpGSEPGELSYPNGIAVDEDGNIYVADSGNGriQVFDKNGKFIKE---LNGSPDGKSG- 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  621 kkhFCQPTDVAVDPvTGNVYVSDGYCNsRILQFSPEGKYISHWGA-GSSDRKrrvpFRIPHSLTFLPDKReLCVADRDNG 699
Cdd:cd14963   194 ---FVNPRGIAVDP-DGNLYVVDNLSH-RVYVFDEQGKELFTFGGrGKDDGQ----FNLPNGLFIDDDGR-LYVTDRENN 263


                  ....*
gi 292618017  700 RIQCF 704
Cdd:cd14963   264 RVAVY 268
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 571-801 4.03e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 62.55  E-value: 4.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  571 MFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAF---EPGSDKKHFCQPTDVAVDPvTGNVYVSDGYcN 647
Cdd:cd14953    75 QFNTPSGVAVDAAGNLYVADTGNHRIRKITPDGVVSTLAGTGTAGfsdDGGATAAQFNYPTGVAVDA-AGNLYVADTG-N 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  648 SRILQFSPEGK----------YISHWGAGSSDRkrrvpFRIPHSLTFlpDKRE-LCVADRDNGRIqcfmadtgefvKEIK 716
Cdd:cd14953   153 HRIRKITPDGVvttvagtggaGYAGDGPATAAQ-----FNNPTGVAV--DAAGnLYVADRGNHRI-----------RKIT 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  717 KDvfgGEVFAIAYSPAQGG---------LLYAvngepPYGQAAPLQG--FVINYSSKEIL-------------------- 765
Cdd:cd14953   215 PD---GVVTTVAGTGTAGFsgdggataaQLNN-----PTGVAVDAAGnlYVADSGNHRIRkitpagvvttvagggagfsg 286

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 292618017  766 DSFSPDTQVFKLPHDIVVTADGTVFVGDAAADSVMK 801
Cdd:cd14953   287 DGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRK 322
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 575-802 6.57e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 61.06  E-value: 6.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLsgNGKDQQLLVLGEAFEPgsdkkHFCQPTDVAVDPvTGNVYVSDGYcNSRILQFS 654
Cdd:cd14962    14 PYGVAADGRGRIYVADTGRGAVFVF--DLPNGKVFVIGNAGPN-----RFVSPIGVAIDA-NGNLYVSDAE-LGKVFVFD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  655 PEGKYISHWGAGsSDRKRrvpfriPHSLTFLPDKRELCVADRDNGRIQCFMADtGEFVKEI-KKDVFGGEVF---AIAYS 730
Cdd:cd14962    85 RDGKFLRAIGAG-ALFKR------PTGIAVDPAGKRLYVVDTLAHKVKVFDLD-GRLLFDIgKRGSGPGEFNlptDLAVD 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 292618017  731 PAqgGLLYAVNGEPPYGQAAPLQGfvinysskEILDSF-----SPDTqvFKLPHDIVVTADGTVFVGDAAADSVMKF 802
Cdd:cd14962   157 RD--GNLYVTDTMNFRVQIFDADG--------KFLRSFgergdGPGS--FARPKGIAVDSEGNIYVVDAAFDNVQIF 221
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 572-655 6.59e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 58.36  E-value: 6.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  572 FYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVlgeafEPGSDKKHFCQPTDVAVDPvTGNVYVSDGYcNSRIL 651
Cdd:cd14955   203 FNAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTFITKWG-----SEGSGDGQFNSPSGIAVDS-AGNVYVADSG-NNRIQ 275


                  ....
gi 292618017  652 QFSP 655
Cdd:cd14955   276 KFAP 279
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 497-731 7.78e-09

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 58.06  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  497 DWPEadlQLGQVSGLALNSNGDLVIFHRGDHiwGIDSFNMNAIYQlRDQGPI----------------QQSTILLVD--- 557
Cdd:cd14961     5 GWPG---TLNNPTGVAVTPTGRVVVADDGNK--RIQVFDSDGNCL-QQFGPKgdagqdirypldvavtPDGHIVVTDagd 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  558 -SVK-----GKVLKASGKNmFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKdqqllvLGEAFEPGSDKKHFCQPTDVA 631
Cdd:cd14961    79 rSVKvfsfdGRLKLFVRKS-FSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFK------LGILKKGQKLCSQLCRPRFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  632 VDPvTGNVYVSD-------GYCNSRILQFSPEGKYIShwGAGSSDRKRRVPFRI-PHSLTFLPDKReLCVADRDNGRIQC 703
Cdd:cd14961   152 VSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLG--QIDSFGLNLVFPSLIcASGVAFDSEGN-VIVADTGSGAILC 227

                         250       260
                  ....*....|....*....|....*....
gi 292618017  704 FMADTGEFV-KEIKKDVFGGEVfAIAYSP 731
Cdd:cd14961   228 LGKPEGFPIlKPIVTQGLSRPV-GLAVTP 255
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 504-706 2.97e-08

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 56.20  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  504 QLGQVSGLALNSNGDLVIFHRGDHIWGIDSFN---MNAIYQLRDQGPI-----QQSTILLVDSvKGK---VLKASGK--- 569
Cdd:cd14960    62 QLQRPTGVAVTLNGDIIIADYDNKWVSIFSPDgkfKSKIGAGKLMGPKgvavdRNGHIIVVDN-KACcvfIFQPNGKlvt 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  570 ---------NMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGngkdQQLLVLGEAFEPGSdkkHFCQPTDVAVDPvTGN 638
Cdd:cd14960   141 rfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVFNAEG----EFLFKFGSNGEGNG---QFNAPTGVAVDS-NGN 212

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292618017  639 VYVSDgYCNSRILQFSPEGKYISHWGAGSSdrkrrvPFRIPHSLTFLPDKRELcVADRDNgriQCFMA 706
Cdd:cd14960   213 IIVAD-WGNSRIQVFDSSGSFLSYINTSAD------PLYGPQGLALTSDGHVV-VADSGN---HCFKV 269
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 575-701 3.57e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 55.68  E-value: 3.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLSGnGKDQQlLVLgeafePGSDKKhfcQPTDVAVDPVtGNVYVSDGYcNSRILQFS 654
Cdd:cd14952    12 PGGVAVDAAGNVYVADSGNNRVLKLAA-GSTTQ-TVL-----PFTGLY---QPQGVAVDAA-GTVYVTDFG-NNRVLKLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 292618017  655 pegkyishwgAGSSDRKrRVPFR---IPHSLTFLPDkRELCVADRDNGRI 701
Cdd:cd14952    80 ----------AGSTTQT-VLPFTglnDPTGVAVDAA-GNVYVADTGNNRV 117
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 561-655 2.68e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 53.36  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  561 GKVLKASGKnmFYLPHGITTDHDDNYWVTDVALH--QVFklsgNGKDQQLLVLGeafEPGSDKKHFCQPTDVAVDPvTGN 638
Cdd:cd14962   185 GERGDGPGS--FARPKGIAVDSEGNIYVVDAAFDnvQIF----NPEGELLLTVG---GPGSGPGEFYLPSGIAIDK-DDR 254

                          90
                  ....*....|....*..
gi 292618017  639 VYVSDGYcNSRILQFSP 655
Cdd:cd14962   255 IYVVDQF-NRRIQVFQY 270
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 575-652 3.40e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.51  E-value: 3.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLVLGEAFepgsdkkhfcQPTDVAVDPvTGNVYVSDgYCNSRILQ 652
Cdd:cd14952   180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVLPFTGLN----------GPLGVAVDA-AGNVYVAD-RGNDRVVK 245
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 575-701 3.87e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.51  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  575 PHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLvlgeafePGSDKKHfcqPTDVAVDPVtGNVYVSDGYcNSRILQfs 654
Cdd:cd14952    96 PTGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVL-------PFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVLK-- 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 292618017  655 pegkyishWGAGSSDrKRRVPF---RIPHSLTfLPDKRELCVADRDNGRI 701
Cdd:cd14952   162 --------LAAGSTT-QTVLPFtglNSPSGVA-VDTAGNVYVTDHGNNRV 201
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 552-655 4.60e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.13  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  552 TILLVDSVKGKVLK-ASGKNMFYL--------PHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQLLvlgeafePGSDKK 622
Cdd:cd14952   106 NVYVADTGNNRVLKlAAGSNTQTVlpftglsnPDGVAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVL-------PFTGLN 178

                          90       100       110
                  ....*....|....*....|....*....|...
gi 292618017  623 HfcqPTDVAVDPvTGNVYVSDgYCNSRILQFSP 655
Cdd:cd14952   179 S---PSGVAVDT-AGNVYVTD-HGNNRVLKLAA 206
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 567-665 9.12e-06

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 48.42  E-value: 9.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  567 SGKNMFYLPHGITTDHDDNYWVTDVALH--QVFKLSGNGKDQqllvLGEafePGSDKKHFCQPTDVAVDPVTGNVYVSD- 643
Cdd:cd14959    16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVFDKEGEFKFQ----FGI---PGKRDGQLWYPNKVAVCRVTGRYVVTDr 88

                          90       100
                  ....*....|....*....|..
gi 292618017  644 GYCNSRILQFSPEGKYISHWGA 665
Cdd:cd14959    89 GNPRHRMQIFTKRGQFVRKFGA 110
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 602-723 1.06e-05

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 48.31  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  602 NGKDQQLLVLGEAfepGSDKKHFCQPTDVAVDPvTGNVYVSDGYcNSRILQFSPEGKYISHWG-AGSSDRKRRVPFRIPH 680
Cdd:cd14954     4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDK-DGRIIVADRS-NNRVQVFDPDGKFLRKFGsYGSRDGQFDRPAGVAV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 292618017  681 SltflpDKRELCVADRDNGRIQCFMADtGEFVKEikkdvFGGE 723
Cdd:cd14954    79 N-----SRGRIIVADKDNHRIQVFDLN-GRFLLK-----FGER 110
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 572-710 1.08e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  572 FYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKDQQL------------------LVLGE------AFEPGSDK------ 621
Cdd:COG3386     7 FRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVfaepsgrpnglafdpdgrLLVADhgrglvRFDPADGEvtvlad 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  622 ---KHFCQPTDVAVDPvTGNVYVSD---GYCNSRILQFSPEGKyishwgagssdrKRRV--PFRIPHSLTFLPDKRELCV 693
Cdd:COG3386    87 eygKPLNRPNDGVVDP-DGRLYFTDmgeYLPTGALYRVDPDGS------------LRVLadGLTFPNGIAFSPDGRTLYV 153

                         170
                  ....*....|....*...
gi 292618017  694 ADRDNGRIQCF-MADTGE 710
Cdd:COG3386   154 ADTGAGRIYRFdLDADGT 171
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 486-651 1.13e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  486 DQQGAHLVEVSDWPEADLQLGQVSGLALNSNGDLVIFHRGDHiwGIDSFNMNAIYQLRDQGpiqqstillvdsvkgkvlK 565
Cdd:cd14963   128 DLEGKLLLEFGKPGSEPGELSYPNGIAVDEDGNIYVADSGNG--RIQVFDKNGKFIKELNG------------------S 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  566 ASGKNMFYLPHGITTDHDDNYWVTDVALHQVFKLSGNGKdqQLLVLGeafEPGSDKKHFCQPTDVAVDPvTGNVYVSDgY 645
Cdd:cd14963   188 PDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGK--ELFTFG---GRGKDDGQFNLPNGLFIDD-DGRLYVTD-R 260


                  ....*.
gi 292618017  646 CNSRIL 651
Cdd:cd14963   261 ENNRVA 266
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 618-802 4.81e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 43.03  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  618 GSDKKHFCQPTDVAVDPvTGNVYVSD-GycNSRILQFSPEGKYISHWG---------------------------AG--- 666
Cdd:cd14961     4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGpkgdagqdirypldvavtpdghivvtdAGdrs 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  667 ----SSDRKRRV----PFRIPHSLTFLPdKRELCVADRDNGRIQCFMAD--TGEFVKEIKKdvfGGEVF---AIAYSP-- 731
Cdd:cd14961    81 vkvfSFDGRLKLfvrkSFSLPWGVAVNP-SGEILVTDSEAGKLFVLTVDfkLGILKKGQKL---CSQLCrprFVAVSRlg 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  732 ------------------------AQGGLLYAVN------GEPPYGQAAPL----QG--FVINYSSKEILDSFSP----- 770
Cdd:cd14961   157 avavtehlfangtrssstrvkvfsSGGQLLGQIDsfglnlVFPSLICASGVafdsEGnvIVADTGSGAILCLGKPegfpi 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 292618017  771 ----DTQVFKLPHDIVVTADGTVFVGDAAADSVMKF 802
Cdd:cd14961   237 lkpiVTQGLSRPVGLAVTPDGSLVVLDSGNHCVKIY 272
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 588-802 1.04e-03

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 42.26  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  588 VTDVALHQVFKLSGNGKDQqllvlgeafepgsdkkhFCQPTDVAVDpVTGNVYVSDGYcNSRILQFSPEGKYISHWGAGS 667
Cdd:cd14959     2 RSKMIIHCKFGESGSGEGQ-----------------FNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  668 SDRKRRVpfrIPHSLTFLPDKRELCVADRDNG--RIQCFMADtGEFVKEikkdvFGGEVFAIAyspaqGGLlyAVNGEpp 745
Cdd:cd14959    63 KRDGQLW---YPNKVAVCRVTGRYVVTDRGNPrhRMQIFTKR-GQFVRK-----FGARYLQHV-----RGL--TVDAA-- 124

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 292618017  746 yGQAAPLQ---GFVINYS-SKEILDSFSPdTQVFKLPHDIVVTaDGTVFVGDAAADSVMKF 802
Cdd:cd14959   125 -GHIIVVEskvMRVFIFDeSGNVLKWFDC-SKYLEEPSDVAVN-DNEIYICDNKGHCVVVF 182
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 494-740 1.28e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  494 EVSDWPEADlqlGQVSGLALNSNGDLVIFHRGDHIWGIDsfnmnaiyqlrdqgPIQQSTILLVDSVkgkvlkasGKNMFY 573
Cdd:COG3386    40 AVEVFAEPS---GRPNGLAFDPDGRLLVADHGRGLVRFD--------------PADGEVTVLADEY--------GKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  574 lPHGITTDHDDNYWVTDVALHQ----VFKLSGNGKdqqllvlgeafepgsdkkhfcqptdvaVDPVTGNVYVSDGycnsr 649
Cdd:COG3386    95 -PNDGVVDPDGRLYFTDMGEYLptgaLYRVDPDGS---------------------------LRVLADGLTFPNG----- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  650 iLQFSPEGK--YISHWGAG-------SSDRK---RRVPFRIPHSlTFLPD----KRE--LCVADRDNGRIQCFMADtGEF 711
Cdd:COG3386   142 -IAFSPDGRtlYVADTGAGriyrfdlDADGTlgnRRVFADLPDG-PGGPDglavDADgnLWVALWGGGGVVRFDPD-GEL 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 292618017  712 VKEIKKDV-------FGGEVFAIAY-----SPAQGGLLYAV 740
Cdd:COG3386   219 LGRIELPErrptnvaFGGPDLRTLYvttarSLPLAGALFRV 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 624-653 2.24e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 292618017   624 FCQPTDVAVDPvTGNVYVSDgYCNSRILQF 653
Cdd:pfam01436    1 FNRPHGVAVDS-NGDIYVAD-SENHRVQVF 28
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 486-599 4.88e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  486 DQQGAHLVEVSDWPEADLQLGQVSGLALNSNGDLVIfhrgdhiwgIDSFNmNAIYQLRDQGPIQQSTillvdsvkGKVLK 565
Cdd:cd05819   176 DPDGNFLTTFGSTGTGPGQFNYPTGIAVDSDGNIYV---------ADSGN-NRVQVFDPDGAGFGGN--------GNFLG 237

                          90       100       110
                  ....*....|....*....|....*....|....
gi 292618017  566 ASGKnmFYLPHGITTDHDDNYWVTDVALHQVFKL 599
Cdd:cd05819   238 SDGQ--FNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 618-666 5.03e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 40.02  E-value: 5.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 292618017  618 GSDKKHFCQPTDVAVDPvTGNVYVSDgYCNSRILQFSPEGKYISHWGAG 666
Cdd:cd14960    57 GRSPGQLQRPTGVAVTL-NGDIIIAD-YDNKWVSIFSPDGKFKSKIGAG 103
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
551-648 5.75e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292618017  551 STILLVDSVKGKVLK--ASGKNmfylPHGITTDHDDNY-WVTDVALHQVFKL-----SGNGKDQQLLVLGEafepgsdkk 622
Cdd:COG3391   132 GRVSVIDTATGKVVAtiPVGAG----PHGIAVDPDGKRlYVANSGSNTVSVIvsvidTATGKVVATIPVGG--------- 198

                          90       100
                  ....*....|....*....|....*.
gi 292618017  623 hfcQPTDVAVDPVTGNVYVSDGYCNS 648
Cdd:COG3391   199 ---GPVGVAVSPDGRRLYVANRGSNT 221
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 676-704 8.52e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 8.52e-03
                           10        20
                   ....*....|....*....|....*....
gi 292618017   676 FRIPHSLTFLPDkRELCVADRDNGRIQCF 704
Cdd:pfam01436    1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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