syn2a synapsin IIa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: syn2aprovided by ZNC
Official Full Name: synapsin IIaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-341
See related: Ensembl:ENSDARG00000045945 AllianceGenome:ZFIN:ZDB-GENE-040718-341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: syn1; syn2; zgc:92311
Summary: Predicted to enable ATP binding activity. Predicted to be involved in synapse organization and synaptic vesicle clustering. Predicted to act upstream of or within neurotransmitter secretion. Predicted to be located in synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (4751959..4775446, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (4816374..4839861, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle clustering	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synapsin-2a

Names: synapsin II; synapsin2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002597.2 → NP_001002597.2 synapsin-2a

Status: VALIDATED

Source sequence(s)

CU468010

UniProtKB/TrEMBL

A0A8M1N0R8, F1R0A8

Related

ENSDARP00000067530.4, ENSDART00000067531.5

Conserved Domains (3) summary

pfam02078
Location:102 → 199

Synapsin; Synapsin, N-terminal domain

pfam10581
Location:1 → 27

Synapsin_N; Synapsin N-terminal

cl17255
Location:201 → 403

ATP-grasp_4; ATP-grasp domain