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    il15l interleukin 15, like [ Danio rerio (zebrafish) ]

    Gene ID: 494451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    il15lprovided by ZNC
    Official Full Name
    interleukin 15, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-173
    See related
    Ensembl:ENSDARG00000007743 AllianceGenome:ZFIN:ZDB-GENE-041111-173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7142994; zgc:123044
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in several processes, including neutrophil activation; positive regulation of T cell proliferation; and positive regulation of cytokine production. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in gill and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See il15l in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20352127..20362560)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20416389..20427796)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene uncharacterized LOC137487742 Neighboring gene uncharacterized LOC110437902 Neighboring gene SPT5 homolog, DSIF elongation factor subunit Neighboring gene ribonuclease T2, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of an interleukin-15 like (IL-15L) gene from zebrafish (Danio rerio). Gunimaladevi I, et al. Fish Shellfish Immunol, 2007 Apr. PMID 16919968
    2. Two interleukin (IL)-15 homologues in fish from two distinct origins. Bei JX, et al. Mol Immunol, 2006 Mar. PMID 16055191
    3. Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2019 Dec 26. PMID 31822609, Free PMC Article
    4. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Yang D, et al. Dev Comp Immunol, 2013 Jun. PMID 23434462
    5. Transcriptomic signatures for ovulation in vertebrates. Liu DT, et al. Gen Comp Endocrinol, 2017 Jun 1. PMID 28111234, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123044, MGC193534

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin 15, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009558.2 → NP_001009558.1  interleukin 15, like isoform A

      See identical proteins and their annotated locations for NP_001009558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      BC162237, CR626887
      UniProtKB/TrEMBL
      A0A0R4ILL3, A0A8N7XJL8, F6NLP7, Q5W7F5
      Related
      ENSDARP00000136823.2, ENSDART00000163532.2
      Conserved Domains (1) summary
      pfam02372
      Location:55 → 150
      IL15; Interleukin 15

    2. NM_001018118.2 → NP_001018128.2  interleukin 15, like isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. It encodes isoform B which is shorter compared to isoform 1.
      Source sequence(s)
      AB196454, CR626887
      UniProtKB/TrEMBL
      A0A8M1N5P0, B3DFL4, F1QRP5, Q5NTA1
      Related
      ENSDARP00000130353.1, ENSDART00000169537.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20352127..20362560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157517.5 → XP_005157574.1  interleukin 15, like isoform X1

      UniProtKB/TrEMBL
      A0A0R4IKC3, A0A8M2B3N9
      Related
      ENSDARP00000134586.2, ENSDART00000161047.2
      Conserved Domains (1) summary
      pfam02372
      Location:55 → 151
      IL15; Interleukin 15

    2. XM_009291645.4 → XP_009289920.1  interleukin 15, like isoform X2

      UniProtKB/TrEMBL
      A0A8M3ASP6
      Conserved Domains (1) summary
      pfam02372
      Location:55 → 149
      IL15; Interleukin 15

    3. XM_005157518.5 → XP_005157575.1  interleukin 15, like isoform X3

      See identical proteins and their annotated locations for XP_005157575.1

      UniProtKB/TrEMBL
      A0A8M2B3V5, Q32PM5
      Related
      ENSDARP00000027129.7, ENSDART00000011030.9
      Conserved Domains (1) summary
      pfam02372
      Location:55 → 148
      IL15; Interleukin 15

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394946.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      255455..266667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001018119.1: Suppressed sequence

      Description
      NM_001018119.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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