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    apaf1 apoptotic peptidase activating factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 58131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apaf1provided by ZNC
    Official Full Name
    apoptotic peptidase activating factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-4
    See related
    Ensembl:ENSDARG00000021239 AllianceGenome:ZFIN:ZDB-GENE-000616-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apaf-1; zgc:136543
    Summary
    Predicted to enable ADP binding activity; ATP binding activity; and peptidase activity. Predicted to act upstream of or within apoptotic signaling pathway; proteolysis; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of apoptosome. Is expressed in skeletal muscle. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See apaf1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17828621..17874172)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17854731..17884595)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B9b Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) Neighboring gene arginine vasopressin receptor 2, like Neighboring gene uncharacterized LOC103910447 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. Orzáez M, et al. PLoS One, 2014. PMID 25330150, Free PMC Article
    2. Chronic Toxic Effects of Flutolanil on the Liver of Zebrafish ( Danio rerio). Teng M, et al. Chem Res Toxicol, 2019 Jun 17. PMID 30942079
    3. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria-mediated apoptosis in zebrafish embryos. Zhao X, et al. Aquat Toxicol, 2016 Nov. PMID 27658222
    4. Enantioselective bioaccumulation of hexaconazole and its toxic effects in adult zebrafish (Danio rerio). Wang Y, et al. Chemosphere, 2015 Nov. PMID 26291761
    5. α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Shang X, et al. Toxicol Lett, 2020 May 15. PMID 32035120

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.
      Title: Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC92565, MGC136543

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of apoptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    apoptotic protease-activating factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131608.1 → NP_571683.1  apoptotic protease-activating factor 1

      See identical proteins and their annotated locations for NP_571683.1

      Status: PROVISIONAL

      Source sequence(s)
      AF251502
      UniProtKB/Swiss-Prot
      Q9I9H8
      Conserved Domains (6) summary
      COG2319
      Location:641 → 1042
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:616 → 912
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00931
      Location:132 → 411
      NB-ARC; NB-ARC domain
      sd00039
      Location:625 → 657
      7WD40; WD40 repeat [structural motif]
      cl14633
      Location:7 → 92
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl21455
      Location:150 → 297
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17828621..17874172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219732.1 → XP_068075833.1  apoptotic protease-activating factor 1 isoform X1

    2. XM_068219731.1 → XP_068075832.1  apoptotic protease-activating factor 1 isoform X1

    3. XM_005164770.5 → XP_005164827.1  apoptotic protease-activating factor 1 isoform X2

      See identical proteins and their annotated locations for XP_005164827.1

      UniProtKB/TrEMBL
      A0A8M2BC28, A5WVJ8, E7F2V1
      Related
      ENSDARP00000008347.6, ENSDART00000019165.8
      Conserved Domains (4) summary
      cd00200
      Location:616 → 912
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd08323
      Location:7 → 92
      CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
      sd00039
      Location:625 → 657
      7WD40; WD40 repeat [structural motif]
      pfam00931
      Location:132 → 415
      NB-ARC; NB-ARC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I9H8.1 GenPept UniProtKB/Swiss-Prot:Q9I9H8

    Gene LinkOut

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