LOCUS NM_131608 3786 bp mRNA linear VRT 12-OCT-2024
DEFINITION Danio rerio apoptotic peptidase activating factor 1 (apaf1), mRNA.
ACCESSION NM_131608 NM_001045243
VERSION NM_131608.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 3786)
AUTHORS Li,X., Zeng,L., Qu,Z. and Zhang,F.
TITLE Huoxin pill protects verapamil-induced zebrafish heart failure
through inhibition of oxidative stress-triggered inflammation and
apoptosis
JOURNAL Heliyon 10 (1), e23402 (2023)
PUBMED 38169776
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3786)
AUTHORS Zhao,Y., Wang,H., Duah,P.A., Retyunskiy,V., Liu,Y. and Chen,G.
TITLE Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses
reveal involvement of oxidative damage, apoptosis, endoplasmic
reticulum (ER) stress and autophagy
JOURNAL Aquat Toxicol 248, 106195 (2022)
PUBMED 35594629
REFERENCE 3 (bases 1 to 3786)
AUTHORS Xie,Z., Lu,G., Zhou,R. and Ma,Y.
TITLE Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the
extrinsic and intrinsic apoptosis pathways regulated by p53
signaling pathway
JOURNAL Aquat Toxicol 246, 106147 (2022)
PUBMED 35349858
REFERENCE 4 (bases 1 to 3786)
AUTHORS Gao,M., Hu,J., Zhu,Y., Wang,X., Zeng,S., Hong,Y. and Zhao,G.
TITLE Ferroptosis and Apoptosis Are Involved in the Formation of
L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos
JOURNAL Int J Mol Sci 23 (9), 4783 (2022)
PUBMED 35563172
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3786)
AUTHORS Sun,C.C., Zhou,Z.Q., Chen,Z.L., Zhu,R.K., Yang,D., Peng,X.Y.,
Zheng,L. and Tang,C.F.
TITLE Identification of Potentially Related Genes and Mechanisms Involved
in Skeletal Muscle Atrophy Induced by Excessive Exercise in
Zebrafish
JOURNAL Biology (Basel) 10 (8), 761 (2021)
PUBMED 34439993
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3786)
AUTHORS Sorrells,S., Carbonneau,S., Harrington,E., Chen,A.T., Hast,B.,
Milash,B., Pyati,U., Major,M.B., Zhou,Y., Zon,L.I., Stewart,R.A.,
Look,A.T. and Jette,C.
TITLE Ccdc94 protects cells from ionizing radiation by inhibiting the
expression of p53
JOURNAL PLoS Genet 8 (8), e1002922 (2012)
PUBMED 22952453
REFERENCE 7 (bases 1 to 3786)
AUTHORS Jin,Y., Zheng,S. and Fu,Z.
TITLE Embryonic exposure to cypermethrin induces apoptosis and
immunotoxicity in zebrafish (Danio rerio)
JOURNAL Fish Shellfish Immunol 30 (4-5), 1049-1054 (2011)
PUBMED 21316461
REFERENCE 8 (bases 1 to 3786)
AUTHORS Jin,Y., Zheng,S., Pu,Y., Shu,L., Sun,L., Liu,W. and Fu,Z.
TITLE Cypermethrin has the potential to induce hepatic oxidative stress,
DNA damage and apoptosis in adult zebrafish (Danio rerio)
JOURNAL Chemosphere 82 (3), 398-404 (2011)
PUBMED 20965546
REFERENCE 9 (bases 1 to 3786)
AUTHORS Deng,J., Yu,L., Liu,C., Yu,K., Shi,X., Yeung,L.W., Lam,P.K.,
Wu,R.S. and Zhou,B.
TITLE Hexabromocyclododecane-induced developmental toxicity and apoptosis
in zebrafish embryos
JOURNAL Aquat Toxicol 93 (1), 29-36 (2009)
PUBMED 19356805
REFERENCE 10 (bases 1 to 3786)
AUTHORS Stein,C., Caccamo,M., Laird,G. and Leptin,M.
TITLE Conservation and divergence of gene families encoding components of
innate immune response systems in zebrafish
JOURNAL Genome Biol 8 (11), R251 (2007)
PUBMED 18039395
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF251502.1.
On Jun 7, 2012 this sequence version replaced NM_001045243.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF251502.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA4476731, SAMEA4476732
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..3786
/organism="Danio rerio"
/mol_type="mRNA"
/db_xref="taxon:7955"
/chromosome="4"
/map="4"
gene 1..3786
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="apoptotic peptidase activating factor 1"
/db_xref="GeneID:58131"
/db_xref="ZFIN:ZDB-GENE-000616-4"
CDS 1..3786
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/codon_start=1
/product="apoptotic protease-activating factor 1"
/protein_id="NP_571683.1"
/db_xref="GeneID:58131"
/db_xref="ZFIN:ZDB-GENE-000616-4"
/translation="MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVL
SKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLLHSDLPLLSPEGEKSF
ADGVSPSVQAILSVGGVPQRPVVFVSRPPLLNLIREMLYQLRDTPGWVTVFGMAGSGK
SVMAAEVVRDRSLIKECFPDGVHWLSVGQCERADLLVRMQSLCFRLEQCQSSDTSQRP
PSTVEEAKERLRFLMLRRFPRSLLILDDVWDSSSLRSFDIQCRVLLTTRNRALTDSVS
GVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSLIGALLR
EFPDRWSYYLRQLQQKQFKRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDLSVMQ
KDIKVPAKVLSVLWGLELEEVEDVLQEFVNKSLLFRDCNQRPYRYYLHDLQLDFLAEQ
NRDQIAELHKKMVRQYQRFYSKRPPDSADKDSLYWYQFIPYHMAKAGLSKELYSLMFS
LDWVKEKARIMGSAHLINDYVEYGEILDKENSEVRVQFQEFLSLNGHHLEQRPFPDVV
QLALSQPDRSEVYRQALMQAQKRASRGQIYLNWVNKNIEEGLSRLVMHPHQGAVYYAC
FSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDRK
VKLWNVERGVLIREFEVEHEEQINHCQFTNTGRRVLLATCSNDKFTNTRLWNPNKKTS
QNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWKSIDVDSFFPESDEE
IKAMVKCSTWSADGSQIICAARNTVFVFDVETSDLLLKLKTSRLSTIQFCHACPNSSL
LAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETD
RVHTSSAVALKRDTDVLSSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSRIRCS
CISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDS
TIRVWKWRTGECMVLQGHMEPVRKFHLLSSSSSPHLFSWSFDGTVKVWDLTRGQMLQD
LVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSSASWKMLFLLEGHKDCVRSCRFSWD
NKRLATGDDNGEIRLWSMLDGALLKICPRDTKDSMNSYHAGWVTDLHFSPDNRVLVST
AGYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGILYILKRLEGEGT"
misc_feature 1843..1962
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 1"
misc_feature 1969..2088
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 2"
misc_feature 2098..2229
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 3"
misc_feature 2236..2355
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 4"
misc_feature 2392..2508
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 5"
misc_feature 2518..2637
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 6"
misc_feature 2644..2763
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 7"
misc_feature 2890..3009
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 8"
misc_feature 3016..3135
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 9"
misc_feature 3139..3264
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 10"
misc_feature 3271..3390
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 11"
misc_feature 3397..3516
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 12"
misc_feature 3550..3669
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
Region: WD 13"
exon 1..138
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 139..328
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 329..526
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 527..716
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 717..829
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 830..961
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 962..1200
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1201..1368
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1369..1500
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1501..1614
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1615..1799
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1800..1926
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 1927..2052
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2053..2193
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2194..2319
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2320..2472
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2473..2601
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2602..2727
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2728..2847
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2848..2973
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 2974..3099
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 3100..3228
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 3229..3354
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 3355..3480
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 3481..3627
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
exon 3628..3786
/gene="apaf1"
/gene_synonym="apaf-1; zgc:136543"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 atggaggaac gtgcccgcag ccgcctgctg cgctccaaag ccactctgga gcaggacatc
61 aaagcctcct acctgatgga ccacatgatc agcgatggcg ttctaaccaa tgatgaggaa
121 gcaaaagtgc tcagcaaggc cactagaaaa gagcaggccg tggctctgct tgagaccctg
181 ttgaggaaag acaatcgtgc ctacatttcc ttctacaacg ccctgatcag ggagagttat
241 ggagatctgg ccagtctcct tcacagtgat ctgcctctgc tcagccctga gggagagaag
301 agcttcgctg atggagtctc tccctctgtc caggcgattc tgagtgtagg aggtgttcct
361 cagagacctg tggtgttcgt gagtcgacct ccactgctca atctgatccg ggagatgctg
421 taccagctgc gggacacacc gggctgggtg actgtatttg gcatggctgg ctcagggaag
481 tctgtgatgg ctgccgaggt tgttcgagat cgttcactca ttaaggagtg ttttcctgat
541 ggtgttcact ggctgtctgt gggtcagtgt gagcgggcag acctgttggt taggatgcag
601 tctctgtgct ttcgtttgga gcagtgtcaa agttcagaca ccagtcagcg gccacccagc
661 actgtggagg aggccaaaga gcgcctgcgc ttcctaatgc tccgcagatt ccccaggtct
721 ctgctgatcc tggatgatgt ctgggacagt tcttccctca ggtcttttga tatccaatgc
781 agagttcttc tgaccacacg caatcgagct ctgactgatt ccgtcagcgg tgtaaggtat
841 gaagtgcctg tagagaacgg tctggatgag gaaaaagcct tggaaattct tgctttgtac
901 gttaatggga agatgcacaa actcccagaa caggcccgca gcattgtaag cgaatgtaaa
961 ggttctcctc tggtggtttc tctgattgga gctctgctga gggagttccc tgaccgctgg
1021 agctattacc tgcgacagtt gcagcagaag cagttcaagc gcattcgcaa gtcttcatcc
1081 tatgactatg aagcactgga ccaggccatg gacgctagcc tgcaggttct ggaggccgaa
1141 caccaagagc tgtacagaga cctgagcgtc atgcagaaag acatcaaagt gcctgctaag
1201 gttctgtctg ttctgtgggg tcttgagctg gaggaggtag aggacgtcct gcaggagttt
1261 gtcaataaat ctctgctttt tcgggactgt aatcagcgac catatcgata ttaccttcat
1321 gatctgcagc tggatttcct cgctgaacaa aaccgtgatc agattgctga actacataaa
1381 aagatggttc gtcagtatca gaggttctac agtaaacgcc cacctgactc tgcagataaa
1441 gactcgttgt actggtacca gttcatcccg tatcacatgg ctaaagcagg actgtcgaag
1501 gagctttatt cactgatgtt ttccttggac tgggtcaaag agaaggctcg gattatggga
1561 tctgcccatc tcatcaatga ctatgtggaa tatggggaaa tactagataa agagaatagt
1621 gaagtgcgag tgcagtttca ggagttcctt tctctgaatg gtcatcatct ggagcagagg
1681 ccgttccctg atgtggtcca gttggctctg tctcagcccg atcgctctga ggtttacaga
1741 caggcactga tgcaggcgca gaaacgggcc agcagagggc agatctacct caactgggtg
1801 aataaaaata ttgaggaggg tttgtctcgg ctagtcatgc accctcacca gggggctgtc
1861 tactatgcct gcttctcaaa agacgggagt aaaattgcct cttgtggagc cagcaaggca
1921 cttcgggtgt ttaaatcgac ctctggagag aagcttttgg agcttcaggc tcacgaggaa
1981 gatgttttat gctgtgcctt ttcccctgat gaccggcata tagcaacatg tgccagtgac
2041 aggaaggtga agttgtggaa tgttgagcga ggtgttctta tcagagagtt tgaagttgaa
2101 cacgaggagc agatcaacca ctgccagttc accaacacag gccgaagagt cctgctggcc
2161 acctgctcaa atgacaaatt cactaacacc aggttgtgga accctaacaa aaagacgtct
2221 cagaacacta tgtttggaca catggagccg gtcaatcact gctgtttttc tcctaatgac
2281 ctttacctcg ccacttcatc cagtgatggc agcttgaagc tgtttgaagt gtcatctgcg
2341 aacgagtgga aatcaattga tgtcgatagt ttttttcctg agagtgacga agaaataaag
2401 gccatggtga aatgcagcac ttggtcggct gacggctcac aaatcatctg tgctgccaga
2461 aacacagtgt ttgtgtttga tgtggagacg tcagacctgc tgctgaagct gaagacgagt
2521 cgtttgagca ctattcagtt ctgtcatgcg tgtcctaaca gcagcctgct ggccgtcgct
2581 ctctcgcatt acaccgtaga gctgtggaac ttcgaaagca gtaagaagaa agccgaatgc
2641 agtggtcatc tgagctgggt tcactgtgtg cagttttcac ccgacggctc actcctgctg
2701 tcctcctctg atgatcagac tatcaggttg tgggagacgg accgggttca cacttcttct
2761 gctgtggctc tgaagaggga cactgatgtg ctgtcctctc acagtgatgc tacgatcatc
2821 gcacccgata gcagtaacag attacaggtg ctgagtggat ctacaggtgc tgttgtgctt
2881 gagagcgagg agctgtcatc caggatccgc tgttcgtgca tcagcagaaa cgctgcattt
2941 gtggctctgg gatctgagga cggaacagta caggtgattg aggttccttc ttcaaaggca
3001 tcagtgaagc tttcaggcca cactaagact gttcaccact gccagttcac tgacgactgt
3061 gaaatcctta taacatcctc agaagattcc actatccggg tgtggaagtg gaggaccggc
3121 gagtgtatgg tgctgcaggg tcatatggag ccggtcagga agtttcacct cttgagctct
3181 tcatcttctc ctcatctgtt ctcatggtcg tttgatggca cagttaaggt ctgggatttg
3241 accagagggc agatgctgca agaccttgtg tgtcatgagg gtgccgtcct gtcatgtgat
3301 gtgtcctctg atggacgcct ctttgccacc acctcagcta ataggactgc taaggtgtgg
3361 agcagtgcct catggaaaat gttatttttg ttggagggac acaaggattg cgttcgtagc
3421 tgccgttttt cttgggacaa caagagactt gcaactggcg atgacaatgg agaaatccgg
3481 ctgtggagca tgctggatgg agctctcctg aagatctgtc ctcgggacac taaagactcg
3541 atgaactcat accatgcggg atgggtgact gatctgcact tctctcctga taacagggtg
3601 ctcgtctcta ctgcgggata catcaagtgg tggagcgtgg agagcggaga ggcgctgcag
3661 accttctaca cgatgggagg caatctgaag aagatccacg tgtctcctga cttcagcacc
3721 ttcatcactg tggacagcat cggcatcctt tacattttaa agagacttga gggagaggga
3781 acatga
//