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Danio rerio apoptotic peptidase activating factor 1 (apaf1), mRNA

NCBI Reference Sequence: NM_131608.1

FASTA Graphics 

LOCUS       NM_131608               3786 bp    mRNA    linear   VRT 12-OCT-2024
DEFINITION  Danio rerio apoptotic peptidase activating factor 1 (apaf1), mRNA.
ACCESSION   NM_131608 NM_001045243
VERSION     NM_131608.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3786)
  AUTHORS   Li,X., Zeng,L., Qu,Z. and Zhang,F.
  TITLE     Huoxin pill protects verapamil-induced zebrafish heart failure
            through inhibition of oxidative stress-triggered inflammation and
            apoptosis
  JOURNAL   Heliyon 10 (1), e23402 (2023)
   PUBMED   38169776
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3786)
  AUTHORS   Zhao,Y., Wang,H., Duah,P.A., Retyunskiy,V., Liu,Y. and Chen,G.
  TITLE     Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses
            reveal involvement of oxidative damage, apoptosis, endoplasmic
            reticulum (ER) stress and autophagy
  JOURNAL   Aquat Toxicol 248, 106195 (2022)
   PUBMED   35594629
REFERENCE   3  (bases 1 to 3786)
  AUTHORS   Xie,Z., Lu,G., Zhou,R. and Ma,Y.
  TITLE     Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the
            extrinsic and intrinsic apoptosis pathways regulated by p53
            signaling pathway
  JOURNAL   Aquat Toxicol 246, 106147 (2022)
   PUBMED   35349858
REFERENCE   4  (bases 1 to 3786)
  AUTHORS   Gao,M., Hu,J., Zhu,Y., Wang,X., Zeng,S., Hong,Y. and Zhao,G.
  TITLE     Ferroptosis and Apoptosis Are Involved in the Formation of
            L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos
  JOURNAL   Int J Mol Sci 23 (9), 4783 (2022)
   PUBMED   35563172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3786)
  AUTHORS   Sun,C.C., Zhou,Z.Q., Chen,Z.L., Zhu,R.K., Yang,D., Peng,X.Y.,
            Zheng,L. and Tang,C.F.
  TITLE     Identification of Potentially Related Genes and Mechanisms Involved
            in Skeletal Muscle Atrophy Induced by Excessive Exercise in
            Zebrafish
  JOURNAL   Biology (Basel) 10 (8), 761 (2021)
   PUBMED   34439993
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3786)
  AUTHORS   Sorrells,S., Carbonneau,S., Harrington,E., Chen,A.T., Hast,B.,
            Milash,B., Pyati,U., Major,M.B., Zhou,Y., Zon,L.I., Stewart,R.A.,
            Look,A.T. and Jette,C.
  TITLE     Ccdc94 protects cells from ionizing radiation by inhibiting the
            expression of p53
  JOURNAL   PLoS Genet 8 (8), e1002922 (2012)
   PUBMED   22952453
REFERENCE   7  (bases 1 to 3786)
  AUTHORS   Jin,Y., Zheng,S. and Fu,Z.
  TITLE     Embryonic exposure to cypermethrin induces apoptosis and
            immunotoxicity in zebrafish (Danio rerio)
  JOURNAL   Fish Shellfish Immunol 30 (4-5), 1049-1054 (2011)
   PUBMED   21316461
REFERENCE   8  (bases 1 to 3786)
  AUTHORS   Jin,Y., Zheng,S., Pu,Y., Shu,L., Sun,L., Liu,W. and Fu,Z.
  TITLE     Cypermethrin has the potential to induce hepatic oxidative stress,
            DNA damage and apoptosis in adult zebrafish (Danio rerio)
  JOURNAL   Chemosphere 82 (3), 398-404 (2011)
   PUBMED   20965546
REFERENCE   9  (bases 1 to 3786)
  AUTHORS   Deng,J., Yu,L., Liu,C., Yu,K., Shi,X., Yeung,L.W., Lam,P.K.,
            Wu,R.S. and Zhou,B.
  TITLE     Hexabromocyclododecane-induced developmental toxicity and apoptosis
            in zebrafish embryos
  JOURNAL   Aquat Toxicol 93 (1), 29-36 (2009)
   PUBMED   19356805
REFERENCE   10 (bases 1 to 3786)
  AUTHORS   Stein,C., Caccamo,M., Laird,G. and Leptin,M.
  TITLE     Conservation and divergence of gene families encoding components of
            innate immune response systems in zebrafish
  JOURNAL   Genome Biol 8 (11), R251 (2007)
   PUBMED   18039395
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF251502.1.
            
            On Jun 7, 2012 this sequence version replaced NM_001045243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF251502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476731, SAMEA4476732
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3786
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     gene            1..3786
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="apoptotic peptidase activating factor 1"
                     /db_xref="GeneID:58131"
                     /db_xref="ZFIN:ZDB-GENE-000616-4"
     CDS             1..3786
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /codon_start=1
                     /product="apoptotic protease-activating factor 1"
                     /protein_id="NP_571683.1"
                     /db_xref="GeneID:58131"
                     /db_xref="ZFIN:ZDB-GENE-000616-4"
                     /translation="MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVL
                     SKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLLHSDLPLLSPEGEKSF
                     ADGVSPSVQAILSVGGVPQRPVVFVSRPPLLNLIREMLYQLRDTPGWVTVFGMAGSGK
                     SVMAAEVVRDRSLIKECFPDGVHWLSVGQCERADLLVRMQSLCFRLEQCQSSDTSQRP
                     PSTVEEAKERLRFLMLRRFPRSLLILDDVWDSSSLRSFDIQCRVLLTTRNRALTDSVS
                     GVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSLIGALLR
                     EFPDRWSYYLRQLQQKQFKRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDLSVMQ
                     KDIKVPAKVLSVLWGLELEEVEDVLQEFVNKSLLFRDCNQRPYRYYLHDLQLDFLAEQ
                     NRDQIAELHKKMVRQYQRFYSKRPPDSADKDSLYWYQFIPYHMAKAGLSKELYSLMFS
                     LDWVKEKARIMGSAHLINDYVEYGEILDKENSEVRVQFQEFLSLNGHHLEQRPFPDVV
                     QLALSQPDRSEVYRQALMQAQKRASRGQIYLNWVNKNIEEGLSRLVMHPHQGAVYYAC
                     FSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDRK
                     VKLWNVERGVLIREFEVEHEEQINHCQFTNTGRRVLLATCSNDKFTNTRLWNPNKKTS
                     QNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWKSIDVDSFFPESDEE
                     IKAMVKCSTWSADGSQIICAARNTVFVFDVETSDLLLKLKTSRLSTIQFCHACPNSSL
                     LAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETD
                     RVHTSSAVALKRDTDVLSSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSRIRCS
                     CISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDS
                     TIRVWKWRTGECMVLQGHMEPVRKFHLLSSSSSPHLFSWSFDGTVKVWDLTRGQMLQD
                     LVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSSASWKMLFLLEGHKDCVRSCRFSWD
                     NKRLATGDDNGEIRLWSMLDGALLKICPRDTKDSMNSYHAGWVTDLHFSPDNRVLVST
                     AGYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGILYILKRLEGEGT"
     misc_feature    1843..1962
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 1"
     misc_feature    1969..2088
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 2"
     misc_feature    2098..2229
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 3"
     misc_feature    2236..2355
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 4"
     misc_feature    2392..2508
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 5"
     misc_feature    2518..2637
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 6"
     misc_feature    2644..2763
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 7"
     misc_feature    2890..3009
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 8"
     misc_feature    3016..3135
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 9"
     misc_feature    3139..3264
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 10"
     misc_feature    3271..3390
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 11"
     misc_feature    3397..3516
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 12"
     misc_feature    3550..3669
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9I9H8.1);
                     Region: WD 13"
     exon            1..138
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            139..328
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            329..526
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            527..716
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            717..829
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            830..961
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1200
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1368
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1500
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1614
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1799
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1926
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2052
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2193
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2319
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2472
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2601
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2727
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2847
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2973
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3099
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3228
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3354
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3480
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3627
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3786
                     /gene="apaf1"
                     /gene_synonym="apaf-1; zgc:136543"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggaac gtgcccgcag ccgcctgctg cgctccaaag ccactctgga gcaggacatc
       61 aaagcctcct acctgatgga ccacatgatc agcgatggcg ttctaaccaa tgatgaggaa
      121 gcaaaagtgc tcagcaaggc cactagaaaa gagcaggccg tggctctgct tgagaccctg
      181 ttgaggaaag acaatcgtgc ctacatttcc ttctacaacg ccctgatcag ggagagttat
      241 ggagatctgg ccagtctcct tcacagtgat ctgcctctgc tcagccctga gggagagaag
      301 agcttcgctg atggagtctc tccctctgtc caggcgattc tgagtgtagg aggtgttcct
      361 cagagacctg tggtgttcgt gagtcgacct ccactgctca atctgatccg ggagatgctg
      421 taccagctgc gggacacacc gggctgggtg actgtatttg gcatggctgg ctcagggaag
      481 tctgtgatgg ctgccgaggt tgttcgagat cgttcactca ttaaggagtg ttttcctgat
      541 ggtgttcact ggctgtctgt gggtcagtgt gagcgggcag acctgttggt taggatgcag
      601 tctctgtgct ttcgtttgga gcagtgtcaa agttcagaca ccagtcagcg gccacccagc
      661 actgtggagg aggccaaaga gcgcctgcgc ttcctaatgc tccgcagatt ccccaggtct
      721 ctgctgatcc tggatgatgt ctgggacagt tcttccctca ggtcttttga tatccaatgc
      781 agagttcttc tgaccacacg caatcgagct ctgactgatt ccgtcagcgg tgtaaggtat
      841 gaagtgcctg tagagaacgg tctggatgag gaaaaagcct tggaaattct tgctttgtac
      901 gttaatggga agatgcacaa actcccagaa caggcccgca gcattgtaag cgaatgtaaa
      961 ggttctcctc tggtggtttc tctgattgga gctctgctga gggagttccc tgaccgctgg
     1021 agctattacc tgcgacagtt gcagcagaag cagttcaagc gcattcgcaa gtcttcatcc
     1081 tatgactatg aagcactgga ccaggccatg gacgctagcc tgcaggttct ggaggccgaa
     1141 caccaagagc tgtacagaga cctgagcgtc atgcagaaag acatcaaagt gcctgctaag
     1201 gttctgtctg ttctgtgggg tcttgagctg gaggaggtag aggacgtcct gcaggagttt
     1261 gtcaataaat ctctgctttt tcgggactgt aatcagcgac catatcgata ttaccttcat
     1321 gatctgcagc tggatttcct cgctgaacaa aaccgtgatc agattgctga actacataaa
     1381 aagatggttc gtcagtatca gaggttctac agtaaacgcc cacctgactc tgcagataaa
     1441 gactcgttgt actggtacca gttcatcccg tatcacatgg ctaaagcagg actgtcgaag
     1501 gagctttatt cactgatgtt ttccttggac tgggtcaaag agaaggctcg gattatggga
     1561 tctgcccatc tcatcaatga ctatgtggaa tatggggaaa tactagataa agagaatagt
     1621 gaagtgcgag tgcagtttca ggagttcctt tctctgaatg gtcatcatct ggagcagagg
     1681 ccgttccctg atgtggtcca gttggctctg tctcagcccg atcgctctga ggtttacaga
     1741 caggcactga tgcaggcgca gaaacgggcc agcagagggc agatctacct caactgggtg
     1801 aataaaaata ttgaggaggg tttgtctcgg ctagtcatgc accctcacca gggggctgtc
     1861 tactatgcct gcttctcaaa agacgggagt aaaattgcct cttgtggagc cagcaaggca
     1921 cttcgggtgt ttaaatcgac ctctggagag aagcttttgg agcttcaggc tcacgaggaa
     1981 gatgttttat gctgtgcctt ttcccctgat gaccggcata tagcaacatg tgccagtgac
     2041 aggaaggtga agttgtggaa tgttgagcga ggtgttctta tcagagagtt tgaagttgaa
     2101 cacgaggagc agatcaacca ctgccagttc accaacacag gccgaagagt cctgctggcc
     2161 acctgctcaa atgacaaatt cactaacacc aggttgtgga accctaacaa aaagacgtct
     2221 cagaacacta tgtttggaca catggagccg gtcaatcact gctgtttttc tcctaatgac
     2281 ctttacctcg ccacttcatc cagtgatggc agcttgaagc tgtttgaagt gtcatctgcg
     2341 aacgagtgga aatcaattga tgtcgatagt ttttttcctg agagtgacga agaaataaag
     2401 gccatggtga aatgcagcac ttggtcggct gacggctcac aaatcatctg tgctgccaga
     2461 aacacagtgt ttgtgtttga tgtggagacg tcagacctgc tgctgaagct gaagacgagt
     2521 cgtttgagca ctattcagtt ctgtcatgcg tgtcctaaca gcagcctgct ggccgtcgct
     2581 ctctcgcatt acaccgtaga gctgtggaac ttcgaaagca gtaagaagaa agccgaatgc
     2641 agtggtcatc tgagctgggt tcactgtgtg cagttttcac ccgacggctc actcctgctg
     2701 tcctcctctg atgatcagac tatcaggttg tgggagacgg accgggttca cacttcttct
     2761 gctgtggctc tgaagaggga cactgatgtg ctgtcctctc acagtgatgc tacgatcatc
     2821 gcacccgata gcagtaacag attacaggtg ctgagtggat ctacaggtgc tgttgtgctt
     2881 gagagcgagg agctgtcatc caggatccgc tgttcgtgca tcagcagaaa cgctgcattt
     2941 gtggctctgg gatctgagga cggaacagta caggtgattg aggttccttc ttcaaaggca
     3001 tcagtgaagc tttcaggcca cactaagact gttcaccact gccagttcac tgacgactgt
     3061 gaaatcctta taacatcctc agaagattcc actatccggg tgtggaagtg gaggaccggc
     3121 gagtgtatgg tgctgcaggg tcatatggag ccggtcagga agtttcacct cttgagctct
     3181 tcatcttctc ctcatctgtt ctcatggtcg tttgatggca cagttaaggt ctgggatttg
     3241 accagagggc agatgctgca agaccttgtg tgtcatgagg gtgccgtcct gtcatgtgat
     3301 gtgtcctctg atggacgcct ctttgccacc acctcagcta ataggactgc taaggtgtgg
     3361 agcagtgcct catggaaaat gttatttttg ttggagggac acaaggattg cgttcgtagc
     3421 tgccgttttt cttgggacaa caagagactt gcaactggcg atgacaatgg agaaatccgg
     3481 ctgtggagca tgctggatgg agctctcctg aagatctgtc ctcgggacac taaagactcg
     3541 atgaactcat accatgcggg atgggtgact gatctgcact tctctcctga taacagggtg
     3601 ctcgtctcta ctgcgggata catcaagtgg tggagcgtgg agagcggaga ggcgctgcag
     3661 accttctaca cgatgggagg caatctgaag aagatccacg tgtctcctga cttcagcacc
     3721 ttcatcactg tggacagcat cggcatcctt tacattttaa agagacttga gggagaggga
     3781 acatga
//
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