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    Nub1 negative regulator of ubiquitin-like proteins 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296731, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nub1provided by RGD
    Official Full Name
    negative regulator of ubiquitin-like proteins 1provided by RGD
    Primary source
    RGD:1359489
    See related
    EnsemblRapid:ENSRNOG00000009282 AllianceGenome:RGD:1359489
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BS4; NYREN18
    Summary
    Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; response to tumor necrosis factor; and response to type II interferon. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be located in Lewy body; cytosol; and nuclear lumen. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 307.0), Adrenal (RPKM 244.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nub1 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11335376..11366263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10442917..10473689, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6950870..6981400, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene crystallin, gamma N Neighboring gene WD repeat domain 86 Neighboring gene uncharacterized LOC134486541 Neighboring gene glycerol-3-phosphate dehydrogenase 1 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Parry G, et al. Semin Cell Dev Biol, 2004 Apr. PMID 15209382
    2. NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression. Kito K, et al. J Biol Chem, 2001 Jun 8. PMID 11259415
    3. NUB1 modulation of GSK3β reduces tau aggregation. Richet E, et al. Hum Mol Genet, 2012 Dec 15. PMID 22965877
    4. The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10. Schmidtke G, et al. J Biol Chem, 2006 Jul 21. PMID 16707496
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Lewy body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8 ultimate buster 1
    Names
    NY-REN-18 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013925.1 → NP_001013947.1  NEDD8 ultimate buster 1

      See identical proteins and their annotated locations for NP_001013947.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083586
      UniProtKB/TrEMBL
      A0A8I6A4A9, Q5XIT4
      Related
      ENSRNOP00000078815.1, ENSRNOT00000108045.2
      Conserved Domains (3) summary
      cd14291
      Location:374 → 409
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:491 → 526
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:434 → 466
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11335376..11366263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107214.2 → XP_038963142.1  NEDD8 ultimate buster 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4A9
      Conserved Domains (4) summary
      cd14291
      Location:398 → 433
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:515 → 550
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:94 → 187
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:458 → 490
      UBA_like_SF; UBA domain-like superfamily

    2. XM_063285691.1 → XP_063141761.1  NEDD8 ultimate buster 1 isoform X2

      Related
      ENSRNOP00000107436.1, ENSRNOT00000161628.1

    3. XM_039107215.1 → XP_038963143.1  NEDD8 ultimate buster 1 isoform X3

      Conserved Domains (3) summary
      cd14291
      Location:221 → 256
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14293
      Location:338 → 373
      UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:281 → 313
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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