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Conserved domains on  [gi|62078579|ref|NP_001013947|]
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NEDD8 ultimate buster 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ubiquitin_5 pfam18037
Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such ...
70-163 5.59e-44

Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such as NEDD8 ultimate buster protein.


:

Pssm-ID: 436228  Cd Length: 96  Bit Score: 151.77  E-value: 5.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078579    70 RGTGNEHYRTTGIATIEVFLPPRLRKD----KKSLLETRLHVTGRDLRSKIAETFGFQenYIKIVINKKQLQLGKSLEEQ 145
Cdd:pfam18037   1 RGKGNQTFRETGVATLELLLPRDQRKAtktrKKNYLETKLDVTGQELRSRIAETFGLQ--YIKLILNGKTLQLDKTLEEQ 78
                          90
                  ....*....|....*...
gi 62078579   146 GVTHNVKAMVLELKQSEE 163
Cdd:pfam18037  79 GVKHNSKVMVLELSDSEE 96
UBA1_NUB1_like cd14291
UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
374-409 1.47e-12

UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain.


:

Pssm-ID: 270477 [Multi-domain]  Cd Length: 36  Bit Score: 62.08  E-value: 1.47e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 374 DPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:cd14291   1 DEDKLQQLMEMGFSEAEARLALRACNGNVERAVDYI 36
UBA3_NUB1 cd14293
UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
491-526 2.55e-12

UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA3 domain.


:

Pssm-ID: 270479  Cd Length: 36  Bit Score: 61.31  E-value: 2.55e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 491 ESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTLAH 526
Cdd:cd14293   1 EKLDQLVYMGFERDVAESALRLTGGDVQQATQLLLD 36
UBA_like_SF super family cl21463
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ...
434-466 3.32e-10

UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains.


The actual alignment was detected with superfamily member cd14292:

Pssm-ID: 473871  Cd Length: 35  Bit Score: 55.11  E-value: 3.32e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 62078579 434 VNTLRGMGYSTQAAKQALHQARGNLDDALKILL 466
Cdd:cd14292   3 INTLKEMGYSERAAQRALHQADGNVDRAYKILL 35
 
Name Accession Description Interval E-value
Ubiquitin_5 pfam18037
Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such ...
70-163 5.59e-44

Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such as NEDD8 ultimate buster protein.


Pssm-ID: 436228  Cd Length: 96  Bit Score: 151.77  E-value: 5.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078579    70 RGTGNEHYRTTGIATIEVFLPPRLRKD----KKSLLETRLHVTGRDLRSKIAETFGFQenYIKIVINKKQLQLGKSLEEQ 145
Cdd:pfam18037   1 RGKGNQTFRETGVATLELLLPRDQRKAtktrKKNYLETKLDVTGQELRSRIAETFGLQ--YIKLILNGKTLQLDKTLEEQ 78
                          90
                  ....*....|....*...
gi 62078579   146 GVTHNVKAMVLELKQSEE 163
Cdd:pfam18037  79 GVKHNSKVMVLELSDSEE 96
Ubl_NUB1 cd17062
ubiquitin-like (Ubl) domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, ...
81-158 2.06e-27

ubiquitin-like (Ubl) domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also termed negative regulator of ubiquitin-like proteins 1, or renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), which may function in the regulation of cell cycle progression. NUB1 contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif.


Pssm-ID: 340582  Cd Length: 78  Bit Score: 105.30  E-value: 2.06e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62078579  81 GIATIEVFLPPRLRKDKKSLLETRLHVTGRDLRSKIAETFGFQENYIKIVINKKQLQLGKSLEEQGVTHNVKAMVLEL 158
Cdd:cd17062   1 GVATLRVRLPGQGSKKKKITLETSLDITGSELREKIAEELGVPEDRIKLISNGKVLKDEKTLAEQGVKNNSQVMVLVL 78
UBA1_NUB1_like cd14291
UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
374-409 1.47e-12

UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain.


Pssm-ID: 270477 [Multi-domain]  Cd Length: 36  Bit Score: 62.08  E-value: 1.47e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 374 DPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:cd14291   1 DEDKLQQLMEMGFSEAEARLALRACNGNVERAVDYI 36
UBA3_NUB1 cd14293
UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
491-526 2.55e-12

UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA3 domain.


Pssm-ID: 270479  Cd Length: 36  Bit Score: 61.31  E-value: 2.55e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 491 ESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTLAH 526
Cdd:cd14293   1 EKLDQLVYMGFERDVAESALRLTGGDVQQATQLLLD 36
UBA2_NUB1 cd14292
UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
434-466 3.32e-10

UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA2 domain.


Pssm-ID: 270478  Cd Length: 35  Bit Score: 55.11  E-value: 3.32e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 62078579 434 VNTLRGMGYSTQAAKQALHQARGNLDDALKILL 466
Cdd:cd14292   3 INTLKEMGYSERAAQRALHQADGNVDRAYKILL 35
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
374-409 1.46e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 42.09  E-value: 1.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 62078579    374 DPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:smart00165   1 DEEKIDQLLEMGFSREEALKALRAANGNVERAAEYL 36
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
490-524 2.12e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 41.70  E-value: 2.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 62078579    490 QESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTL 524
Cdd:smart00165   2 EEKIDQLLEMGFSREEALKALRAANGNVERAAEYL 36
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
373-409 2.21e-05

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 41.66  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 62078579   373 IDPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
488-524 2.79e-05

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 41.27  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 62078579   488 PSQESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTL 524
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
433-466 5.02e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 40.55  E-value: 5.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 62078579    433 SVNTLRGMGYSTQAAKQALHQARGNLDDALKILL 466
Cdd:smart00165   4 KIDQLLEMGFSREEALKALRAANGNVERAAEYLL 37
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
433-465 2.70e-04

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 38.58  E-value: 2.70e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 62078579   433 SVNTLRGMGYSTQAAKQALHQARGNLDDALKIL 465
Cdd:pfam00627   5 AIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
 
Name Accession Description Interval E-value
Ubiquitin_5 pfam18037
Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such ...
70-163 5.59e-44

Ubiquitin-like domain; This entry includes N-terminal ubiquitin-like domain from proteins such as NEDD8 ultimate buster protein.


Pssm-ID: 436228  Cd Length: 96  Bit Score: 151.77  E-value: 5.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078579    70 RGTGNEHYRTTGIATIEVFLPPRLRKD----KKSLLETRLHVTGRDLRSKIAETFGFQenYIKIVINKKQLQLGKSLEEQ 145
Cdd:pfam18037   1 RGKGNQTFRETGVATLELLLPRDQRKAtktrKKNYLETKLDVTGQELRSRIAETFGLQ--YIKLILNGKTLQLDKTLEEQ 78
                          90
                  ....*....|....*...
gi 62078579   146 GVTHNVKAMVLELKQSEE 163
Cdd:pfam18037  79 GVKHNSKVMVLELSDSEE 96
Ubl_NUB1 cd17062
ubiquitin-like (Ubl) domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, ...
81-158 2.06e-27

ubiquitin-like (Ubl) domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also termed negative regulator of ubiquitin-like proteins 1, or renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), which may function in the regulation of cell cycle progression. NUB1 contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif.


Pssm-ID: 340582  Cd Length: 78  Bit Score: 105.30  E-value: 2.06e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62078579  81 GIATIEVFLPPRLRKDKKSLLETRLHVTGRDLRSKIAETFGFQENYIKIVINKKQLQLGKSLEEQGVTHNVKAMVLEL 158
Cdd:cd17062   1 GVATLRVRLPGQGSKKKKITLETSLDITGSELREKIAEELGVPEDRIKLISNGKVLKDEKTLAEQGVKNNSQVMVLVL 78
UBA1_NUB1_like cd14291
UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
374-409 1.47e-12

UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain.


Pssm-ID: 270477 [Multi-domain]  Cd Length: 36  Bit Score: 62.08  E-value: 1.47e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 374 DPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:cd14291   1 DEDKLQQLMEMGFSEAEARLALRACNGNVERAVDYI 36
UBA3_NUB1 cd14293
UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
491-526 2.55e-12

UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA3 domain.


Pssm-ID: 270479  Cd Length: 36  Bit Score: 61.31  E-value: 2.55e-12
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 62078579 491 ESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTLAH 526
Cdd:cd14293   1 EKLDQLVYMGFERDVAESALRLTGGDVQQATQLLLD 36
UBA2_NUB1 cd14292
UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
434-466 3.32e-10

UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA2 domain.


Pssm-ID: 270478  Cd Length: 35  Bit Score: 55.11  E-value: 3.32e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 62078579 434 VNTLRGMGYSTQAAKQALHQARGNLDDALKILL 466
Cdd:cd14292   3 INTLKEMGYSERAAQRALHQADGNVDRAYKILL 35
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
92-156 1.07e-06

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 46.44  E-value: 1.07e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62078579  92 RLRKDKKSLLETRLHVTGRDLRSKIAETFGFQENYIKIVINKKQLQLGKSLEEQGVTHNVKAMVL 156
Cdd:cd17039   4 KTLDGKTYTVEVDPDDTVADLKEKIEEKTGIPVEQQRLIYNGKELKDDKTLSDYGIKDGSTIHLV 68
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
374-409 1.46e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 42.09  E-value: 1.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 62078579    374 DPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:smart00165   1 DEEKIDQLLEMGFSREEALKALRAANGNVERAAEYL 36
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
490-524 2.12e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 41.70  E-value: 2.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 62078579    490 QESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTL 524
Cdd:smart00165   2 EEKIDQLLEMGFSREEALKALRAANGNVERAAEYL 36
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
373-409 2.21e-05

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 41.66  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 62078579   373 IDPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHI 409
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
488-524 2.79e-05

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 41.27  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 62078579   488 PSQESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTL 524
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
433-466 5.02e-05

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 40.55  E-value: 5.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 62078579    433 SVNTLRGMGYSTQAAKQALHQARGNLDDALKILL 466
Cdd:smart00165   4 KIDQLLEMGFSREEALKALRAANGNVERAAEYLL 37
UBA_scDdi1_like cd14309
UBA domain found in Saccharomyces cerevisiae DNA-damage response protein Ddi1 and similar ...
376-406 2.61e-04

UBA domain found in Saccharomyces cerevisiae DNA-damage response protein Ddi1 and similar proteins; Ddi1, also called v-SNARE-master 1 (Vsm1), is a ubiquitin receptor involved in regulation of the cell cycle and late secretory pathway in Saccharomyces cerevisiae. It functions as a ubiquitin association domain (UBA)- ubiquitin-like-domain (UBL) shuttle protein that is required for the proteasome to enable ubiquitin-dependent degradation of its ligands. For instance, Ddi1 plays an essential role in the final stages of proteasomal degradation of Ho endonuclease and of its cognate FBP, Ufo1. Moreover, Ddi1 and its associated protein Rad23p play a cooperative role as negative regulators in yeast PHO pathway. Ddi1 contains an N-terminal UBL domain and a C-terminal UBA domain. It also harbors a central retroviral aspartyl-protease-like domain (RVP) which may be important in cell-cycle control. At this point, Ddi1 may function proteolytically during regulated protein turnover in the cell. This family also includes mammalian regulatory solute carrier protein family 1 member 1 (RSC1A1), also called transporter regulator RS1 (RS1) which mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1.


Pssm-ID: 270494  Cd Length: 36  Bit Score: 38.67  E-value: 2.61e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 62078579 376 SKVHNLLQLGFTAQEARLGLRACDGNVDHAA 406
Cdd:cd14309   2 EKIAQLMDLGFSREEAIQALEATNGNVELAA 32
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
433-465 2.70e-04

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 38.58  E-value: 2.70e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 62078579   433 SVNTLRGMGYSTQAAKQALHQARGNLDDALKIL 465
Cdd:pfam00627   5 AIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
UBA cd14270
UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ...
434-462 3.45e-04

UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ubiquitin-associated (UBA) domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only the bind UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains.


Pssm-ID: 270456 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 3.45e-04
                        10        20
                ....*....|....*....|....*....
gi 62078579 434 VNTLRGMGYSTQAAKQALHQARGNLDDAL 462
Cdd:cd14270   1 LAQLVEMGFSREQARRALRATNGDVEAAV 29
UBA_RUP1p cd14307
UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins; RUP1p is a ...
490-524 1.11e-03

UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins; RUP1p is a ubiquitin-associated (UBA) domain-containing protein encoded by a nonessential yeast gene RUP1. It can mediate the association of Rsp5 and Ubp2. The N-terminal UBA domain is responsible for antagonizing Rsp5 function, as well as bridging the Rsp5-Ubp2 interaction. No other characterized functional domains or motifs are found in RUP1p.


Pssm-ID: 270492  Cd Length: 38  Bit Score: 36.89  E-value: 1.11e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 62078579 490 QESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTL 524
Cdd:cd14307   1 EEAVASLLEMGIPREVAIEALRETNGDVEAAANYI 35
UBA2_UBP5 cd14386
UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5); UBP5, also called ...
373-415 1.54e-03

UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5); UBP5, also called deubiquitinating enzyme 5, Isopeptidase T (IsoT), ubiquitin thioesterase 5, or ubiquitin-specific-processing protease 5, is a deubiquitinating enzyme largely responsible for the disassembly of the majority of unanchored polyubiquitin in the cell. Zinc is required for its catalytic activity. UBP5 contains four ubiquitin (Ub)-binding sites including an N-terminal zinc finger (ZnF) domain, a catalytic ubiquitin-specific processing protease (UBP) domain (catalytic C-box and H-box), and two ubiquitin-associated (UBA) domains. ZnF domain binds the proximal ubiquitin. UBP domain forms the active site. UBA domains are involved in binding linear or K48-linked polyubiquitin. This model corresponds to the UBA2 domain.


Pssm-ID: 270569 [Multi-domain]  Cd Length: 43  Bit Score: 36.54  E-value: 1.54e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 62078579 373 IDPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHISNRREE 415
Cdd:cd14386   1 VPEEAVAMLVSMGFTRDQAIKALKATDNNVERAADWIFSHPDE 43
UBA cd14270
UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ...
493-522 1.96e-03

UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ubiquitin-associated (UBA) domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only the bind UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains.


Pssm-ID: 270456 [Multi-domain]  Cd Length: 30  Bit Score: 35.79  E-value: 1.96e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 62078579 493 IDQLVYMGFDTVVAEAALRVFAGNVQLAAQ 522
Cdd:cd14270   1 LAQLVEMGFSREQARRALRATNGDVEAAVE 30
UBA1_NUB1_like cd14291
UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ...
489-522 3.17e-03

UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain.


Pssm-ID: 270477 [Multi-domain]  Cd Length: 36  Bit Score: 35.50  E-value: 3.17e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 62078579 489 SQESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQ 522
Cdd:cd14291   1 DEDKLQQLMEMGFSEAEARLALRACNGNVERAVD 34
UBA2_UBP5 cd14386
UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5); UBP5, also called ...
433-470 5.55e-03

UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5); UBP5, also called deubiquitinating enzyme 5, Isopeptidase T (IsoT), ubiquitin thioesterase 5, or ubiquitin-specific-processing protease 5, is a deubiquitinating enzyme largely responsible for the disassembly of the majority of unanchored polyubiquitin in the cell. Zinc is required for its catalytic activity. UBP5 contains four ubiquitin (Ub)-binding sites including an N-terminal zinc finger (ZnF) domain, a catalytic ubiquitin-specific processing protease (UBP) domain (catalytic C-box and H-box), and two ubiquitin-associated (UBA) domains. ZnF domain binds the proximal ubiquitin. UBP domain forms the active site. UBA domains are involved in binding linear or K48-linked polyubiquitin. This model corresponds to the UBA2 domain.


Pssm-ID: 270569 [Multi-domain]  Cd Length: 43  Bit Score: 35.00  E-value: 5.55e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 62078579 433 SVNTLRGMGYSTQAAKQALHQARGNLDDALKILLSNPH 470
Cdd:cd14386   5 AVAMLVSMGFTRDQAIKALKATDNNVERAADWIFSHPD 42
UBA2_spUBP14_like cd14297
UBA2 domain found in Schizosaccharomyces pombe ubiquitin carboxyl-terminal hydrolase 14 ...
493-527 6.53e-03

UBA2 domain found in Schizosaccharomyces pombe ubiquitin carboxyl-terminal hydrolase 14 (spUBP14) and similar proteins; spUBP14, also called deubiquitinating enzyme 14, UBA domain-containing protein 2, ubiquitin thioesterase 14, or ubiquitin-specific-processing protease 14, functions as a deubiquitinating enzyme that is involved in protein degradation in fission yeast. Members in this family contain two tandem ubiquitin-association (UBA) domains. This model corresponds to the UBA2 domain.


Pssm-ID: 270483 [Multi-domain]  Cd Length: 39  Bit Score: 34.76  E-value: 6.53e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 62078579 493 IDQLVYMGFDTVVAEAALRVFAGNVQLAAQTLAHH 527
Cdd:cd14297   4 VKQLVDMGFTEAQARKALRKTNNNVERAVDWLFEG 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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