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    Slc17a5 solute carrier family 17 member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc17a5provided by RGD
    Official Full Name
    solute carrier family 17 member 5provided by RGD
    Primary source
    RGD:1311388
    See related
    EnsemblRapid:ENSRNOG00000090360 AllianceGenome:RGD:1311388
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AST; VEAT
    Summary
    Enables sialic acid transmembrane transporter activity. Involved in sialic acid transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be active in bounding membrane of organelle; glutamatergic synapse; and plasma membrane. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 116.7), Liver (RPKM 45.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc17a5 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (88274497..88309734, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79394416..79429387, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85891245..85926466, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene uncharacterized LOC134480209 Neighboring gene cytochrome c, somatic-like Neighboring gene CD109 molecule Neighboring gene myosin light chain 6, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis. Wang B, et al. Oral Dis, 2023 Jul. PMID 35593110
    2. Vesicular uptake and exocytosis of L-aspartate is independent of sialin. Morland C, et al. FASEB J, 2013 Mar. PMID 23221336, Free PMC Article
    3. Varied mechanisms underlie the free sialic acid storage disorders. Wreden CC, et al. J Biol Chem, 2005 Jan 14. PMID 15516337
    4. Defective sialic acid egress from isolated fibroblast lysosomes of patients with Salla disease. Renlund M, et al. Science, 1986 May 9. PMID 3961501
    5. Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes. Courville P, et al. J Biol Chem, 2010 Jun 18. PMID 20424173, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis.
      Title: Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis.
    2. l-aspartate is exocytotically released from nerve terminals after vesicular accumulation by a transporter other than sialin.
      Title: Vesicular uptake and exocytosis of L-aspartate is independent of sialin.
    3. analysis of crucial residues and substrate-induced conformational changes in SLC17 transporter sialin
      Title: Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes.
    4. sialin possesses dual physiological functions and acts as a vesicular aspartate/glutamate transporter
      Title: Identification of a vesicular aspartate transporter.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucuronate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter loading into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sialic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sialin
    Names
    H(+)/nitrate cotransporter
    H(+)/sialic acid cotransporter
    proton-coupled sialic acid transporter
    solute carrier family 17 (acidic sugar transporter), member 5
    solute carrier family 17 (anion/sugar transporter), member 5
    vesicular excitatory amino acid transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009713.2 → NP_001009713.1  sialin

      See identical proteins and their annotated locations for NP_001009713.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097482
      UniProtKB/Swiss-Prot
      Q5Q0U0
      Related
      ENSRNOP00000098782.1, ENSRNOT00000141108.1
      Conserved Domains (2) summary
      cd06174
      Location:99 → 478
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:30 → 491
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      88274497..88309734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265787.1 → XP_063121857.1  sialin isoform X4

      Related
      ENSRNOP00000111035.1, ENSRNOT00000122421.1

    2. XM_063265784.1 → XP_063121854.1  sialin isoform X2

    3. XM_063265785.1 → XP_063121855.1  sialin isoform X3

      UniProtKB/TrEMBL
      A6I1K9

    4. XM_063265783.1 → XP_063121853.1  sialin isoform X1

    RNA

    1. XR_010053993.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Q0U0.1 GenPept UniProtKB/Swiss-Prot:Q5Q0U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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