|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-478 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 673.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 42 LALLAFCGFFVLYALRVNLSVALVDMVDSNSTLTDNRTSKECAEHSAPVKVHHNHTGKKYQWDAETQGWILGSFFYGYIV 121
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 122 TQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTI 201
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 202 SYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvp 281
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 282 wvsilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTI 361
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 362 SVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGP 441
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 57527612 442 IIAKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-478 |
7.84e-180 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 509.47 E-value: 7.84e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 43 ALLAFCGFFVLYALRVNLSVALVDMVDSNSTLTDNRTSKEcaehsapvKVHHNHTGKKYQWDAETQGWILGSFFYGYIVT 122
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD--------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 123 QIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 202
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvpw 282
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 283 vsilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTIS 362
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 363 VRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPI 442
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 57527612 443 IAKSLTPDN-TIKEWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17318 353 IVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-478 |
2.78e-120 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 357.42 E-value: 2.78e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 43 ALLAFCGFFVLYALRVNLSVALVDMVdSNSTLtdnrtskecaEHSAPVKVHhnhtGKKYQWDAETQGWILGSFFYGYIVT 122
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMV-NNFTD----------AYGGKVIVH----KAEFNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 123 QIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 202
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIvsdtpethktishyekeyivsslknqlssqkvvpw 282
Cdd:cd17382 146 FCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 283 vsilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTIS 362
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 363 VRRIFSLIGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPI 442
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
410 420 430
....*....|....*....|....*....|....*.
gi 57527612 443 IAKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17382 345 IVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-491 |
1.28e-115 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 348.66 E-value: 1.28e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 30 EAAPACCSARYNLALLAFCGFFVLYALRVNLSVALVDMVDSnstltDNRTSKECAEHSAPVKVHHNhtgKKYQWDAETQG 109
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 110 WILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 190 APPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISHYEKEYIVS 268
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 269 SLKNQ-LSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQ 347
Cdd:TIGR00894 240 SLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 348 AADYLRVKWNFSTISVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLG 427
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57527612 428 ITNTFATIPGMIGPIIAKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWALSDHH 491
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-478 |
5.09e-105 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 317.57 E-value: 5.09e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 44 LLAFCGFFVLYALRVNLSVALVDMvdsnstltdnrtSKEcaehsapvkvhhnhtgkkYQWDAETQGWILGSFFYGYIVTQ 123
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPM------------AKE------------------FGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 124 IPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 203
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 204 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSdtpethktishyekeyivsslknqlssqkvvpwv 283
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 284 silkslPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKwNFSTISV 363
Cdd:cd17380 178 ------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 364 RRIFSLIGMVGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPII 443
Cdd:cd17380 250 RKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328
|
410 420 430
....*....|....*....|....*....|....*
gi 57527612 444 AKSLTpdNTIKEWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17380 329 TGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-472 |
3.12e-46 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 164.67 E-value: 3.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 39 RYNLALLAFCGFFVLYALRVNLSVALVDMvdsnstltdnrtskecaehsapvkvhhnhtGKKYQWDAETQGWILGSFFYG 118
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 119 YIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAAdlGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 199 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDtpethktishyekeyivsslknqlssqk 278
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 279 vvpwvsilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKwnf 358
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 359 stisVRRIFSLIGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAP-SYAGILLGITNTFATIPG 437
Cdd:cd17319 246 ----ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGG 320
|
410 420 430
....*....|....*....|....*....|....*
gi 57527612 438 MIGPIIAKSLTpdNTIKEWQTVFCIAAAINVFGAI 472
Cdd:cd17319 321 FVAPLLIGYLV--DATGSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-479 |
7.82e-40 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 147.32 E-value: 7.82e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 39 RYNLALLAFCGFFVLYALRVNLSVALVDMVDSnstltdnrtskecaehsapvkvhhnhtgkkYQWDAETQGWILGSFFYG 118
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 119 YIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAAdlGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 199 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFIlwmwivsdtpethktishyekeyivsslknqlssqk 278
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 279 vvpwvsilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLrvkwnf 358
Cdd:COG2271 180 ----------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL------ 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 359 stISVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGM 438
Cdd:COG2271 244 --GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 57527612 439 IGPIIAKSLTpdnTIKEWQTVFCIAAAINVFGAIFFTLFAK 479
Cdd:COG2271 322 LGPLLVGYLL---DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-474 |
2.02e-38 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 144.11 E-value: 2.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 101 YQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFP 180
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--LLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 181 AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYY--MNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKti 258
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 259 shyekeyivSSLKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 338
Cdd:cd06174 182 ---------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 339 WLCMIVCGQAADYLRvkwnfstisVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIA 418
Cdd:cd06174 253 ALGSLLLGLLSDRLI---------GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 57527612 419 PSYAGILLGITNTFATIPGMIGPIIAKSLTPDNTIkeWQTVFCIAAAINVFGAIFF 474
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-441 |
1.74e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.07 E-value: 1.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 98 GKKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAAdlGVVALIVLRALEGLGEGV 177
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 178 TFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILwmWIVSDTPETHKT 257
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 258 ISHYEKEYIVSslknqlssqkVVPWVSILKSLPLWAIVVAhFSYNWTFYTLLTLLPTYMkEILRFNVQENGFLSALPYFG 337
Cdd:pfam07690 180 PKPAEEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 338 CWLCMIVCGQAADYLRVKwnfstisVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDI 417
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 57527612 418 APSYAGILLGITNTFATIPGMIGP 441
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
99-477 |
4.96e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.50 E-value: 4.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 99 KKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVT 178
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPEthkti 258
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 259 shyekeyivssLKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 338
Cdd:COG2223 186 -----------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 339 WLCMIVCGQAADYLRvkwnfstisvRRIFSLIGMVGPAVFLVAAGFIGCDYSLA-VAFLTISTTLGGFASSGFSINHLDI 417
Cdd:COG2223 255 ALGRPLGGWLSDRIG----------GRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 418 APSYAGILLGITNTFATIPGMIGPIIAKSLTpdNTIKEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-478 |
1.78e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.58 E-value: 1.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--LLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTishyekeyivs 268
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 269 slKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQA 348
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 349 ADYLRvkwnfstisvRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 57527612 429 TNTFATIPGMIGPIIAKSLTPDNTikeWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-435 |
7.45e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.66 E-value: 7.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 101 YQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFP 180
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 181 AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIV-WFILWMWIVSDTPETHKTIS 259
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARARLR 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 260 HyekeyivsslknqlssqkvvPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 339
Cdd:COG2814 198 G--------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 340 LCMIVCGQAADYLRvkwnfstisvRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAP 419
Cdd:COG2814 258 LGALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*.
gi 57527612 420 SYAGILLGITNTFATI 435
Cdd:COG2814 328 EARGRASGLYNSAFFL 343
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-446 |
3.46e-17 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 83.45 E-value: 3.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 110 WILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGvvALIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG--GLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 190 APPLERSKLLTISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTIS 259
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 260 HYEKEYIVSSLK-NQ--LSSQKVVP--WVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALP 334
Cdd:cd17327 199 EEEKELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 335 YFGCwLCMIVCGQAADYLRVKWNFSTisvrrIFSLIGMVGPAVflvaagFIGCDYSLAVAFLTISTTLGGFASSGFSINH 414
Cdd:cd17327 279 ALGA-VSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII------LLAAPNPPGAYFAAYILGGGSYAGFPILLSW 346
|
330 340 350
....*....|....*....|....*....|....*
gi 57527612 415 L-DIAPSYAG--ILLGITNTFATIPGMIGPIIAKS 446
Cdd:cd17327 347 IsSNCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
109-443 |
5.42e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 76.65 E-value: 5.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFtpLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGI-ICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTIS-----HYE 262
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 263 KEYIVSSLKNQLSSQKVVPWvSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 342
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQ-YVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 343 IVCGQAADYLrvkwnfstisVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF----SINHLDIA 418
Cdd:TIGR00881 270 LLAGWLSDKL----------FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELA 339
|
330 340
....*....|....*....|....*.
gi 57527612 419 PSYA-GILLGITNTFATIPGMIGPII 443
Cdd:TIGR00881 340 PKKAaGTAAGFVGFFAYLGGILAGLP 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
95-447 |
3.01e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 74.32 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 95 NHTGKKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADlgVVALIVLRALEGLG 174
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 175 EGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWM--------W 246
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 247 IVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVP--WVSILK----------SLPLWaivVAHFSYNWTFYTLLTLLPT 314
Cdd:TIGR00895 199 LVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 315 YMKEiLRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKwnfstisVRRIFSLIGmvgpAVFLVAAGFigcDYSLAVA 394
Cdd:TIGR00895 276 LMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-------VTALLLLLG----AVFAVLVGS---TLFSPTL 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57527612 395 FLTISTTLGGFASSGFSINHLDIAPSYA--------GILLGITNTFAtipgMIGPIIAKSL 447
Cdd:TIGR00895 341 LLLLGAIAGFFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGA----IIGPILAGYL 397
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-477 |
1.60e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 65.67 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--LLAGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPEThktishyekeyivs 268
Cdd:cd17474 115 LFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 269 slKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALpyfgcwlcMIVCGQA 348
Cdd:cd17474 180 --AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG--------WSVLLAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 349 ADYLRVKWNFSTISVRRIFsLIGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLG 427
Cdd:cd17474 250 GSLFVGRLLKKRFGARRIL-VIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 57527612 428 ITNTFATIPGMIGPIIAKSLTpdnTIKEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
163-428 |
1.08e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 163 ALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYyMNWTYVFYLFgLVGIVWFI 242
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 243 LWMWIVSDTPETHKTISHYEKEyivsslknqlsSQKVVPWVSIlkslplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRF 322
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 323 NVQENGFLSAlpyfgcwlcmivcgqaadylrvkwnfstisvrrIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTL 402
Cdd:cd17473 231 SAALIGLALA---------------------------------IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260
....*....|....*....|....*.
gi 57527612 403 GGFAssgfsinhldIAPSYAGILLGI 428
Cdd:cd17473 278 LLLA----------LASGLWVVLLGA 293
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-475 |
3.17e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTishyekeyivs 268
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 269 slknqlSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLsalpYFGCWLCMIVCGQA 348
Cdd:cd17324 184 ------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----LLLFGVAGVVGSPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 349 ADYLRVKWNFSTISVrrIFSLIGMVGPAVFLVAAGFIgcdysLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17324 254 AGRLADRGGRRALLI--ALLLLAAALLLLTLLGPSPL-----LLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 57527612 429 TNTFATIPGMIGPIIAKSLTpdnTIKEWQTVFCIAAAINVFGAIFFT 475
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVL---DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
147-477 |
1.20e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 147 AVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAP-----PLERSKLLTISYAGAQLGTVISLPLSGIIC 221
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 222 YYM------NWTYVFYLFGLVGIVWFILWMWIVSDTPETHKtishyEKEYIVSSLKnqlssqkvvpwvSILKSLPLWAIV 295
Cdd:COG2211 172 AAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLKESLK------------ALLKNRPFLLLL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 296 VAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYlrvkwnfstISVRRIFsLIGMVGP 375
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAF-IIGLLLA 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 376 AVFLVAAGFIGcdySLAVAFLTISTTLGGFASSGFSINHL----DIAP--------SYAGILLGITNTFATIPGMIGPII 443
Cdd:COG2211 305 ALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydewktgrRREGLYFGIFTFAIKLGQALAGAL 381
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 57527612 444 -----------AKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2211 382 aglllalfgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-243 |
8.12e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.74 E-value: 8.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 104 DAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAadLGVVALIVLRALEGLGEGVTFPAMH 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFIL 243
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
147-474 |
3.20e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 55.77 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 147 AVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLG----TVISLPLSGIICY 222
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 223 YMNWTYVFylfgLVGIVWFILWMWIVSDTPEThktishyeKEYIVSSLKNQLSSQKVVPWV---SILKSLPLWAIVVAHF 299
Cdd:cd17371 153 EIAWRVLF----LLGALPALLVLFIRRFVKEP--------PQWQAARAARRHFADRPSLRElfsPPLLRTTLLASLLATG 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 300 SYnWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFstisvrrifsLIGMVGPAVFL 379
Cdd:cd17371 221 AL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF----------ALFALGSAISI 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 380 VAAGFIGCDYSLavaFLTISTTLGGFASSGFSINHLDIAPSYA----GILLGITNTFATIPGMIGPIIAKSLTPDNTIKE 455
Cdd:cd17371 290 LLYFFLPLSPTL---ILILGFPLGFFASGPFSGMGAYLTELFPtavrATAQGFCYNVGRIIGALFPFLVGFLATSGSLGT 366
|
330
....*....|....*....
gi 57527612 456 WQTVFCIAAAINVFGAIFF 474
Cdd:cd17371 367 AIAVFAAVYYIAGLVLALL 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-443 |
2.01e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.00 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVValIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLF--AIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHktishyekeyivs 268
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKR------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 269 slKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPyfgcwLCMIVCGQa 348
Cdd:cd17329 182 --RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN-----ALLIVLLQ- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 349 adYLRVKWnFSTISVRRIFsLIGMVGPAVFLVAAGFIGCDYSL--AVAFLTISTTLGGFASSGFsINHLdIAPSYAGILL 426
Cdd:cd17329 254 --FPVARL-VERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLilAMIVLTLGEMLVFPAVQTL-VAAL-APPDKRGSYM 327
|
330
....*....|....*..
gi 57527612 427 GITNTFATIPGMIGPII 443
Cdd:cd17329 328 GFYALAWGLGRAIGPLV 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-443 |
2.76e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.55 E-value: 2.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGV--VALIVLraleGLGEGVTFPAMHAMw 186
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLllLALFLL----GLGLGLLDVAANPY- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 187 SSWAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMN----WTYVFYLFGLVGIVWFILWMWivSDTPETHKTISHye 262
Cdd:COG0738 121 VAALGPETAASRLNLLHAFFSLGALLG-PLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEE-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 263 keyivsslknqlSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQEngflSALPYFGCWLCM 342
Cdd:COG0738 196 ------------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAT----AALGLSLFWGGM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 343 IVCGQAADYLRVKWNFSTisVRRIFSLIGMVGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFASSGFS-INHL--DIAP 419
Cdd:COG0738 260 TIGRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLG 329
|
330 340
....*....|....*....|....
gi 57527612 420 SYAGILLGITNTFATIPGMIGPII 443
Cdd:COG0738 330 KRTAAAVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-474 |
3.04e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 52.62 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 107 TQGWILGSFF-YGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGvvALIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--QLLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 186 WSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISHYEKE 264
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 265 YIVSSLKNqlssqkvvpWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSAlpYFGCWLCM-- 342
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 343 ----IVCGQAADYLRVKwnfsTISVRRIFSLIGMVGPAVFLVAAgFIGCDYSLAVAFLTI--STTLGG--FASSGFSINH 414
Cdd:cd17328 261 vlgvLLGGILADRLRRK----TPRADPLVCAVGLLAAAPFLFLA-LVLALSNLLLAWVLLflGEFLLSlnWAPVFAILLY 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 57527612 415 LDI----APSYAGILLGITNTFATIPGMIGPIIAKSLTPDNT-----IKEWQTVFCIAAAINVFGAIFF 474
Cdd:cd17328 336 VVIptrrSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDsplaeAASLQYALLLCSFVLVLGGFFF 404
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
294-477 |
4.46e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 294 IVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRvkwnfstisvRRIFSLIGMV 373
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKSLTpdnTI 453
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 57527612 454 KEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
146-477 |
5.49e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 5.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 146 TAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMN 225
Cdd:cd06173 77 LAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 226 WTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKnqlssqkvvpwvsILKSLPLWAIVVAHFSYNWTF 305
Cdd:cd06173 157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLR-------------YLRRSPLLRLLLLALALFALL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 306 YT-LLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRvkwnfstisvRRIFSLIGMVGPAVFLVAAGF 384
Cdd:cd06173 224 GGaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR----------RGRLLLIGALLLGLALLVLGL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 385 IGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKSLTPDNTIkewQTVFCIAA 464
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL---SAVFLLAG 370
|
330
....*....|...
gi 57527612 465 AINVFGAIFFTLF 477
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
146-243 |
6.23e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 6.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 146 TAVFTLFTPLAA---DLGVvaLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICY 222
Cdd:cd17503 68 LALFTLGSLLCGlapNLAS--LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD 145
|
90 100
....*....|....*....|.
gi 57527612 223 YMNWTYVFYLFGLVGIVWFIL 243
Cdd:cd17503 146 NLSWRWIFYINLPIGILALLL 166
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
160-483 |
6.76e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 6.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 160 GVVALIVLRALEGLGEGVTFPAMHAMWSSWAPpLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIV 239
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 240 WFILWMWIVSDTPETHKtishyekeyivsslknqlSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEi 319
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 320 LRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTisvrrIFSLIGMVGPAVFLVAAGFigcdySLAVAFLTIS 399
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL-----LLGLLGLAGLLGLLLAPGS-----LPWLWAVLLG 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 400 TTLGGFASSGFS-INHLDIAPSYAGILLGITNTFATIPGMIGPIIA---KSLTPDntikeWQTVFCIAAAINVFGAIFFT 475
Cdd:COG2807 315 LGQGGLFPLALTlIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVgalHDATGS-----WTAALLLLAALAVLMLVAGL 389
|
....*...
gi 57527612 476 LFAKGEVQ 483
Cdd:COG2807 390 LAGRPYVE 397
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-443 |
9.57e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.08 E-value: 9.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLglgilgtAVFTLFTPLAADL-----GVVALIVLRALEGLGEGVTFPAMH 183
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVL-------AVGLLLMGAAALLmalvgSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFIL-WMWIvsdtpethktishye 262
Cdd:cd17475 107 RAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFY--------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 263 KEYIVSSLKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 342
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 343 IVCGQAADYLRVKwnfstisvRRIFSLIGMVGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF-SINHLDIA--- 418
Cdd:cd17475 252 IGLGRVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesa 322
|
330 340
....*....|....*....|....*.
gi 57527612 419 -PSYAGILLGITNTFATIPGMIGPII 443
Cdd:cd17475 323 gPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
99-477 |
4.47e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.78 E-value: 4.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 99 KKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLF--TPLAADLGVVALIVLRALEGLGEG 176
Cdd:cd17345 31 EQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 177 VTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM---NWTYVFYLFGLVGIVWFILWMWIVSDTPE 253
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 254 T------HKTISHYEKEYIVSSLKNQLSSQKVVpWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQEN 327
Cdd:cd17345 191 SeglppiEEYKGDYPEEADGEEEEQELSAWEIF-VKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 328 GFLSALPYFGCWLCMIVCGQAADYLrVKWNfstisvRRIFSLIGMVGPAVFLVAagfigcdYSLA--VAFLTISTTLGGF 405
Cdd:cd17345 270 MWAFSLFEWAAIPGTLLAGWLSDKL-FKGR------RAPTGIIFMILVIVALIV-------YWLApnVLVDLIALIALGF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 406 ASSG----FSINHLDIAPSYA-GILLGITNTFATIpgmIGPIIAKSLTP---DNTikEWQTVFcIAAAINVFGAIFFTLF 477
Cdd:cd17345 336 LIYGpvmlIGLQALELVPKKAaGTAAGLTGLFGYL---GGSVLATALIGiivDHF--GWNGGF-IVLLASCILAIIFLAL 409
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-248 |
8.50e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 8.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 99 KKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAAdlGVVALIVLRALEGLGEGVT 178
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIV 248
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
149-252 |
9.42e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 47.64 E-value: 9.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 149 FTLFTPLAA-DLGVVALIVLRALEGLGEGVTFP-AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 226
Cdd:cd17476 73 FAIWSLIAGfSPNFIFFIICRALQGLGPAFLLPnAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWW 152
|
90 100
....*....|....*....|....*..
gi 57527612 227 TYVFYLFGLVGIVWFIL-WMWIVSDTP 252
Cdd:cd17476 153 PWIFWFLAILAAIVAVAaIFWTSPSFI 179
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-477 |
9.82e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 9.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 39 RYNLALLAFCGFFVLYALRVNLSVALVDMVDsnstltdnrtskecaehsapvkvhhnhtgkKYQWDAETQGWILGSFFYG 118
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------------------EIGLSKDDLGIIGSAFLIA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 119 YIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVAliVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17312 51 YAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFA--VLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 199 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPEThktishyekeyivsslknqlssqk 278
Cdd:cd17312 129 YGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY------------------------ 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 279 vvpwvsilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLrvkWNF 358
Cdd:cd17312 185 ------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL---FGG 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 359 STISVRRIFSLIGMVGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLGITNTFATIPG 437
Cdd:cd17312 250 RRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLGA 326
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 57527612 438 MIGPIIAKSLTPDNTikeWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd17312 327 SLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLLLLSL 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
99-253 |
2.06e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 99 KKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVT 178
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57527612 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPE 253
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-443 |
2.60e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 104 DAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLgvVALIVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM----NWTYVFYLFGLVGIVWFILWMWIvsdtpethktis 259
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLLRRRT------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 260 hyekeyivsslknqlssqkvvpwvsilkslplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 339
Cdd:cd17316 180 --------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 340 LCMIVCGQAADYLRvkwnfstisvRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTIstTLGGFASSGFSINHLDIAP 419
Cdd:cd17316 228 VGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAE 295
|
330 340
....*....|....*....|....*...
gi 57527612 420 SYA----GILLGITNTFATIPGMIGPII 443
Cdd:cd17316 296 LFPtevrATGVGLSYNLGRLGGGGAPPL 323
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
164-440 |
7.28e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 164 LIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFIL 243
Cdd:cd17321 87 LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 244 wmwivsdtpethktishyekeyivsslknqlssqkvvpwvsilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFN 323
Cdd:cd17321 167 --------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 324 VQENGFLSaLPYFgcwLCMIVCGQAADYLRVKWNFstisvrRIFSLIGMVGPAVFLVAAGFIGCDYS---LAVAFLTIST 400
Cdd:cd17321 203 PLQAGLAL-LPLA---LAMLVAAPLAGRLADRFGP------RLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLVLLGL 272
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 57527612 401 TLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIG 440
Cdd:cd17321 273 GLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
102-444 |
8.82e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.60 E-value: 8.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 102 QWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAadLGVVALIVLRALEGLGEGVTFPA 181
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALT--SGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 182 MHAMWSSWAPPLERSKLLTISYAGAQLGTVIS-LPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISh 260
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 261 yekeyivsslknqlSSQKVVPWVsilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWL 340
Cdd:cd06180 187 --------------AAESAPGLN-----RPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 341 CMIVCGQAADYLRVKWNFSTISVRRIFSLIGMVGPAVFLVAAGFIGCdyslAVAFLTISTTLGGFASsgfsinhlDIAPS 420
Cdd:cd06180 248 CFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLF----GGTFMAITALVMALAR--------ELAPP 315
|
330 340
....*....|....*....|....
gi 57527612 421 YAGILLGITNTFATIPGMIGPIIA 444
Cdd:cd06180 316 AAPRALALMTASFGVGQILGPLLA 339
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
294-477 |
1.20e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 294 IVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMIVCGQAADYLRvkwnfstisvRRIFSLIGMV 373
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAkSLTPDNTI 453
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 57527612 454 KEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-476 |
1.86e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVvaLIVLRALEGLGEGVTFPAM----HA 184
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL--FVVLMFLAGLGAGILDTGAntfvGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 185 MWSSwapplERSKLLTISYAGAQLGTVISLPLSG-IICYYMNWTYVFYLFGLVGIVWFILWMWIVSdtPETHKTishyek 263
Cdd:cd17333 112 LFEE-----SSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLF--PELPSA------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 264 eyivsSLKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSAlpyfGCWLCMI 343
Cdd:cd17333 179 -----RNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS----GFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 344 VCGQAADYLRVKWNFSTISVrrIFSLIGMVGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFASSGFSINhLDIAPSYAG 423
Cdd:cd17333 250 IGRLLGGPISRRIKPHTLLV--LSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAALFPTILSLG-ISNLPYAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 57527612 424 ILLGITNTFATIPGMIGPIIAKSLTPDNTIkewQTVFCIaaaINVFGAIFFTL 476
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFIAEAVGI---QTAMLL---ITILYAIIFVL 369
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-243 |
3.13e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 104 DAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALivLRALEGLGEGVTFPAMH 183
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL--LRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFIL 243
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
121-445 |
3.83e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 121 VTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVlrALEGLGEGVTFPAMHAMWSSWAPPlERSKLLT 200
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGIGSAAFHPEGARLASQAAGG-RRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 201 ISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTIshyekeyivsslKNQLSSQKVV 280
Cdd:cd17478 123 IFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK------------AAAKSSARST 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 281 PWVSILKSLPLWAIVvahFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALpYFGCWLCMIVCGQAADYlrvkwnfst 360
Cdd:cd17478 190 LKGVWRALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGAIGTLIGGPLSDR--------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 361 ISVRRIFsLIGMVGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFASSGFSINHL---DIAPSYAGILLGITNTFA-TIP 436
Cdd:cd17478 257 FGRRRVI-IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLG 330
|
....*....
gi 57527612 437 GMIGPIIAK 445
Cdd:cd17478 331 GIGAPVLGA 339
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
109-252 |
3.91e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.64 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGvvALIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP--SLLVARLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTP 252
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESR 194
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
109-477 |
5.46e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAAdlGVVALIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIIcyYMNWTY--VFYLFGLVGIVWFILwMWIVSDTPETHKTIShyekeyi 266
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFL--YQHLGFavLFIVAAVLALLALLL-VFLVKDPPPVAAEEA------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 267 vsslknqlSSQKVVPWVSILKSLPLWAIVVAHFSYnwTFYTLLTLLPTYMKEILRFNVqenGFLSALPYFGCWLCMIVCG 346
Cdd:cd17489 182 --------EAGTRAFRRLVEKKVLPPALILFLASI--AYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 347 QAADYLRVKWnfsTISVRRIFSLIGMV------GPAVFLVAAGFIGCDYSLAVAFLTISTtlggfassgfsinhLDIAPS 420
Cdd:cd17489 249 KLSDRKGPKT---VIIPGLLLLALGLLllsfagSPWMLLLAAVLYGLGFGLLFPALQALA--------------VDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 57527612 421 YA-GILLGITNTFATIPGMIGPIIAKSLTPdntIKEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd17489 312 HRrGAANGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
287-477 |
7.68e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 287 KSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMIVCGQAADylrvkwnfsTISVRRI 366
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 367 FsLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKS 446
Cdd:COG2814 78 L-LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|.
gi 57527612 447 LTpdnTIKEWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2814 157 LA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-247 |
2.52e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 109 GWILGSFFYGYIVTQIPGGYMASRIggklllglgilgTAVFTLFT-PLAADLGVVALIVLRALEGLGEGVTFPAMHAMWS 187
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLLLIG------------ALLLGLALlVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 188 SWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWI 247
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
293-477 |
3.18e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.92 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 293 AIVVAHFSYNWTFYTLLTLLPTYMKEILrfNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWnfstisvrrifsliGM 372
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRW--------------FF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 373 VGPAVFLVAaGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIA----PSYAGILLGITNTFATIPGMIGPIIAKSLT 448
Cdd:cd06179 66 IGGNLLGVV-GSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASelvpNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
170 180
....*....|....*....|....*....
gi 57527612 449 PDNTIKeWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd06179 145 EANAAG-WRWIFYINAIFNALALILLFFF 172
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-209 |
5.25e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 100 KYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLgvVALIVLRALEGLGEGVTF 179
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL--WLLLLALFLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|
gi 57527612 180 PAMHAMWSSWAPPLERSKLLTISYAGAQLG 209
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
155-245 |
6.13e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57527612 155 LAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYL-- 232
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLaa 353
|
90
....*....|....
gi 57527612 233 -FGLVGIVWFILWM 245
Cdd:cd17489 354 vVVLLALVLYIFLL 367
|
|
| |
