KCS2 3-ketoacyl-CoA synthase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: KCS2
Official Full Name: 3-ketoacyl-CoA synthase 2
Primary source: TAIR:AT1G04220
Locus tag: AT1G04220
See related: Araport:AT1G04220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 3-ketoacyl-CoA synthase 2; F20D22.1; F20D22_1
Summary: Encodes KCS2, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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demonstrate that the KCS20 and KCS2/DAISY genes are functionally redundant in the two-carbon elongation to C22 fatty acids that is required for cuticular wax and root suberin biosynthesis.
Title: Two Arabidopsis 3-ketoacyl CoA synthase genes, KCS20 and KCS2/DAISY, are functionally redundant in cuticular wax and root suberin biosynthesis, but differentially controlled by osmotic stress.
DAISY is transcriptionally activated by NaCl application, and also by polyethylene glycol-induced drought stress and wounding, and is involved in suberin biosynthesis.
Title: The DAISY gene from Arabidopsis encodes a fatty acid elongase condensing enzyme involved in the biosynthesis of aliphatic suberin in roots and the chalaza-micropyle region of seeds.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_100303.4

Function	Evidence Code	Pubs
enables fatty acid elongase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to osmotic stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within suberin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

NP_171918.1

3-ketoacyl-CoA synthase 2 (KCS2); FUNCTIONS IN: fatty acid elongase activity; INVOLVED IN: response to wounding, response to osmotic stress, suberin biosynthetic process; LOCATED IN: membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 20 (TAIR:AT5G43760.1); Has 5259 Blast hits to 5241 proteins in 1449 species: Archae - 0; Bacteria - 2406; Metazoa - 0; Fungi - 4; Plants - 2679; Viruses - 0; Other Eukaryotes - 170 (source: NCBI BLink).