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    Atxn2l ataxin 2-like [ Mus musculus (house mouse) ]

    Gene ID: 233871, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atxn2lprovided by MGI
    Official Full Name
    ataxin 2-likeprovided by MGI
    Primary source
    MGI:MGI:2446242
    See related
    Ensembl:ENSMUSG00000032637 AllianceGenome:MGI:2446242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A2D; A2LG; A2RP; A2lp; Atxnl2
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA metabolic process and stress granule assembly. Predicted to be located in cytosol; membrane; and nuclear speck. Predicted to be active in cytoplasmic stress granule. Orthologous to human ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 219.2), thymus adult (RPKM 135.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atxn2l in Genome Data Viewer
    Location:
    7 F3; 7 69.09 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126090880..126106991, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126491708..126507819, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133630590-133630777 Neighboring gene predicted gene, 46001 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E555 Neighboring gene STARR-positive B cell enhancer ABC_E10474 Neighboring gene STARR-positive B cell enhancer ABC_E8209 Neighboring gene STARR-seq mESC enhancer starr_20151 Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene predicted gene, 24596 Neighboring gene predicted gene, 25579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mid-Gestation lethality of Atxn2l-Ablated Mice. Key J, et al. Int J Mol Sci, 2020 Jul 20. PMID 32698485, Free PMC Article
    2. Specific expression and alternative splicing of mouse genes during spermatogenesis. Li Q, et al. Mol Omics, 2020 Jun 1. PMID 32211685
    3. RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex. Liu W, et al. Cell Rep, 2023 Feb 28. PMID 36800290
    4. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
    5. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specific expression and alternative splicing of mouse genes during spermatogenesis.
      Title: Specific expression and alternative splicing of mouse genes during spermatogenesis.
    2. Mid-Gestation lethality of Atxn2l-Ablated Mice.
      Title: Mid-Gestation lethality of Atxn2l-Ablated Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ataxin-2-like protein
    Names
    ataxin 2 related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347658.2 → NP_001334587.1  ataxin-2-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125322
      Consensus CDS
      CCDS85413.1
      UniProtKB/TrEMBL
      E9Q5Q0, Q3TGG2
      Related
      ENSMUSP00000132959.2, ENSMUST00000167759.8

    2. NM_001361487.2 → NP_001348416.1  ataxin-2-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125322
      UniProtKB/TrEMBL
      Q3TYH7
      Conserved Domains (4) summary
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain
      cl25764
      Location:749 → 950
      PAT1; Topoisomerase II-associated protein PAT1
      cl26464
      Location:334 → 940
      Atrophin-1; Atrophin-1 family

    3. NM_183020.3 → NP_898841.1  ataxin-2-like protein isoform 1

      See identical proteins and their annotated locations for NP_898841.1

      Status: VALIDATED

      Source sequence(s)
      AC125322
      Consensus CDS
      CCDS21831.1
      UniProtKB/Swiss-Prot
      Q7TQH0, Q80XN9, Q8K059
      UniProtKB/TrEMBL
      E9Q5Q0
      Related
      ENSMUSP00000035415.9, ENSMUST00000040202.15
      Conserved Domains (2) summary
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:120 → 188
      SM-ATX; Ataxin 2 SM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126090880..126106991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507725.3 → XP_006507788.1  ataxin-2-like protein isoform X5

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:334 → 940
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:830 → 1035
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    2. XM_030242516.2 → XP_030098376.1  ataxin-2-like protein isoform X4

      Conserved Domains (5) summary
      PHA03247
      Location:547 → 1073
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 532
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:749 → 950
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    3. XM_006507721.3 → XP_006507784.1  ataxin-2-like protein isoform X2

      UniProtKB/TrEMBL
      A0A0U1RPL0
      Related
      ENSMUSP00000146023.2, ENSMUST00000206577.2
      Conserved Domains (5) summary
      PHA03247
      Location:588 → 1031
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 532
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:749 → 950
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    4. XM_006507723.3 → XP_006507786.1  ataxin-2-like protein isoform X3

      See identical proteins and their annotated locations for XP_006507786.1

      UniProtKB/TrEMBL
      Q3TYH7
      Conserved Domains (4) summary
      PHA03247
      Location:401 → 946
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:755 → 956
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    5. XM_006507722.3 → XP_006507785.1  ataxin-2-like protein isoform X3

      See identical proteins and their annotated locations for XP_006507785.1

      UniProtKB/TrEMBL
      Q3TYH7
      Conserved Domains (4) summary
      PHA03247
      Location:401 → 946
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:755 → 956
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    6. XM_006507720.4 → XP_006507783.1  ataxin-2-like protein isoform X1

      See identical proteins and their annotated locations for XP_006507783.1

      Conserved Domains (4) summary
      PHA03247
      Location:401 → 946
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:755 → 956
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    7. XM_011241775.2 → XP_011240077.1  ataxin-2-like protein isoform X1

      See identical proteins and their annotated locations for XP_011240077.1

      Conserved Domains (4) summary
      PHA03247
      Location:401 → 946
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam09770
      Location:755 → 956
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:118 → 194
      SM-ATX; Ataxin 2 SM domain

    8. XM_006507728.3 → XP_006507791.1  ataxin-2-like protein isoform X17

      Conserved Domains (2) summary
      PHA03247
      Location:3 → 499
      PHA03247; large tegument protein UL36; Provisional
      PRK14971
      Location:427 → 502
      PRK14971; DNA polymerase III subunit gamma/tau

    9. XM_030242522.2 → XP_030098382.1  ataxin-2-like protein isoform X11

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:248 → 854
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:663 → 864
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    10. XM_030242521.2 → XP_030098381.1  ataxin-2-like protein isoform X11

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:248 → 854
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:663 → 864
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    11. XM_030242519.2 → XP_030098379.1  ataxin-2-like protein isoform X9

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (5) summary
      PHA03247
      Location:248 → 854
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:782 → 1006
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:663 → 864
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    12. XM_030242520.2 → XP_030098380.1  ataxin-2-like protein isoform X10

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (3) summary
      PHA03247
      Location:315 → 860
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam14438
      Location:35 → 108
      SM-ATX; Ataxin 2 SM domain

    13. XM_036153014.1 → XP_036008907.1  ataxin-2-like protein isoform X10

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (3) summary
      PHA03247
      Location:315 → 860
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam14438
      Location:35 → 108
      SM-ATX; Ataxin 2 SM domain

    14. XM_030242518.2 → XP_030098378.1  ataxin-2-like protein isoform X8

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:315 → 860
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:669 → 870
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    15. XM_030242527.1 → XP_030098387.1  ataxin-2-like protein isoform X17

      Conserved Domains (2) summary
      PHA03247
      Location:3 → 499
      PHA03247; large tegument protein UL36; Provisional
      PRK14971
      Location:427 → 502
      PRK14971; DNA polymerase III subunit gamma/tau

    16. XM_017322209.2 → XP_017177698.1  ataxin-2-like protein isoform X13

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:281 → 826
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:142 → 204
      LsmAD; LsmAD domain
      pfam09770
      Location:635 → 836
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    17. XM_030242526.2 → XP_030098386.1  ataxin-2-like protein isoform X16

      UniProtKB/TrEMBL
      E9Q5Q0
      Related
      ENSMUSP00000125881.3, ENSMUST00000166682.9
      Conserved Domains (4) summary
      PHA03247
      Location:214 → 820
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:142 → 204
      LsmAD; LsmAD domain
      pfam09770
      Location:710 → 915
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    18. XM_030242524.1 → XP_030098384.1  ataxin-2-like protein isoform X14

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:214 → 820
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:142 → 204
      LsmAD; LsmAD domain
      pfam09770
      Location:629 → 830
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    19. XM_030242523.2 → XP_030098383.1  ataxin-2-like protein isoform X12

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:248 → 854
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:663 → 864
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    20. XM_030242517.1 → XP_030098377.1  ataxin-2-like protein isoform X7

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:277 → 883
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:205 → 267
      LsmAD; LsmAD domain
      pfam09770
      Location:692 → 893
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:61 → 137
      SM-ATX; Ataxin 2 SM domain

    21. XM_030242525.2 → XP_030098385.1  ataxin-2-like protein isoform X15

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (4) summary
      PHA03247
      Location:315 → 860
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam09770
      Location:790 → 957
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:32 → 108
      SM-ATX; Ataxin 2 SM domain

    22. XM_036153013.1 → XP_036008906.1  ataxin-2-like protein isoform X6

      UniProtKB/TrEMBL
      E9Q5Q0
      Conserved Domains (3) summary
      PHA03247
      Location:344 → 889
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:205 → 267
      LsmAD; LsmAD domain
      pfam14438
      Location:64 → 137
      SM-ATX; Ataxin 2 SM domain

    23. XM_036153015.1 → XP_036008908.1  ataxin-2-like protein isoform X17

      Conserved Domains (2) summary
      PHA03247
      Location:3 → 499
      PHA03247; large tegument protein UL36; Provisional
      PRK14971
      Location:427 → 502
      PRK14971; DNA polymerase III subunit gamma/tau
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQH0.1 GenPept UniProtKB/Swiss-Prot:Q7TQH0

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