U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATMIN7 HOPM interactor 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823405, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATMIN7
    Official Full Name
    HOPM interactor 7
    Primary source
    TAIR:AT3G43300
    Locus tag
    AT3G43300
    See related
    Araport:AT3G43300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BEN1; BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1; HOPM interactor 7; MIN7
    Summary
    AtMIN7 is an immunity associated Arabidopsis protein targeted by HopM1, a conserved Pseudomonas syringae virulence protein. AtMIN7 encodes one of the eight members of the Arabidopsis adenosine diphosphate (ADP) ribosylation factor (ARF) guanine nucleotide exchange factor (GEF) protein family. The AFR GEF proteins are key components of the vesicle trafficking system in eukaryotic cells. HopM1 mediates the destruction of AtMIN7 via the host proteasome.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATMIN7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Sequence:
    Chromosome: 3; NC_003074.8 (15233845..15245281, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection. Zhao Z, et al. Int J Mol Sci, 2020 Aug 3. PMID 32756392, Free PMC Article
    2. The Pseudomonas syringae pv. tomato type III effector HopM1 suppresses Arabidopsis defenses independent of suppressing salicylic acid signaling and of targeting AtMIN7. Gangadharan A, et al. PLoS One, 2013. PMID 24324742, Free PMC Article
    3. Effector-triggered immunity blocks pathogen degradation of an immunity-associated vesicle traffic regulator in Arabidopsis. Nomura K, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670267, Free PMC Article
    4. HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis. Sparks JA, et al. Plant Cell, 2016 Mar. PMID 26941089, Free PMC Article
    5. Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking. Tanaka H, et al. Curr Biol, 2009 Mar 10. PMID 19230664

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection.
      Title: Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection.
    2. BIG5 functions redundantly with BIG3 in plant growth and gravitropism, and BIG5 participates in Brassinosteroid signal transduction pathway through regulating BRI1 trafficking.[BIG5]
      Title: Involvement of BIG5 and BIG3 in BRI1 Trafficking Reveals Diverse Functions of BIG-subfamily ARF-GEFs in Plant Growth and Gravitropism.
    3. HLB1 together with MIN7/BEN1 form a complex with actin to modulate the function of the trans-Golgi network (TGN)/early endosome (EE) at the intersection of the exocytic and endocytic pathways in plants.
      Title: HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis.
    4. HopM1 enhances the growth of Pseudomonas syringae pv tomato strain DC3000 in salicylic acid-signaling deficient plants. AtMIN7 contributes to Pph-induced PR-1 expression.
      Title: The Pseudomonas syringae pv. tomato type III effector HopM1 suppresses Arabidopsis defenses independent of suppressing salicylic acid signaling and of targeting AtMIN7.
    5. BEN1 and BEN2 are collectively required for polar PIN localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes. [BEN1]
      Title: Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana.
    6. AtMIN7 is an immunity-associated protein which is the target for P. syringae virulence protein, HopM1; HopM1 mediates the destruction of AtMIN7 via the host proteasome [AtMIN7]
      Title: A bacterial virulence protein suppresses host innate immunity to cause plant disease.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001203077.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    HOPM interactor 7
    NP_001190006.1
    • HOPM interactor 7 (ATMIN7); CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1).
    NP_189916.4
    • HOPM interactor 7 (ATMIN7); FUNCTIONS IN: protein binding, guanyl-nucleotide exchange factor activity; INVOLVED IN: defense response to bacterium, vesicle-mediated transport, growth; LOCATED IN: trans-Golgi network, early endosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15233845..15245281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339097.1 → NP_001327198.1  HOPM interactor 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IXW1, F4IXW2, Q0WM86, Q9LXK4
      UniProtKB/TrEMBL
      A0A178V911
      Conserved Domains (1) summary
      PLN03076
      Location:24 → 1739
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

    2. NM_114198.4 → NP_189916.4  HOPM interactor 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189916.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V911
      Conserved Domains (6) summary
      PLN03076
      Location:24 → 1758
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:599 → 780
      Sec7; Sec7 domain
      pfam09324
      Location:1092 → 1175
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:334 → 501
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:1188 → 1341
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:102 → 238
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    3. NM_001203077.1 → NP_001190006.1  HOPM interactor 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V911
      Conserved Domains (6) summary
      PLN03076
      Location:68 → 1727
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:580 → 761
      Sec7; Sec7 domain
      pfam09324
      Location:1073 → 1156
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:334 → 482
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:1220 → 1310
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:102 → 238
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IXW2.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.