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Conserved domains on  [gi|334185713|ref|NP_001190006|]
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HOPM interactor 7 [Arabidopsis thaliana]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 68-1727 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1103.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   68 PQKVTSAEVAQQASQSKSETINVSLANAG-HTLGGAEVELVLKPLRLAFETKNLKIFDAALDCLHKLIAYDHLEGDPGLD 146
Cdd:PLN03076   47 PEKNPPSTSSAAADSASASSLPGPLHDGGsIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  147 GGKNSAPFTDILNMVCSCVDNSSpDSTVLQVLKVLLTAVASGKFKVHGEPLLGVIRVCYNIALNSKSPINQATSKAMLTQ 226
Cdd:PLN03076  127 GGPEALLLAKLIESVCKCHDLGD-EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQ 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  227 MISIVFRRMETDivsaSSTVSQEEHVSGDTSSPKneEITAADEN----------------EKEMTLGDALTQAKDTTLAS 290
Cdd:PLN03076  206 MLVIVFRRMEAD----SSTVPIQPIVVAELMEPA--EKSDSDTSmtqfvqgfitkimqdiDGVLNPATAGKSSGSGAHDG 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  291 VEELHTLVGGADIKGLEAALDK----AVHLE--------DGKK-------IKRGIELEsMSIG---QRDALLVFRTLCKM 348
Cdd:PLN03076  280 AFETTATVETTNPADLLDSTDKdmldAKYWEismyksalEGRKgeladgeVEKDDDLE-VQIGnklRRDAFLVFRALCKL 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  349 GMK-----EDSDEVTTKTRILSLELLQGMLEGVSHSFTKNFHFIDSVKAYLSYALLRASVSQSSVIFQYASGIFSVLLLR 423
Cdd:PLN03076  359 SMKtppkeALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  424 FRDSLKGEIGIFFPIIVLRSLDNSECPN-DQKMGVLRMLEKVCKDPQMLVDVYVNYDCDLEAPNLFERMVTTLSKIAQGS 502
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENVAQPNfQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGV 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  503 QSADPNPAMASQTASVKGSSLQCLVNVLKSLVDW--EKIRREAENSTR--NANEDSASTG----------EPIETKSRED 568
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmnKQLRLPDPASLKklDAVENNLEPGslpvangngdENGEGSDSHS 598

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  569 VPSN-------FEKAKAHKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPL 641
Cdd:PLN03076  599 ELSSetsdaatIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSL 678

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  642 AVMHAYVDSMKFSEMKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPM 721
Cdd:PLN03076  679 KVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPM 758

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  722 VWPKMSKSDFTRMNATNDPEDCAPTELLEEIYDSIVQEEIKLKDDDTMkkLSSQRPGGEERG-GLVSILNLGLPKRisAA 800
Cdd:PLN03076  759 VKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV--PQQKQSANSNRIlGLDSILNIVIRKR--GE 834

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  801 DAKSET-EDIVRKTQEIFR-KHGVKRGVFHTVEQVDIIRPMVEAVGWPLLAAFSVTMEVGDNKPRILLCMEGFKAGIHIA 878
Cdd:PLN03076  835 DSYMETsDDLIKHMQEQFKeKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVT 914

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  879 YVLGMDTMRYAFLTSLVRFTFLHAPKEMRSKNVEALRILLGLCDSEPDTLQDTWNAVLECVSRLE--------------- 943
Cdd:PLN03076  915 AVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEhlhllgegappdatf 994

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  944 FII---------------------STPG----IAATVMHGSNQIS-----RDGVVQS------------LKELAGRPAEQ 981
Cdd:PLN03076  995 FAApqnesdkskqakspilpvlkrKGPGklqyAAAAVRRGSYDSAgvggkASGVVTSeqmnnlvsnlnmLEQVGSFEMNR 1074

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  982 VFVNSVKLPSESVVEFFTALCGVSAEELKQ-SPARVFSLQKLVEISYYNIARIRMVWARIWSVLAEHFVSAGSHHDEKIA 1060
Cdd:PLN03076 1075 IFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIA 1154

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1061 MYAIDSLRQLGMKYLERAELTNFTFQNDILKPFVIIMRNTQSQTIRSLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAAD 1140
Cdd:PLN03076 1155 IFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAY 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1141 DEVESIVEKSFENVEQGDKQ---------------SIKLLHLFANNKASDRISLKAIALLRICEDRLAEGLI-------- 1197
Cdd:PLN03076 1235 DDHKNIVLLAFEIIEKIIREyfpyitetetttftdCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLgsssrnkd 1314

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1198 ----PGGVLKPVDGNEDE-TF---DVTEHYWFPMLAGLSDLTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRI 1269
Cdd:PLN03076 1315 keapPSSPQSGKDGKQESgEFtdkDDHLYFWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESV 1394

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1270 LFPIFDHVSHA-------GKESLISSGDVK-------FRETSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKSDQ 1335
Cdd:PLN03076 1395 LFPIFDYVRHAidpsggdEPEGQGVDGDQGeldqdawLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQ 1474

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1336 TVVSISLGALVHLIEVGGHQFSEGDWDMLLKSIRDASYTTQPlellnALSFdnpkknlVLAGDIeadasdsprvdRNPDD 1415
Cdd:PLN03076 1475 SLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLP-----DFSY-------VVSGEY-----------MPAEN 1531

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1416 IKDNGKVSAQASPRIGthgtslesgippkaDGSEGRPSSSgraqkdvddvnlqrsqtfgqrfmdnlfLRNLTSQPKSSVA 1495
Cdd:PLN03076 1532 IQDSENAEAASSSTAD--------------NDAEAERSRR---------------------------LYAAISDAKCRAA 1570

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1496 evtvpsspykhedptepdsreeespalgairgkciTQLLLLGAINSIQQKYWSNLKTPQKIAIMDILFSFIEFASSYNSY 1575
Cdd:PLN03076 1571 -----------------------------------VQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALHTVASHAHKINSD 1615

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1576 SNLRTRMNHI--PTERPPLNLLRQELEGTTIYLDVLQKttsgLADDASNSEDRLEgaAEEKLVSFCEQVLK-----ETSD 1648
Cdd:PLN03076 1616 TALRSKLQELgsMTQMQDPPLLRLENESYQICLTFLQN----LILDKPPLAKEAE--VESRLVELCEEVLQfyietSTAG 1689

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1649 LQSTLGETTN--------MDVHRVLELRSPVIVKVLEGMCFMNNTIFRKHMREFYPLLTRLVCCEQ--MEIRGALANLFK 1718
Cdd:PLN03076 1690 QDSEDSSSQQprwliplgSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHgsNEVQVALSDMLS 1769


                  ....*....
gi 334185713 1719 AQLKPLLQQ 1727
Cdd:PLN03076 1770 SWVGPVLLQ 1778
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 68-1727 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1103.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   68 PQKVTSAEVAQQASQSKSETINVSLANAG-HTLGGAEVELVLKPLRLAFETKNLKIFDAALDCLHKLIAYDHLEGDPGLD 146
Cdd:PLN03076   47 PEKNPPSTSSAAADSASASSLPGPLHDGGsIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  147 GGKNSAPFTDILNMVCSCVDNSSpDSTVLQVLKVLLTAVASGKFKVHGEPLLGVIRVCYNIALNSKSPINQATSKAMLTQ 226
Cdd:PLN03076  127 GGPEALLLAKLIESVCKCHDLGD-EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQ 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  227 MISIVFRRMETDivsaSSTVSQEEHVSGDTSSPKneEITAADEN----------------EKEMTLGDALTQAKDTTLAS 290
Cdd:PLN03076  206 MLVIVFRRMEAD----SSTVPIQPIVVAELMEPA--EKSDSDTSmtqfvqgfitkimqdiDGVLNPATAGKSSGSGAHDG 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  291 VEELHTLVGGADIKGLEAALDK----AVHLE--------DGKK-------IKRGIELEsMSIG---QRDALLVFRTLCKM 348
Cdd:PLN03076  280 AFETTATVETTNPADLLDSTDKdmldAKYWEismyksalEGRKgeladgeVEKDDDLE-VQIGnklRRDAFLVFRALCKL 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  349 GMK-----EDSDEVTTKTRILSLELLQGMLEGVSHSFTKNFHFIDSVKAYLSYALLRASVSQSSVIFQYASGIFSVLLLR 423
Cdd:PLN03076  359 SMKtppkeALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  424 FRDSLKGEIGIFFPIIVLRSLDNSECPN-DQKMGVLRMLEKVCKDPQMLVDVYVNYDCDLEAPNLFERMVTTLSKIAQGS 502
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENVAQPNfQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGV 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  503 QSADPNPAMASQTASVKGSSLQCLVNVLKSLVDW--EKIRREAENSTR--NANEDSASTG----------EPIETKSRED 568
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmnKQLRLPDPASLKklDAVENNLEPGslpvangngdENGEGSDSHS 598

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  569 VPSN-------FEKAKAHKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPL 641
Cdd:PLN03076  599 ELSSetsdaatIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSL 678

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  642 AVMHAYVDSMKFSEMKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPM 721
Cdd:PLN03076  679 KVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPM 758

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  722 VWPKMSKSDFTRMNATNDPEDCAPTELLEEIYDSIVQEEIKLKDDDTMkkLSSQRPGGEERG-GLVSILNLGLPKRisAA 800
Cdd:PLN03076  759 VKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV--PQQKQSANSNRIlGLDSILNIVIRKR--GE 834

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  801 DAKSET-EDIVRKTQEIFR-KHGVKRGVFHTVEQVDIIRPMVEAVGWPLLAAFSVTMEVGDNKPRILLCMEGFKAGIHIA 878
Cdd:PLN03076  835 DSYMETsDDLIKHMQEQFKeKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVT 914

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  879 YVLGMDTMRYAFLTSLVRFTFLHAPKEMRSKNVEALRILLGLCDSEPDTLQDTWNAVLECVSRLE--------------- 943
Cdd:PLN03076  915 AVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEhlhllgegappdatf 994

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  944 FII---------------------STPG----IAATVMHGSNQIS-----RDGVVQS------------LKELAGRPAEQ 981
Cdd:PLN03076  995 FAApqnesdkskqakspilpvlkrKGPGklqyAAAAVRRGSYDSAgvggkASGVVTSeqmnnlvsnlnmLEQVGSFEMNR 1074

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  982 VFVNSVKLPSESVVEFFTALCGVSAEELKQ-SPARVFSLQKLVEISYYNIARIRMVWARIWSVLAEHFVSAGSHHDEKIA 1060
Cdd:PLN03076 1075 IFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIA 1154

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1061 MYAIDSLRQLGMKYLERAELTNFTFQNDILKPFVIIMRNTQSQTIRSLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAAD 1140
Cdd:PLN03076 1155 IFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAY 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1141 DEVESIVEKSFENVEQGDKQ---------------SIKLLHLFANNKASDRISLKAIALLRICEDRLAEGLI-------- 1197
Cdd:PLN03076 1235 DDHKNIVLLAFEIIEKIIREyfpyitetetttftdCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLgsssrnkd 1314

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1198 ----PGGVLKPVDGNEDE-TF---DVTEHYWFPMLAGLSDLTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRI 1269
Cdd:PLN03076 1315 keapPSSPQSGKDGKQESgEFtdkDDHLYFWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESV 1394

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1270 LFPIFDHVSHA-------GKESLISSGDVK-------FRETSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKSDQ 1335
Cdd:PLN03076 1395 LFPIFDYVRHAidpsggdEPEGQGVDGDQGeldqdawLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQ 1474

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1336 TVVSISLGALVHLIEVGGHQFSEGDWDMLLKSIRDASYTTQPlellnALSFdnpkknlVLAGDIeadasdsprvdRNPDD 1415
Cdd:PLN03076 1475 SLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLP-----DFSY-------VVSGEY-----------MPAEN 1531

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1416 IKDNGKVSAQASPRIGthgtslesgippkaDGSEGRPSSSgraqkdvddvnlqrsqtfgqrfmdnlfLRNLTSQPKSSVA 1495
Cdd:PLN03076 1532 IQDSENAEAASSSTAD--------------NDAEAERSRR---------------------------LYAAISDAKCRAA 1570

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1496 evtvpsspykhedptepdsreeespalgairgkciTQLLLLGAINSIQQKYWSNLKTPQKIAIMDILFSFIEFASSYNSY 1575
Cdd:PLN03076 1571 -----------------------------------VQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALHTVASHAHKINSD 1615

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1576 SNLRTRMNHI--PTERPPLNLLRQELEGTTIYLDVLQKttsgLADDASNSEDRLEgaAEEKLVSFCEQVLK-----ETSD 1648
Cdd:PLN03076 1616 TALRSKLQELgsMTQMQDPPLLRLENESYQICLTFLQN----LILDKPPLAKEAE--VESRLVELCEEVLQfyietSTAG 1689

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1649 LQSTLGETTN--------MDVHRVLELRSPVIVKVLEGMCFMNNTIFRKHMREFYPLLTRLVCCEQ--MEIRGALANLFK 1718
Cdd:PLN03076 1690 QDSEDSSSQQprwliplgSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHgsNEVQVALSDMLS 1769


                  ....*....
gi 334185713 1719 AQLKPLLQQ 1727
Cdd:PLN03076 1770 SWVGPVLLQ 1778
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 579-761 4.14e-87

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 281.66  E-value: 4.14e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   579 HKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSEMKF 658
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   659 HSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNATN 738
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGI 160

                          170       180
                   ....*....|....*....|...
gi 334185713   739 DPEDCAPTELLEEIYDSIVQEEI 761
Cdd:pfam01369  161 NDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 579-761 3.20e-69

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 230.57  E-value: 3.20e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  579 HKSTMEAAISEFNRNSVKGVEYLIANKLVE-RNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSEMK 657
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEdDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  658 FHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFK-NADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNA 736
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*.
gi 334185713  737 -TNDPEDcAPTELLEEIYDSIVQEEI 761
Cdd:cd00171   161 gINDGED-FPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 577-761 2.49e-61

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 208.30  E-value: 2.49e-61
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713    577 KAHKSTMEAaISEFNRNSVKGVEYLIANKLV-ERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSE 655
Cdd:smart00222    3 GRKKLLSEG-IVKFNDKPKKGIQSLQEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713    656 MKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFK--NADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTR 733
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*....
gi 334185713    734 MNA-TNDPEDcAPTELLEEIYDSIVQEEI 761
Cdd:smart00222  162 NVRgSNDGED-LPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 68-1727 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1103.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   68 PQKVTSAEVAQQASQSKSETINVSLANAG-HTLGGAEVELVLKPLRLAFETKNLKIFDAALDCLHKLIAYDHLEGDPGLD 146
Cdd:PLN03076   47 PEKNPPSTSSAAADSASASSLPGPLHDGGsIEYSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  147 GGKNSAPFTDILNMVCSCVDNSSpDSTVLQVLKVLLTAVASGKFKVHGEPLLGVIRVCYNIALNSKSPINQATSKAMLTQ 226
Cdd:PLN03076  127 GGPEALLLAKLIESVCKCHDLGD-EGIELLVLKTLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQ 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  227 MISIVFRRMETDivsaSSTVSQEEHVSGDTSSPKneEITAADEN----------------EKEMTLGDALTQAKDTTLAS 290
Cdd:PLN03076  206 MLVIVFRRMEAD----SSTVPIQPIVVAELMEPA--EKSDSDTSmtqfvqgfitkimqdiDGVLNPATAGKSSGSGAHDG 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  291 VEELHTLVGGADIKGLEAALDK----AVHLE--------DGKK-------IKRGIELEsMSIG---QRDALLVFRTLCKM 348
Cdd:PLN03076  280 AFETTATVETTNPADLLDSTDKdmldAKYWEismyksalEGRKgeladgeVEKDDDLE-VQIGnklRRDAFLVFRALCKL 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  349 GMK-----EDSDEVTTKTRILSLELLQGMLEGVSHSFTKNFHFIDSVKAYLSYALLRASVSQSSVIFQYASGIFSVLLLR 423
Cdd:PLN03076  359 SMKtppkeALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  424 FRDSLKGEIGIFFPIIVLRSLDNSECPN-DQKMGVLRMLEKVCKDPQMLVDVYVNYDCDLEAPNLFERMVTTLSKIAQGS 502
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENVAQPNfQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGV 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  503 QSADPNPAMASQTASVKGSSLQCLVNVLKSLVDW--EKIRREAENSTR--NANEDSASTG----------EPIETKSRED 568
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmnKQLRLPDPASLKklDAVENNLEPGslpvangngdENGEGSDSHS 598

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  569 VPSN-------FEKAKAHKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPL 641
Cdd:PLN03076  599 ELSSetsdaatIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSL 678

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  642 AVMHAYVDSMKFSEMKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPM 721
Cdd:PLN03076  679 KVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPM 758

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  722 VWPKMSKSDFTRMNATNDPEDCAPTELLEEIYDSIVQEEIKLKDDDTMkkLSSQRPGGEERG-GLVSILNLGLPKRisAA 800
Cdd:PLN03076  759 VKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV--PQQKQSANSNRIlGLDSILNIVIRKR--GE 834

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  801 DAKSET-EDIVRKTQEIFR-KHGVKRGVFHTVEQVDIIRPMVEAVGWPLLAAFSVTMEVGDNKPRILLCMEGFKAGIHIA 878
Cdd:PLN03076  835 DSYMETsDDLIKHMQEQFKeKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVT 914

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  879 YVLGMDTMRYAFLTSLVRFTFLHAPKEMRSKNVEALRILLGLCDSEPDTLQDTWNAVLECVSRLE--------------- 943
Cdd:PLN03076  915 AVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEhlhllgegappdatf 994

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  944 FII---------------------STPG----IAATVMHGSNQIS-----RDGVVQS------------LKELAGRPAEQ 981
Cdd:PLN03076  995 FAApqnesdkskqakspilpvlkrKGPGklqyAAAAVRRGSYDSAgvggkASGVVTSeqmnnlvsnlnmLEQVGSFEMNR 1074

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  982 VFVNSVKLPSESVVEFFTALCGVSAEELKQ-SPARVFSLQKLVEISYYNIARIRMVWARIWSVLAEHFVSAGSHHDEKIA 1060
Cdd:PLN03076 1075 IFTRSQKLNSEAIIDFVKALCKVSMEELRSpSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIA 1154

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1061 MYAIDSLRQLGMKYLERAELTNFTFQNDILKPFVIIMRNTQSQTIRSLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAAD 1140
Cdd:PLN03076 1155 IFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAY 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1141 DEVESIVEKSFENVEQGDKQ---------------SIKLLHLFANNKASDRISLKAIALLRICEDRLAEGLI-------- 1197
Cdd:PLN03076 1235 DDHKNIVLLAFEIIEKIIREyfpyitetetttftdCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLgsssrnkd 1314

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1198 ----PGGVLKPVDGNEDE-TF---DVTEHYWFPMLAGLSDLTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRI 1269
Cdd:PLN03076 1315 keapPSSPQSGKDGKQESgEFtdkDDHLYFWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESV 1394

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1270 LFPIFDHVSHA-------GKESLISSGDVK-------FRETSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKSDQ 1335
Cdd:PLN03076 1395 LFPIFDYVRHAidpsggdEPEGQGVDGDQGeldqdawLYETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQ 1474

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1336 TVVSISLGALVHLIEVGGHQFSEGDWDMLLKSIRDASYTTQPlellnALSFdnpkknlVLAGDIeadasdsprvdRNPDD 1415
Cdd:PLN03076 1475 SLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLP-----DFSY-------VVSGEY-----------MPAEN 1531

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1416 IKDNGKVSAQASPRIGthgtslesgippkaDGSEGRPSSSgraqkdvddvnlqrsqtfgqrfmdnlfLRNLTSQPKSSVA 1495
Cdd:PLN03076 1532 IQDSENAEAASSSTAD--------------NDAEAERSRR---------------------------LYAAISDAKCRAA 1570

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1496 evtvpsspykhedptepdsreeespalgairgkciTQLLLLGAINSIQQKYWSNLKTPQKIAIMDILFSFIEFASSYNSY 1575
Cdd:PLN03076 1571 -----------------------------------VQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALHTVASHAHKINSD 1615

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1576 SNLRTRMNHI--PTERPPLNLLRQELEGTTIYLDVLQKttsgLADDASNSEDRLEgaAEEKLVSFCEQVLK-----ETSD 1648
Cdd:PLN03076 1616 TALRSKLQELgsMTQMQDPPLLRLENESYQICLTFLQN----LILDKPPLAKEAE--VESRLVELCEEVLQfyietSTAG 1689

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713 1649 LQSTLGETTN--------MDVHRVLELRSPVIVKVLEGMCFMNNTIFRKHMREFYPLLTRLVCCEQ--MEIRGALANLFK 1718
Cdd:PLN03076 1690 QDSEDSSSQQprwliplgSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHgsNEVQVALSDMLS 1769


                  ....*....
gi 334185713 1719 AQLKPLLQQ 1727
Cdd:PLN03076 1770 SWVGPVLLQ 1778
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 579-761 4.14e-87

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 281.66  E-value: 4.14e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   579 HKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSEMKF 658
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   659 HSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNATN 738
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGI 160

                          170       180
                   ....*....|....*....|...
gi 334185713   739 DPEDCAPTELLEEIYDSIVQEEI 761
Cdd:pfam01369  161 NDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 579-761 3.20e-69

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 230.57  E-value: 3.20e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  579 HKSTMEAAISEFNRNSVKGVEYLIANKLVE-RNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSEMK 657
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEdDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  658 FHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFK-NADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNA 736
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*.
gi 334185713  737 -TNDPEDcAPTELLEEIYDSIVQEEI 761
Cdd:cd00171   161 gINDGED-FPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 577-761 2.49e-61

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 208.30  E-value: 2.49e-61
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713    577 KAHKSTMEAaISEFNRNSVKGVEYLIANKLV-ERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSE 655
Cdd:smart00222    3 GRKKLLSEG-IVKFNDKPKKGIQSLQEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713    656 MKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFK--NADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTR 733
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*....
gi 334185713    734 MNA-TNDPEDcAPTELLEEIYDSIVQEEI 761
Cdd:smart00222  162 NVRgSNDGED-LPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 334-483 6.07e-41

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 148.41  E-value: 6.07e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   334 GQRDALLVFRTLCKM-----GMKEDSDEVTTKTRILSLELLQGMLEGVSHSFTKNFHFIDSVKAYLSYALLRASVSQSSV 408
Cdd:pfam12783    1 AAKDAFLVFRDLCKLsngkpLSKSDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSSFP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185713   409 IFQYASGIFSVLLLRFRDSLKGEIGIFFPIIVLRSLDnSECPNDQKMGVLRMLEKVCKDPQMLVDVYVNYDCDLE 483
Cdd:pfam12783   81 VFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1073-1156 4.07e-32

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 120.29  E-value: 4.07e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  1073 KYLERAELTNFTFQNDILKPFVIIMRNTQSQTIRSLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAADDEVESIVEKSFE 1152
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 334185713  1153 NVEQ 1156
Cdd:pfam09324   81 ILEL 84
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1530-1718 2.83e-26

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 107.33  E-value: 2.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  1530 ITQLLLLGAINSIQQKYWSNLKTPQKIAIMDILFSFIEFASSYNSYSNLRTR------MNHIPterpplNLLRQELEGTT 1603
Cdd:pfam20252    1 VVQLLLIQTVNEILDEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLELRTAlwragfMKQLP------NLLKQETSSLS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  1604 IYLDVLQKTTSGLADDASNSEdrlegAAEEKLVSFCEQVLKETSDLQSTlgettnmDVHRVLELRSPVIVKVLEGMCFMN 1683
Cdd:pfam20252   75 TYLRILFRLYADDEPRTSQRE-----EVEERLIPLCEDILEYYLSLDEE-------EKQRELAAWTPVVVLILQGLLALP 142

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 334185713  1684 NTIFRKHMREFYPLLTRLVCCEQ-MEIRGALANLFK 1718
Cdd:pfam20252  143 DDDFRRHLPEFYPLLCDLILCELsPEVRLALREFFS 178
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 102-235 1.49e-24

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 101.95  E-value: 1.49e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713   102 AEVELVLKPLRLAFETKNLKIFDAALDCLHKLIAYDHLEGdpgldggkNSAPftDILNMVCSCVDNSSPDStvLQVLKVL 181
Cdd:pfam16213   53 SASEDILKPFVLACETKNPKLVQIALGCLQKLISHDAISQ--------SAAP--YILDTLWMLMELGSEIE--LKVLQTV 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 334185713   182 LTAVASGKFkVHGEPLLGVIRVCYNIALnSKSPINQATSKAMLTQMISIVFRRM 235
Cdd:pfam16213  121 LLLITTNSV-IHGDTLAKALVLCFRLHF-SKDPTVQNTASATLRQLVSVVFERV 172
Mon2_C pfam16206
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
 1220-1310 3.48e-07

C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.


Pssm-ID: 465066  Cd Length: 827  Bit Score: 55.12  E-value: 3.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185713  1220 WFPMLAGLSDLTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRILFPIFDHV----SHAGKESLIS-SGDV--- 1291
Cdd:pfam16206   93 WLCLYAKLGELCVDLRPAVRKSAGQTLFSTIGAHGSLLNHPTWHALIWKVLFNLLDNVralsSSADKEKIDAgGGNIlih 172

                           90       100
                   ....*....|....*....|....*..
gi 334185713  1292 --------KFRETSIHSLQLLCNLFNT 1310
Cdd:pfam16206  173 hsrdtaekQWAETQVLTLAGVARIFNT 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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