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    ARF2 auxin response factor 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836321, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARF2
    Official Full Name
    auxin response factor 2
    Primary source
    TAIR:AT5G62000
    Locus tag
    AT5G62000
    See related
    Araport:AT5G62000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARF1-BINDING PROTEIN; ARF1-BP; AT5G62010; AtARF2; auxin response factor 2; HLS1 SUPPRESSOR; HSS; MTG10.1; MTG10_1; ORE14; ORESARA 14
    Summary
    Encodes an auxin response factor. Mutants have many defects including enlarged rosette leaves, reduced fertility, later senescence, hypocotyl elongation defects, enlarged seeds and enlarged cotyledons. May not mediate auxin effects. Increase in seed size due to increased cell proliferation.
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    Genomic context

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    See ARF2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (24910191..24915395)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene heat shock transcription factor B2A Neighboring gene diphthamide synthesis DPH2 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AUXIN RESPONSE FACTOR 2 (ARF2): a pleiotropic developmental regulator. Okushima Y, et al. Plant J, 2005 Jul. PMID 15960614
    2. The AUXIN RESPONSE FACTOR 2 gene of Arabidopsis links auxin signalling, cell division, and the size of seeds and other organs. Schruff MC, et al. Development, 2006 Jan. PMID 16339187
    3. Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity. Lim PO, et al. J Exp Bot, 2010 Mar. PMID 20164142, Free PMC Article
    4. Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis. Wang L, et al. PLoS Genet, 2011 Jul. PMID 21779177, Free PMC Article
    5. ARF1, a transcription factor that binds to auxin response elements. Ulmasov T, et al. Science, 1997 Jun 20. PMID 9188533

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic Interaction of SEEDSTICK, GORDITA and AUXIN RESPONSE FACTOR 2 during Seed Development.
      Title: Genetic Interaction of SEEDSTICK, GORDITA and AUXIN RESPONSE FACTOR 2 during Seed Development.
    2. Results indicate that auxin response factors AtARF2-AtARF4 and AtARF5 play significant roles in regulating both female and male gametophyte development.
      Title: ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    3. results demonstrate that ARF2 plays important roles in the response to external K(+) supply in Arabidopsis and regulates HAK5 transcription accordingly.
      Title: Phosphorylation of ARF2 Relieves Its Repression of Transcription of the K+ Transporter Gene HAK5 in Response to Low Potassium Stress.
    4. ABA treatment reduced the expression levels of the PIN-FORMEDs (PIN) auxin efflux carriers, PIN1, PIN3, PIN4, and PIN7, to a greater extent in the root meristems of arf2-101 mutant than in the wild type. ARF2 positively mediates the transcripts of transcription factor PLETHORA 1 (PLT1) gene but negatively mediates PLT2 at protein level in root meristems.
      Title: ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
    5. Data indicate that CARBON-METABOLISM INVOLVED (GNC) and GNC-LIKE (GNL)/CYTOKININ-RESPONSIVE GATA FACTOR1 (CGA1) expression is repressed by AUXIN RESPONSE FACTO ARF2 and ARF7.
      Title: Convergence of auxin and gibberellin signaling on the regulation of the GATA transcription factors GNC and GNL in Arabidopsis thaliana.
    6. ARF2 and HB33 are novel regulators in the abscissic acid signal pathway, which has crosstalk with auxin signal pathway in regulating plant growth.
      Title: Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis.
    7. Data suggest that ARF2 positively regulates leaf senescence in Arabidopsis.
      Title: Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity.
    8. study describes a direct connection between the brassinosteroid-regulated BIN2 kinase and ARF2; phosphorylation by BIN2 results in loss of ARF2 DNA binding and repression activities
      Title: Integration of auxin and brassinosteroid pathways by Auxin Response Factor 2.
    9. IAA28 overexpressing and knock-down lines showed no major morphological changes, whereas IAA13 and ARF2 overexpressing plants grew more slowly than the wild type.
      Title: Transcription factors relevant to auxin signalling coordinate broad-spectrum metabolic shifts including sulphur metabolism.
    10. ARF2 expression was induced in senescing leaves. ARF2 regulated leaf senescence and floral organ abscission independently of the ethylene and cytokinin response pathways
      Title: AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: 24910449-24910520 AT5G62000.uORF1
    NM_001203662.1
    NM_001345519.1
    NM_125593.5
    NM_180913.4
    NM_203251.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral organ abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fruit dehiscence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of potassium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    auxin response factor 2
    NP_001190591.1
    • auxin response factor 2 (ARF2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 1 (TAIR:AT1G59750.2).
    NP_201006.2
    • auxin response factor 2 (ARF2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 1 (TAIR:AT1G59750.2); Has 2952 Blast hits to 2532 proteins in 92 species: Archae - 0; Bacteria - 2; Metazoa - 4; Fungi - 2; Plants - 2935; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).
    NP_851244.1
    • auxin response factor 2 (ARF2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 1 (TAIR:AT1G59750.2); Has 2589 Blast hits to 2182 proteins in 92 species: Archae - 0; Bacteria - 2; Metazoa - 4; Fungi - 2; Plants - 2572; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).
    NP_974980.1
    • auxin response factor 2 (ARF2); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 1 (TAIR:AT1G59750.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24910191..24915395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125593.5 → NP_201006.2  auxin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201006.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23671, Q56YL7, Q56YP4, Q56YR7, Q94JM3, Q9C5W5, Q9FIT6
      UniProtKB/TrEMBL
      A0A5S9YGE7, A0A654GD70
      Conserved Domains (3) summary
      pfam02309
      Location:716 → 812
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:164 → 265
      B3; B3 DNA binding domain
      pfam06507
      Location:290 → 372
      Auxin_resp; Auxin response factor

    2. NM_180913.4 → NP_851244.1  auxin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23671, Q56YL7, Q56YP4, Q56YR7, Q94JM3, Q9C5W5, Q9FIT6
      UniProtKB/TrEMBL
      A0A5S9YGE7, A0A654GD70
      Conserved Domains (3) summary
      pfam02309
      Location:716 → 812
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:164 → 265
      B3; B3 DNA binding domain
      pfam06507
      Location:290 → 372
      Auxin_resp; Auxin response factor

    3. NM_203251.4 → NP_974980.1  auxin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23671, Q56YL7, Q56YP4, Q56YR7, Q94JM3, Q9C5W5, Q9FIT6
      UniProtKB/TrEMBL
      A0A5S9YGE7, A0A654GD70
      Conserved Domains (3) summary
      pfam02309
      Location:716 → 812
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:164 → 265
      B3; B3 DNA binding domain
      pfam06507
      Location:290 → 372
      Auxin_resp; Auxin response factor

    4. NM_001345519.1 → NP_001330603.1  auxin response factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23671, Q56YL7, Q56YP4, Q56YR7, Q94JM3, Q9C5W5, Q9FIT6
      UniProtKB/TrEMBL
      A0A5S9YGE7, A0A654GD70
      Conserved Domains (3) summary
      pfam02309
      Location:716 → 812
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:164 → 265
      B3; B3 DNA binding domain
      pfam06507
      Location:290 → 372
      Auxin_resp; Auxin response factor

    5. NM_001203662.1 → NP_001190591.1  auxin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YGE7, F4K536
      Conserved Domains (3) summary
      pfam02309
      Location:716 → 812
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:164 → 265
      B3; B3 DNA binding domain
      pfam06507
      Location:290 → 372
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94JM3.2

    Gene LinkOut

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