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    eef2k eukaryotic elongation factor 2 kinase [ Danio rerio (zebrafish) ]

    Gene ID: 437013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef2kprovided by ZNC
    Official Full Name
    eukaryotic elongation factor 2 kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020916-2
    See related
    Ensembl:ENSDARG00000035835 AllianceGenome:ZFIN:ZDB-GENE-020916-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb365; fa04b08; wu:fa04b08; zgc:100973
    Summary
    Predicted to enable elongation factor-2 kinase activity. Acts upstream of or within cerebellum vasculature development. Is expressed in epidermis; hatching gland; musculature system; and myotome. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eef2k in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10381957..10409970, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10344124..10372484, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene NDC80 kinetochore complex component Neighboring gene marker of proliferation Ki-67 Neighboring gene transfer RNA leucine (anticodon UAG) Neighboring gene modulator of smoothened b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Dovey M, et al. Mol Cell Biol, 2009 Jul. PMID 19380487, Free PMC Article
    2. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Xu B, et al. Cell Res, 2017 Jul. PMID 28429770, Free PMC Article
    3. Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis. Zhao Y, et al. J Proteomics, 2020 Oct 30. PMID 32891890
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables elongation factor-2 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables elongation factor-2 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellum vasculature development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myosin II filament disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic elongation factor 2 kinase
    Names
    elongation factor-2 kinase
    NP_001002740.1
    XP_005156124.1
    XP_005156125.1
    XP_005156126.1
    XP_005156127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002740.1 → NP_001002740.1  eukaryotic elongation factor 2 kinase

      See identical proteins and their annotated locations for NP_001002740.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076410
      UniProtKB/TrEMBL
      A0A8M1N198, Q6DGE0
      Related
      ENSDARP00000052000.5, ENSDART00000052001.7
      Conserved Domains (3) summary
      smart00811
      Location:127 → 325
      Alpha_kinase; Alpha-kinase family
      COG0790
      Location:505 → 671
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:524 → 567
      SLR; SLR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      10381957..10409970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156070.5 → XP_005156127.1  eukaryotic elongation factor 2 kinase isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2Y1
      Conserved Domains (3) summary
      smart00811
      Location:127 → 325
      Alpha_kinase; Alpha-kinase family
      COG0790
      Location:468 → 690
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:543 → 586
      SLR; SLR repeat [structural motif]

    2. XM_005156068.5 → XP_005156125.1  eukaryotic elongation factor 2 kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M2B219
      Conserved Domains (3) summary
      smart00811
      Location:146 → 344
      Alpha_kinase; Alpha-kinase family
      COG0790
      Location:486 → 708
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:561 → 604
      SLR; SLR repeat [structural motif]

    3. XM_005156069.5 → XP_005156126.1  eukaryotic elongation factor 2 kinase isoform X4

      UniProtKB/TrEMBL
      A0A8M2B2E3
      Conserved Domains (3) summary
      smart00811
      Location:146 → 344
      Alpha_kinase; Alpha-kinase family
      COG0790
      Location:524 → 690
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:543 → 586
      SLR; SLR repeat [structural motif]

    4. XM_005156067.5 → XP_005156124.1  eukaryotic elongation factor 2 kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B253, E7F318, F8W2K9
      Related
      ENSDARP00000124692.2, ENSDART00000149521.3
      Conserved Domains (3) summary
      smart00811
      Location:146 → 344
      Alpha_kinase; Alpha-kinase family
      COG0790
      Location:487 → 709
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:562 → 605
      SLR; SLR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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