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Conserved domains on  [gi|528495542|ref|XP_005156126|]
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eukaryotic elongation factor 2 kinase isoform X4 [Danio rerio]

Protein Classification

Alpha_kinase_eEF2K and TPR domain-containing protein( domain architecture ID 13015117)

Alpha_kinase_eEF2K and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 129-344 1.57e-161

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


:

Pssm-ID: 341217  Cd Length: 216  Bit Score: 464.50  E-value: 1.57e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 129 HLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYF 208
Cdd:cd16967    1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 209 EDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFT 288
Cdd:cd16967   81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528495542 289 FERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16967  161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
TPR COG0790
TPR repeat [General function prediction only];
532-693 1.10e-11

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 65.33  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 532 RYHEAGRFCEKDEPwdqiSAMYHLETAAMCGELEAIVALGQCYLqlphhilpeiELEPSEENSQKGFRFLLQAAEAGDRP 611
Cdd:COG0790  107 LMYEEGLGVPQDYA----KALEWYEKAAEQGDADAQYNLGLLYL----------NGEGVPKDPAKAAEWYRKAAEQGDAD 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 612 SMILVARAFDTGLKLPSDRAmdwtEAVHWYDSALkmtdydEGGEFDGMqdeprylllARLAEMYQEgGNNLDADPQRAGD 691
Cdd:COG0790  173 AQYNLGVLYENGRGVPKDPA----KALEWYRKAA------EQGDADAQ---------YNLGRLYLN-GEGVEKDLEKALR 232


                 ..
gi 528495542 692 LF 693
Cdd:COG0790  233 WL 234
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 129-344 1.57e-161

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 464.50  E-value: 1.57e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 129 HLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYF 208
Cdd:cd16967    1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 209 EDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFT 288
Cdd:cd16967   81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528495542 289 FERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16967  161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 146-344 4.25e-95

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 293.11  E-value: 4.25e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542   146 ITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNfsHSHNWKSASNYVAKRYMETVdRSVYFEDVRLQMEAKLWGEEFN 225
Cdd:smart00811   1 SSGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSE--DGSGTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542   226 RHRP-PKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQG 303
Cdd:smart00811  78 QLKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQG 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 528495542   304 VGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:smart00811 158 VGDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 165-344 7.67e-74

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 236.84  E-value: 7.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542  165 GKGAMRECFRAKKLsnfshsHNWKSASNYVAKRYME---TVDRSVYFEDVRLQMEAKLWGEEFN------RHRPPKQVDI 235
Cdd:pfam02816   1 AEGAMRKAFKAKVD------PGDESGQNYVAKEFKKivyGVELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542  236 MQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 313
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 528495542  314 HTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
TPR COG0790
TPR repeat [General function prediction only];
532-693 1.10e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 65.33  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 532 RYHEAGRFCEKDEPwdqiSAMYHLETAAMCGELEAIVALGQCYLqlphhilpeiELEPSEENSQKGFRFLLQAAEAGDRP 611
Cdd:COG0790  107 LMYEEGLGVPQDYA----KALEWYEKAAEQGDADAQYNLGLLYL----------NGEGVPKDPAKAAEWYRKAAEQGDAD 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 612 SMILVARAFDTGLKLPSDRAmdwtEAVHWYDSALkmtdydEGGEFDGMqdeprylllARLAEMYQEgGNNLDADPQRAGD 691
Cdd:COG0790  173 AQYNLGVLYENGRGVPKDPA----KALEWYRKAA------EQGDADAQ---------YNLGRLYLN-GEGVEKDLEKALR 232


                 ..
gi 528495542 692 LF 693
Cdd:COG0790  233 WL 234
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 129-344 1.57e-161

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 464.50  E-value: 1.57e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 129 HLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYF 208
Cdd:cd16967    1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 209 EDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFT 288
Cdd:cd16967   81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528495542 289 FERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16967  161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 146-344 4.25e-95

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 293.11  E-value: 4.25e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542   146 ITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNfsHSHNWKSASNYVAKRYMETVdRSVYFEDVRLQMEAKLWGEEFN 225
Cdd:smart00811   1 SSGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSE--DGSGTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542   226 RHRP-PKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQG 303
Cdd:smart00811  78 QLKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQG 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 528495542   304 VGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:smart00811 158 VGDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase_MHCK_like cd16968
Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed ...
 137-344 1.41e-91

Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed of alpha-kinase domains of Dictyostelium discoideum myosin heavy chain kinases A-D (MHCKA, MHCKB, MHCKC, MHCKD), alpha-protein kinase 1 (AK1), and similar proteins. The myosin heavy chain kinases are involved in regulating myosin II filament assembly in Dictyostelium discoideum. They phosphorylate target threonine residues located in the carboxyl-terminal portion of the myosin II heavy chain (MHC) tail, resulting in filament disassembly. The different MHCK isoforms display different spatial regulation, indicating specific roles for each isoform in fine tuning the Dictyostelium actomyosin cytoskeleton. They all contain an alpha-kinase domain as well as WD40 repeats at the C-terminus. AK1 contains an N-terminal Arf-GAP domain and a central alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341218  Cd Length: 202  Bit Score: 284.12  E-value: 1.41e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 137 RCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFShshnwkSASNYVAKRYM-ETVDRSVYFEDVRLQM 215
Cdd:cd16968    1 RAIKHEFDPETGKWTSTATKVKIDPKPFAEGALREAYHLKDLSAPG------PSTLFVAKLSKdPNESRETYFEDVEMQM 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 216 EAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQ 295
Cdd:cd16968   75 VCKKWAEKFNAKNPPKKVEFLPAWVLELVDRPPPPLCGVEPFIEGEYVKHNNNFGYVDEDE-RNTPQAFSHFTYEASGHQ 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528495542 296 LIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16968  154 LLVVDIQGVGDLYTDPQIHTIDGKGFGKGNLGQKGIEKFLETHKCNAIC 202
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 165-344 7.67e-74

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 236.84  E-value: 7.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542  165 GKGAMRECFRAKKLsnfshsHNWKSASNYVAKRYME---TVDRSVYFEDVRLQMEAKLWGEEFN------RHRPPKQVDI 235
Cdd:pfam02816   1 AEGAMRKAFKAKVD------PGDESGQNYVAKEFKKivyGVELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542  236 MQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 313
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 528495542  314 HTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
Alpha_kinase cd04515
Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase ...
 141-344 4.22e-68

Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341214  Cd Length: 213  Bit Score: 222.66  E-value: 4.22e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 141 YRYSAITGEWAKDEIFIKVSSQT-FGKGAMRECFRAKKLSNfshshnwkSASNYVAKRY----METVDRSVYFEDVRLQM 215
Cdd:cd04515    6 RLISVTDLKWTTEETTVRVAKKKpFAQGAMREAFKAKDLDS--------KGKKYVAKRFkrigDPEENLEDLFDELRMQA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 216 EAKLWGEEFNRH-----RPPKQVDIMQMCVVEMTTR--PGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFT 288
Cdd:cd04515   78 LAQYLAKEFNARaksknLIAPKINFVDPFVVKLGDRddPGKVVFLVEPFLEGKFVKYNNNNGMVNDEDLGETAQAFSHFT 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528495542 289 FERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd04515  158 YERSGGQLLVTDLQGVGLVLTDPQIHTVDGGGFGLGNLGEEGIKRFFKTHKCNEIC 213
Alpha_kinase_VwkA_like cd16970
Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium ...
 152-344 1.49e-35

Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium discoideum alpha-protein kinase VwkA is also called von Willebrand factor A alpha-kinase or vWF kinase. It influences myosin II abundance and assembly behavior as vWKA gene disruption leads to significant myosin II overassembly. VwkA also serves a critical conserved role in the periodic contractions of the contractile vacuole through its regulation of the myosin II cortical cytoskeleton. It contains a vWFa domain (named after its homology to von Willebrand factor A, a plasma glycoprotein essential for proper blood clotting) and a C-terminal alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341220  Cd Length: 227  Bit Score: 134.39  E-value: 1.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 152 KDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHShnwksasNYVAKRYMETVDRSV-----YFEDVRLQ-MEAKLwGEEFN 225
Cdd:cd16970   29 IREITVKIAPPPFAKGAERWAYYALDTTSDSTK-------KVVLKEFKTPGSAQRnsrerYLESMEVQtVAAKL-AFEFN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 226 ----RHRPPKQVDIMQMCVVEMTTRpGSPLFH-LEHYIEGKYTKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQLIVVD 300
Cdd:cd16970  101 kllaRAGINKKITFLEAKVLRVANG-DSPQYYtMESFLEGEYKKFNNNVGVVNEDE-VEILQAFSHWTYEASKGYLMVVD 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528495542 301 IQGV-----GDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16970  179 LQGVrtdddGFLLTDPAIHCTDVLRFGRTNLGKEGIDKFFATHKCNQHC 227
Alpha_kinase cd17508
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 157-344 9.11e-32

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341225  Cd Length: 243  Bit Score: 124.03  E-value: 9.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 157 IKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASN-YVAK--RYMETVDRSVYFED--VRLQMEAKLWGEEFNR----- 226
Cdd:cd17508   19 IAVRKLPFGEGAERNVFRCTEISKEGGTKTATKIGPrLVAKesRHAEDESFDIKFHKkfCKTQSTAQELAERFNKrlral 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 227 -HRPPKQVDIMQMCV--VEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVR------------DDNIRLT----PQAFSHF 287
Cdd:cd17508   99 pGGPAPRVKFLPCHVykTKDVSYRGRAWVLVEKELEGKFTKWNTNAGGVKksiesvgegrgeSNSSRLRvddvPQAFSHF 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528495542 288 TFERSGHQLIVVDIQGV------GDLYTDPQIHTSKGT--DFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd17508  179 TYEHSGGRFLVCDLQGVwnatpdGFLLTDPVIHHVSGKrhRFGATDKGLEGIRNFLRTHKCSPLC 243
Alpha_kinase_ALPK1 cd16969
Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called ...
 142-345 1.24e-25

Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called chromosome 4 kinase or lymphocyte alpha-protein kinase (LAK). ALPK1 is implicated in epithelial cell polarity and exocytic vesicular transport towards the apical plasma membrane. It resides on Golgi-derived vesicles where it phosphorylates myosin IA, a motor protein that regulates the delivery of vesicles to the plasma-membrane. It may be associated with inflammation-related diseases such as gout and type 2 diabetes mellitus. ALPK1 contains a C-terminal alpha-kinase domain, an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341219  Cd Length: 227  Bit Score: 105.63  E-value: 1.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 142 RYSAITGEWAKDEI--FIKVSSQTFGKGAMRECFRAKKLsnfshsHNWKSASNYVAKRYMETVDRSVYFEDVRLQMEAKL 219
Cdd:cd16969   14 KYSKKSGLWTAQETmvYIGDNLQVGKQGKQRNAFWVHFL------HQEETLGRYVGKEYKKPKELQYHFNDVERQMTAQH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 220 WGEEFNRhRPPKQVDIMQ--------MCVVEMTTRPGspLFHLEHYIEGKYTKYNSNSGFVRDDNiRLTPQ--AFSHFTF 289
Cdd:cd16969   88 YVTEFNK-RLYEQNIPTQiffipsviLLILEDKGIKG--CVSVEPYMLGEFVKLTNNTTVKKEEY-KATDYglAYGHFTY 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528495542 290 ERSGHQLIVVDIQG------VGDLY-TDPQIHTSKGTdFGDGNLGVRGMALFFHSH--LCNKICR 345
Cdd:cd16969  164 EFSNHQDVVVDLQGwvtangKGLTYlTDPQIHSVVKK-SGTTNFGKKGIEYFFNNQhtECNEICR 227
Alpha_kinase cd17509
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 255-344 1.16e-16

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341226  Cd Length: 221  Bit Score: 79.70  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 255 EHYIEGkYTKYNSNSG-FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGD----LYTDPQIHTSKGTDFGDGNLGVR 329
Cdd:cd17509  128 EPFIEN-YEKFNSNSGwNDDSKGWGEVMQALSHFSYHISGGKYLLCDLQGGVYkneyVLTDPVILSRTGREYGVTDLGPE 206

                         90
                 ....*....|....*
gi 528495542 330 GMALFFHSHLCNKIC 344
Cdd:cd17509  207 GIWNFFANHKCNKYC 221
Alpha_kinase_ChaK2_TRPM6 cd16972
Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation ...
 254-345 2.19e-16

Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6; Channel kinase 2 (ChaK2), also called transient receptor potential cation channel subfamily M member 6 (TRMP6) or melastatin-related TRP cation channel 6, is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is highly expressed in the kidney and instestine. It is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM6 is considered to be the Mg2+ entry pathway in the distal convoluted tubule of the kidney, where it functions as a gatekeeper for controlling the body's Mg2+ balance. Mutations in the TRPM6 gene cause the autosomal recessive disorder hypomagnesemia with secondary hypocalcemia, which often results in severe muscular and neurologic complications from early infancy that can lead to neurologic damage or cardiac arrest if left untreated. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341222  Cd Length: 239  Bit Score: 79.28  E-value: 2.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 254 LEHYIEGKYTKYNSNSGfvrdDNIrlTPQ--------AFSHFTFERSGHQLIVVDIQGVGDLYTDPQI-----HTSKGTD 320
Cdd:cd16972  140 IEKYLTGEFRKYNNNNG----DEI--TPTslleetllAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikpedKQSRGMV 213

                         90       100
                 ....*....|....*....|....*
gi 528495542 321 FGDGNLGVRGMALFFHSHLCNKICR 345
Cdd:cd16972  214 FGPANLGEDAIRNFIAKHHCNSCCR 238
Alpha_kinase_ChaK cd16965
Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) ...
 157-345 2.90e-16

Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) and 2 (ChaK2), and similar proteins. ChaK1 and ChaK2 are also called transient receptor potential cation channel subfamily M members 7 (TRMP7) and 6 (TRMP6), respectively. They are fusion proteins containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. They are both cation-selective channels that preferentially permeate Zn2+, Mg2+, and Ca2+ ions. They are central regulators of Mg2+ and Ca2+ homeostasis. TRMP7 is ubiquitously expressed while TRMP6 is highly expressed in specific tissues such as the kidney and intestine. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341215  Cd Length: 239  Bit Score: 78.84  E-value: 2.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 157 IKVSSQTFGKGAMRECFRAkkLSNFSHSHNWKSASNYVAKRYMETVDR---SVYFEDVRL---------QMEAKLWGEEF 224
Cdd:cd16965   32 IQPLSQEEMDGGLRRATKV--VCTWSEGDILKLGSVYIVKSFLPEVVRtwqKIFPESTVLhlclreiqqQRAAQKLMQRF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 225 NRHRP------PKQVDimqmcVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQL 296
Cdd:cd16965  110 NQVKPssipysPRFLE-----VFLLYCHSAGQWLTVENNMTGEFRKYNNNNGdeILPTNTLEETMLAFSHWTYEYTRGEL 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528495542 297 IVVDIQGVGDLYTDPQI-----HTSKGTDFGDGNLGVRGMALFFHSHLCNKICR 345
Cdd:cd16965  185 LVLDLQGVGENLTDPSVikvedKSSGEMVFGPANLGEDAIQNFVAKHHCNSCCR 238
Alpha_kinase_ChaK1_TRMP7 cd16971
Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation ...
 150-345 2.83e-14

Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7; Channel kinase 1 (ChaK1), also called transient receptor potential cation channel subfamily M member 7 (TRMP7) or long transient receptor potential channel 7 (LTrpC7), is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is ubiquitously expressed and is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM7 plays a role in cancer proliferation, stroke, hydrogen peroxide dependent neurodegeneration, and heavy metal toxicity. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341221  Cd Length: 239  Bit Score: 73.11  E-value: 2.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 150 WAKDEIFIKV---SSQTFGKGAMREcfrAKKLSNFSHSHNWKSASNYVAKRYM-ETVD--RSVYFEDVRL---------Q 214
Cdd:cd16971   23 WSQLGLCAKIeflSKEEMGGGLRRA---LKVVCTWSENDILKSGHLYIIKSFLpEVVNtwSSIYKEDTVLhlclreiqqQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 215 MEAKLWGEEFNRHRP---PKQVDIMQmcVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSG--FVRDDNIRLTPQAFSHFTF 289
Cdd:cd16971  100 RAAQKLTFAFNQMKPksiPYSPRFLE--VFLLYCHSAGQWFAVEECMTGEFRKYNNNNGdeIIPTNMLEETMLAFSHWTY 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528495542 290 ERSGHQLIVVDIQGVGDLYTDPQIHTS--KGTD---FGDGNLGVRGMALFFHSHLCNKICR 345
Cdd:cd16971  178 EYTRGELLVLDLQGVGENLTDPSVIKAgeKRSYdmvFGPANLGEDAIKNFRAKHHCNSCCR 238
TPR COG0790
TPR repeat [General function prediction only];
532-693 1.10e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 65.33  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 532 RYHEAGRFCEKDEPwdqiSAMYHLETAAMCGELEAIVALGQCYLqlphhilpeiELEPSEENSQKGFRFLLQAAEAGDRP 611
Cdd:COG0790  107 LMYEEGLGVPQDYA----KALEWYEKAAEQGDADAQYNLGLLYL----------NGEGVPKDPAKAAEWYRKAAEQGDAD 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 612 SMILVARAFDTGLKLPSDRAmdwtEAVHWYDSALkmtdydEGGEFDGMqdeprylllARLAEMYQEgGNNLDADPQRAGD 691
Cdd:COG0790  173 AQYNLGVLYENGRGVPKDPA----KALEWYRKAA------EQGDADAQ---------YNLGRLYLN-GEGVEKDLEKALR 232


                 ..
gi 528495542 692 LF 693
Cdd:COG0790  233 WL 234
TPR COG0790
TPR repeat [General function prediction only];
527-694 4.84e-10

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 60.71  E-value: 4.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 527 HLAMVRYHEAGRFCEKDEPwdqiSAMYHLETAAMCGELEAIVALGQCYLqlphhilpeiELEPSEENSQKGFRFLLQAAE 606
Cdd:COG0790   66 QYNLGLMYAEGRGVPKDYE----KALEWFEKAAEQGDAEAQYNLGLMYE----------EGLGVPQDYAKALEWYEKAAE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 607 AGDRPSMILVARAFDTGLKLPSDRAmdwtEAVHWYDSALkmtdydEGGEFDGMqdeprylllARLAEMYQEGgNNLDADP 686
Cdd:COG0790  132 QGDADAQYNLGLLYLNGEGVPKDPA----KAAEWYRKAA------EQGDADAQ---------YNLGVLYENG-RGVPKDP 191


                 ....*...
gi 528495542 687 QRAGDLFT 694
Cdd:COG0790  192 AKALEWYR 199
TPR COG0790
TPR repeat [General function prediction only];
541-694 6.27e-07

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 51.08  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 541 EKDEPWDQISAMYHLETAAMCGELEAIVALGQCYLqlphhilpeiELEPSEENSQKGFRFLLQAAEAGDRPSMILVARAF 620
Cdd:COG0790   40 ALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYA----------EGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528495542 621 DTGLKLPSDRAmdwtEAVHWYDSALkmtdydEGGEFDGMqdeprylllARLAEMYQEgGNNLDADPQRAGDLFT 694
Cdd:COG0790  110 EEGLGVPQDYA----KALEWYEKAA------EQGDADAQ---------YNLGLLYLN-GEGVPKDPAKAAEWYR 163
Alpha_kinase_ALPK2_3 cd16966
Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 ...
 246-344 1.12e-05

Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 (ALPK3) are also called heart alpha-protein kinase (HAK) and muscle alpha-protein kinase (MAK), respectively. They both contain a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Loss of function mutations in ALPK3 can cause early-onset and familial cardiomyopathy in humans. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341216  Cd Length: 239  Bit Score: 47.57  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 246 RPGS--PLFHLEHYIEGKYTKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHT-SK 317
Cdd:cd16966  133 RPANniPYATVEEELIGPFVKYSIRDGkeinfLRSESEAGQKCCTFQHWVYQWTNGCLLVTDLQGVGMKLTDVGIATlAK 212

                         90       100
                 ....*....|....*....|....*..
gi 528495542 318 GTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16966  213 GYQGLKGNCSMTFIDQFAALHQCNKYC 239
Alpha_kinase_ALPK2 cd16974
Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called ...
 164-344 5.53e-05

Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called heart alpha-protein kinase (HAK). Little functional information is known about ALPK2. In a three-dimensional colonic-crypt model, it has been identified as crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. ALPK2 contains a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341224  Cd Length: 239  Bit Score: 45.20  E-value: 5.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 164 FGKGAMRECFRAK------KLSNFSHS-----HNwksASNYVAKRYMETVDRS--VYFEDVRLQMEAKLWGEEFNRHRPP 230
Cdd:cd16974   39 FGEGMHRKAFRSKvmcgllPVFLPGHAcvlkvHN---AIAYGTKNNDELIQKNykLAVQECYVQNTAREYAKIYAAEAQP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528495542 231 KQV--DIMQMCVVEMTTRPGS--PLFHLEHYIEGKYTKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDI 301
Cdd:cd16974  116 LEGfgEVPEIIPIFLIHRPANniPYATVEEELIGDFVKYSVRDGkeinvLRRDSEAGQKCCTFQHWVYQKTDGNLLVTDM 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 528495542 302 QGVGDLYTDPQIHT-SKGTDFGDGNLGVRGMALFFHSHLCNKIC 344
Cdd:cd16974  196 QGVGMKLTDVGIATcSKGYKGFKGNCSVSFIDQFKALHQCNKYC 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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