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    il20ra interleukin 20 receptor, alpha [ Danio rerio (zebrafish) ]

    Gene ID: 556728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    il20raprovided by ZNC
    Official Full Name
    interleukin 20 receptor, alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-249
    See related
    Ensembl:ENSDARG00000032571 AllianceGenome:ZFIN:ZDB-GENE-040724-249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    crfb8; im:7156745; zgc:158705; si:ch211-272f15.1
    Summary
    Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human IL20RA (interleukin 20 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See il20ra in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (2589406..2609275)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (2572230..2592113)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene A kinase (PRKA) anchor protein 7 Neighboring gene mediator complex subunit 23 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Neighboring gene zgc:101562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio). Ray A, et al. J Hazard Mater, 2017 Jan 5. PMID 27614325
    2. Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes. Zheng SY, et al. Fish Shellfish Immunol, 2023 Nov. PMID 37863126
    3. Cloning, identification of the two cytokine receptor family B subunits CRFB1 and CRFB5 from grass carp (Ctenopharyngodon idella). Chen H, et al. Fish Shellfish Immunol, 2015 Aug. PMID 25891274
    4. Molecular characterization of nineteen cytokine receptor family B (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama amblycephala. Deng YH, et al. Dev Comp Immunol, 2023 Aug. PMID 37146740
    5. Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Chen SN, et al. Nat Commun, 2022 Feb 22. PMID 35194032, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20 receptor subunit alpha
    Names
    class II cytokine receptor crfb8
    cytokine receptor family member b8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079676.2 → NP_001073144.2  interleukin-20 receptor subunit alpha precursor

      Status: VALIDATED

      Source sequence(s)
      BC129396, EF014958, EH437695, EH511358
      UniProtKB/TrEMBL
      A0A8M1NAW2, A0FJI3, F1RBF1
      Related
      ENSDARP00000043625.5, ENSDART00000043626.6
      Conserved Domains (2) summary
      pfam01108
      Location:23 → 117
      Tissue_fac; Tissue factor
      pfam09294
      Location:130 → 235
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      2589406..2609275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160336.5 → XP_005160393.1  interleukin-20 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M2B761, A0FJI3
      Conserved Domains (2) summary
      pfam01108
      Location:23 → 117
      Tissue_fac; Tissue factor
      pfam09294
      Location:130 → 235
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    Nucleotide Protein Strain
    Heading Accession and Version

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