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Conserved domains on  [gi|528510854|ref|XP_005160393|]
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interleukin-20 receptor subunit alpha isoform X1 [Danio rerio]

Protein Classification

Tissue_fac and Interfer-bind domain-containing protein( domain architecture ID 10471435)

Tissue_fac and Interfer-bind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 5-117 1.12e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 128.27  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854    5 LSICLCFLLRAL-SASSADGPPEPRDVHFYSESLRNVVKWTAGHGSPSDTVYTVEYAIYGDADekipeqvrWRPVDQCIS 83
Cdd:pfam01108   2 LTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGD--------WKNVPNCTN 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528510854   84 VSQTECDVSQETFDLRDEYFARVRATSKHGQSVW 117
Cdd:pfam01108  74 ITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 130-235 4.95e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 104.35  E-value: 4.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854  130 TVLGAPLVDVTVRQNHIDITLKGPFRwrmkRMKKEKSLWKIIPNMIYKVSVFNSRSN-RTDVFRLTNGSLSLGELEFSTQ 208
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 528510854  209 FCVVAQAQSESIPLSYIPSQKQCVHTP 235
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 5-117 1.12e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 128.27  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854    5 LSICLCFLLRAL-SASSADGPPEPRDVHFYSESLRNVVKWTAGHGSPSDTVYTVEYAIYGDADekipeqvrWRPVDQCIS 83
Cdd:pfam01108   2 LTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGD--------WKNVPNCTN 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528510854   84 VSQTECDVSQETFDLRDEYFARVRATSKHGQSVW 117
Cdd:pfam01108  74 ITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 130-235 4.95e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 104.35  E-value: 4.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854  130 TVLGAPLVDVTVRQNHIDITLKGPFRwrmkRMKKEKSLWKIIPNMIYKVSVFNSRSN-RTDVFRLTNGSLSLGELEFSTQ 208
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 528510854  209 FCVVAQAQSESIPLSYIPSQKQCVHTP 235
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 24-121 1.89e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854  24 PPEPRDVHFYSESLRNV-VKWTAGHGSPSD-TVYTVEYaiygdadeKIPEQVRWRPVDQCiSVSQTECDVSqetfDLRD- 100
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVtLSWTPPEDDGGPiTGYVVEY--------REKGSGDWKEVEVT-PGSETSYTLT----GLKPg 67

                         90       100
                 ....*....|....*....|..
gi 528510854 101 -EYFARVRATSKHGQSVWSESI 121
Cdd:cd00063   68 tEYEFRVRAVNGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 24-115 5.04e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854    24 PPEPRDVHFYSESLRNV-VKWTAGHgSPSDTVYTVEYAIYGDadekiPEQVRWRPVDQciSVSQTECDVSqetfDLRD-- 100
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVtLSWEPPP-DDGITGYIVGYRVEYR-----EEGSEWKEVNV--TPSSTSYTLT----GLKPgt 68

                           90
                   ....*....|....*
gi 528510854   101 EYFARVRATSKHGQS 115
Cdd:smart00060  69 EYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 5-117 1.12e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 128.27  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854    5 LSICLCFLLRAL-SASSADGPPEPRDVHFYSESLRNVVKWTAGHGSPSDTVYTVEYAIYGDADekipeqvrWRPVDQCIS 83
Cdd:pfam01108   2 LTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGD--------WKNVPNCTN 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528510854   84 VSQTECDVSQETFDLRDEYFARVRATSKHGQSVW 117
Cdd:pfam01108  74 ITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 130-235 4.95e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 104.35  E-value: 4.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854  130 TVLGAPLVDVTVRQNHIDITLKGPFRwrmkRMKKEKSLWKIIPNMIYKVSVFNSRSN-RTDVFRLTNGSLSLGELEFSTQ 208
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 528510854  209 FCVVAQAQSESIPLSYIPSQKQCVHTP 235
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 24-121 1.89e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854  24 PPEPRDVHFYSESLRNV-VKWTAGHGSPSD-TVYTVEYaiygdadeKIPEQVRWRPVDQCiSVSQTECDVSqetfDLRD- 100
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVtLSWTPPEDDGGPiTGYVVEY--------REKGSGDWKEVEVT-PGSETSYTLT----GLKPg 67

                         90       100
                 ....*....|....*....|..
gi 528510854 101 -EYFARVRATSKHGQSVWSESI 121
Cdd:cd00063   68 tEYEFRVRAVNGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 24-115 5.04e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528510854    24 PPEPRDVHFYSESLRNV-VKWTAGHgSPSDTVYTVEYAIYGDadekiPEQVRWRPVDQciSVSQTECDVSqetfDLRD-- 100
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVtLSWEPPP-DDGITGYIVGYRVEYR-----EEGSEWKEVNV--TPSSTSYTLT----GLKPgt 68

                           90
                   ....*....|....*
gi 528510854   101 EYFARVRATSKHGQS 115
Cdd:smart00060  69 EYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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