rad51 RAD51 recombinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rad51provided by ZNC
Official Full Name: RAD51 recombinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2286
See related: Ensembl:ENSDARG00000041411 AllianceGenome:ZFIN:ZDB-GENE-040426-2286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77754; wu:fb38e12
Summary: Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; response to cadmium ion; and response to methylmercury. Predicted to be located in nucleus. Predicted to be active in condensed nuclear chromosome. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46428020..46442006)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46524300..46538286)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Describe and demonstrate a model showing loss of RAD51 leads to Fanconi anemia-like symptoms in zebrafish.
Title: Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb38e12.x1 (e-PCR)
- UniSTS:203173

fj14a12.x1 (e-PCR)
- UniSTS:198590

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA strand exchange activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome organization involved in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic recombination-dependent replication fork processing	IEA Inferred from Electronic Annotation more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to methylmercury	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA repair protein RAD51 homolog 1

Names: RAD51 homolog (RecA homolog, E. coli)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213206.2 → NP_998371.2 DNA repair protein RAD51 homolog 1

Status: VALIDATED

Source sequence(s)

BX936455

UniProtKB/TrEMBL

A0A8N1TQV8, Q5TYR1

Related

ENSDARP00000060705.3, ENSDART00000060706.5

Conserved Domains (3) summary

cd01123
Location:103 → 336

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

TIGR02239
Location:26 → 340

recomb_RAD51; DNA repair protein RAD51

pfam14520
Location:32 → 81

HHH_5; Helix-hairpin-helix domain