cdc34a cell division cycle 34 homolog (S. cerevisiae) a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc34aprovided by ZNC
Official Full Name: cell division cycle 34 homolog (S. cerevisiae) aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-713
See related: Ensembl:ENSDARG00000069708 AllianceGenome:ZFIN:ZDB-GENE-040426-713
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ube2r2; zgc:55452
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (22141040..22164338, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (22116062..22139360, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cell division cycle 34 homolog (S. cerevisiae) a

Names: ubiquitin-conjugating enzyme E2 R2

NP_957252.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200958.1 → NP_957252.1 cell division cycle 34 homolog (S. cerevisiae) a

See identical proteins and their annotated locations for NP_957252.1

Status: PROVISIONAL

Source sequence(s)

BC044173

UniProtKB/TrEMBL

A0A2R8Q6T1, B2GRD7, Q803V7

Related

ENSDARP00000148743.1, ENSDART00000183840.1

Conserved Domains (2) summary

COG5078
Location:9 → 172

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00195
Location:14 → 172

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...