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    CCH copper chaperone [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824790, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CCH
    Official Full Name
    copper chaperone
    Primary source
    TAIR:AT3G56240
    Locus tag
    AT3G56240
    See related
    Araport:AT3G56240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    copper chaperone; COPPER HOMEOSTASIS FACTOR
    Summary
    CCH protein belongs to a family of eukaryotic proteins that participate in intracellular copper homeostasis by delivering this metal to the secretory pathway; mainly located along the vascular bundles of senescing leaves and petioles as well as in stem sieve elements; hypothesized to have a role in copper mobilization from decaying organs towards reproductive structures, as a result of metalloprotein breakdown. The plant-specific C-terminal domain of the CCH protein forms amyloid-like fibrils in vitro.
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    Genomic context

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    See CCH in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20863139..20864727, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcription regulator Neighboring gene BTB/POZ domain-containing protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene WEB family protein (DUF827)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. Alvarez-Venegas R, et al. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16585509, Free PMC Article
    2. Higher plants possess two different types of ATX1-like copper chaperones. Puig S, et al. Biochem Biophys Res Commun, 2007 Mar 9. PMID 17223078
    3. The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots. Andrés-Colás N, et al. Plant J, 2006 Jan. PMID 16367966
    4. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Himelblau E, et al. Plant Physiol, 1998 Aug. PMID 9701579, Free PMC Article
    5. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339779.1
    NM_001339780.1
    NM_115482.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular copper ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to reactive oxygen species IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    copper chaperone
    NP_191183.1
    • copper chaperone (CCH); FUNCTIONS IN: copper chaperone activity; INVOLVED IN: in 6 processes; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: homolog of anti-oxidant 1 (TAIR:AT1G66240.1); Has 2051 Blast hits to 1937 proteins in 366 species: Archae - 10; Bacteria - 382; Metazoa - 168; Fungi - 207; Plants - 1221; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20863139..20864727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115482.4 → NP_191183.1  copper chaperone [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82089
      UniProtKB/TrEMBL
      A0A178V898, A0A5S9XM21, A0A654FG96
      Conserved Domains (1) summary
      cd00371
      Location:10 → 65
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    2. NM_001339779.1 → NP_001326129.1  copper chaperone [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNC0, A0A654FG96
      Conserved Domains (1) summary
      cd00371
      Location:1 → 55
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    3. NM_001339780.1 → NP_001326128.1  copper chaperone [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82089
      UniProtKB/TrEMBL
      A0A178V898, A0A5S9XM21, A0A654FG96
      Conserved Domains (1) summary
      cd00371
      Location:10 → 65
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82089.1

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