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Conserved domains on  [gi|15228869|ref|NP_191183|]
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copper chaperone [Arabidopsis thaliana]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10086127)

heavy-metal-associated domain-containing protein such as heavy metal-associated isoprenylated plant proteins and Saccharomyces cerevisiae copper transport protein ATX1, which shuttles copper to the transport ATPase CCC2 and protects against oxygen toxicity

CATH:  3.30.70.100
Gene Ontology:  GO:0046872
PubMed:  12443926|8905098
SCOP:  4001253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 10-65 9.29e-13

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


:

Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 58.39  E-value: 9.29e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15228869  10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGN--VEPEAVFQTVSKTGKKTS 65
Cdd:cd00371   6 GMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 10-65 9.29e-13

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 58.39  E-value: 9.29e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15228869  10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGN--VEPEAVFQTVSKTGKKTS 65
Cdd:cd00371   6 GMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
3-61 1.60e-08

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 47.59  E-value: 1.60e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15228869   3 QTVVLKV-GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGN---VEPEAVFQTVSKTG 61
Cdd:COG2608   2 KTVTLKVeGMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAG 64
copA PRK10671
copper-exporting P-type ATPase CopA;
1-100 8.68e-08

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 48.97  E-value: 8.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228869    1 MAQTVVLKV-GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTvkGNVEPEAVFQTVSKTGKKTSywpveaeaepkaEA 79
Cdd:PRK10671   1 MSQTIDLTLdGLSCGHCVKRVKESLEQRPDVEQADVSITEAHVT--GTASAEALIETIKQAGYDAS------------VS 66

                         90       100
                 ....*....|....*....|.
gi 15228869   80 DPKVETVTETKTEAETKTEAK 100
Cdd:PRK10671  67 HPKAKPLTESSIPSEALTAAS 87
HMA pfam00403
Heavy-metal-associated domain;
5-50 1.16e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 45.30  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15228869     5 VVLKVGMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGNVEP 50
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAES 46
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 10-45 2.40e-03

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 34.05  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15228869    10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVK 45
Cdd:TIGR00003   8 GMSCNHCVDKIEKFVGEIEGVSKVKVQLEKEKVVVE 43
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 10-65 9.29e-13

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 58.39  E-value: 9.29e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15228869  10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGN--VEPEAVFQTVSKTGKKTS 65
Cdd:cd00371   6 GMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
3-61 1.60e-08

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 47.59  E-value: 1.60e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15228869   3 QTVVLKV-GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGN---VEPEAVFQTVSKTG 61
Cdd:COG2608   2 KTVTLKVeGMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAG 64
copA PRK10671
copper-exporting P-type ATPase CopA;
1-100 8.68e-08

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 48.97  E-value: 8.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228869    1 MAQTVVLKV-GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTvkGNVEPEAVFQTVSKTGKKTSywpveaeaepkaEA 79
Cdd:PRK10671   1 MSQTIDLTLdGLSCGHCVKRVKESLEQRPDVEQADVSITEAHVT--GTASAEALIETIKQAGYDAS------------VS 66

                         90       100
                 ....*....|....*....|.
gi 15228869   80 DPKVETVTETKTEAETKTEAK 100
Cdd:PRK10671  67 HPKAKPLTESSIPSEALTAAS 87
HMA pfam00403
Heavy-metal-associated domain;
5-50 1.16e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 45.30  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15228869     5 VVLKVGMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGNVEP 50
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAES 46
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
3-61 2.67e-06

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 44.75  E-value: 2.67e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15228869   3 QTVVLKV-GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTV---KGNVEPEAVFQTVSKTG 61
Cdd:COG2217   1 ERVRLRIeGMTCAACAWLIEKALRKLPGVLSARVNLATERARVeydPGKVSLEELIAAVEKAG 63
PLN02957 PLN02957
copper, zinc superoxide dismutase
 9-63 4.33e-06

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 43.97  E-value: 4.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15228869    9 VGMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGNVEPEAVFQTVSKTGKK 63
Cdd:PLN02957  12 VDMKCEGCVAAVKNKLETLEGVKAVEVDLSNQVVRVLGSSPVKAMTAALEQTGRK 66
copA PRK10671
copper-exporting P-type ATPase CopA;
10-61 8.68e-06

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 43.19  E-value: 8.68e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15228869   10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVKGNVEPEAVFQTVSKTG 61
Cdd:PRK10671 107 GMSCASCVSRVQNALQSVPGVTQARVNLAERTALVMGSASPQDLVQAVEKAG 158
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 10-45 2.40e-03

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 34.05  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15228869    10 GMSCQGCVGAVNRVLGKMEGVESFDIDIKEQKVTVK 45
Cdd:TIGR00003   8 GMSCNHCVDKIEKFVGEIEGVSKVKVQLEKEKVVVE 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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