Shoc2 Shoc2, leucine rich repeat scaffold protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shoc2provided by MGI
Official Full Name: Shoc2, leucine rich repeat scaffold proteinprovided by MGI
Primary source: MGI:MGI:1927197
See related: Ensembl:ENSMUSG00000024976 AllianceGenome:MGI:1927197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sur8; mKIAA0862
Summary: Predicted to enable protein phosphatase 1 binding activity and volume-sensitive anion channel activity. Predicted to be involved in several processes, including cyclic-GMP-AMP transmembrane import across plasma membrane; nerve growth factor signaling pathway; and regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 12.8), placenta adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 48.83 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (53932018..54021711)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (53944232..54033280)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
Title: SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
Title: The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments.
Title: SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling.
Data suggest that SUR-8 may act in an ERK-independent pathway to regulate AVC development.
Title: Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction
Title: Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables volume-sensitive anion channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to growth hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein phosphatase type 1 complex	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat protein SHOC-2

Names: Ras-binding protein SUR-8; protein soc-2 homolog; protein sur-8 homolog; soc-2 (suppressor of clear) homolog; soc-2-like protein; suppressor of clear, C. elegans, homolog of

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168505.1 → NP_001161977.1 leucine-rich repeat protein SHOC-2

See identical proteins and their annotated locations for NP_001161977.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC117612

Consensus CDS

CCDS29904.1

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8

Related

ENSMUSP00000127932.2, ENSMUST00000169861.9

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
NM_001355242.2 → NP_001342171.1 leucine-rich repeat protein SHOC-2

Status: VALIDATED

Source sequence(s)

AC117612

Consensus CDS

CCDS29904.1

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
NM_001414663.1 → NP_001401592.1 leucine-rich repeat protein SHOC-2

Status: VALIDATED

Source sequence(s)

AC117612

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8
NM_001414664.1 → NP_001401593.1 leucine-rich repeat protein SHOC-2

Status: VALIDATED

Source sequence(s)

AC117612

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8
NM_019658.7 → NP_062632.2 leucine-rich repeat protein SHOC-2

See identical proteins and their annotated locations for NP_062632.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC117612

Consensus CDS

CCDS29904.1

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8

Related

ENSMUSP00000025932.8, ENSMUST00000025932.9

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

53932018..54021711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527228.5 → XP_006527291.1 leucine-rich repeat protein SHOC-2 isoform X1

See identical proteins and their annotated locations for XP_006527291.1

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]
XM_036161642.1 → XP_036017535.1 leucine-rich repeat protein SHOC-2 isoform X1

UniProtKB/Swiss-Prot

O88520, Q3UJH6, Q8BVL0, Q91VH8

Conserved Domains (3) summary

PLN03150
Location:453 → 527

PLN03150; hypothetical protein; Provisional

PLN00113
Location:115 → 483

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:240 → 262

LRR_RI; leucine-rich repeat [structural motif]