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Conserved domains on  [gi|31543701|ref|NP_062632|]
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leucine-rich repeat protein SHOC-2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 4.03e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.07  E-value: 4.03e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 194 LTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 31543701 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 4.96e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 4.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 467 IAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 31543701 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 4.03e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.07  E-value: 4.03e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 194 LTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 31543701 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.10e-24

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 109.17  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  194 LTTLYLRFNRIT-TVEKDIKNLPKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  271 NDLLD-LPDTIGNLSSLNRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31543701  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 4.96e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 4.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 467 IAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 31543701 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.77e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 3.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLSTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 31543701 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 5.01e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 5.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLS-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.60e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 5.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543701   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.92e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQLS-----TLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 31543701 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.80e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 4.03e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.07  E-value: 4.03e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 114 ILPPSVKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 194 LTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 274 LDLPDtIGNLSSLNRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 31543701 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
260-556 1.17e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 1.17e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 260 CTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRInkipfgiFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHL 499
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31543701 500 GLGENLLTHLPeEIGTLENLEELYLNDNpNLHSLPFELALcSKLSIMSIENCPLSHL 556
Cdd:COG4886 234 DLSNNQLTDLP-ELGNLTNLEELDLSNN-QLTDLPPLANL-TNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-498 1.12e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.28  E-value: 1.12e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  81 TRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 161 LPDSLDNLKKLRMLDLRHNKLreipsvVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNL 240
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 321 TLPEslLSSLVKLNSLTLARNcfQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 401 WTsMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Cdd:COG4886 318 LL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396

                       410
                ....*....|....*...
gi 31543701 481 NQLSTLPRGIGHLTNLTH 498
Cdd:COG4886 397 TAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
319-557 1.55e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 1.55e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31543701 479 TNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Cdd:COG4886 167 SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-539 1.67e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 1.67e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIR 223
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 224 ENKIKQLPAEIGELCNLITLDVAHNqlehlpKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSL 303
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 304 AKCSAleelnlennnistlpesllsslvklnsltlarncfqlypvggpsqfstiyslnmehnrinkipfgifsrakvLSK 383
Cdd:COG4886 156 GNLTN------------------------------------------------------------------------LKS 163

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701 464 PnEIAYLKDLQKLVLTNNQLSTLPrGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 539
Cdd:COG4886 244 P-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.10e-24

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 109.17  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  194 LTTLYLRFNRIT-TVEKDIKNLPKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  271 NDLLD-LPDTIGNLSSLNRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31543701  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 4.96e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 4.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 467 IAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 31543701 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-543 1.09e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.00  E-value: 1.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  101 NSMR---LDLSKRSIH-ILPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLV-NLMTLALSENSLTSlPDSLDNLKKLRML 174
Cdd:PLN00113  67 NSSRvvsIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG-SIPRGSIPNLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  175 DLRHNKLR-EIPSVVYRLDSLTTLYLRFNRIT-TVEKDIKNLPKLSMLSIRENK-IKQLPAEIGELCNLITLDVAHNQLE 251
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  252 -HLPKEIGNCTQITNLDLQHNDLL-DLPDTIGNLSSLNRLGLRYNRLSA-IPRSLAkcsaleelnlennnistlpeslls 328
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIF------------------------ 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  329 SLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFGIFSRAKvLSKLNMKDNQLT-SLPLDFGTWTSMVE 406
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSgEIPKNLGKHNNLTV 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  407 LNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  484 S-------------------------TLPRGIGHlTNLTHLGLGENLLTH-LPEEIGTLENLEELYLNDNPNLHSLPFEL 537
Cdd:PLN00113 441 QgrinsrkwdmpslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDEL 519


                 ....*.
gi 31543701  538 ALCSKL 543
Cdd:PLN00113 520 SSCKKL 525
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 148-527 5.89e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  148 LMTLALSENSLT-SLPDSLDNL-KKLRMLDLRHNKLR-EIPSvvYRLDSLTTLYLRFNRIT-TVEKDIKNLPKLSMLSIR 223
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  224 ENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQHNDLL-DLPDTIGNLSSLNRLGLRYNRLSA-I 299
Cdd:PLN00113 173 GNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpI 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  300 PRSLAKCSALEELNLENNNIS-TLPESLLsSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFGIFSR 377
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  378 AKvLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKLRELD 454
Cdd:PLN00113 332 PR-LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSLRRVR 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  455 LEENKLE-SLPNEIAYL-----------------------------------------------KDLQKLVLTNNQLS-T 485
Cdd:PLN00113 411 LQDNSFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdmpslqmlslarnkffgglpdsfgsKRLENLDLSRNQFSgA 490

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 31543701  486 LPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 527
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHN 533
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
78-371 4.11e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.38  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   78 APgTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPPSVKEltQLTELYLYSNKLQSLPAEVGClvNLMTLALSENS 157
Cdd:PRK15370 157 AP-AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  158 LTSLPDSLDNlkKLRMLDLRHNKLREIPSvvyRLDS-LTTLYLRFNRITTVEkdiKNLPK-LSMLSIRENKIKQLPaeig 235
Cdd:PRK15370 232 LTSIPATLPD--TIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLP---ENLPEeLRYLSVYDNSIRTLP---- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  236 elcnlitldvahnqlEHLPkeigncTQITNLDLQHNDLLDLPDTIGnlSSLNRLGLRYNRLSAIPRSLAkcSALEELNLE 315
Cdd:PRK15370 300 ---------------AHLP------SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVS 354

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701  316 NNNISTLPESLLSSlvkLNSLTLARNCFQLYPVGGPSQFSTiysLNMEHNRINKIP 371
Cdd:PRK15370 355 KNQITVLPETLPPT---ITTLDVSRNALTNLPENLPAALQI---MQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-414 1.78e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 86.44  E-value: 1.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  115 LPPSVKELTQLTELYL-YSNKLQSLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVVYRL 191
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  192 DSLTTLYLRFNRIT-TVEKDIKNLPKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE------------------ 251
Cdd:PLN00113 308 QNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklil 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  252 -------HLPKEIGNCTQITNLDLQHNDL----------------LD--------------------------------- 275
Cdd:PLN00113 388 fsnslegEIPKSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDisnnnlqgrinsrkwdmpslqmlslarnkffgg 467

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  276 LPDTIGNlSSLNRLGLRYNRLS-AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLnsltlarncfqlypvggpsqf 354
Cdd:PLN00113 468 LPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKL--------------------- 525

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31543701  355 stiYSLNMEHNRIN-KIPFGiFSRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQL 414
Cdd:PLN00113 526 ---VSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.77e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 3.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLSTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 31543701 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 5.01e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 5.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLS-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
262-554 8.09e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.98  E-value: 8.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  262 QITNLDLQHNDLLDLPDTI-GNLSSLNrlgLRYNRLSAIPrslakcsaleelnlennniSTLPESLlsslvklNSLTLAR 340
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP-------------------ATLPDTI-------QEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  341 NCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFGTwtSMVELNLATNQLTKIPED 420
Cdd:PRK15370 251 NRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  421 VSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLTNNQLSTLPRGIGhlTNLTHLG 500
Cdd:PRK15370 323 LP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVSKNQITVLPETLP--PTITTLD 373

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31543701  501 LGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PRK15370 374 VSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
172-448 1.07e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  172 RMLD-LRHNKLReipsvvYRLDSLttlylrfnRITTVEKDIKNlpKLSMLSIRENKIKQLPAEIGelCNLITLDVAHNQL 250
Cdd:PRK15370 171 RMRDcLKNNKTE------LRLKIL--------GLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  251 EHLPKEIGNCTQItnLDLQHNDLLDLPDTIGnlSSLNRLGLRYNRLSAIPRSLAKcsALEELNLENNNISTLPESLLSSL 330
Cdd:PRK15370 233 TSIPATLPDTIQE--MELSINRITELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPSGI 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  331 VKLNsltLARNCFQLYPVGGPSQFSTiysLNMEHNRINKIPFGIFSRAKVLSklnMKDNQLTSLPLDFGtwTSMVELNLA 410
Cdd:PRK15370 307 THLN---VQSNSLTALPETLPPGLKT---LEAGENALTSLPASLPPELQVLD---VSKNQITVLPETLP--PTITTLDVS 375

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 31543701  411 TNQLTKIPEDVSGlvSLEVLILSNNLLKKLPHGLGNLR 448
Cdd:PRK15370 376 RNALTNLPENLPA--ALQIMQASRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-301 9.46e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 9.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 122 LTQLTELYLYSNKLQSLPAEVGCLvNLMTLALSENSLTSLPDsLDNLKKLRMLDLRHNKLREIPSVVyRLDSLTTLYLRF 201
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 202 NRITTVEkDIKNLPKLSMLSI------RENKIKQLPAEIGELCN-LITLDVAHNQLEHLpKEIGNCTQITNLDLQHNDLL 274
Cdd:cd21340  78 NRISVVE-GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                       170       180       190
                ....*....|....*....|....*....|
gi 31543701 275 DLPD---TIGNLSSLNRLGLRYNRLSAIPR 301
Cdd:cd21340 156 DLEElldLLSSWPSLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
73-460 4.96e-13

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 72.12  E-value: 4.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   73 KRPNPAPGTRKKssnAEVIKELNKCREENSMRLDLSKRSIHILPPSVKelTQLTELYLYSNKLQSLPAevgCLVNLMTLA 152
Cdd:PRK15387 177 RRAAPAEESRGR---AAVVQKMRACLNNGNAVLNVGESGLTTLPDCLP--AHITTLVIPDNNLTSLPA---LPPELRTLE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  153 LSENSLTSLPDSLDNLKKLRMLDlrhNKLREIPSVVyrlDSLTTLYLRFNRITTVEKdikNLPKLSMLSIRENKIKQLPA 232
Cdd:PRK15387 249 VSGNQLTSLPVLPPGLLELSIFS---NPLTHLPALP---SGLCKLWIFGNQLTSLPV---LPPGLQELSVSDNQLASLPA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  233 EIGELCNLITLDvahNQLEHLPKeignctqitnldlqhndlldLPdtignlSSLNRLGLRYNRLSAIPrslakcsaleel 312
Cdd:PRK15387 320 LPSELCKLWAYN---NQLTSLPT--------------------LP------SGLQELSVSDNQLASLP------------ 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  313 nlennnisTLPesllsslvklnsltlarncfqlypvggpsqfSTIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLT 392
Cdd:PRK15387 359 --------TLP-------------------------------SELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLT 395

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543701  393 SLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLEVLilsNNLLKKLPHGLGNLRKLRELDLEENKL 460
Cdd:PRK15387 396 SLPV---LPSELKELMVSGNRLTSLPMLPSGLLSLSVY---RNQLTRLPESLIHLSSETTVNLEGNPL 457
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-560 3.90e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 3.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Cdd:COG4886   4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 459 KLESLPNEIAYLKDLQKLVLTNNQlstlprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELA 538
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLG 156

                       170       180
                ....*....|....*....|..
gi 31543701 539 LCSKLSIMSIENCPLSHLPPQI 560
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEEL 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-286 8.42e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 8.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  105 LDLSKRSIHILPPSVKelTQLTELYLYSNKLQSLPAEVGclVNLMTLALSENSLTSLPDSLDnlKKLRMLDLRHNKLREI 184
Cdd:PRK15370 288 LSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  185 PSVVyrLDSLTTLYLRFNRITtvekdikNLPklsmlsirENkikqLPAEigelcnLITLDVAHNQL----EHLPKEIGNC 260
Cdd:PRK15370 362 PETL--PPTITTLDVSRNALT-------NLP--------EN----LPAA------LQIMQASRNNLvrlpESLPHFRGEG 414

                        170       180
                 ....*....|....*....|....*.
gi 31543701  261 TQITNLDLQHNDLLDlpDTIGNLSSL 286
Cdd:PRK15370 415 PQPTRIIVEYNPFSE--RTIQNMQRL 438
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
217-522 1.83e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 64.03  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  217 LSMLSIRENKIKQLPAEIGELcnlITLDVAHNQLEHLPKEIGNctqITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRL 296
Cdd:PRK15387 224 ITTLVIPDNNLTSLPALPPEL---RTLEVSGNQLTSLPVLPPG---LLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  297 SAIPRSLAKCSaleelnlennnistLPESLLSSLVKLnsltlarncfqlypvggPSQFSTIYSLNMEHNRINKIPFGifs 376
Cdd:PRK15387 298 PVLPPGLQELS--------------VSDNQLASLPAL-----------------PSELCKLWAYNNQLTSLPTLPSG--- 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  377 rakvLSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLvslEVLILSNNLLKKLPHGLGnlrKLRELDLE 456
Cdd:PRK15387 344 ----LQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLPALPSGL---KELIVSGNRLTSLPVLPS---ELKELMVS 410

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701  457 ENKLESLPneiAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLpeeigTLENLEEL 522
Cdd:PRK15387 411 GNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSER-----TLQALREI 468
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
243-528 6.57e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.10  E-value: 6.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  243 LDVAHNQLEHLPkeigNC--TQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSaleELNLENNNIS 320
Cdd:PRK15387 206 LNVGESGLTTLP----DClpAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  321 TLPESLLSSLVKLNSLTLarncfqlYPVGGPSqfstIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLTSLPLdfgT 400
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTS-------LPVLPPG----LQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPT---L 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLgnlrklRELDLEENKLESLPneiAYLKDLQKLVLTN 480
Cdd:PRK15387 341 PSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGL------KELIVSGNRLTSLP---VLPSELKELMVSG 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 31543701  481 NQLSTLPRgigHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Cdd:PRK15387 412 NRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
381-557 1.01e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 58.25  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  381 LSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLevLILSNNL--LKKLPHGlgnlrkLRELDLEEN 458
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLTHLPALPSGLCKL--WIFGNQLtsLPVLPPG------LQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  459 KLESLPneiAYLKDLQKLVLTNNQLSTLPRgigHLTNLTHLGLGENLLTHLPeeigTL-ENLEELYLNDNpNLHSLPfel 537
Cdd:PRK15387 313 QLASLP---ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLP----TLpSELYKLWAYNN-RLTSLP--- 378

                        170       180
                 ....*....|....*....|
gi 31543701  538 ALCSKLSIMSIENCPLSHLP 557
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSLP 398
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.60e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 5.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543701   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
147-204 2.32e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   147 NLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVV-YRLDSLTTLYLRFNRI 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.92e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQLS-----TLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 31543701 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.80e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 229-303 2.35e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 2.35e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543701  229 QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQHNDLL-DLPDTIGNLSSLNRLGLRYNRLSA-IPRSL 303
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAAL 510
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 377-560 3.06e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 50.26  E-value: 3.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   377 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL-ATNQLTKIPeDVSGLVSLEVLILSN-NLLKKLPHGLGNLRKLRELD 454
Cdd:PLN03210  609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   455 LEE-NKLESLPNEI-------------AYLK-------DLQKLVLTNNQLSTLPRGIgHLTNLTHLGLGENLLTHLPEEI 513
Cdd:PLN03210  688 MSRcENLEILPTGInlkslyrlnlsgcSRLKsfpdistNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSEKLWERV 766

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31543701   514 GTL--------ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP-LSHLPPQI 560
Cdd:PLN03210  767 QPLtplmtmlsPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGI 822
PLN03150 PLN03150
hypothetical protein; Provisional
 417-491 4.52e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.43  E-value: 4.52e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543701  417 IPEDVSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLS-TLPRGIG 491
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 453-527 1.50e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543701  453 LDLEENKLES-LPNEIAYLKDLQKLVLTNNQL-STLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 527
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
402-460 1.59e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.59e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543701   402 TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKL 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
473-528 2.95e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.95e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31543701   473 LQKLVLTNNQLSTLPRGI-GHLTNLTHLGLGENLLTHL-PEEIGTLENLEELYLNDNP 528
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
448-506 3.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31543701   448 RKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLSTL-PRGIGHLTNLTHLGLGENLL 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 191-458 8.95e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 8.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 191 LDSLTTLYLrfnrittVEKDIKNLPKLSMLsirenkikqlpaeigelCNLITLDVAHNQLEHLPKeIGNCTQITNLDLQH 270
Cdd:cd21340   1 LKRITHLYL-------NDKNITKIDNLSLC-----------------KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQN 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 271 NDLLDLPDtIGNLSSLNRLGLRYNRLSAIprslakcsaleelnlennnistlpeSLLSSLVKLNSLTLARncfQLYPVGG 350
Cdd:cd21340  56 NQIEKIEN-LENLVNLKKLYLGGNRISVV-------------------------EGLENLTNLEELHIEN---QRLPPGE 106

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 351 PSQFStiyslnmehnrinkiPFGIFSRAKVLSKLNMKDNQLTSLpldfgtwtsmvelnlatnqltkipEDVSGLVSLEVL 430
Cdd:cd21340 107 KLTFD---------------PRSLAALSNSLRVLNISGNNIDSL------------------------EPLAPLRNLEQL 147

                       250       260       270
                ....*....|....*....|....*....|.
gi 31543701 431 ILSNNLL---KKLPHGLGNLRKLRELDLEEN 458
Cdd:cd21340 148 DASNNQIsdlEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
193-250 8.95e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 8.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   193 SLTTLYLRFNRITTVEKDI-KNLPKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQL 250
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
170-227 1.93e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701   170 KLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTVEKD-IKNLPKLSMLSIRENKI 227
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 376-445 2.18e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 2.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31543701  376 SRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILSNNLLK-KLPHGLG 445
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 115-188 6.97e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 6.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31543701  115 LPPSVKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVV 188
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 327-507 7.47e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 7.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 327 LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL---NMEHNRINKIPF-----GIFSRAKVLSKLNMKDNQLTS----- 393
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGascea 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701 394 LPLDFGTWTSMVELNLATNQL-----TKIPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLRELDLEENKLESL 463
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDA 236

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31543701 464 PneIAYLKD--------LQKLVLTNNQLS-----TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:cd00116 237 G--AAALASallspnisLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFG 291
PLN03150 PLN03150
hypothetical protein; Provisional
 430-534 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543701  430 LILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLS-TLPRGIGHLTNLTHLGLGENLL 506
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                         90       100       110
                 ....*....|....*....|....*....|.
gi 31543701  507 T-HLPEEIGTLEnLEELYLN--DNPNLHSLP 534
Cdd:PLN03150 503 SgRVPAALGGRL-LHRASFNftDNAGLCGIP 532
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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