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    Tmem108 transmembrane protein 108 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300967, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tmem108provided by RGD
    Official Full Name
    transmembrane protein 108provided by RGD
    Primary source
    RGD:1311530
    See related
    EnsemblRapid:ENSRNOG00000010911 AllianceGenome:RGD:1311530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311530
    Summary
    Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.2), Adrenal (RPKM 9.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem108 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112944925..113238996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104066081..104360172, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111968568..112265623, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550226 Neighboring gene beaded filament structural protein 2 Neighboring gene uncharacterized LOC134480226 Neighboring gene uncharacterized LOC134480225 Neighboring gene uncharacterized LOC134480227 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 7 Neighboring gene uncharacterized LOC102550471 Neighboring gene uncharacterized LOC134479986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. Jiao HF, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096412, Free PMC Article
    2. Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. Xu C, et al. Mol Biol Cell, 2016 Nov 1. PMID 27605705, Free PMC Article
    3. Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Fu X, et al. Mol Biol Cell, 2011 Oct. PMID 21849472, Free PMC Article
    4. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Liu JJ, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17287360, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to brain-derived neurotrophic factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dentate gyrus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic density organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic density organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 108

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399273.1 → NP_001386202.1  transmembrane protein 108 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112944925..113238996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082601.2 → XP_038938529.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    2. XM_039082589.2 → XP_038938517.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    3. XM_008766590.4 → XP_008764812.2  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    4. XM_063265234.1 → XP_063121304.1  transmembrane protein 108 isoform X5

    5. XM_063265233.1 → XP_063121303.1  transmembrane protein 108 isoform X5

    6. XM_039082607.2 → XP_038938535.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    7. XM_039082604.2 → XP_038938532.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Related
      ENSRNOP00000014520.9, ENSRNOT00000014519.9
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    8. XM_039082592.2 → XP_038938520.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    9. XM_063265236.1 → XP_063121306.1  transmembrane protein 108 isoform X5

    10. XM_039082593.2 → XP_038938521.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    11. XM_039082605.2 → XP_038938533.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    12. XM_039082594.2 → XP_038938522.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    13. XM_039082590.2 → XP_038938518.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95 → 607
      TMEM108; TMEM108 family

    14. XM_039082606.2 → XP_038938534.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    15. XM_039082603.2 → XP_038938531.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63 → 575
      TMEM108; TMEM108 family

    16. XM_063265235.1 → XP_063121305.1  transmembrane protein 108 isoform X5

    17. XM_063265232.1 → XP_063121302.1  transmembrane protein 108 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GI14, A6I2K3
      Related
      ENSRNOP00000094794.2, ENSRNOT00000104880.2

    18. XM_063265231.1 → XP_063121301.1  transmembrane protein 108 isoform X3

      UniProtKB/TrEMBL
      A6I2K3
    Nucleotide Protein Strain
    Heading Accession and Version

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