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    Clip1 CAP-GLY domain containing linker protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clip1provided by RGD
    Official Full Name
    CAP-GLY domain containing linker protein 1provided by RGD
    Primary source
    RGD:67404
    See related
    EnsemblRapid:ENSRNOG00000001247 AllianceGenome:RGD:67404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rsn; CLIP-170
    Summary
    Enables microtubule plus-end binding activity. Involved in positive regulation of dendrite development. Located in cytoplasmic microtubule and microtubule plus-end. Orthologous to human CLIP1 (CAP-Gly domain containing linker protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 275.7), Heart (RPKM 149.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clip1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38571533..38678779)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32910932..33017891)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38345203..38452650)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene protein S100-A11-like Neighboring gene uncharacterized LOC134481295 Neighboring gene uncharacterized LOC120095846 Neighboring gene VPS33A core subunit of CORVET and HOPS complexes Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. Sahin U, et al. Blood, 2002 Dec 1. PMID 12433698
    2. CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. Swiech L, et al. J Neurosci, 2011 Mar 23. PMID 21430156, Free PMC Article
    3. Cytoplasmic linker proteins regulate neuronal polarization through microtubule and growth cone dynamics. Neukirchen D, et al. J Neurosci, 2011 Jan 26. PMID 21273437, Free PMC Article
    4. Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. Yang X, et al. J Biol Chem, 2009 Oct 16. PMID 19687009, Free PMC Article
    5. CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1. Hayashi I, et al. Nat Struct Mol Biol, 2007 Oct. PMID 17828275

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We postulate that mTOR controls dendritic arbor morphology by enhancing cross talk between dynamic microtubules and actin through CLIP-170 and IQGAP1
      Title: CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology.
    2. CLIPs enable neuronal polarization by controlling the stabilization of microtubules and growth cone dynamics.
      Title: Cytoplasmic linker proteins regulate neuronal polarization through microtubule and growth cone dynamics.
    3. Cdc2-mediated phosphorylation of CLIP-170 is essential for the normal function of this protein during cell cycle progression
      Title: Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication.
    4. indicating that CLIPs possess an intrinsic affinity for growing microtubule ends, which is enhanced by an interaction with the EBs.
      Title: EB1 and EB3 control CLIP dissociation from the ends of growing microtubules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114234

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport into plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 1
    Names
    cytoplasmic linker protein 170
    restin (Reed-Steinberg cell-espressed intermediate filament-associated protein)
    restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408966.1 → NP_001395895.1  CAP-Gly domain-containing linker protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZNR1
      Related
      ENSRNOP00000079550.2, ENSRNOT00000102474.2

    2. NM_031745.3 → NP_113933.2  CAP-Gly domain-containing linker protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      A0A0G2K3T3, Q9JK25
      UniProtKB/TrEMBL
      F1MAH8
      Related
      ENSRNOP00000093663.2, ENSRNOT00000105680.2
      Conserved Domains (4) summary
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:993 → 1093
      TMPIT; TMPIT-like protein
      pfam10174
      Location:462 → 1135
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:1298 → 1314
      CLIP1_ZNF; CLIP1 zinc knuckle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38571533..38678779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271620.1 → XP_063127690.1  CAP-Gly domain-containing linker protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    2. XM_008769251.4 → XP_008767473.1  CAP-Gly domain-containing linker protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNR1
      Conserved Domains (4) summary
      COG1196
      Location:353 → 1206
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:838 → 1885
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:2171 → 2187
      CLIP1_ZNF; CLIP1 zinc knuckle

    3. XM_008769257.4 → XP_008767479.1  CAP-Gly domain-containing linker protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K681, A0A8I6A7M2
      Related
      ENSRNOP00000073711.2, ENSRNOT00000088002.3
      Conserved Domains (4) summary
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:846 → 976
      TMPIT; TMPIT-like protein
      pfam10174
      Location:473 → 1185
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:1415 → 1431
      CLIP1_ZNF; CLIP1 zinc knuckle

    4. XM_063271639.1 → XP_063127709.1  CAP-Gly domain-containing linker protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A0G2K681

    5. XM_063271627.1 → XP_063127697.1  CAP-Gly domain-containing linker protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    6. XM_063271631.1 → XP_063127701.1  CAP-Gly domain-containing linker protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    7. XM_063271642.1 → XP_063127712.1  CAP-Gly domain-containing linker protein 1 isoform X20

      UniProtKB/TrEMBL
      F1MAH8

    8. XM_063271622.1 → XP_063127692.1  CAP-Gly domain-containing linker protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    9. XM_063271637.1 → XP_063127707.1  CAP-Gly domain-containing linker protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2K681, A0A8I6AFK9

    10. XM_008769258.4 → XP_008767480.1  CAP-Gly domain-containing linker protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K681, A0A8I6AJJ0
      Related
      ENSRNOP00000093783.2, ENSRNOT00000098458.2
      Conserved Domains (4) summary
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:835 → 965
      TMPIT; TMPIT-like protein
      pfam10174
      Location:462 → 1174
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:1404 → 1420
      CLIP1_ZNF; CLIP1 zinc knuckle

    11. XM_063271633.1 → XP_063127703.1  CAP-Gly domain-containing linker protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    12. XM_063271643.1 → XP_063127713.1  CAP-Gly domain-containing linker protein 1 isoform X22

      UniProtKB/TrEMBL
      F1MAH8
      Related
      ENSRNOP00000072766.2, ENSRNOT00000078530.3

    13. XM_039089733.2 → XP_038945661.1  CAP-Gly domain-containing linker protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNR1
      Related
      ENSRNOP00000090148.2, ENSRNOT00000096011.2
      Conserved Domains (5) summary
      COG1196
      Location:351 → 1160
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK11281
      Location:1824 → 2049
      PRK11281; mechanosensitive channel MscK
      TIGR02168
      Location:1001 → 1873
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2125 → 2141
      CLIP1_ZNF; CLIP1 zinc knuckle

    14. XM_008769259.4 → XP_008767481.1  CAP-Gly domain-containing linker protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A0G2K681
      Conserved Domains (4) summary
      TIGR02169
      Location:588 → 1298
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:800 → 930
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1369 → 1385
      CLIP1_ZNF; CLIP1 zinc knuckle

    15. XM_063271632.1 → XP_063127702.1  CAP-Gly domain-containing linker protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    16. XM_039089738.2 → XP_038945666.1  CAP-Gly domain-containing linker protein 1 isoform X21

      UniProtKB/TrEMBL
      F1MAH8
      Conserved Domains (3) summary
      COG1196
      Location:404 → 1173
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1293 → 1309
      CLIP1_ZNF; CLIP1 zinc knuckle

    17. XM_063271634.1 → XP_063127704.1  CAP-Gly domain-containing linker protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    18. XM_063271644.1 → XP_063127714.1  CAP-Gly domain-containing linker protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AKB1, F1MAH8

    19. XM_063271625.1 → XP_063127695.1  CAP-Gly domain-containing linker protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    20. XM_063271635.1 → XP_063127705.1  CAP-Gly domain-containing linker protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    21. XM_063271618.1 → XP_063127688.1  CAP-Gly domain-containing linker protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    22. XM_063271636.1 → XP_063127706.1  CAP-Gly domain-containing linker protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K681, A0A8I6A7M2
      Related
      ENSRNOP00000087368.1, ENSRNOT00000110644.2

    23. XM_063271623.1 → XP_063127693.1  CAP-Gly domain-containing linker protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    24. XM_063271638.1 → XP_063127708.1  CAP-Gly domain-containing linker protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2K681, A0A8I6AFK9
      Related
      ENSRNOP00000092485.1, ENSRNOT00000105301.2

    25. XM_063271640.1 → XP_063127710.1  CAP-Gly domain-containing linker protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A0G2K681

    26. XM_063271619.1 → XP_063127689.1  CAP-Gly domain-containing linker protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    27. XM_063271621.1 → XP_063127691.1  CAP-Gly domain-containing linker protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    28. XM_063271624.1 → XP_063127694.1  CAP-Gly domain-containing linker protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    29. XM_063271626.1 → XP_063127696.1  CAP-Gly domain-containing linker protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    30. XM_063271628.1 → XP_063127698.1  CAP-Gly domain-containing linker protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNR1

    31. XM_063271629.1 → XP_063127699.1  CAP-Gly domain-containing linker protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNR1, A0A8I6GIN2
      Related
      ENSRNOP00000001685.9, ENSRNOT00000001685.9

    32. XM_063271630.1 → XP_063127700.1  CAP-Gly domain-containing linker protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNR1, A0A8I6GIN2

    33. XM_063271641.1 → XP_063127711.1  CAP-Gly domain-containing linker protein 1 isoform X19

    34. XM_063271645.1 → XP_063127715.1  CAP-Gly domain-containing linker protein 1 isoform X24

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK25.2 GenPept UniProtKB/Swiss-Prot:Q9JK25

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