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    LUG transcriptional corepressor LEUNIG [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829390, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LUG
    Official Full Name
    transcriptional corepressor LEUNIG
    Primary source
    TAIR:AT4G32551
    Locus tag
    AT4G32551
    See related
    Araport:AT4G32551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    L23H3.30; L23H3_30; LEUNIG; RON2; ROTUNDA 2
    Summary
    LEUNIG regulates floral organ identity,gynoecium and ovule development. Negatively regulates AGAMOUS . Encodes a glutamine-rich protein with seven WD repeats similar to transcriptional corepressors.
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    Genomic context

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    See LUG in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (15707425..15713662)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ATPase, F0/V0 complex, subunit C protein Neighboring gene uncharacterized protein Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene paramyosin-like protein Neighboring gene TIFY domain protein 8 Neighboring gene Thioredoxin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LEUNIG regulates AGAMOUS expression in Arabidopsis flowers. Liu Z, et al. Development, 1995 Apr. PMID 7743940
    2. LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development. Conner J, et al. Proc Natl Acad Sci U S A, 2000 Nov 7. PMID 11058164, Free PMC Article
    3. The rotunda2 mutants identify a role for the LEUNIG gene in vegetative leaf morphogenesis. Cnops G, et al. J Exp Bot, 2004 Jul. PMID 15208345
    4. LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers. Grigorova B, et al. Development, 2011 Jun. PMID 21610026, Free PMC Article
    5. SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG. Franks RG, et al. Development, 2002 Jan. PMID 11782418

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis.
      Title: The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis.
    2. transcriptional repression and activation mediated by the WOX, LUG and AN3 regulators function in concert to promote leaf and flower development.
      Title: Control of leaf blade outgrowth and floral organ development by LEUNIG, ANGUSTIFOLIA3 and WOX transcriptional regulators.
    3. LUH is allelic to MUM1, and MUM2 is a likely target of LUH regulation. The transcriptional corepressor LEUNIG (LUG) is functionally interchangeable with LUH, raising the possibility that LUH functions as a repressor during seed coat maturation.
      Title: The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release from the Arabidopsis testa.
    4. LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer whorls of Arabidopsis thaliana flowers.
      Title: LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers.
    5. lug mutant seeds but not seu exhibited weak mucilage defects.
      Title: LEUNIG_HOMOLOG and LEUNIG regulate seed mucilage extrusion in Arabidopsis.
    6. YABs interact with LUG and LUH. Together these proteins maintain leaf polarity and meristem activity in Arabidopsis.
      Title: YABBYs and the transcriptional corepressors LEUNIG and LEUNIG_HOMOLOG maintain leaf polarity and meristem activity in Arabidopsis.
    7. Functional diversification between LUH and LUG is evidenced by the inability of 35S::LUH overexpression to rescue lug mutants and by the opposite expression trends of LUG and LUH in response to biotic and abiotic stresses
      Title: LEUNIG_HOMOLOG and LEUNIG perform partially redundant functions during Arabidopsis embryo and floral development.
    8. SEUSS and LEUNIG control blade cell number and vasculature development within the petal and regulate petal polarity along the adaxial/abaxial axis.
      Title: SEUSS and LEUNIG regulate cell proliferation, vascular development and organ polarity in Arabidopsis petals.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203962.1
    NM_119407.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to external biotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galacturonan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meristem maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mucilage extrusion from seed coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mucilage extrusion from seed coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mucilage metabolic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polarity specification of adaxial/abaxial axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of shoot apical meristem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cycloheximide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nematode IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to silver ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional corepressor LEUNIG
    NP_001190891.1
    • LEUNIG (LUG); FUNCTIONS IN: transcription repressor activity, protein heterodimerization activity; INVOLVED IN: flower development, negative regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LEUNIG_homolog (TAIR:AT2G32700.6).
    NP_567896.1
    • LEUNIG (LUG); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LEUNIG_homolog (TAIR:AT2G32700.6); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15707425..15713662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119407.3 → NP_567896.1  transcriptional corepressor LEUNIG [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FUY2, Q9SZY9
      UniProtKB/TrEMBL
      A0A178UVW2, A0A654FVC7
      Conserved Domains (3) summary
      cd00200
      Location:643 → 931
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:654 → 691
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:11 → 35
      LisH

    2. NM_001203962.1 → NP_001190891.1  transcriptional corepressor LEUNIG [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UVW2, F4JUD2
      Conserved Domains (4) summary
      COG2319
      Location:679 → 969
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:681 → 969
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08513
      Location:10 → 36
      LisH; LisH
      sd00039
      Location:692 → 729
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FUY2.2

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