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Conserved domains on  [gi|334187092|ref|NP_001190891|]
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transcriptional corepressor LEUNIG [Arabidopsis thaliana]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10553538)

WD40 domain-containing protein similar to Homo sapiens F-box-like/WD repeat-containing protein TBL1X/TBL1Y/TBL1XR1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 681-969 4.99e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.97  E-value: 4.99e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 681 EVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDA 760
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 761 dNKGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGS---TQIRFQPrVGKYLAASSAN- 836
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSQDg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 837 LVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDM-VKVWTLgtgSEGECVHELSCNGNKFQSCVFHPayPSL 915
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDL---STGKCLGTLRGHENGVNSVAFSP--DGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334187092 916 LVIGCY--QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLWK 969
Cdd:cd00200  233 LLASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 3.48e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 41.53  E-value: 3.48e-05
                          10        20
                  ....*....|....*....|....*
gi 334187092   11 MLDVYIHDYLVKRDLKATAQAFQAE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 681-969 4.99e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.97  E-value: 4.99e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 681 EVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDA 760
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 761 dNKGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGS---TQIRFQPrVGKYLAASSAN- 836
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSQDg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 837 LVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDM-VKVWTLgtgSEGECVHELSCNGNKFQSCVFHPayPSL 915
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDL---STGKCLGTLRGHENGVNSVAFSP--DGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334187092 916 LVIGCY--QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLWK 969
Cdd:cd00200  233 LLASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
664-968 5.95e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.84  E-value: 5.95e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 664 RDAVTRCMDVSKGftfTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQ 743
Cdd:COG2319   98 ADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 744 LRLATSSFDKTVRVWDADNkGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIR-- 821
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRsv 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 822 -FQPRvGKYLAASSA-NLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSED-MVKVWTLGTgseGECVHELSC 898
Cdd:COG2319  253 aFSPD-GRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVRLWDLAT---GKLLRTLTG 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334187092 899 NGNKFQSCVFHPAyPSLLVIGCY-QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:COG2319  329 HTGAVRSVAFSPD-GKTLASGSDdGTVRLWDLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 720-759 6.97e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 6.97e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334187092   720 TMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 688-890 4.90e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 4.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 688 STTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTM--------KPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:PLN00181 482 SSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIikdgrdihYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 760 ADNKgySLRTFMG-HSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINNGSC--TRVYKGGSTQIRFQPRVGKYLAASSAN 836
Cdd:PLN00181 562 VARS--QLVTEMKeHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSigTIKTKANICCVQFPSESGRSLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187092 837 -LVNVLDVETQAIRH-SLQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGTGSEG 890
Cdd:PLN00181 640 hKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISG 695
WD40 pfam00400
WD domain, G-beta repeat;
721-759 1.71e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 334187092  721 MKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 3.48e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 41.53  E-value: 3.48e-05
                          10        20
                  ....*....|....*....|....*
gi 334187092   11 MLDVYIHDYLVKRDLKATAQAFQAE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 10-39 6.71e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.80  E-value: 6.71e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 334187092    10 KMLDVYIHDYLVKRDLKATAQAFQAEGKVS 39
Cdd:smart00667   4 SELNRLILEYLLRNGYEETAETLQKESGLS 33
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 681-969 4.99e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.97  E-value: 4.99e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 681 EVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDA 760
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 761 dNKGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGS---TQIRFQPrVGKYLAASSAN- 836
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSQDg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 837 LVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDM-VKVWTLgtgSEGECVHELSCNGNKFQSCVFHPayPSL 915
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDL---STGKCLGTLRGHENGVNSVAFSP--DGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334187092 916 LVIGCY--QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLWK 969
Cdd:cd00200  233 LLASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
664-968 5.95e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.84  E-value: 5.95e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 664 RDAVTRCMDVSKGftfTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQ 743
Cdd:COG2319   98 ADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 744 LRLATSSFDKTVRVWDADNkGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIR-- 821
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRsv 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 822 -FQPRvGKYLAASSA-NLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSED-MVKVWTLGTgseGECVHELSC 898
Cdd:COG2319  253 aFSPD-GRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVRLWDLAT---GKLLRTLTG 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334187092 899 NGNKFQSCVFHPAyPSLLVIGCY-QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:COG2319  329 HTGAVRSVAFSPD-GKTLASGSDdGTVRLWDLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
678-968 1.26e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 1.26e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 678 TFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRV 757
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 758 WDADNkGYSLRTFMGHSSMVTSLDFHPikD-DLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIR---FQPRvGKYLAAS 833
Cdd:COG2319  147 WDLAT-GKLLRTLTGHSGAVTSVAFSP--DgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRsvaFSPD-GKLLASG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 834 SA-NLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSED-MVKVWTLGTgseGECVHELSCNGNKFQSCVFHPA 911
Cdd:COG2319  223 SAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLAT---GELLRTLTGHSGGVNSVAFSPD 299

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334187092 912 yPSLLVIGCY-QSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:COG2319  300 -GKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
678-886 7.65e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 7.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 678 TFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRV 757
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 758 WDADNkGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIR---FQPrVGKYLAASS 834
Cdd:COG2319  273 WDLAT-GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRsvaFSP-DGKTLASGS 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334187092 835 A-NLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSED-MVKVWTLGT 886
Cdd:COG2319  350 DdGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADgTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
697-968 8.51e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 8.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 697 FSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDADNkGYSLRTFMGHSSM 776
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 777 VTSLDFHPIKDDLIcSCDNDNEIRYWSINNGSCTRVYKGGSTQIR---FQPrVGKYLAASSA-NLVNVLDVETQAIRHSL 852
Cdd:COG2319  123 VRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTsvaFSP-DGKLLASGSDdGTVRLWDLATGKLLRTL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 853 QGHANPINSVCWDPSGDFLASVSED-MVKVWTLGTgseGECVHELSCNGNKFQSCVFHPAYPSLLVIGCYQSLELWNMSE 931
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADgTVRLWDLAT---GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 334187092 932 NKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:COG2319  278 GELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 678-759 1.49e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 678 TFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRV 757
Cdd:cd00200  208 TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 ..
gi 334187092 758 WD 759
Cdd:cd00200  288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
821-968 7.65e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 7.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 821 RFQPRVGKYLAASSANLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDM-VKVWTLGTgseGECVHELSCN 899
Cdd:COG2319   43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGtVRLWDLAT---GLLLRTLTGH 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 900 GNKFQSCVFHPAYPSLLVIGCYQSLELWNMSENKTM-TLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 720-759 6.97e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 6.97e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334187092   720 TMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 688-890 4.90e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 4.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 688 STTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTM--------KPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:PLN00181 482 SSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIikdgrdihYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 760 ADNKgySLRTFMG-HSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINNGSC--TRVYKGGSTQIRFQPRVGKYLAASSAN 836
Cdd:PLN00181 562 VARS--QLVTEMKeHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSigTIKTKANICCVQFPSESGRSLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187092 837 -LVNVLDVETQAIRH-SLQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGTGSEG 890
Cdd:PLN00181 640 hKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISG 695
WD40 pfam00400
WD domain, G-beta repeat;
721-759 1.71e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 334187092  721 MKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWD 759
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 845-882 5.09e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 334187092   845 TQAIRHSLQGHANPINSVCWDPSGDFLASVSED-MVKVW 882
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
850-882 4.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 334187092  850 HSLQGHANPINSVCWDPSGDFLASVSED-MVKVW 882
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 723-806 1.11e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 723 PKTTLEEHTAMITDIRFSP--SQLrLATSSFDKTVRVWDADNKGYSLR-------TFMGHSSMVTSLDFHPIKDDLICSC 793
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEI-LASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|...
gi 334187092 794 DNDNEIRYWSINN 806
Cdd:PTZ00420 145 GFDSFVNIWDIEN 157
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 3.48e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 41.53  E-value: 3.48e-05
                          10        20
                  ....*....|....*....|....*
gi 334187092   11 MLDVYIHDYLVKRDLKATAQAFQAE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 763-803 8.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.06e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 334187092   763 KGYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWS 803
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 930-969 8.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334187092   930 SENKTMTLPAHEGLITSLAVSTATGLVASASHDKLVKLWK 969
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 678-716 8.98e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 334187092   678 TFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLW 716
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
764-803 9.29e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 9.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334187092  764 GYSLRTFMGHSSMVTSLDFHPiKDDLICSCDNDNEIRYWS 803
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 830-920 4.51e-04

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 44.24  E-value: 4.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092  830 LAASSANLVNVLDV---ETQAIRHS-----LQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGT-----GSEGECVHEL 896
Cdd:pfam04762 271 LIASIQRKDDRLDVvffERNGLRHGeftlrLNPAEEKVQSLAWNSDSEVLAVVLEDRVQLWTTGNyhwylKQELYYPQSA 350

                          90       100
                  ....*....|....*....|....
gi 334187092  897 SCNGNKFQscvFHPAYPSLLVIGC 920
Cdd:pfam04762 351 SLAGVFLK---WHPEKPLTLMVGT 371
WD40 pfam00400
WD domain, G-beta repeat;
932-968 5.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 334187092  932 NKTMTLPAHEGLITSLAVSTATGLVASASHDKLVKLW 968
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 10-39 6.71e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.80  E-value: 6.71e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 334187092    10 KMLDVYIHDYLVKRDLKATAQAFQAEGKVS 39
Cdd:smart00667   4 SELNRLILEYLLRNGYEETAETLQKESGLS 33
PTZ00421 PTZ00421
coronin; Provisional
 734-919 8.78e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 8.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 734 ITDIRFSP-SQLRLATSSFDKTVRVWDADNKGYSLRT------FMGHSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINN 806
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187092 807 GSCTRVYKGGSTQI---RFQPRVGKYLAASSANLVNVLDVETQAIRHSLQGHANPINSVC-WDPSGDFLASV-----SED 877
Cdd:PTZ00421 158 GKAVEVIKCHSDQItslEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRClWAKRKDLIITLgcsksQQR 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 334187092 878 MVKVWTLGTGSEGECVHELScngnkfQSC-VFHPAYP---SLLVIG 919
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLD------QSSaLFIPFFDedtNLLYIG 277
WD40 pfam00400
WD domain, G-beta repeat;
679-716 1.23e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 334187092  679 FTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLW 716
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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