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    CETN2 centrin 2 [ Homo sapiens (human) ]

    Gene ID: 1069, updated on 10-Dec-2024

    Summary

    Official Symbol
    CETN2provided by HGNC
    Official Full Name
    centrin 2provided by HGNC
    Primary source
    HGNC:HGNC:1867
    See related
    Ensembl:ENSG00000147400 MIM:300006; AllianceGenome:HGNC:1867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALT; CEN2
    Summary
    Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 47.2), endometrium (RPKM 42.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CETN2 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152826994..152830757, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151093478..151097241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151995538..151999301, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGEA6 divergent transcript Neighboring gene MAGE family member A6 Neighboring gene MAGE family member A4 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:151987738-151988937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21058 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152010347-152010520 Neighboring gene NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152065863-152066363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152070232-152070754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152072629-152073160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30028 Neighboring gene zinc finger protein 185 with LIM domain Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152084281-152084854 Neighboring gene uncharacterized LOC124905237

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed
    Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding  
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables heterotrimeric G-protein binding  
    enables microtubule binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in centriole replication  
    involved_in centriole replication PubMed 
    involved_in mRNA transport  
    involved_in microtubule cytoskeleton organization  
    involved_in mitotic cell cycle PubMed 
    involved_in nucleotide-excision repair  
    involved_in nucleotide-excision repair PubMed 
    involved_in protein transport  
    involved_in regulation of cytokinesis PubMed 
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium  
    part_of XPC complex PubMed 
    located_in apical part of cell  
    is_active_in centriole  
    located_in centriole PubMed 
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in centrosome PubMed 
    located_in ciliary basal body  
    located_in cytosol  
    part_of nuclear pore nuclear basket PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in photoreceptor connecting cilium  
    part_of transcription export complex 2 PubMed 

    General protein information

    Preferred Names
    centrin-2
    Names
    caltractin (20kD calcium-binding protein)
    centrin, EF-hand protein, 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004344.3 → NP_004335.1  centrin-2

      See identical proteins and their annotated locations for NP_004335.1

      Status: REVIEWED

      Source sequence(s)
      U82671, X72964
      Consensus CDS
      CCDS14716.1
      UniProtKB/Swiss-Prot
      B2R4T4, P41208, Q53XW1
      Related
      ENSP00000359300.3, ENST00000370277.5
      Conserved Domains (1) summary
      PTZ00183
      Location:16 → 172
      PTZ00183; centrin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152826994..152830757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791818.1 Reference GRCh38.p14 PATCHES

      Range
      442184..445947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151093478..151097241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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