ATG14 autophagy related 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATG14provided by HGNC
Official Full Name: autophagy related 14provided by HGNC
Primary source: HGNC:HGNC:19962
See related: Ensembl:ENSG00000126775 MIM:613515; AllianceGenome:HGNC:19962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATG14L; BARKOR; KIAA0831
Summary: Enables GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Involved in several processes, including early endosome to late endosome transport; macroautophagy; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Part of phosphatidylinositol 3-kinase complex, class III. Is active in phagophore assembly site. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q22.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (55366391..55411830, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (49572142..49617561, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (55833109..55878548, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
Title: Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
Title: KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
ATG14 plays a critical role in hepatic lipid droplet homeostasis.
Title: ATG14 plays a critical role in hepatic lipid droplet homeostasis.
CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
Title: CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
Title: ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
Title: Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
HIF-1alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
Title: HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
Title: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
[miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
Title: [miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
[MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].
Title: [MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of ATG14 autophagy related 14 homolog (S. cerevisiae, ATG14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64855 (e-PCR)
- UniSTS:57638

RH68681 (e-PCR)
- UniSTS:46672

G35867 (e-PCR)
- UniSTS:57936

G33017 (e-PCR)
- UniSTS:117594

RH103043 (e-PCR)
- UniSTS:97377

D1S1423 (e-PCR)
- UniSTS:149619

RH36905 (e-PCR)
- UniSTS:87932

G35363 (e-PCR)
- UniSTS:57751

D1S3699 (e-PCR)
- UniSTS:474277

SHGC-52499 (e-PCR)
- UniSTS:2488

A009Z21 (e-PCR)
- UniSTS:20935

SHGC-33813 (e-PCR)
- UniSTS:12792

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome membrane docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome membrane docking	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endosome to lysosome transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein complex stability	IC Inferred by Curator more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to mitochondrial depolarisation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in extrinsic component of omegasome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of omegasome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex, class III	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: beclin 1-associated autophagy-related key regulator

Names: ATG14 autophagy related 14 homolog; Beclin 1-Interacting protein; autophagy-related protein 14-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014924.5 → NP_055739.2 beclin 1-associated autophagy-related key regulator

Status: VALIDATED

Source sequence(s)

AA988343, AK131251, AL158801

Consensus CDS

CCDS32087.1

UniProtKB/Swiss-Prot

A6NJE4, A8K9U5, B7ZWP5, O94920, Q32MK7, Q32MK8, Q6ZNE5

Related

ENSP00000247178.5, ENST00000247178.6

Conserved Domains (1) summary

pfam10186
Location:43 → 388

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

55366391..55411830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536563.3 → XP_011534865.1 beclin 1-associated autophagy-related key regulator isoform X1

UniProtKB/Swiss-Prot

Q6ZNE5

Related

ENST00000558189.1

Conserved Domains (1) summary

pfam10186
Location:1 → 275

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14