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    tyn trynity [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354987, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tynprovided by FlyBase
    Official Full Name
    trynityprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284435
    Locus tag
    Dmel_CG17131
    See related
    AllianceGenome:FB:FBgn0284435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17131; CG17131-ORFA; CG17131-ORFB; Dmel\CG17131; EP(X)1421; EP1421; l(1)G0259; P277; SP71; Tyn
    Summary
    Involved in several processes, including apical constriction; cell-matrix adhesion; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in trichome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tyn in Genome Data Viewer
    Location:
    1A1-1A1; 1-0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (140318..200663)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (38595..97667)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 1A Neighboring gene long non-coding RNA:CR45473 Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR43863 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene G9a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trynity controls epidermal barrier function and respiratory tube maturation in Drosophila by modulating apical extracellular matrix nano-patterning. Itakura Y, et al. PLoS One, 2018. PMID 30576352, Free PMC Article
    2. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Chung YD, et al. Neuron, 2001 Feb. PMID 11239432
    3. Trynity models a tube valve in the Drosophila larval airway system. Wang Y, et al. Dev Biol, 2018 May 15. PMID 29518377
    4. Apical cell expansion maintained by Dusky-like establishes a scaffold for corneal lens morphogenesis. Ghosh N, et al. Sci Adv, 2024 Aug 23. PMID 39167639, Free PMC Article
    5. Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila. Lee SK, et al. Nat Commun, 2018 Nov 23. PMID 30470739, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trynity is needed for efficient tracheal gas-filling in Drosophila embryos
      Title: Trynity models a tube valve in the Drosophila larval airway system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 149973-150355 mobile_element_type = transposon:INE-1{}4648
    • Loc: 155425-155930 mobile_element_type = transposon:INE-1{}4654
    • Loc: 158644-158727 mobile_element_type = transposon:INE-1{}4660
    • Loc: 160809-168004 mobile_element_type = transposon:roo{}4733
    • Loc: 168124-168274 mobile_element_type = transposon:INE-1{}4674
    • Loc: 168328-168947 mobile_element_type = transposon:INE-1{}4677
    • Loc: 180078-180176 mobile_element_type = transposon:INE-1{}4678
    • Loc: 180225-180273 mobile_element_type = transposon:INE-1{}4679
    • Loc: 185555-185624 mobile_element_type = transposon:1360{}4749
    • Loc: 192473-192505 mobile_element_type = transposon:INE-1{}4699
    • Loc: 193508-193913 mobile_element_type = transposon:INE-1{}4701
    • Loc: 194144-194188 mobile_element_type = transposon:INE-1{}4702
    • Loc: 195822-196233 mobile_element_type = transposon:INE-1{}4704

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trynity
    Names
    CG17131-PA
    CG17131-PB
    CG17131-PC
    CG17131-PD
    CG17131-PE
    CG17131-PF
    EP1421
    SP71
    lethal (1) G0259
    tyn-PA
    tyn-PB
    tyn-PC
    tyn-PD
    tyn-PE
    tyn-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      140318..200663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382036.1 → NP_001368965.1  trynity, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain

    2. NM_001297801.1 → NP_001284730.1  trynity, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain

    3. NM_001297799.1 → NP_001284728.1  trynity, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain

    4. NM_001297798.1 → NP_001284727.1  trynity, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain

    5. NM_001038726.2 → NP_001033815.1  trynity, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain

    6. NM_001031861.2 → NP_001027032.1  trynity, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS37, Q9U3X0, Q9W5Z0
      Conserved Domains (4) summary
      smart00241
      Location:382 → 598
      ZP; Zona pellucida (ZP) domain
      cd01099
      Location:131 → 210
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00024
      Location:236 → 327
      PAN_1; PAN domain
      pfam14295
      Location:46 → 97
      PAN_4; PAN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS37 Q8MS37

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